AustralieFrV1, PubMed, Curation, bibRecord, 002042

RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever.

Identifieur interne : 002042 ( PubMed/Curation ); précédent : 002041; suivant : 002043

RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever.

Auteurs : Justin J-L Wong [Australie] ; Amy Y M. Au [Australie] ; Dadi Gao [Australie] ; Natalia Pinello [Australie] ; Chau-To Kwok [Australie] ; Annora Thoeng [Australie] ; Katherine A. Lau [Australie] ; Jane E A. Gordon [Australie] ; Ulf Schmitz [Australie] ; Yue Feng [Australie] ; Trung V. Nguyen [Australie] ; Robert Middleton [Australie] ; Charles G. Bailey [Australie] ; Jeff Holst [Australie] ; John E J. Rasko [Australie] ; William Ritchie [France]

Source :

Nucleic acids research [ 1362-4962 ] ; 2016.

RBID : pubmed:26825461

Descripteurs français

English descriptors

KwdEn :
- Body Temperature, Body Temperature Regulation (genetics), Cell Line, Cytokine Receptor gp130 (genetics), Cytokine Receptor gp130 (immunology), Feedback, Physiological, Fever (genetics), Fever (immunology), Fever (pathology), Gene Expression Profiling, Gene Expression Regulation, Humans, Interleukin-6 (genetics), Interleukin-6 (immunology), Leukocytes, Mononuclear (cytology), Leukocytes, Mononuclear (immunology), Leukocytes, Mononuclear (metabolism), Macrophages (cytology), Macrophages (immunology), MicroRNAs (genetics), MicroRNAs (immunology), Primary Cell Culture, RNA, Small Interfering (genetics), RNA, Small Interfering (metabolism), RNA-Binding Proteins (antagonists & inhibitors), RNA-Binding Proteins (genetics), RNA-Binding Proteins (immunology), Receptors, Prostaglandin E (genetics), Receptors, Prostaglandin E (immunology), Signal Transduction, Toll-Like Receptor 2 (genetics), Toll-Like Receptor 2 (immunology), Tumor Necrosis Factor-alpha (genetics), Tumor Necrosis Factor-alpha (immunology).
MESH :
- chemical , antagonists & inhibitors : RNA-Binding Proteins.
- chemical , genetics : Cytokine Receptor gp130, Interleukin-6, MicroRNAs, RNA, Small Interfering, RNA-Binding Proteins, Receptors, Prostaglandin E, Toll-Like Receptor 2, Tumor Necrosis Factor-alpha.
- cytology : Leukocytes, Mononuclear, Macrophages.
- genetics : Body Temperature Regulation, Fever.
- chemical , immunology : Cytokine Receptor gp130, Fever, Interleukin-6, Leukocytes, Mononuclear, Macrophages, MicroRNAs, RNA-Binding Proteins, Receptors, Prostaglandin E, Toll-Like Receptor 2, Tumor Necrosis Factor-alpha.
- metabolism : Leukocytes, Mononuclear, RNA, Small Interfering.
- pathology : Fever.
- Body Temperature, Cell Line, Feedback, Physiological, Gene Expression Profiling, Gene Expression Regulation, Humans, Primary Cell Culture, Signal Transduction.

Abstract

Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls of elevated body temperature are poorly understood. We discovered that the expression of RNA-binding motif protein 3 (RBM3), known to respond to cold stress and to modulate microRNA (miRNA) expression, was reduced in 30 patients with fever, and in THP-1-derived macrophages maintained at a fever-like temperature (40 °C). Notably, RBM3 expression is reduced during fever whether or not infection is demonstrable. Reduced RBM3 expression resulted in increased expression of RBM3-targeted temperature-sensitive miRNAs, we termed thermomiRs. ThermomiRs such as miR-142-5p and miR-143 in turn target endogenous pyrogens including IL-6, IL6ST, TLR2, PGE2 and TNF to complete a negative feedback mechanism, which may be crucial to prevent pathological hyperthermia. Using normal PBMCs that were exogenously exposed to fever-like temperature (40 °C), we further demonstrate the trend by which decreased levels of RBM3 were associated with increased levels of miR-142-5p and miR-143 and vice versa over a 24 h time course. Collectively, our results indicate the existence of a negative feedback loop that regulates fever via reduced RBM3 levels and increased expression of miR-142-5p and miR-143.

DOI: 10.1093/nar/gkw041
PubMed: 26825461

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<author><name sortKey="Thoeng, Annora" sort="Thoeng, Annora" uniqKey="Thoeng A" first="Annora" last="Thoeng">Annora Thoeng</name>
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<author><name sortKey="Lau, Katherine A" sort="Lau, Katherine A" uniqKey="Lau K" first="Katherine A" last="Lau">Katherine A. Lau</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea>
</affiliation>
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<author><name sortKey="Gordon, Jane E A" sort="Gordon, Jane E A" uniqKey="Gordon J" first="Jane E A" last="Gordon">Jane E A. Gordon</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea>
</affiliation>
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<author><name sortKey="Schmitz, Ulf" sort="Schmitz, Ulf" uniqKey="Schmitz U" first="Ulf" last="Schmitz">Ulf Schmitz</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea>
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<author><name sortKey="Feng, Yue" sort="Feng, Yue" uniqKey="Feng Y" first="Yue" last="Feng">Yue Feng</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea>
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<author><name sortKey="Nguyen, Trung V" sort="Nguyen, Trung V" uniqKey="Nguyen T" first="Trung V" last="Nguyen">Trung V. Nguyen</name>
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<wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea>
</affiliation>
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<author><name sortKey="Middleton, Robert" sort="Middleton, Robert" uniqKey="Middleton R" first="Robert" last="Middleton">Robert Middleton</name>
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<country xml:lang="fr">Australie</country>
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</affiliation>
</author>
<author><name sortKey="Bailey, Charles G" sort="Bailey, Charles G" uniqKey="Bailey C" first="Charles G" last="Bailey">Charles G. Bailey</name>
<affiliation wicri:level="1"><nlm:affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006</wicri:regionArea>
</affiliation>
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<author><name sortKey="Holst, Jeff" sort="Holst, Jeff" uniqKey="Holst J" first="Jeff" last="Holst">Jeff Holst</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sydney Medical School, University of Sydney, NSW 2006, Australia Origins of Cancer Program, Centenary Institute, Camperdown 2050</wicri:regionArea>
</affiliation>
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<author><name sortKey="Rasko, John E J" sort="Rasko, John E J" uniqKey="Rasko J" first="John E J" last="Rasko">John E J. Rasko</name>
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<author><name sortKey="Ritchie, William" sort="Ritchie, William" uniqKey="Ritchie W" first="William" last="Ritchie">William Ritchie</name>
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<series><title level="j">Nucleic acids research</title>
<idno type="eISSN">1362-4962</idno>
<imprint><date when="2016" type="published">2016</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Body Temperature</term>
<term>Body Temperature Regulation (genetics)</term>
<term>Cell Line</term>
<term>Cytokine Receptor gp130 (genetics)</term>
<term>Cytokine Receptor gp130 (immunology)</term>
<term>Feedback, Physiological</term>
<term>Fever (genetics)</term>
<term>Fever (immunology)</term>
<term>Fever (pathology)</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Interleukin-6 (genetics)</term>
<term>Interleukin-6 (immunology)</term>
<term>Leukocytes, Mononuclear (cytology)</term>
<term>Leukocytes, Mononuclear (immunology)</term>
<term>Leukocytes, Mononuclear (metabolism)</term>
<term>Macrophages (cytology)</term>
<term>Macrophages (immunology)</term>
<term>MicroRNAs (genetics)</term>
<term>MicroRNAs (immunology)</term>
<term>Primary Cell Culture</term>
<term>RNA, Small Interfering (genetics)</term>
<term>RNA, Small Interfering (metabolism)</term>
<term>RNA-Binding Proteins (antagonists & inhibitors)</term>
<term>RNA-Binding Proteins (genetics)</term>
<term>RNA-Binding Proteins (immunology)</term>
<term>Receptors, Prostaglandin E (genetics)</term>
<term>Receptors, Prostaglandin E (immunology)</term>
<term>Signal Transduction</term>
<term>Toll-Like Receptor 2 (genetics)</term>
<term>Toll-Like Receptor 2 (immunology)</term>
<term>Tumor Necrosis Factor-alpha (genetics)</term>
<term>Tumor Necrosis Factor-alpha (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Agranulocytes (cytologie)</term>
<term>Agranulocytes (immunologie)</term>
<term>Agranulocytes (métabolisme)</term>
<term>Analyse de profil d'expression de gènes</term>
<term>Culture primaire de cellules</term>
<term>Facteur de nécrose tumorale alpha (génétique)</term>
<term>Facteur de nécrose tumorale alpha (immunologie)</term>
<term>Fièvre (anatomopathologie)</term>
<term>Fièvre (génétique)</term>
<term>Fièvre (immunologie)</term>
<term>Humains</term>
<term>Interleukine-6 (génétique)</term>
<term>Interleukine-6 (immunologie)</term>
<term>Lignée cellulaire</term>
<term>Macrophages (cytologie)</term>
<term>Macrophages (immunologie)</term>
<term>Petit ARN interférent (génétique)</term>
<term>Petit ARN interférent (métabolisme)</term>
<term>Protéines de liaison à l'ARN (antagonistes et inhibiteurs)</term>
<term>Protéines de liaison à l'ARN (génétique)</term>
<term>Protéines de liaison à l'ARN (immunologie)</term>
<term>Récepteur de type Toll-2 (génétique)</term>
<term>Récepteur de type Toll-2 (immunologie)</term>
<term>Récepteur gp130 de cytokines (génétique)</term>
<term>Récepteur gp130 de cytokines (immunologie)</term>
<term>Récepteur prostaglandine E (génétique)</term>
<term>Récepteur prostaglandine E (immunologie)</term>
<term>Régulation de l'expression des gènes</term>
<term>Régulation de la température corporelle (génétique)</term>
<term>Rétrocontrôle physiologique</term>
<term>Température du corps</term>
<term>Transduction du signal</term>
<term>microARN (génétique)</term>
<term>microARN (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>RNA-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytokine Receptor gp130</term>
<term>Interleukin-6</term>
<term>MicroRNAs</term>
<term>RNA, Small Interfering</term>
<term>RNA-Binding Proteins</term>
<term>Receptors, Prostaglandin E</term>
<term>Toll-Like Receptor 2</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Fièvre</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines de liaison à l'ARN</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Agranulocytes</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Leukocytes, Mononuclear</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Body Temperature Regulation</term>
<term>Fever</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term>
<term>Fièvre</term>
<term>Interleukine-6</term>
<term>Petit ARN interférent</term>
<term>Protéines de liaison à l'ARN</term>
<term>Récepteur de type Toll-2</term>
<term>Récepteur gp130 de cytokines</term>
<term>Récepteur prostaglandine E</term>
<term>Régulation de la température corporelle</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Agranulocytes</term>
<term>Facteur de nécrose tumorale alpha</term>
<term>Fièvre</term>
<term>Interleukine-6</term>
<term>Macrophages</term>
<term>Protéines de liaison à l'ARN</term>
<term>Récepteur de type Toll-2</term>
<term>Récepteur gp130 de cytokines</term>
<term>Récepteur prostaglandine E</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Cytokine Receptor gp130</term>
<term>Fever</term>
<term>Interleukin-6</term>
<term>Leukocytes, Mononuclear</term>
<term>Macrophages</term>
<term>MicroRNAs</term>
<term>RNA-Binding Proteins</term>
<term>Receptors, Prostaglandin E</term>
<term>Toll-Like Receptor 2</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Leukocytes, Mononuclear</term>
<term>RNA, Small Interfering</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Agranulocytes</term>
<term>Petit ARN interférent</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Fever</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Body Temperature</term>
<term>Cell Line</term>
<term>Feedback, Physiological</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Primary Cell Culture</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Culture primaire de cellules</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Régulation de l'expression des gènes</term>
<term>Rétrocontrôle physiologique</term>
<term>Température du corps</term>
<term>Transduction du signal</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls of elevated body temperature are poorly understood. We discovered that the expression of RNA-binding motif protein 3 (RBM3), known to respond to cold stress and to modulate microRNA (miRNA) expression, was reduced in 30 patients with fever, and in THP-1-derived macrophages maintained at a fever-like temperature (40 °C). Notably, RBM3 expression is reduced during fever whether or not infection is demonstrable. Reduced RBM3 expression resulted in increased expression of RBM3-targeted temperature-sensitive miRNAs, we termed thermomiRs. ThermomiRs such as miR-142-5p and miR-143 in turn target endogenous pyrogens including IL-6, IL6ST, TLR2, PGE2 and TNF to complete a negative feedback mechanism, which may be crucial to prevent pathological hyperthermia. Using normal PBMCs that were exogenously exposed to fever-like temperature (40 °C), we further demonstrate the trend by which decreased levels of RBM3 were associated with increased levels of miR-142-5p and miR-143 and vice versa over a 24 h time course. Collectively, our results indicate the existence of a negative feedback loop that regulates fever via reduced RBM3 levels and increased expression of miR-142-5p and miR-143.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26825461</PMID>
<DateCreated><Year>2016</Year>
<Month>04</Month>
<Day>08</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>08</Month>
<Day>24</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1362-4962</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>44</Volume>
<Issue>6</Issue>
<PubDate><Year>2016</Year>
<Month>Apr</Month>
<Day>07</Day>
</PubDate>
</JournalIssue>
<Title>Nucleic acids research</Title>
<ISOAbbreviation>Nucleic Acids Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever.</ArticleTitle>
<Pagination><MedlinePgn>2888-97</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/nar/gkw041</ELocationID>
<Abstract><AbstractText>Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls of elevated body temperature are poorly understood. We discovered that the expression of RNA-binding motif protein 3 (RBM3), known to respond to cold stress and to modulate microRNA (miRNA) expression, was reduced in 30 patients with fever, and in THP-1-derived macrophages maintained at a fever-like temperature (40 °C). Notably, RBM3 expression is reduced during fever whether or not infection is demonstrable. Reduced RBM3 expression resulted in increased expression of RBM3-targeted temperature-sensitive miRNAs, we termed thermomiRs. ThermomiRs such as miR-142-5p and miR-143 in turn target endogenous pyrogens including IL-6, IL6ST, TLR2, PGE2 and TNF to complete a negative feedback mechanism, which may be crucial to prevent pathological hyperthermia. Using normal PBMCs that were exogenously exposed to fever-like temperature (40 °C), we further demonstrate the trend by which decreased levels of RBM3 were associated with increased levels of miR-142-5p and miR-143 and vice versa over a 24 h time course. Collectively, our results indicate the existence of a negative feedback loop that regulates fever via reduced RBM3 levels and increased expression of miR-142-5p and miR-143.</AbstractText>
<CopyrightInformation>© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wong</LastName>
<ForeName>Justin J-L</ForeName>
<Initials>JJ</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Au</LastName>
<ForeName>Amy Y M</ForeName>
<Initials>AY</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Dadi</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia Bioinformatics Laboratory, Centenary Institute, Camperdown 2050, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pinello</LastName>
<ForeName>Natalia</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kwok</LastName>
<ForeName>Chau-To</ForeName>
<Initials>CT</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thoeng</LastName>
<ForeName>Annora</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lau</LastName>
<ForeName>Katherine A</ForeName>
<Initials>KA</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gordon</LastName>
<ForeName>Jane E A</ForeName>
<Initials>JE</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schmitz</LastName>
<ForeName>Ulf</ForeName>
<Initials>U</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feng</LastName>
<ForeName>Yue</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nguyen</LastName>
<ForeName>Trung V</ForeName>
<Initials>TV</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Middleton</LastName>
<ForeName>Robert</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia Bioinformatics Laboratory, Centenary Institute, Camperdown 2050, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bailey</LastName>
<ForeName>Charles G</ForeName>
<Initials>CG</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holst</LastName>
<ForeName>Jeff</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Sydney Medical School, University of Sydney, NSW 2006, Australia Origins of Cancer Program, Centenary Institute, Camperdown 2050, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rasko</LastName>
<ForeName>John E J</ForeName>
<Initials>JE</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia Cell and Molecular Therapies, Royal Prince Alfred Hospital, Camperdown 2050, Australia j.rasko@centenary.usyd.edu.au.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ritchie</LastName>
<ForeName>William</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown 2050, Australia Sydney Medical School, University of Sydney, NSW 2006, Australia Bioinformatics Laboratory, Centenary Institute, Camperdown 2050, Australia CNRS, UMR 5203, Montpellier 34094, France william.ritchie@igf.cnrs.fr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>01</Month>
<Day>28</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nucleic Acids Res</MedlineTA>
<NlmUniqueID>0411011</NlmUniqueID>
<ISSNLinking>0305-1048</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C508600">IL6 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C494199">IL6ST protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015850">Interleukin-6</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C555159">MIRN142 microRNA, human</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C542359">MIRN143 microRNA, human</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D035683">MicroRNAs</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D034741">RNA, Small Interfering</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016601">RNA-Binding Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018078">Receptors, Prostaglandin E</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C495342">TLR2 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C439524">TNF protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051195">Toll-Like Receptor 2</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance>
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<Chemical><RegistryNumber>133483-10-0</RegistryNumber>
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<CitationSubset>IM</CitationSubset>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D001831" MajorTopicYN="N">Body Temperature</DescriptorName>
</MeshHeading>
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   |texte=   RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever.
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	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever.

RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever.

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