RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever
Identifieur interne : 001855 ( Main/Merge ); précédent : 001854; suivant : 001856RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever
Auteurs : Justin J.-L. Wong [Australie] ; Amy Y. M. Au [Australie] ; Dadi Gao [Australie] ; Natalia Pinello [Australie] ; Chau-To Kwok [Australie] ; Annora Thoeng [Australie] ; Katherine A. Lau [Australie] ; Jane E. A. Gordon [Australie] ; Ulf Schmitz [Australie] ; Yue Feng [Australie] ; Trung V. Nguyen [Australie] ; Robert Middleton [Australie] ; Charles G. Bailey [Australie] ; Jeff Holst [Australie] ; John E. J. Rasko [Australie] ; William Ritchie [Australie, France]Source :
- Nucleic Acids Research [ 0305-1048 ] ; 2016.
Descripteurs français
- KwdFr :
- Agranulocytes (cytologie), Agranulocytes (immunologie), Agranulocytes (métabolisme), Analyse de profil d'expression de gènes, Culture primaire de cellules, Facteur de nécrose tumorale alpha (génétique), Facteur de nécrose tumorale alpha (immunologie), Fièvre (anatomopathologie), Fièvre (génétique), Fièvre (immunologie), Humains, Interleukine-6 (génétique), Interleukine-6 (immunologie), Lignée cellulaire, Macrophages (cytologie), Macrophages (immunologie), Petit ARN interférent (génétique), Petit ARN interférent (métabolisme), Protéines de liaison à l'ARN (antagonistes et inhibiteurs), Protéines de liaison à l'ARN (génétique), Protéines de liaison à l'ARN (immunologie), Récepteur de type Toll-2 (génétique), Récepteur de type Toll-2 (immunologie), Récepteur gp130 de cytokines (génétique), Récepteur gp130 de cytokines (immunologie), Récepteur prostaglandine E (génétique), Récepteur prostaglandine E (immunologie), Régulation de l'expression des gènes, Régulation de la température corporelle (génétique), Rétrocontrôle physiologique, Température du corps, Transduction du signal, microARN (génétique), microARN (immunologie).
- MESH :
- anatomopathologie : Fièvre.
- antagonistes et inhibiteurs : Protéines de liaison à l'ARN.
- cytologie : Agranulocytes, Macrophages.
- génétique : Facteur de nécrose tumorale alpha, Fièvre, Interleukine-6, Petit ARN interférent, Protéines de liaison à l'ARN, Récepteur de type Toll-2, Récepteur gp130 de cytokines, Récepteur prostaglandine E, Régulation de la température corporelle, microARN.
- immunologie : Agranulocytes, Facteur de nécrose tumorale alpha, Fièvre, Interleukine-6, Macrophages, Protéines de liaison à l'ARN, Récepteur de type Toll-2, Récepteur gp130 de cytokines, Récepteur prostaglandine E, microARN.
- métabolisme : Agranulocytes, Petit ARN interférent.
- Analyse de profil d'expression de gènes, Culture primaire de cellules, Humains, Lignée cellulaire, Régulation de l'expression des gènes, Rétrocontrôle physiologique, Température du corps, Transduction du signal.
English descriptors
- KwdEn :
- Body Temperature, Body Temperature Regulation (genetics), Cell Line, Cytokine Receptor gp130 (genetics), Cytokine Receptor gp130 (immunology), Feedback, Physiological, Fever (genetics), Fever (immunology), Fever (pathology), Gene Expression Profiling, Gene Expression Regulation, Humans, Interleukin-6 (genetics), Interleukin-6 (immunology), Leukocytes, Mononuclear (cytology), Leukocytes, Mononuclear (immunology), Leukocytes, Mononuclear (metabolism), Macrophages (cytology), Macrophages (immunology), MicroRNAs (genetics), MicroRNAs (immunology), Primary Cell Culture, RNA, Small Interfering (genetics), RNA, Small Interfering (metabolism), RNA-Binding Proteins (antagonists & inhibitors), RNA-Binding Proteins (genetics), RNA-Binding Proteins (immunology), Receptors, Prostaglandin E (genetics), Receptors, Prostaglandin E (immunology), Signal Transduction, Toll-Like Receptor 2 (genetics), Toll-Like Receptor 2 (immunology), Tumor Necrosis Factor-alpha (genetics), Tumor Necrosis Factor-alpha (immunology).
- MESH :
- chemical , antagonists & inhibitors : RNA-Binding Proteins.
- chemical , genetics : Cytokine Receptor gp130, Interleukin-6, MicroRNAs, RNA, Small Interfering, RNA-Binding Proteins, Receptors, Prostaglandin E, Toll-Like Receptor 2, Tumor Necrosis Factor-alpha.
- cytology : Leukocytes, Mononuclear, Macrophages.
- genetics : Body Temperature Regulation, Fever.
- chemical , immunology : Cytokine Receptor gp130, Fever, Interleukin-6, Leukocytes, Mononuclear, Macrophages, MicroRNAs, RNA-Binding Proteins, Receptors, Prostaglandin E, Toll-Like Receptor 2, Tumor Necrosis Factor-alpha.
- metabolism : Leukocytes, Mononuclear, RNA, Small Interfering.
- pathology : Fever.
- Body Temperature, Cell Line, Feedback, Physiological, Gene Expression Profiling, Gene Expression Regulation, Humans, Primary Cell Culture, Signal Transduction.
Abstract
Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls of elevated body temperature are poorly understood. We discovered that the expression of RNA-binding motif protein 3 (RBM3), known to respond to cold stress and to modulate microRNA (miRNA) expression, was reduced in 30 patients with fever, and in THP-1-derived macrophages maintained at a fever-like temperature (40°C). Notably, RBM3 expression is reduced during fever whether or not infection is demonstrable. Reduced RBM3 expression resulted in increased expression of RBM3-targeted temperature-sensitive miRNAs, we termed thermomiRs. ThermomiRs such as miR-142–5p and miR-143 in turn target endogenous pyrogens including
Url:
DOI: 10.1093/nar/gkw041
PubMed: 26825461
PubMed Central: 4824108
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PMC:4824108Le document en format XML
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Nguyen</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Middleton, Robert" sort="Middleton, Robert" uniqKey="Middleton R" first="Robert" last="Middleton">Robert Middleton</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF3">Bioinformatics Laboratory, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Laboratory, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation></author><author><name sortKey="Bailey, Charles G" sort="Bailey, Charles G" uniqKey="Bailey C" first="Charles G." last="Bailey">Charles G. Bailey</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Holst, Jeff" sort="Holst, Jeff" uniqKey="Holst J" first="Jeff" last="Holst">Jeff Holst</name><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF4">Origins of Cancer Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Origins of Cancer Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation></author><author><name sortKey="Rasko, John E J" sort="Rasko, John E J" uniqKey="Rasko J" first="John E. J." last="Rasko">John E. J. Rasko</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF5">Cell and Molecular Therapies, Royal Prince Alfred Hospital, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cell and Molecular Therapies, Royal Prince Alfred Hospital, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation></author><author><name sortKey="Ritchie, William" sort="Ritchie, William" uniqKey="Ritchie W" first="William" last="Ritchie">William Ritchie</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF3">Bioinformatics Laboratory, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Laboratory, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF6">CNRS, UMR 5203, Montpellier 34094, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 5203, Montpellier 34094</wicri:regionArea><wicri:noRegion>34094</wicri:noRegion><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26825461</idno><idno type="pmc">4824108</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824108</idno><idno type="RBID">PMC:4824108</idno><idno type="doi">10.1093/nar/gkw041</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000566</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000566</idno><idno type="wicri:Area/Pmc/Curation">000566</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000566</idno><idno type="wicri:Area/Pmc/Checkpoint">000659</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000659</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002067</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002067</idno><idno type="wicri:Area/PubMed/Curation">002042</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002042</idno><idno type="wicri:Area/PubMed/Checkpoint">002042</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002042</idno><idno type="wicri:Area/Ncbi/Merge">003068</idno><idno type="wicri:Area/Ncbi/Curation">003068</idno><idno type="wicri:Area/Ncbi/Checkpoint">003068</idno><idno type="wicri:doubleKey">0305-1048:2016:Wong J:rbm:regulates:temperature</idno><idno type="wicri:Area/Main/Merge">001855</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever</title><author><name sortKey="Wong, Justin J L" sort="Wong, Justin J L" uniqKey="Wong J" first="Justin J.-L." last="Wong">Justin J.-L. Wong</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Au, Amy Y M" sort="Au, Amy Y M" uniqKey="Au A" first="Amy Y. M." last="Au">Amy Y. M. Au</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Gao, Dadi" sort="Gao, Dadi" uniqKey="Gao D" first="Dadi" last="Gao">Dadi Gao</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF3">Bioinformatics Laboratory, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Laboratory, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation></author><author><name sortKey="Pinello, Natalia" sort="Pinello, Natalia" uniqKey="Pinello N" first="Natalia" last="Pinello">Natalia Pinello</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Kwok, Chau To" sort="Kwok, Chau To" uniqKey="Kwok C" first="Chau-To" last="Kwok">Chau-To Kwok</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Thoeng, Annora" sort="Thoeng, Annora" uniqKey="Thoeng A" first="Annora" last="Thoeng">Annora Thoeng</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Lau, Katherine A" sort="Lau, Katherine A" uniqKey="Lau K" first="Katherine A." last="Lau">Katherine A. Lau</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Gordon, Jane E A" sort="Gordon, Jane E A" uniqKey="Gordon J" first="Jane E. A." last="Gordon">Jane E. A. Gordon</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Schmitz, Ulf" sort="Schmitz, Ulf" uniqKey="Schmitz U" first="Ulf" last="Schmitz">Ulf Schmitz</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Feng, Yue" sort="Feng, Yue" uniqKey="Feng Y" first="Yue" last="Feng">Yue Feng</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Nguyen, Trung V" sort="Nguyen, Trung V" uniqKey="Nguyen T" first="Trung V." last="Nguyen">Trung V. Nguyen</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Middleton, Robert" sort="Middleton, Robert" uniqKey="Middleton R" first="Robert" last="Middleton">Robert Middleton</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF3">Bioinformatics Laboratory, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Laboratory, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation></author><author><name sortKey="Bailey, Charles G" sort="Bailey, Charles G" uniqKey="Bailey C" first="Charles G." last="Bailey">Charles G. Bailey</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Holst, Jeff" sort="Holst, Jeff" uniqKey="Holst J" first="Jeff" last="Holst">Jeff Holst</name><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF4">Origins of Cancer Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Origins of Cancer Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation></author><author><name sortKey="Rasko, John E J" sort="Rasko, John E J" uniqKey="Rasko J" first="John E. J." last="Rasko">John E. J. Rasko</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF5">Cell and Molecular Therapies, Royal Prince Alfred Hospital, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cell and Molecular Therapies, Royal Prince Alfred Hospital, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation></author><author><name sortKey="Ritchie, William" sort="Ritchie, William" uniqKey="Ritchie W" first="William" last="Ritchie">William Ritchie</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="AFF2">Sydney Medical School, University of Sydney, NSW 2006, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF3">Bioinformatics Laboratory, Centenary Institute, Camperdown 2050, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Bioinformatics Laboratory, Centenary Institute, Camperdown 2050</wicri:regionArea><wicri:noRegion>Camperdown 2050</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF6">CNRS, UMR 5203, Montpellier 34094, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 5203, Montpellier 34094</wicri:regionArea><wicri:noRegion>34094</wicri:noRegion><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation></author></analytic><series><title level="j">Nucleic Acids Research</title><idno type="ISSN">0305-1048</idno><idno type="eISSN">1362-4962</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Body Temperature</term><term>Body Temperature Regulation (genetics)</term><term>Cell Line</term><term>Cytokine Receptor gp130 (genetics)</term><term>Cytokine Receptor gp130 (immunology)</term><term>Feedback, Physiological</term><term>Fever (genetics)</term><term>Fever (immunology)</term><term>Fever (pathology)</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation</term><term>Humans</term><term>Interleukin-6 (genetics)</term><term>Interleukin-6 (immunology)</term><term>Leukocytes, Mononuclear (cytology)</term><term>Leukocytes, Mononuclear (immunology)</term><term>Leukocytes, Mononuclear (metabolism)</term><term>Macrophages (cytology)</term><term>Macrophages (immunology)</term><term>MicroRNAs (genetics)</term><term>MicroRNAs (immunology)</term><term>Primary Cell Culture</term><term>RNA, Small Interfering (genetics)</term><term>RNA, Small Interfering (metabolism)</term><term>RNA-Binding Proteins (antagonists & inhibitors)</term><term>RNA-Binding Proteins (genetics)</term><term>RNA-Binding Proteins (immunology)</term><term>Receptors, Prostaglandin E (genetics)</term><term>Receptors, Prostaglandin E (immunology)</term><term>Signal Transduction</term><term>Toll-Like Receptor 2 (genetics)</term><term>Toll-Like Receptor 2 (immunology)</term><term>Tumor Necrosis Factor-alpha (genetics)</term><term>Tumor Necrosis Factor-alpha (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agranulocytes (cytologie)</term><term>Agranulocytes (immunologie)</term><term>Agranulocytes (métabolisme)</term><term>Analyse de profil d'expression de gènes</term><term>Culture primaire de cellules</term><term>Facteur de nécrose tumorale alpha (génétique)</term><term>Facteur de nécrose tumorale alpha (immunologie)</term><term>Fièvre (anatomopathologie)</term><term>Fièvre (génétique)</term><term>Fièvre (immunologie)</term><term>Humains</term><term>Interleukine-6 (génétique)</term><term>Interleukine-6 (immunologie)</term><term>Lignée cellulaire</term><term>Macrophages (cytologie)</term><term>Macrophages (immunologie)</term><term>Petit ARN interférent (génétique)</term><term>Petit ARN interférent (métabolisme)</term><term>Protéines de liaison à l'ARN (antagonistes et inhibiteurs)</term><term>Protéines de liaison à l'ARN (génétique)</term><term>Protéines de liaison à l'ARN (immunologie)</term><term>Récepteur de type Toll-2 (génétique)</term><term>Récepteur de type Toll-2 (immunologie)</term><term>Récepteur gp130 de cytokines (génétique)</term><term>Récepteur gp130 de cytokines (immunologie)</term><term>Récepteur prostaglandine E (génétique)</term><term>Récepteur prostaglandine E (immunologie)</term><term>Régulation de l'expression des gènes</term><term>Régulation de la température corporelle (génétique)</term><term>Rétrocontrôle physiologique</term><term>Température du corps</term><term>Transduction du signal</term><term>microARN (génétique)</term><term>microARN (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>RNA-Binding Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytokine Receptor gp130</term><term>Interleukin-6</term><term>MicroRNAs</term><term>RNA, Small Interfering</term><term>RNA-Binding Proteins</term><term>Receptors, Prostaglandin E</term><term>Toll-Like Receptor 2</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Fièvre</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines de liaison à l'ARN</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Agranulocytes</term><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Leukocytes, Mononuclear</term><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Body Temperature Regulation</term><term>Fever</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term><term>Fièvre</term><term>Interleukine-6</term><term>Petit ARN interférent</term><term>Protéines de liaison à l'ARN</term><term>Récepteur de type Toll-2</term><term>Récepteur gp130 de cytokines</term><term>Récepteur prostaglandine E</term><term>Régulation de la température corporelle</term><term>microARN</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Agranulocytes</term><term>Facteur de nécrose tumorale alpha</term><term>Fièvre</term><term>Interleukine-6</term><term>Macrophages</term><term>Protéines de liaison à l'ARN</term><term>Récepteur de type Toll-2</term><term>Récepteur gp130 de cytokines</term><term>Récepteur prostaglandine E</term><term>microARN</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Cytokine Receptor gp130</term><term>Fever</term><term>Interleukin-6</term><term>Leukocytes, Mononuclear</term><term>Macrophages</term><term>MicroRNAs</term><term>RNA-Binding Proteins</term><term>Receptors, Prostaglandin E</term><term>Toll-Like Receptor 2</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Leukocytes, Mononuclear</term><term>RNA, Small Interfering</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Agranulocytes</term><term>Petit ARN interférent</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Fever</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Body Temperature</term><term>Cell Line</term><term>Feedback, Physiological</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation</term><term>Humans</term><term>Primary Cell Culture</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Culture primaire de cellules</term><term>Humains</term><term>Lignée cellulaire</term><term>Régulation de l'expression des gènes</term><term>Rétrocontrôle physiologique</term><term>Température du corps</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls of elevated body temperature are poorly understood. We discovered that the expression of RNA-binding motif protein 3 (RBM3), known to respond to cold stress and to modulate microRNA (miRNA) expression, was reduced in 30 patients with fever, and in THP-1-derived macrophages maintained at a fever-like temperature (40°C). Notably, RBM3 expression is reduced during fever whether or not infection is demonstrable. Reduced RBM3 expression resulted in increased expression of RBM3-targeted temperature-sensitive miRNAs, we termed thermomiRs. ThermomiRs such as miR-142–5p and miR-143 in turn target endogenous pyrogens including <italic>IL-6, IL6ST, TLR2, PGE2</italic> and <italic>TNF</italic> to complete a negative feedback mechanism, which may be crucial to prevent pathological hyperthermia. Using normal PBMCs that were exogenously exposed to fever-like temperature (40°C), we further demonstrate the trend by which decreased levels of <italic>RBM3</italic> were associated with increased levels of miR-142–5p and miR-143 and <italic>vice versa</italic> over a 24 h time course. Collectively, our results indicate the existence of a negative feedback loop that regulates fever via reduced RBM3 levels and increased expression of miR-142–5p and miR-143.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Leon, L R" uniqKey="Leon L">L.R. Leon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogoina, D" uniqKey="Ogoina D">D. Ogoina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greer, D M" uniqKey="Greer D">D.M. Greer</name></author><author><name sortKey="Funk, S E" uniqKey="Funk S">S.E. 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