δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails
Identifieur interne : 002621 ( Main/Exploration ); précédent : 002620; suivant : 002622δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails
Auteurs : Ai-Hua Jin [Australie] ; Mathilde R. Israel [Australie] ; Marco C. Inserra [Australie] ; Jennifer J. Smith [Australie] ; Richard J. Lewis [Australie] ; Paul F. Alewood [Australie] ; Irina Vetter [Australie] ; Sébastien Dutertre [Australie, France]Source :
- Proceedings of the Royal Society B: Biological Sciences [ 0962-8452 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Conotoxines, Conus.
- métabolisme : Conotoxines.
- pharmacologie : Conotoxines.
- physiologie : Conus, Souris.
- Alignement de séquences, Animaux, Comportement prédateur, Douleur, Mâle, Souris de lignée C57BL, Séquence d'acides aminés, Évolution biologique.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Conotoxins.
- chemical , metabolism : Conotoxins.
- chemical , pharmacology : Conotoxins.
- genetics : Conus Snail.
- physiology : Conus Snail, Mice.
- Amino Acid Sequence, Animals, Biological Evolution, Male, Mice, Inbred C57BL, Pain, Predatory Behavior, Sequence Alignment.
Abstract
Some venomous cone snails feed on small fishes using an immobilizing combination of synergistic venom peptides that target Kv and Nav channels. As part of this envenomation strategy, δ-conotoxins are potent ichtyotoxins that enhance Nav channel function. δ-Conotoxins belong to an ancient and widely distributed gene superfamily, but any evolutionary link from ancestral worm-eating cone snails to modern piscivorous species has not been elucidated. Here, we report the discovery of SuVIA, a potent vertebrate-active δ-conotoxin characterized from a vermivorous cone snail (
Url:
DOI: 10.1098/rspb.2015.0817
PubMed: 26156767
PubMed Central: 4528551
Affiliations:
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Le document en format XML
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<series><title level="j">Proceedings of the Royal Society B: Biological Sciences</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Biological Evolution</term>
<term>Conotoxins (genetics)</term>
<term>Conotoxins (metabolism)</term>
<term>Conotoxins (pharmacology)</term>
<term>Conus Snail (genetics)</term>
<term>Conus Snail (physiology)</term>
<term>Male</term>
<term>Mice (physiology)</term>
<term>Mice, Inbred C57BL</term>
<term>Pain</term>
<term>Predatory Behavior</term>
<term>Sequence Alignment</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term>
<term>Animaux</term>
<term>Comportement prédateur</term>
<term>Conotoxines (génétique)</term>
<term>Conotoxines (métabolisme)</term>
<term>Conotoxines (pharmacologie)</term>
<term>Conus (génétique)</term>
<term>Conus (physiologie)</term>
<term>Douleur</term>
<term>Mâle</term>
<term>Souris (physiologie)</term>
<term>Souris de lignée C57BL</term>
<term>Séquence d'acides aminés</term>
<term>Évolution biologique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Conotoxins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Conotoxins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Conotoxins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Conus Snail</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Conotoxines</term>
<term>Conus</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Conotoxines</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Conotoxines</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Conus</term>
<term>Souris</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Conus Snail</term>
<term>Mice</term>
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<term>Biological Evolution</term>
<term>Male</term>
<term>Mice, Inbred C57BL</term>
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<term>Sequence Alignment</term>
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<term>Comportement prédateur</term>
<term>Douleur</term>
<term>Mâle</term>
<term>Souris de lignée C57BL</term>
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<front><div type="abstract" xml:lang="en"><p>Some venomous cone snails feed on small fishes using an immobilizing combination of synergistic venom peptides that target K<sub>v</sub>
and Na<sub>v</sub>
channels. As part of this envenomation strategy, δ-conotoxins are potent ichtyotoxins that enhance Na<sub>v</sub>
channel function. δ-Conotoxins belong to an ancient and widely distributed gene superfamily, but any evolutionary link from ancestral worm-eating cone snails to modern piscivorous species has not been elucidated. Here, we report the discovery of SuVIA, a potent vertebrate-active δ-conotoxin characterized from a vermivorous cone snail (<italic>Conus suturatus</italic>
). SuVIA is equipotent at hNa<sub>V</sub>
1.3, hNa<sub>V</sub>
1.4 and hNa<sub>V</sub>
1.6 with EC<sub>50</sub>
s in the low nanomolar range. SuVIA also increased peak hNa<sub>V</sub>
1.7 current by approximately 75% and shifted the voltage-dependence of activation to more hyperpolarized potentials from –15 mV to –25 mV, with little effect on the voltage-dependence of inactivation. Interestingly, the proximal venom gland expression and pain-inducing effect of SuVIA in mammals suggest that δ-conotoxins in vermivorous cone snails play a defensive role against higher order vertebrates. We propose that δ-conotoxins originally evolved in ancestral vermivorous cones to defend against larger predators including fishes have been repurposed to facilitate a shift to piscivorous behaviour, suggesting an unexpected underlying mechanism for this remarkable evolutionary transition.</p>
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<name sortKey="Inserra, Marco C" sort="Inserra, Marco C" uniqKey="Inserra M" first="Marco C." last="Inserra">Marco C. Inserra</name>
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<name sortKey="Vetter, Irina" sort="Vetter, Irina" uniqKey="Vetter I" first="Irina" last="Vetter">Irina Vetter</name>
<name sortKey="Vetter, Irina" sort="Vetter, Irina" uniqKey="Vetter I" first="Irina" last="Vetter">Irina Vetter</name>
</country>
<country name="France"><noRegion><name sortKey="Dutertre, Sebastien" sort="Dutertre, Sebastien" uniqKey="Dutertre S" first="Sébastien" last="Dutertre">Sébastien Dutertre</name>
</noRegion>
</country>
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