δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails
Identifieur interne : 002816 ( Ncbi/Merge ); précédent : 002815; suivant : 002817δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails
Auteurs : Ai-Hua Jin [Australie] ; Mathilde R. Israel [Australie] ; Marco C. Inserra [Australie] ; Jennifer J. Smith [Australie] ; Richard J. Lewis [Australie] ; Paul F. Alewood [Australie] ; Irina Vetter [Australie] ; Sébastien Dutertre [Australie, France]Source :
- Proceedings of the Royal Society B: Biological Sciences [ 0962-8452 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Conotoxines, Conus.
- métabolisme : Conotoxines.
- pharmacologie : Conotoxines.
- physiologie : Conus, Souris.
- Alignement de séquences, Animaux, Comportement prédateur, Douleur, Mâle, Souris de lignée C57BL, Séquence d'acides aminés, Évolution biologique.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Conotoxins.
- chemical , metabolism : Conotoxins.
- chemical , pharmacology : Conotoxins.
- genetics : Conus Snail.
- physiology : Conus Snail, Mice.
- Amino Acid Sequence, Animals, Biological Evolution, Male, Mice, Inbred C57BL, Pain, Predatory Behavior, Sequence Alignment.
Abstract
Some venomous cone snails feed on small fishes using an immobilizing combination of synergistic venom peptides that target Kv and Nav channels. As part of this envenomation strategy, δ-conotoxins are potent ichtyotoxins that enhance Nav channel function. δ-Conotoxins belong to an ancient and widely distributed gene superfamily, but any evolutionary link from ancestral worm-eating cone snails to modern piscivorous species has not been elucidated. Here, we report the discovery of SuVIA, a potent vertebrate-active δ-conotoxin characterized from a vermivorous cone snail (
Url:
DOI: 10.1098/rspb.2015.0817
PubMed: 26156767
PubMed Central: 4528551
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000219
- to stream Pmc, to step Curation: 000219
- to stream Pmc, to step Checkpoint: 000C24
- to stream PubMed, to step Corpus: 002B43
- to stream PubMed, to step Curation: 002A71
- to stream PubMed, to step Checkpoint: 002A71
Links to Exploration step
PMC:4528551Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails</title>
<author><name sortKey="Jin, Ai Hua" sort="Jin, Ai Hua" uniqKey="Jin A" first="Ai-Hua" last="Jin">Ai-Hua Jin</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Israel, Mathilde R" sort="Israel, Mathilde R" uniqKey="Israel M" first="Mathilde R." last="Israel">Mathilde R. Israel</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Inserra, Marco C" sort="Inserra, Marco C" uniqKey="Inserra M" first="Marco C." last="Inserra">Marco C. Inserra</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>The School of Pharmacy</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>Woolloongabba, Queensland 4102</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smith, Jennifer J" sort="Smith, Jennifer J" uniqKey="Smith J" first="Jennifer J." last="Smith">Jennifer J. Smith</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lewis, Richard J" sort="Lewis, Richard J" uniqKey="Lewis R" first="Richard J." last="Lewis">Richard J. Lewis</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alewood, Paul F" sort="Alewood, Paul F" uniqKey="Alewood P" first="Paul F." last="Alewood">Paul F. Alewood</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vetter, Irina" sort="Vetter, Irina" uniqKey="Vetter I" first="Irina" last="Vetter">Irina Vetter</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>The School of Pharmacy</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>Woolloongabba, Queensland 4102</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dutertre, Sebastien" sort="Dutertre, Sebastien" uniqKey="Dutertre S" first="Sébastien" last="Dutertre">Sébastien Dutertre</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Institut des Biomolécules Max Mousseron, UMR 5247</addr-line>
,<institution>Université Montpellier - CNRS</institution>
,<addr-line>Place Eugène Bataillon, Montpellier Cedex 5 34095</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26156767</idno>
<idno type="pmc">4528551</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528551</idno>
<idno type="RBID">PMC:4528551</idno>
<idno type="doi">10.1098/rspb.2015.0817</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000219</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000219</idno>
<idno type="wicri:Area/Pmc/Curation">000219</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000219</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C24</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C24</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">002B43</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B43</idno>
<idno type="wicri:Area/PubMed/Curation">002A71</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002A71</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002A71</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002A71</idno>
<idno type="wicri:Area/Ncbi/Merge">002816</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails</title>
<author><name sortKey="Jin, Ai Hua" sort="Jin, Ai Hua" uniqKey="Jin A" first="Ai-Hua" last="Jin">Ai-Hua Jin</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Israel, Mathilde R" sort="Israel, Mathilde R" uniqKey="Israel M" first="Mathilde R." last="Israel">Mathilde R. Israel</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Inserra, Marco C" sort="Inserra, Marco C" uniqKey="Inserra M" first="Marco C." last="Inserra">Marco C. Inserra</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>The School of Pharmacy</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>Woolloongabba, Queensland 4102</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smith, Jennifer J" sort="Smith, Jennifer J" uniqKey="Smith J" first="Jennifer J." last="Smith">Jennifer J. Smith</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lewis, Richard J" sort="Lewis, Richard J" uniqKey="Lewis R" first="Richard J." last="Lewis">Richard J. Lewis</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alewood, Paul F" sort="Alewood, Paul F" uniqKey="Alewood P" first="Paul F." last="Alewood">Paul F. Alewood</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vetter, Irina" sort="Vetter, Irina" uniqKey="Vetter I" first="Irina" last="Vetter">Irina Vetter</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>The School of Pharmacy</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>Woolloongabba, Queensland 4102</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dutertre, Sebastien" sort="Dutertre, Sebastien" uniqKey="Dutertre S" first="Sébastien" last="Dutertre">Sébastien Dutertre</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Institut des Biomolécules Max Mousseron, UMR 5247</addr-line>
,<institution>Université Montpellier - CNRS</institution>
,<addr-line>Place Eugène Bataillon, Montpellier Cedex 5 34095</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the Royal Society B: Biological Sciences</title>
<idno type="ISSN">0962-8452</idno>
<idno type="eISSN">1471-2954</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Biological Evolution</term>
<term>Conotoxins (genetics)</term>
<term>Conotoxins (metabolism)</term>
<term>Conotoxins (pharmacology)</term>
<term>Conus Snail (genetics)</term>
<term>Conus Snail (physiology)</term>
<term>Male</term>
<term>Mice (physiology)</term>
<term>Mice, Inbred C57BL</term>
<term>Pain</term>
<term>Predatory Behavior</term>
<term>Sequence Alignment</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term>
<term>Animaux</term>
<term>Comportement prédateur</term>
<term>Conotoxines (génétique)</term>
<term>Conotoxines (métabolisme)</term>
<term>Conotoxines (pharmacologie)</term>
<term>Conus (génétique)</term>
<term>Conus (physiologie)</term>
<term>Douleur</term>
<term>Mâle</term>
<term>Souris (physiologie)</term>
<term>Souris de lignée C57BL</term>
<term>Séquence d'acides aminés</term>
<term>Évolution biologique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Conotoxins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Conotoxins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Conotoxins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Conus Snail</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Conotoxines</term>
<term>Conus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Conotoxines</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Conotoxines</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Conus</term>
<term>Souris</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Conus Snail</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Biological Evolution</term>
<term>Male</term>
<term>Mice, Inbred C57BL</term>
<term>Pain</term>
<term>Predatory Behavior</term>
<term>Sequence Alignment</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term>
<term>Animaux</term>
<term>Comportement prédateur</term>
<term>Douleur</term>
<term>Mâle</term>
<term>Souris de lignée C57BL</term>
<term>Séquence d'acides aminés</term>
<term>Évolution biologique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Some venomous cone snails feed on small fishes using an immobilizing combination of synergistic venom peptides that target K<sub>v</sub>
and Na<sub>v</sub>
channels. As part of this envenomation strategy, δ-conotoxins are potent ichtyotoxins that enhance Na<sub>v</sub>
channel function. δ-Conotoxins belong to an ancient and widely distributed gene superfamily, but any evolutionary link from ancestral worm-eating cone snails to modern piscivorous species has not been elucidated. Here, we report the discovery of SuVIA, a potent vertebrate-active δ-conotoxin characterized from a vermivorous cone snail (<italic>Conus suturatus</italic>
). SuVIA is equipotent at hNa<sub>V</sub>
1.3, hNa<sub>V</sub>
1.4 and hNa<sub>V</sub>
1.6 with EC<sub>50</sub>
s in the low nanomolar range. SuVIA also increased peak hNa<sub>V</sub>
1.7 current by approximately 75% and shifted the voltage-dependence of activation to more hyperpolarized potentials from –15 mV to –25 mV, with little effect on the voltage-dependence of inactivation. Interestingly, the proximal venom gland expression and pain-inducing effect of SuVIA in mammals suggest that δ-conotoxins in vermivorous cone snails play a defensive role against higher order vertebrates. We propose that δ-conotoxins originally evolved in ancestral vermivorous cones to defend against larger predators including fishes have been repurposed to facilitate a shift to piscivorous behaviour, suggesting an unexpected underlying mechanism for this remarkable evolutionary transition.</p>
</div>
</front>
</TEI>
<double pmid="26156767"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails</title>
<author><name sortKey="Jin, Ai Hua" sort="Jin, Ai Hua" uniqKey="Jin A" first="Ai-Hua" last="Jin">Ai-Hua Jin</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Israel, Mathilde R" sort="Israel, Mathilde R" uniqKey="Israel M" first="Mathilde R." last="Israel">Mathilde R. Israel</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Inserra, Marco C" sort="Inserra, Marco C" uniqKey="Inserra M" first="Marco C." last="Inserra">Marco C. Inserra</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>The School of Pharmacy</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>Woolloongabba, Queensland 4102</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smith, Jennifer J" sort="Smith, Jennifer J" uniqKey="Smith J" first="Jennifer J." last="Smith">Jennifer J. Smith</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lewis, Richard J" sort="Lewis, Richard J" uniqKey="Lewis R" first="Richard J." last="Lewis">Richard J. Lewis</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alewood, Paul F" sort="Alewood, Paul F" uniqKey="Alewood P" first="Paul F." last="Alewood">Paul F. Alewood</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vetter, Irina" sort="Vetter, Irina" uniqKey="Vetter I" first="Irina" last="Vetter">Irina Vetter</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>The School of Pharmacy</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>Woolloongabba, Queensland 4102</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dutertre, Sebastien" sort="Dutertre, Sebastien" uniqKey="Dutertre S" first="Sébastien" last="Dutertre">Sébastien Dutertre</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Institut des Biomolécules Max Mousseron, UMR 5247</addr-line>
,<institution>Université Montpellier - CNRS</institution>
,<addr-line>Place Eugène Bataillon, Montpellier Cedex 5 34095</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26156767</idno>
<idno type="pmc">4528551</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528551</idno>
<idno type="RBID">PMC:4528551</idno>
<idno type="doi">10.1098/rspb.2015.0817</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000219</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000219</idno>
<idno type="wicri:Area/Pmc/Curation">000219</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000219</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C24</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C24</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails</title>
<author><name sortKey="Jin, Ai Hua" sort="Jin, Ai Hua" uniqKey="Jin A" first="Ai-Hua" last="Jin">Ai-Hua Jin</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Israel, Mathilde R" sort="Israel, Mathilde R" uniqKey="Israel M" first="Mathilde R." last="Israel">Mathilde R. Israel</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Inserra, Marco C" sort="Inserra, Marco C" uniqKey="Inserra M" first="Marco C." last="Inserra">Marco C. Inserra</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>The School of Pharmacy</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>Woolloongabba, Queensland 4102</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smith, Jennifer J" sort="Smith, Jennifer J" uniqKey="Smith J" first="Jennifer J." last="Smith">Jennifer J. Smith</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lewis, Richard J" sort="Lewis, Richard J" uniqKey="Lewis R" first="Richard J." last="Lewis">Richard J. Lewis</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alewood, Paul F" sort="Alewood, Paul F" uniqKey="Alewood P" first="Paul F." last="Alewood">Paul F. Alewood</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vetter, Irina" sort="Vetter, Irina" uniqKey="Vetter I" first="Irina" last="Vetter">Irina Vetter</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>The School of Pharmacy</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>Woolloongabba, Queensland 4102</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dutertre, Sebastien" sort="Dutertre, Sebastien" uniqKey="Dutertre S" first="Sébastien" last="Dutertre">Sébastien Dutertre</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>The Institute for Molecular Bioscience</addr-line>
,<institution>The University of Queensland</institution>
,<addr-line>St Lucia, Queensland 4072</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Institut des Biomolécules Max Mousseron, UMR 5247</addr-line>
,<institution>Université Montpellier - CNRS</institution>
,<addr-line>Place Eugène Bataillon, Montpellier Cedex 5 34095</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the Royal Society B: Biological Sciences</title>
<idno type="ISSN">0962-8452</idno>
<idno type="eISSN">1471-2954</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Some venomous cone snails feed on small fishes using an immobilizing combination of synergistic venom peptides that target K<sub>v</sub>
and Na<sub>v</sub>
channels. As part of this envenomation strategy, δ-conotoxins are potent ichtyotoxins that enhance Na<sub>v</sub>
channel function. δ-Conotoxins belong to an ancient and widely distributed gene superfamily, but any evolutionary link from ancestral worm-eating cone snails to modern piscivorous species has not been elucidated. Here, we report the discovery of SuVIA, a potent vertebrate-active δ-conotoxin characterized from a vermivorous cone snail (<italic>Conus suturatus</italic>
). SuVIA is equipotent at hNa<sub>V</sub>
1.3, hNa<sub>V</sub>
1.4 and hNa<sub>V</sub>
1.6 with EC<sub>50</sub>
s in the low nanomolar range. SuVIA also increased peak hNa<sub>V</sub>
1.7 current by approximately 75% and shifted the voltage-dependence of activation to more hyperpolarized potentials from –15 mV to –25 mV, with little effect on the voltage-dependence of inactivation. Interestingly, the proximal venom gland expression and pain-inducing effect of SuVIA in mammals suggest that δ-conotoxins in vermivorous cone snails play a defensive role against higher order vertebrates. We propose that δ-conotoxins originally evolved in ancestral vermivorous cones to defend against larger predators including fishes have been repurposed to facilitate a shift to piscivorous behaviour, suggesting an unexpected underlying mechanism for this remarkable evolutionary transition.</p>
</div>
</front>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails.</title>
<author><name sortKey="Jin, Ai Hua" sort="Jin, Ai Hua" uniqKey="Jin A" first="Ai-Hua" last="Jin">Ai-Hua Jin</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea>
<wicri:noRegion>Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Israel, Mathilde R" sort="Israel, Mathilde R" uniqKey="Israel M" first="Mathilde R" last="Israel">Mathilde R. Israel</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea>
<wicri:noRegion>Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Inserra, Marco C" sort="Inserra, Marco C" uniqKey="Inserra M" first="Marco C" last="Inserra">Marco C. Inserra</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia The School of Pharmacy, The University of Queensland, Woolloongabba, Queensland 4102, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia The School of Pharmacy, The University of Queensland, Woolloongabba, Queensland 4102</wicri:regionArea>
<wicri:noRegion>Queensland 4102</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smith, Jennifer J" sort="Smith, Jennifer J" uniqKey="Smith J" first="Jennifer J" last="Smith">Jennifer J. Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea>
<wicri:noRegion>Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lewis, Richard J" sort="Lewis, Richard J" uniqKey="Lewis R" first="Richard J" last="Lewis">Richard J. Lewis</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea>
<wicri:noRegion>Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alewood, Paul F" sort="Alewood, Paul F" uniqKey="Alewood P" first="Paul F" last="Alewood">Paul F. Alewood</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea>
<wicri:noRegion>Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vetter, Irina" sort="Vetter, Irina" uniqKey="Vetter I" first="Irina" last="Vetter">Irina Vetter</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia The School of Pharmacy, The University of Queensland, Woolloongabba, Queensland 4102, Australia i.vetter@uq.edu.au.</nlm:affiliation>
<country wicri:rule="url">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia The School of Pharmacy, The University of Queensland, Woolloongabba, Queensland 4102</wicri:regionArea>
<wicri:noRegion>Queensland 4102</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dutertre, Sebastien" sort="Dutertre, Sebastien" uniqKey="Dutertre S" first="Sébastien" last="Dutertre">Sébastien Dutertre</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia Institut des Biomolécules Max Mousseron, UMR 5247, Université Montpellier - CNRS, Place Eugène Bataillon, Montpellier Cedex 5 34095, France sebastien.dutertre@univ-montp2.fr.</nlm:affiliation>
<country wicri:rule="url">France</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia Institut des Biomolécules Max Mousseron, UMR 5247, Université Montpellier - CNRS, Place Eugène Bataillon, Montpellier Cedex 5 34095</wicri:regionArea>
<wicri:noRegion>34095</wicri:noRegion>
<wicri:noRegion>34095</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:26156767</idno>
<idno type="pmid">26156767</idno>
<idno type="doi">10.1098/rspb.2015.0817</idno>
<idno type="wicri:Area/PubMed/Corpus">002B43</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B43</idno>
<idno type="wicri:Area/PubMed/Curation">002A71</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002A71</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002A71</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002A71</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails.</title>
<author><name sortKey="Jin, Ai Hua" sort="Jin, Ai Hua" uniqKey="Jin A" first="Ai-Hua" last="Jin">Ai-Hua Jin</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea>
<wicri:noRegion>Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Israel, Mathilde R" sort="Israel, Mathilde R" uniqKey="Israel M" first="Mathilde R" last="Israel">Mathilde R. Israel</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea>
<wicri:noRegion>Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Inserra, Marco C" sort="Inserra, Marco C" uniqKey="Inserra M" first="Marco C" last="Inserra">Marco C. Inserra</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia The School of Pharmacy, The University of Queensland, Woolloongabba, Queensland 4102, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia The School of Pharmacy, The University of Queensland, Woolloongabba, Queensland 4102</wicri:regionArea>
<wicri:noRegion>Queensland 4102</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smith, Jennifer J" sort="Smith, Jennifer J" uniqKey="Smith J" first="Jennifer J" last="Smith">Jennifer J. Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea>
<wicri:noRegion>Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lewis, Richard J" sort="Lewis, Richard J" uniqKey="Lewis R" first="Richard J" last="Lewis">Richard J. Lewis</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea>
<wicri:noRegion>Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alewood, Paul F" sort="Alewood, Paul F" uniqKey="Alewood P" first="Paul F" last="Alewood">Paul F. Alewood</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072</wicri:regionArea>
<wicri:noRegion>Queensland 4072</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vetter, Irina" sort="Vetter, Irina" uniqKey="Vetter I" first="Irina" last="Vetter">Irina Vetter</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia The School of Pharmacy, The University of Queensland, Woolloongabba, Queensland 4102, Australia i.vetter@uq.edu.au.</nlm:affiliation>
<country wicri:rule="url">Australie</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia The School of Pharmacy, The University of Queensland, Woolloongabba, Queensland 4102</wicri:regionArea>
<wicri:noRegion>Queensland 4102</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dutertre, Sebastien" sort="Dutertre, Sebastien" uniqKey="Dutertre S" first="Sébastien" last="Dutertre">Sébastien Dutertre</name>
<affiliation wicri:level="1"><nlm:affiliation>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia Institut des Biomolécules Max Mousseron, UMR 5247, Université Montpellier - CNRS, Place Eugène Bataillon, Montpellier Cedex 5 34095, France sebastien.dutertre@univ-montp2.fr.</nlm:affiliation>
<country wicri:rule="url">France</country>
<wicri:regionArea>The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia Institut des Biomolécules Max Mousseron, UMR 5247, Université Montpellier - CNRS, Place Eugène Bataillon, Montpellier Cedex 5 34095</wicri:regionArea>
<wicri:noRegion>34095</wicri:noRegion>
<wicri:noRegion>34095</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings. Biological sciences</title>
<idno type="eISSN">1471-2954</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Biological Evolution</term>
<term>Conotoxins (genetics)</term>
<term>Conotoxins (metabolism)</term>
<term>Conotoxins (pharmacology)</term>
<term>Conus Snail (genetics)</term>
<term>Conus Snail (physiology)</term>
<term>Male</term>
<term>Mice (physiology)</term>
<term>Mice, Inbred C57BL</term>
<term>Pain</term>
<term>Predatory Behavior</term>
<term>Sequence Alignment</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term>
<term>Animaux</term>
<term>Comportement prédateur</term>
<term>Conotoxines (génétique)</term>
<term>Conotoxines (métabolisme)</term>
<term>Conotoxines (pharmacologie)</term>
<term>Conus (génétique)</term>
<term>Conus (physiologie)</term>
<term>Douleur</term>
<term>Mâle</term>
<term>Souris (physiologie)</term>
<term>Souris de lignée C57BL</term>
<term>Séquence d'acides aminés</term>
<term>Évolution biologique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Conotoxins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Conotoxins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Conotoxins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Conus Snail</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Conotoxines</term>
<term>Conus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Conotoxines</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Conotoxines</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Conus</term>
<term>Souris</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Conus Snail</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Biological Evolution</term>
<term>Male</term>
<term>Mice, Inbred C57BL</term>
<term>Pain</term>
<term>Predatory Behavior</term>
<term>Sequence Alignment</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term>
<term>Animaux</term>
<term>Comportement prédateur</term>
<term>Douleur</term>
<term>Mâle</term>
<term>Souris de lignée C57BL</term>
<term>Séquence d'acides aminés</term>
<term>Évolution biologique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Some venomous cone snails feed on small fishes using an immobilizing combination of synergistic venom peptides that target Kv and Nav channels. As part of this envenomation strategy, δ-conotoxins are potent ichtyotoxins that enhance Nav channel function. δ-Conotoxins belong to an ancient and widely distributed gene superfamily, but any evolutionary link from ancestral worm-eating cone snails to modern piscivorous species has not been elucidated. Here, we report the discovery of SuVIA, a potent vertebrate-active δ-conotoxin characterized from a vermivorous cone snail (Conus suturatus). SuVIA is equipotent at hNaV1.3, hNaV1.4 and hNaV1.6 with EC50s in the low nanomolar range. SuVIA also increased peak hNaV1.7 current by approximately 75% and shifted the voltage-dependence of activation to more hyperpolarized potentials from -15 mV to -25 mV, with little effect on the voltage-dependence of inactivation. Interestingly, the proximal venom gland expression and pain-inducing effect of SuVIA in mammals suggest that δ-conotoxins in vermivorous cone snails play a defensive role against higher order vertebrates. We propose that δ-conotoxins originally evolved in ancestral vermivorous cones to defend against larger predators including fishes have been repurposed to facilitate a shift to piscivorous behaviour, suggesting an unexpected underlying mechanism for this remarkable evolutionary transition.</div>
</front>
</TEI>
</pubmed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002816 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 002816 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:4528551 |texte= δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:26156767" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |