No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects
Identifieur interne : 003683 ( Main/Exploration ); précédent : 003682; suivant : 003684No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects
Auteurs : Jens Baumert [Allemagne] ; Jie Huang [États-Unis, Royaume-Uni] ; Barbara Mcknight [États-Unis] ; Maria Sabater-Lleal [Suède] ; Maristella Steri [Italie] ; Audrey Y. Chu [États-Unis] ; Stella Trompet [Pays-Bas] ; Lorna M. Lopez [Royaume-Uni] ; Myriam Fornage [États-Unis] ; Alexander Teumer [Allemagne] ; Weihong Tang [États-Unis] ; Alicja R. Rudnicka [Royaume-Uni] ; Anders M Larstig [Suède] ; Jouke-Jan Hottenga [Pays-Bas] ; Maryam Kavousi [Pays-Bas] ; Jari Lahti [Finlande] ; Toshiko Tanaka [États-Unis] ; Caroline Hayward [Royaume-Uni] ; Jennifer E. Huffman [Royaume-Uni] ; Pierre-Emmanuel Morange [France] ; Lynda M. Rose [États-Unis] ; Saonli Basu [États-Unis] ; Ann Rumley [Royaume-Uni] ; David J. Stott [Royaume-Uni] ; Brendan M. Buckley [Irlande (pays)] ; Anton J. M. De Craen [Pays-Bas] ; Serena Sanna [Italie] ; Marco Masala [Italie] ; Reiner Biffar [Allemagne] ; Georg Homuth [Allemagne] ; Angela Silveira [Suède] ; Bengt Sennblad [Suède] ; Anuj Goel [Royaume-Uni] ; Hugh Watkins [Royaume-Uni] ; Martina Müller-Nurasyid [Allemagne] ; Regina Rückerl [Allemagne] ; Kent Taylor [États-Unis] ; Ming-Huei Chen [États-Unis] ; Eco J. C. De Geus [Pays-Bas] ; Albert Hofman [Pays-Bas] ; Jacqueline C. M. Witteman [Pays-Bas] ; Moniek P. M. De Maat [Pays-Bas] ; Aarno Palotie [Royaume-Uni, Finlande] ; Gail Davies [Royaume-Uni] ; David S. Siscovick [États-Unis] ; Ivana Kolcic [Croatie] ; Sarah H. Wild [Royaume-Uni] ; Jaejoon Song [États-Unis] ; Wendy L. Mcardle [Royaume-Uni] ; Ian Ford [Royaume-Uni] ; Naveed Sattar [Royaume-Uni] ; David Schlessinger [États-Unis] ; Anne Grotevendt [Allemagne] ; Maria Grazia Franzosi [Italie] ; Thomas Illig [Allemagne] ; Melanie Waldenberger [Allemagne] ; Thomas Lumley [Nouvelle-Zélande] ; Geoffrey H. Tofler [Australie] ; Gonneke Willemsen [Pays-Bas] ; André G. Uitterlinden [Pays-Bas] ; Fernando Rivadeneira [États-Unis] ; Katri R Ikkönen [Finlande] ; Daniel I. Chasman [États-Unis] ; Aaron R. Folsom [États-Unis] ; Gordon D. Lowe [Royaume-Uni] ; Rudi G. J. Westendorp [Pays-Bas] ; P. Eline Slagboom [Pays-Bas] ; Francesco Cucca [Italie] ; Henri Wallaschofski [États-Unis, Allemagne] ; Rona J. Strawbridge [Suède] ; Udo Seedorf [Allemagne] ; Wolfgang Koenig [Allemagne] ; Joshua C. Bis [États-Unis] ; Kenneth J. Mukamal [États-Unis] ; Jenny Van Dongen [Pays-Bas] ; Elisabeth Widen [Royaume-Uni] ; Oscar H. Franco [Pays-Bas] ; John M. Starr [Royaume-Uni] ; Kiang Liu [États-Unis] ; Luigi Ferrucci [États-Unis] ; Ozren Polasek [États-Unis] ; James F. Wilson [Croatie] ; Tiphaine Oudot-Mellakh [France] ; Harry Campbell [Croatie] ; Pau Navarro [Royaume-Uni] ; Stefania Bandinelli [Italie] ; Johan Eriksson [Finlande] ; Dorret I. Boomsma [Pays-Bas] ; Abbas Dehghan [Pays-Bas] ; Robert Clarke [Royaume-Uni] ; Anders Hamsten [Suède] ; Eric Boerwinkle [États-Unis] ; J. Wouter Jukema [Pays-Bas] ; Silvia Naitza [Italie] ; Paul M. Ridker [États-Unis] ; Henry Völzke [Allemagne] ; Ian J. Deary [Royaume-Uni] ; Alexander P. Reiner [Finlande] ; David-Alexandre Trégouët [France] ; Christopher J. O'Donnell [États-Unis] ; David P. Strachan [Royaume-Uni] ; Annette Peters [Allemagne] ; Nicholas L. Smith [Finlande, États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Consommation d'alcool, Tabagisme.
- métabolisme : Fibrinogène.
- Génomique, Humains, Indice de masse corporelle, Interaction entre gènes et environnement.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Fibrinogen.
- genetics : Alcohol Drinking, Smoking.
- methods : Genomics.
- Body Mass Index, Gene-Environment Interaction, Humans.
Abstract
Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-scale meta-analyses of genome-wide interaction studies to identify possible interactions of genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentration. The present study included 80,607 subjects of European ancestry from 22 studies. Genome-wide interaction analyses were performed separately in each study for about 2.6 million single nucleotide polymorphisms (SNPs) across the 22 autosomal chromosomes. For each SNP and risk factor, we performed a linear regression under an additive genetic model including an interaction term between SNP and risk factor. Interaction estimates were meta-analysed using a fixed-effects model. No genome-wide significant interaction with smoking status, alcohol consumption or BMI was observed in the meta-analyses. The most suggestive interaction was found for smoking and rs10519203, located in the LOC123688 region on chromosome 15, with a p value of 6.2×10−8. This large genome-wide interaction study including 80,607 participants found no strong evidence of interaction between genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentrations. Further studies are needed to yield deeper insight in the interplay between environmental factors and gene variants on the regulation of fibrinogen concentrations.
Url:
DOI: 10.1371/journal.pone.0111156
PubMed: 25551457
PubMed Central: 4281156
Affiliations:
- Allemagne, Australie, Croatie, Finlande, France, Irlande (pays), Italie, Nouvelle-Zélande, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Bade-Wurtemberg, Basse-Saxe, Bavière, Californie, District de Haute-Bavière, District de Münster, District de Souabe, District de Tübingen, Grand Londres, Hollande-Méridionale, Hollande-Septentrionale, Illinois, Lombardie, Maryland, Massachusetts, Minnesota, Nouvelle-Galles du Sud, Oxfordshire, Provence-Alpes-Côte d'Azur, Rhénanie-du-Nord-Westphalie, Svealand, Texas, Utrecht (province), Uusimaa, Washington (État), Écosse, Île-de-France
- Amsterdam, Augsbourg, Glasgow, Hanovre, Helsinki, Leyde, Londres, Marseille, Milan, Munich, Münster, Oxford, Paris, Rotterdam, Seattle, Stockholm, Sydney, Ulm, Utrecht, Édimbourg
- Université Louis-et-Maximilien de Munich, Université d'Aix-Marseille, Université d'Helsinki, Université d'Oxford, Université d'Édimbourg, Université de Glasgow, Université de Londres, Université de Sydney, Université de Washington
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Le document en format XML
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<author><name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R." last="Rudnicka">Alicja R. Rudnicka</name>
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<country xml:lang="fr">Suède</country>
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<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam</wicri:regionArea>
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<author><name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name>
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<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff21"><addr-line>Folkhalsan Research Centre, Helsinki, Finland</addr-line>
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<author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland</wicri:regionArea>
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</placeName>
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<author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
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</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland</wicri:regionArea>
<wicri:noRegion>Scotland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E." last="Huffman">Jennifer E. Huffman</name>
<affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name>
<affiliation wicri:level="4"><nlm:aff id="aff24"><addr-line>INSERM UMR_S 1062, Aix-Marseille Université, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR_S 1062, Aix-Marseille Université, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M." last="Rose">Lynda M. Rose</name>
<affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name>
<affiliation wicri:level="2"><nlm:aff id="aff25"><addr-line>Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name>
<affiliation wicri:level="4"><nlm:aff id="aff26"><addr-line>Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J." last="Stott">David J. Stott</name>
<affiliation wicri:level="4"><nlm:aff id="aff27"><addr-line>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name>
<affiliation wicri:level="1"><nlm:aff id="aff28"><addr-line>Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland</addr-line>
</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Pharmacology and Therapeutics, University College Cork, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J. M." last="De Craen">Anton J. M. De Craen</name>
<affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Masala, Marco" sort="Masala, Marco" uniqKey="Masala M" first="Marco" last="Masala">Marco Masala</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name>
<affiliation wicri:level="1"><nlm:aff id="aff29"><addr-line>Department of Prosthetic Dentistry, Gerostomatology and Dental Materials, University Medicine Greifswald, Greifswald, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Prosthetic Dentistry, Gerostomatology and Dental Materials, University Medicine Greifswald, Greifswald</wicri:regionArea>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name>
<affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald</wicri:regionArea>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Silveira, Angela" sort="Silveira, Angela" uniqKey="Silveira A" first="Angela" last="Silveira">Angela Silveira</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff30"><addr-line>Science for Life Laboratory, Karolinska Insitutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Science for Life Laboratory, Karolinska Insitutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name>
<affiliation wicri:level="4"><nlm:aff id="aff31"><addr-line>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff32"><addr-line>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name>
<affiliation wicri:level="4"><nlm:aff id="aff31"><addr-line>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff32"><addr-line>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name>
<affiliation wicri:level="1"><nlm:aff id="aff33"><addr-line>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff34"><addr-line>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff35"><addr-line>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ruckerl, Regina" sort="Ruckerl, Regina" uniqKey="Ruckerl R" first="Regina" last="Rückerl">Regina Rückerl</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff36"><addr-line>ESC-Environmental Science Center, University of Augsburg, Augsburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>ESC-Environmental Science Center, University of Augsburg, Augsburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Souabe</region>
<settlement type="city">Augsbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taylor, Kent" sort="Taylor, Kent" uniqKey="Taylor K" first="Kent" last="Taylor">Kent Taylor</name>
<affiliation wicri:level="2"><nlm:aff id="aff37"><addr-line>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<affiliation wicri:level="2"><nlm:aff id="aff38"><addr-line>Department of Biostatistics, Boston University, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name>
<affiliation wicri:level="3"><nlm:aff id="aff39"><addr-line>Department of Haematology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Haematology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="aff18"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C. M." last="Witteman">Jacqueline C. M. Witteman</name>
<affiliation wicri:level="3"><nlm:aff id="aff18"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Maat, Moniek P M" sort="De Maat, Moniek P M" uniqKey="De Maat M" first="Moniek P. M." last="De Maat">Moniek P. M. De Maat</name>
<affiliation wicri:level="3"><nlm:aff id="aff39"><addr-line>Department of Haematology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Haematology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<affiliation wicri:level="1"><nlm:aff id="aff40"><addr-line>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff41"><addr-line>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name>
<affiliation wicri:level="4"><nlm:aff id="aff11"><addr-line>Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff12"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name>
<affiliation wicri:level="4"><nlm:aff id="aff43"><addr-line>Department of Epidemiology, University of Washington, Seattle, Washington, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name>
<affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Department of Public Health, University of Split Medical School, Split, Croatia</addr-line>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Public Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name>
<affiliation wicri:level="4"><nlm:aff id="aff45"><addr-line>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Song, Jaejoon" sort="Song, Jaejoon" uniqKey="Song J" first="Jaejoon" last="Song">Jaejoon Song</name>
<affiliation wicri:level="2"><nlm:aff id="aff25"><addr-line>Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name>
<affiliation wicri:level="1"><nlm:aff id="aff46"><addr-line>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation wicri:level="4"><nlm:aff id="aff47"><addr-line>Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Robertson Center for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow</wicri:regionArea>
<wicri:noRegion>Glasgow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name>
<affiliation wicri:level="2"><nlm:aff id="aff49"><addr-line>Intramural Research Program, National Institute on Aging, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute on Aging, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grotevendt, Anne" sort="Grotevendt, Anne" uniqKey="Grotevendt A" first="Anne" last="Grotevendt">Anne Grotevendt</name>
<affiliation wicri:level="1"><nlm:aff id="aff50"><addr-line>Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald</wicri:regionArea>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Franzosi, Maria Grazia" sort="Franzosi, Maria Grazia" uniqKey="Franzosi M" first="Maria Grazia" last="Franzosi">Maria Grazia Franzosi</name>
<affiliation wicri:level="3"><nlm:aff id="aff51"><addr-line>Department of Cardiovascular Research, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Cardiovascular Research, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name>
<affiliation wicri:level="1"><nlm:aff id="aff52"><addr-line>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff53"><addr-line>Hannover Unified Biobank, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hannover Unified Biobank, Hannover Medical School, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name>
<affiliation wicri:level="1"><nlm:aff id="aff52"><addr-line>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name>
<affiliation wicri:level="1"><nlm:aff id="aff54"><addr-line>Department of Statistics, University of Auckland, Auckland, New Zealand</addr-line>
</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Statistics, University of Auckland, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tofler, Geoffrey H" sort="Tofler, Geoffrey H" uniqKey="Tofler G" first="Geoffrey H." last="Tofler">Geoffrey H. Tofler</name>
<affiliation wicri:level="4"><nlm:aff id="aff55"><addr-line>Royal North Shore Hospital, University of Sydney, Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal North Shore Hospital, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name>
<affiliation wicri:level="3"><nlm:aff id="aff17"><addr-line>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="aff18"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff56"><addr-line>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation wicri:level="2"><nlm:aff id="aff57"><addr-line>Division of Preventive Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name>
<affiliation wicri:level="4"><nlm:aff id="aff20"><addr-line>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Behavioural Sciences, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name>
<affiliation wicri:level="2"><nlm:aff id="aff57"><addr-line>Division of Preventive Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name>
<affiliation wicri:level="2"><nlm:aff id="aff15"><addr-line>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lowe, Gordon D" sort="Lowe, Gordon D" uniqKey="Lowe G" first="Gordon D." last="Lowe">Gordon D. Lowe</name>
<affiliation wicri:level="4"><nlm:aff id="aff58"><addr-line>Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Westendorp, Rudi G J" sort="Westendorp, Rudi G J" uniqKey="Westendorp R" first="Rudi G. J." last="Westendorp">Rudi G. J. Westendorp</name>
<affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P. Eline" last="Slagboom">P. Eline Slagboom</name>
<affiliation wicri:level="3"><nlm:aff id="aff59"><addr-line>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name>
<affiliation wicri:level="2"><nlm:aff id="aff49"><addr-line>Intramural Research Program, National Institute on Aging, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute on Aging, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff60"><addr-line>DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald</wicri:regionArea>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J." last="Strawbridge">Rona J. Strawbridge</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seedorf, Udo" sort="Seedorf, Udo" uniqKey="Seedorf U" first="Udo" last="Seedorf">Udo Seedorf</name>
<affiliation wicri:level="3"><nlm:aff id="aff61"><addr-line>Leibniz-Institut für Arterioskleroseforschung an der Universität Münster, Münster, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Leibniz-Institut für Arterioskleroseforschung an der Universität Münster, Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name>
<affiliation wicri:level="3"><nlm:aff id="aff62"><addr-line>Department of Internal Medicine II - Cardiology, University of Ulm Medical Center, Ulm, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine II - Cardiology, University of Ulm Medical Center, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="4"><nlm:aff id="aff63"><addr-line>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Mukamal, Kenneth J" sort="Mukamal, Kenneth J" uniqKey="Mukamal K" first="Kenneth J." last="Mukamal">Kenneth J. Mukamal</name>
<affiliation wicri:level="2"><nlm:aff id="aff64"><addr-line>Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff65"><addr-line>Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Dongen, Jenny" sort="Van Dongen, Jenny" uniqKey="Van Dongen J" first="Jenny" last="Van Dongen">Jenny Van Dongen</name>
<affiliation wicri:level="3"><nlm:aff id="aff17"><addr-line>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name>
<affiliation wicri:level="1"><nlm:aff id="aff40"><addr-line>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name>
<affiliation wicri:level="3"><nlm:aff id="aff18"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name>
<affiliation wicri:level="4"><nlm:aff id="aff12"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff66"><addr-line>Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Liu, Kiang" sort="Liu, Kiang" uniqKey="Liu K" first="Kiang" last="Liu">Kiang Liu</name>
<affiliation wicri:level="2"><nlm:aff id="aff67"><addr-line>Department of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<affiliation wicri:level="2"><nlm:aff id="aff22"><addr-line>Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation wicri:level="4"><nlm:aff id="aff43"><addr-line>Department of Epidemiology, University of Washington, Seattle, Washington, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name>
<affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Department of Public Health, University of Split Medical School, Split, Croatia</addr-line>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Public Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oudot Mellakh, Tiphaine" sort="Oudot Mellakh, Tiphaine" uniqKey="Oudot Mellakh T" first="Tiphaine" last="Oudot-Mellakh">Tiphaine Oudot-Mellakh</name>
<affiliation wicri:level="3"><nlm:aff id="aff68"><addr-line>INSERM, UMR_S 1166, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, UMR_S 1166, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff69"><addr-line>Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff70"><addr-line>ICAN Institute for Cardiometabolism and Nutrition, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ICAN Institute for Cardiometabolism and Nutrition, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Department of Public Health, University of Split Medical School, Split, Croatia</addr-line>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Public Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name>
<affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland</wicri:regionArea>
<wicri:noRegion>Scotland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name>
<affiliation wicri:level="1"><nlm:aff id="aff71"><addr-line>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence</wicri:regionArea>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
<affiliation wicri:level="1"><nlm:aff id="aff21"><addr-line>Folkhalsan Research Centre, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Folkhalsan Research Centre, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>National Institute for Health and Welfare, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff73"><addr-line>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff74"><addr-line>Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Helsinki University Central Hospital, Unit of General Practice, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name>
<affiliation wicri:level="3"><nlm:aff id="aff17"><addr-line>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<affiliation wicri:level="3"><nlm:aff id="aff18"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
<affiliation wicri:level="4"><nlm:aff id="aff75"><addr-line>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
<affiliation wicri:level="2"><nlm:aff id="aff76"><addr-line>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff77"><addr-line>Durrer Center for Cardiogenetic Research, Amsterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Durrer Center for Cardiogenetic Research, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff78"><addr-line>Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Interuniversity Cardiology Institute of the Netherlands, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Naitza, Silvia" sort="Naitza, Silvia" uniqKey="Naitza S" first="Silvia" last="Naitza">Silvia Naitza</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="2"><nlm:aff id="aff79"><addr-line>Division of Preventive Medicine, Division of Cardiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Division of Cardiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<affiliation wicri:level="1"><nlm:aff id="aff80"><addr-line>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald</wicri:regionArea>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name>
<affiliation wicri:level="4"><nlm:aff id="aff11"><addr-line>Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff12"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Reiner, Alexander P" sort="Reiner, Alexander P" uniqKey="Reiner A" first="Alexander P." last="Reiner">Alexander P. Reiner</name>
<affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Trégouët">David-Alexandre Trégouët</name>
<affiliation wicri:level="3"><nlm:aff id="aff68"><addr-line>INSERM, UMR_S 1166, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, UMR_S 1166, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff69"><addr-line>Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff70"><addr-line>ICAN Institute for Cardiometabolism and Nutrition, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ICAN Institute for Cardiometabolism and Nutrition, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>National Heart, Lung and Blood Institute Division of Intramural Research, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Heart, Lung and Blood Institute Division of Intramural Research, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name>
<affiliation wicri:level="4"><nlm:aff id="aff16"><addr-line>Division of Population Health Sciences & Education, St George's, University of London, Cranmer Terrace, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Population Health Sciences & Education, St George's, University of London, Cranmer Terrace, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff81"><addr-line>DZHK (German Centre for Cardiovascular Research), partner site Munich, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>DZHK (German Centre for Cardiovascular Research), partner site Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name>
<affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff82"><addr-line>Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Group Health Research Institute, Group Health Cooperative, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff83"><addr-line>Seattle Epidemiologic Research & Information Center, Veterans Affairs Office of Research & Development, Seattle, Washington, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Seattle Epidemiologic Research & Information Center, Veterans Affairs Office of Research & Development, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects</title>
<author><name sortKey="Baumert, Jens" sort="Baumert, Jens" uniqKey="Baumert J" first="Jens" last="Baumert">Jens Baumert</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
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<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>National Heart, Lung and Blood Institute Division of Intramural Research, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Heart, Lung and Blood Institute Division of Intramural Research, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name>
<affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Department of Biostatistics, University of Washington, Seattle, Washington, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Sabater Lleal, Maria" sort="Sabater Lleal, Maria" uniqKey="Sabater Lleal M" first="Maria" last="Sabater-Lleal">Maria Sabater-Lleal</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Steri, Maristella" sort="Steri, Maristella" uniqKey="Steri M" first="Maristella" last="Steri">Maristella Steri</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name>
<affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name>
<affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name>
<affiliation wicri:level="4"><nlm:aff id="aff11"><addr-line>Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff12"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2"><nlm:aff id="aff13"><addr-line>Brown Foundation Institute of Molecular Medicine, Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brown Foundation Institute of Molecular Medicine, Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name>
<affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald</wicri:regionArea>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name>
<affiliation wicri:level="2"><nlm:aff id="aff15"><addr-line>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R." last="Rudnicka">Alicja R. Rudnicka</name>
<affiliation wicri:level="4"><nlm:aff id="aff16"><addr-line>Division of Population Health Sciences & Education, St George's, University of London, Cranmer Terrace, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Population Health Sciences & Education, St George's, University of London, Cranmer Terrace, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="M Larstig, Anders" sort="M Larstig, Anders" uniqKey="M Larstig A" first="Anders" last="M Larstig">Anders M Larstig</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name>
<affiliation wicri:level="3"><nlm:aff id="aff17"><addr-line>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name>
<affiliation wicri:level="3"><nlm:aff id="aff18"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name>
<affiliation wicri:level="4"><nlm:aff id="aff20"><addr-line>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Behavioural Sciences, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff21"><addr-line>Folkhalsan Research Centre, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Folkhalsan Research Centre, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name>
<affiliation wicri:level="2"><nlm:aff id="aff22"><addr-line>Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland</wicri:regionArea>
<wicri:noRegion>Scotland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E." last="Huffman">Jennifer E. Huffman</name>
<affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland</wicri:regionArea>
<wicri:noRegion>Scotland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name>
<affiliation wicri:level="4"><nlm:aff id="aff24"><addr-line>INSERM UMR_S 1062, Aix-Marseille Université, Marseille, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR_S 1062, Aix-Marseille Université, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M." last="Rose">Lynda M. Rose</name>
<affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name>
<affiliation wicri:level="2"><nlm:aff id="aff25"><addr-line>Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name>
<affiliation wicri:level="4"><nlm:aff id="aff26"><addr-line>Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J." last="Stott">David J. Stott</name>
<affiliation wicri:level="4"><nlm:aff id="aff27"><addr-line>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name>
<affiliation wicri:level="1"><nlm:aff id="aff28"><addr-line>Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland</addr-line>
</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Pharmacology and Therapeutics, University College Cork, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J. M." last="De Craen">Anton J. M. De Craen</name>
<affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Masala, Marco" sort="Masala, Marco" uniqKey="Masala M" first="Marco" last="Masala">Marco Masala</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name>
<affiliation wicri:level="1"><nlm:aff id="aff29"><addr-line>Department of Prosthetic Dentistry, Gerostomatology and Dental Materials, University Medicine Greifswald, Greifswald, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Prosthetic Dentistry, Gerostomatology and Dental Materials, University Medicine Greifswald, Greifswald</wicri:regionArea>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name>
<affiliation wicri:level="1"><nlm:aff id="aff14"><addr-line>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald</wicri:regionArea>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Silveira, Angela" sort="Silveira, Angela" uniqKey="Silveira A" first="Angela" last="Silveira">Angela Silveira</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff30"><addr-line>Science for Life Laboratory, Karolinska Insitutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Science for Life Laboratory, Karolinska Insitutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name>
<affiliation wicri:level="4"><nlm:aff id="aff31"><addr-line>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff32"><addr-line>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name>
<affiliation wicri:level="4"><nlm:aff id="aff31"><addr-line>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff32"><addr-line>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name>
<affiliation wicri:level="1"><nlm:aff id="aff33"><addr-line>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff34"><addr-line>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff35"><addr-line>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ruckerl, Regina" sort="Ruckerl, Regina" uniqKey="Ruckerl R" first="Regina" last="Rückerl">Regina Rückerl</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff36"><addr-line>ESC-Environmental Science Center, University of Augsburg, Augsburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>ESC-Environmental Science Center, University of Augsburg, Augsburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Souabe</region>
<settlement type="city">Augsbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taylor, Kent" sort="Taylor, Kent" uniqKey="Taylor K" first="Kent" last="Taylor">Kent Taylor</name>
<affiliation wicri:level="2"><nlm:aff id="aff37"><addr-line>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<affiliation wicri:level="2"><nlm:aff id="aff38"><addr-line>Department of Biostatistics, Boston University, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name>
<affiliation wicri:level="3"><nlm:aff id="aff39"><addr-line>Department of Haematology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Haematology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="aff18"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C. M." last="Witteman">Jacqueline C. M. Witteman</name>
<affiliation wicri:level="3"><nlm:aff id="aff18"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Maat, Moniek P M" sort="De Maat, Moniek P M" uniqKey="De Maat M" first="Moniek P. M." last="De Maat">Moniek P. M. De Maat</name>
<affiliation wicri:level="3"><nlm:aff id="aff39"><addr-line>Department of Haematology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Haematology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<affiliation wicri:level="1"><nlm:aff id="aff40"><addr-line>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff41"><addr-line>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name>
<affiliation wicri:level="4"><nlm:aff id="aff11"><addr-line>Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff12"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name>
<affiliation wicri:level="4"><nlm:aff id="aff43"><addr-line>Department of Epidemiology, University of Washington, Seattle, Washington, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name>
<affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Department of Public Health, University of Split Medical School, Split, Croatia</addr-line>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Public Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name>
<affiliation wicri:level="4"><nlm:aff id="aff45"><addr-line>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Song, Jaejoon" sort="Song, Jaejoon" uniqKey="Song J" first="Jaejoon" last="Song">Jaejoon Song</name>
<affiliation wicri:level="2"><nlm:aff id="aff25"><addr-line>Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name>
<affiliation wicri:level="1"><nlm:aff id="aff46"><addr-line>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation wicri:level="4"><nlm:aff id="aff47"><addr-line>Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Robertson Center for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<affiliation wicri:level="1"><nlm:aff id="aff48"><addr-line>BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow</wicri:regionArea>
<wicri:noRegion>Glasgow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name>
<affiliation wicri:level="2"><nlm:aff id="aff49"><addr-line>Intramural Research Program, National Institute on Aging, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute on Aging, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grotevendt, Anne" sort="Grotevendt, Anne" uniqKey="Grotevendt A" first="Anne" last="Grotevendt">Anne Grotevendt</name>
<affiliation wicri:level="1"><nlm:aff id="aff50"><addr-line>Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald</wicri:regionArea>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Franzosi, Maria Grazia" sort="Franzosi, Maria Grazia" uniqKey="Franzosi M" first="Maria Grazia" last="Franzosi">Maria Grazia Franzosi</name>
<affiliation wicri:level="3"><nlm:aff id="aff51"><addr-line>Department of Cardiovascular Research, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Cardiovascular Research, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name>
<affiliation wicri:level="1"><nlm:aff id="aff52"><addr-line>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff53"><addr-line>Hannover Unified Biobank, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Hannover Unified Biobank, Hannover Medical School, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name>
<affiliation wicri:level="1"><nlm:aff id="aff52"><addr-line>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name>
<affiliation wicri:level="1"><nlm:aff id="aff54"><addr-line>Department of Statistics, University of Auckland, Auckland, New Zealand</addr-line>
</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Statistics, University of Auckland, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tofler, Geoffrey H" sort="Tofler, Geoffrey H" uniqKey="Tofler G" first="Geoffrey H." last="Tofler">Geoffrey H. Tofler</name>
<affiliation wicri:level="4"><nlm:aff id="aff55"><addr-line>Royal North Shore Hospital, University of Sydney, Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal North Shore Hospital, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name>
<affiliation wicri:level="3"><nlm:aff id="aff17"><addr-line>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="aff18"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff56"><addr-line>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation wicri:level="2"><nlm:aff id="aff57"><addr-line>Division of Preventive Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name>
<affiliation wicri:level="4"><nlm:aff id="aff20"><addr-line>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Behavioural Sciences, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name>
<affiliation wicri:level="2"><nlm:aff id="aff57"><addr-line>Division of Preventive Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name>
<affiliation wicri:level="2"><nlm:aff id="aff15"><addr-line>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lowe, Gordon D" sort="Lowe, Gordon D" uniqKey="Lowe G" first="Gordon D." last="Lowe">Gordon D. Lowe</name>
<affiliation wicri:level="4"><nlm:aff id="aff58"><addr-line>Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Westendorp, Rudi G J" sort="Westendorp, Rudi G J" uniqKey="Westendorp R" first="Rudi G. J." last="Westendorp">Rudi G. J. Westendorp</name>
<affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P. Eline" last="Slagboom">P. Eline Slagboom</name>
<affiliation wicri:level="3"><nlm:aff id="aff59"><addr-line>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name>
<affiliation wicri:level="2"><nlm:aff id="aff49"><addr-line>Intramural Research Program, National Institute on Aging, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute on Aging, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff60"><addr-line>DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald</wicri:regionArea>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J." last="Strawbridge">Rona J. Strawbridge</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seedorf, Udo" sort="Seedorf, Udo" uniqKey="Seedorf U" first="Udo" last="Seedorf">Udo Seedorf</name>
<affiliation wicri:level="3"><nlm:aff id="aff61"><addr-line>Leibniz-Institut für Arterioskleroseforschung an der Universität Münster, Münster, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Leibniz-Institut für Arterioskleroseforschung an der Universität Münster, Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name>
<affiliation wicri:level="3"><nlm:aff id="aff62"><addr-line>Department of Internal Medicine II - Cardiology, University of Ulm Medical Center, Ulm, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine II - Cardiology, University of Ulm Medical Center, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="4"><nlm:aff id="aff63"><addr-line>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Mukamal, Kenneth J" sort="Mukamal, Kenneth J" uniqKey="Mukamal K" first="Kenneth J." last="Mukamal">Kenneth J. Mukamal</name>
<affiliation wicri:level="2"><nlm:aff id="aff64"><addr-line>Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff65"><addr-line>Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Dongen, Jenny" sort="Van Dongen, Jenny" uniqKey="Van Dongen J" first="Jenny" last="Van Dongen">Jenny Van Dongen</name>
<affiliation wicri:level="3"><nlm:aff id="aff17"><addr-line>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name>
<affiliation wicri:level="1"><nlm:aff id="aff40"><addr-line>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name>
<affiliation wicri:level="3"><nlm:aff id="aff18"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name>
<affiliation wicri:level="4"><nlm:aff id="aff12"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff66"><addr-line>Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Liu, Kiang" sort="Liu, Kiang" uniqKey="Liu K" first="Kiang" last="Liu">Kiang Liu</name>
<affiliation wicri:level="2"><nlm:aff id="aff67"><addr-line>Department of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<affiliation wicri:level="2"><nlm:aff id="aff22"><addr-line>Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation wicri:level="4"><nlm:aff id="aff43"><addr-line>Department of Epidemiology, University of Washington, Seattle, Washington, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name>
<affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Department of Public Health, University of Split Medical School, Split, Croatia</addr-line>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Public Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oudot Mellakh, Tiphaine" sort="Oudot Mellakh, Tiphaine" uniqKey="Oudot Mellakh T" first="Tiphaine" last="Oudot-Mellakh">Tiphaine Oudot-Mellakh</name>
<affiliation wicri:level="3"><nlm:aff id="aff68"><addr-line>INSERM, UMR_S 1166, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, UMR_S 1166, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff69"><addr-line>Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff70"><addr-line>ICAN Institute for Cardiometabolism and Nutrition, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ICAN Institute for Cardiometabolism and Nutrition, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation wicri:level="1"><nlm:aff id="aff44"><addr-line>Department of Public Health, University of Split Medical School, Split, Croatia</addr-line>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Public Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name>
<affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland</wicri:regionArea>
<wicri:noRegion>Scotland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name>
<affiliation wicri:level="1"><nlm:aff id="aff71"><addr-line>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence</wicri:regionArea>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
<affiliation wicri:level="1"><nlm:aff id="aff21"><addr-line>Folkhalsan Research Centre, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Folkhalsan Research Centre, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>National Institute for Health and Welfare, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>National Institute for Health and Welfare, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff73"><addr-line>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki</wicri:regionArea>
<orgName type="university">Université d'Helsinki</orgName>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff74"><addr-line>Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Helsinki University Central Hospital, Unit of General Practice, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name>
<affiliation wicri:level="3"><nlm:aff id="aff17"><addr-line>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<affiliation wicri:level="3"><nlm:aff id="aff18"><addr-line>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
<affiliation wicri:level="4"><nlm:aff id="aff75"><addr-line>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
<affiliation wicri:level="2"><nlm:aff id="aff76"><addr-line>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<affiliation wicri:level="3"><nlm:aff id="aff9"><addr-line>Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff77"><addr-line>Durrer Center for Cardiogenetic Research, Amsterdam, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Durrer Center for Cardiogenetic Research, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff78"><addr-line>Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Interuniversity Cardiology Institute of the Netherlands, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Naitza, Silvia" sort="Naitza, Silvia" uniqKey="Naitza S" first="Silvia" last="Naitza">Silvia Naitza</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="2"><nlm:aff id="aff79"><addr-line>Division of Preventive Medicine, Division of Cardiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Division of Cardiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<affiliation wicri:level="1"><nlm:aff id="aff80"><addr-line>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Community Medicine, University Medicine Greifswald, Greifswald</wicri:regionArea>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name>
<affiliation wicri:level="4"><nlm:aff id="aff11"><addr-line>Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Psychology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff12"><addr-line>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Reiner, Alexander P" sort="Reiner, Alexander P" uniqKey="Reiner A" first="Alexander P." last="Reiner">Alexander P. Reiner</name>
<affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Trégouët">David-Alexandre Trégouët</name>
<affiliation wicri:level="3"><nlm:aff id="aff68"><addr-line>INSERM, UMR_S 1166, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, UMR_S 1166, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff69"><addr-line>Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff70"><addr-line>ICAN Institute for Cardiometabolism and Nutrition, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ICAN Institute for Cardiometabolism and Nutrition, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>National Heart, Lung and Blood Institute Division of Intramural Research, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Heart, Lung and Blood Institute Division of Intramural Research, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name>
<affiliation wicri:level="4"><nlm:aff id="aff16"><addr-line>Division of Population Health Sciences & Education, St George's, University of London, Cranmer Terrace, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Population Health Sciences & Education, St George's, University of London, Cranmer Terrace, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff81"><addr-line>DZHK (German Centre for Cardiovascular Research), partner site Munich, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>DZHK (German Centre for Cardiovascular Research), partner site Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name>
<affiliation wicri:level="1"><nlm:aff id="aff42"><addr-line>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff82"><addr-line>Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Group Health Research Institute, Group Health Cooperative, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff83"><addr-line>Seattle Epidemiologic Research & Information Center, Veterans Affairs Office of Research & Development, Seattle, Washington, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Seattle Epidemiologic Research & Information Center, Veterans Affairs Office of Research & Development, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcohol Drinking (genetics)</term>
<term>Body Mass Index</term>
<term>Fibrinogen (metabolism)</term>
<term>Gene-Environment Interaction</term>
<term>Genomics (methods)</term>
<term>Humans</term>
<term>Smoking (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Consommation d'alcool (génétique)</term>
<term>Fibrinogène (métabolisme)</term>
<term>Génomique ()</term>
<term>Humains</term>
<term>Indice de masse corporelle</term>
<term>Interaction entre gènes et environnement</term>
<term>Tabagisme (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fibrinogen</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alcohol Drinking</term>
<term>Smoking</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Consommation d'alcool</term>
<term>Tabagisme</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genomics</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Fibrinogène</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Body Mass Index</term>
<term>Gene-Environment Interaction</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Génomique</term>
<term>Humains</term>
<term>Indice de masse corporelle</term>
<term>Interaction entre gènes et environnement</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en"><p>Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-scale meta-analyses of genome-wide interaction studies to identify possible interactions of genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentration. The present study included 80,607 subjects of European ancestry from 22 studies. Genome-wide interaction analyses were performed separately in each study for about 2.6 million single nucleotide polymorphisms (SNPs) across the 22 autosomal chromosomes. For each SNP and risk factor, we performed a linear regression under an additive genetic model including an interaction term between SNP and risk factor. Interaction estimates were meta-analysed using a fixed-effects model. No genome-wide significant interaction with smoking status, alcohol consumption or BMI was observed in the meta-analyses. The most suggestive interaction was found for smoking and rs10519203, located in the LOC123688 region on chromosome 15, with a p value of 6.2×10<sup>−8</sup>
. This large genome-wide interaction study including 80,607 participants found no strong evidence of interaction between genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentrations. Further studies are needed to yield deeper insight in the interplay between environmental factors and gene variants on the regulation of fibrinogen concentrations.</p>
</div>
</front>
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</author>
<author><name sortKey="Tofler, Gh" uniqKey="Tofler G">GH Tofler</name>
</author>
<author><name sortKey="Cupples, La" uniqKey="Cupples L">LA Cupples</name>
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<author><name sortKey="Feng, D" uniqKey="Feng D">D Feng</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kathiresan, S" uniqKey="Kathiresan S">S Kathiresan</name>
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<author><name sortKey="Yang, Q" uniqKey="Yang Q">Q Yang</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jacquemin, B" uniqKey="Jacquemin B">B Jacquemin</name>
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<author><name sortKey="Antoniades, C" uniqKey="Antoniades C">C Antoniades</name>
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<author><name sortKey="Muller, M" uniqKey="Muller M">M Muller</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Danik, Js" uniqKey="Danik J">JS Danik</name>
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<author><name sortKey="Pare, G" uniqKey="Pare G">G Pare</name>
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<author><name sortKey="Kwiatkowski, Dj" uniqKey="Kwiatkowski D">DJ Kwiatkowski</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dehghan, A" uniqKey="Dehghan A">A Dehghan</name>
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</biblStruct>
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</biblStruct>
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</analytic>
</biblStruct>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Maat, Mp" uniqKey="De Maat M">MP de Maat</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Green, F" uniqKey="Green F">F Green</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thomas, Ae" uniqKey="Thomas A">AE Thomas</name>
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<author><name sortKey="Humphries, Se" uniqKey="Humphries S">SE Humphries</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Psaty, Bm" uniqKey="Psaty B">BM Psaty</name>
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<author><name sortKey="O Donnell, Cj" uniqKey="O Donnell C">CJ O'Donnell</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clauss, A" uniqKey="Clauss A">A CLAUSS</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cremer, P" uniqKey="Cremer P">P Cremer</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marchini, J" uniqKey="Marchini J">J Marchini</name>
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<author><name sortKey="Howie, B" uniqKey="Howie B">B Howie</name>
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<author><name sortKey="Donnelly, P" uniqKey="Donnelly P">P Donnelly</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
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<author><name sortKey="Abecasis, Gr" uniqKey="Abecasis G">GR Abecasis</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Devlin, B" uniqKey="Devlin B">B Devlin</name>
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<author><name sortKey="Roeder, K" uniqKey="Roeder K">K Roeder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Willer, Cj" uniqKey="Willer C">CJ Willer</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
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<author><name sortKey="Abecasis, Gr" uniqKey="Abecasis G">GR Abecasis</name>
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<biblStruct><analytic><author><name sortKey="Higgins, Jp" uniqKey="Higgins J">JP Higgins</name>
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<author><name sortKey="Thompson, Sg" uniqKey="Thompson S">SG Thompson</name>
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<author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hung, Rj" uniqKey="Hung R">RJ Hung</name>
</author>
<author><name sortKey="Mckay, Jd" uniqKey="Mckay J">JD McKay</name>
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<biblStruct><analytic><author><name sortKey="Liu, P" uniqKey="Liu P">P Liu</name>
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<biblStruct><analytic><author><name sortKey="Truong, T" uniqKey="Truong T">T Truong</name>
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<author><name sortKey="Hung, Rj" uniqKey="Hung R">RJ Hung</name>
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<author><name sortKey="Amos, Ci" uniqKey="Amos C">CI Amos</name>
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<author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name>
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</biblStruct>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Croatie</li>
<li>Finlande</li>
<li>France</li>
<li>Irlande (pays)</li>
<li>Italie</li>
<li>Nouvelle-Zélande</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Bade-Wurtemberg</li>
<li>Basse-Saxe</li>
<li>Bavière</li>
<li>Californie</li>
<li>District de Haute-Bavière</li>
<li>District de Münster</li>
<li>District de Souabe</li>
<li>District de Tübingen</li>
<li>Grand Londres</li>
<li>Hollande-Méridionale</li>
<li>Hollande-Septentrionale</li>
<li>Illinois</li>
<li>Lombardie</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Minnesota</li>
<li>Nouvelle-Galles du Sud</li>
<li>Oxfordshire</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Svealand</li>
<li>Texas</li>
<li>Utrecht (province)</li>
<li>Uusimaa</li>
<li>Washington (État)</li>
<li>Écosse</li>
<li>Île-de-France</li>
</region>
<settlement><li>Amsterdam</li>
<li>Augsbourg</li>
<li>Glasgow</li>
<li>Hanovre</li>
<li>Helsinki</li>
<li>Leyde</li>
<li>Londres</li>
<li>Marseille</li>
<li>Milan</li>
<li>Munich</li>
<li>Münster</li>
<li>Oxford</li>
<li>Paris</li>
<li>Rotterdam</li>
<li>Seattle</li>
<li>Stockholm</li>
<li>Sydney</li>
<li>Ulm</li>
<li>Utrecht</li>
<li>Édimbourg</li>
</settlement>
<orgName><li>Université Louis-et-Maximilien de Munich</li>
<li>Université d'Aix-Marseille</li>
<li>Université d'Helsinki</li>
<li>Université d'Oxford</li>
<li>Université d'Édimbourg</li>
<li>Université de Glasgow</li>
<li>Université de Londres</li>
<li>Université de Sydney</li>
<li>Université de Washington</li>
</orgName>
</list>
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<name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name>
<name sortKey="Grotevendt, Anne" sort="Grotevendt, Anne" uniqKey="Grotevendt A" first="Anne" last="Grotevendt">Anne Grotevendt</name>
<name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name>
<name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name>
<name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name>
<name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name>
<name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name>
<name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name>
<name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name>
<name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name>
<name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name>
<name sortKey="Ruckerl, Regina" sort="Ruckerl, Regina" uniqKey="Ruckerl R" first="Regina" last="Rückerl">Regina Rückerl</name>
<name sortKey="Ruckerl, Regina" sort="Ruckerl, Regina" uniqKey="Ruckerl R" first="Regina" last="Rückerl">Regina Rückerl</name>
<name sortKey="Seedorf, Udo" sort="Seedorf, Udo" uniqKey="Seedorf U" first="Udo" last="Seedorf">Udo Seedorf</name>
<name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name>
<name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name>
<name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name>
</country>
<country name="États-Unis"><region name="Massachusetts"><name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name>
</region>
<name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name>
<name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
<name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name>
<name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name>
<name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name>
<name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name>
<name sortKey="Liu, Kiang" sort="Liu, Kiang" uniqKey="Liu K" first="Kiang" last="Liu">Kiang Liu</name>
<name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name>
<name sortKey="Mukamal, Kenneth J" sort="Mukamal, Kenneth J" uniqKey="Mukamal K" first="Kenneth J." last="Mukamal">Kenneth J. Mukamal</name>
<name sortKey="Mukamal, Kenneth J" sort="Mukamal, Kenneth J" uniqKey="Mukamal K" first="Kenneth J." last="Mukamal">Kenneth J. Mukamal</name>
<name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name>
<name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name>
<name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name>
<name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M." last="Rose">Lynda M. Rose</name>
<name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name>
<name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name>
<name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name>
<name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name>
<name sortKey="Song, Jaejoon" sort="Song, Jaejoon" uniqKey="Song J" first="Jaejoon" last="Song">Jaejoon Song</name>
<name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name>
<name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name>
<name sortKey="Taylor, Kent" sort="Taylor, Kent" uniqKey="Taylor K" first="Kent" last="Taylor">Kent Taylor</name>
<name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name>
</noRegion>
<name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
<name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name>
<name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name>
<name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name>
<name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name>
<name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name>
<name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name>
<name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E." last="Huffman">Jennifer E. Huffman</name>
<name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name>
<name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name>
<name sortKey="Lowe, Gordon D" sort="Lowe, Gordon D" uniqKey="Lowe G" first="Gordon D." last="Lowe">Gordon D. Lowe</name>
<name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name>
<name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name>
<name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R." last="Rudnicka">Alicja R. Rudnicka</name>
<name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name>
<name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name>
<name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name>
<name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J." last="Stott">David J. Stott</name>
<name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name>
<name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name>
<name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name>
<name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name>
<name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name>
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<name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name>
<name sortKey="M Larstig, Anders" sort="M Larstig, Anders" uniqKey="M Larstig A" first="Anders" last="M Larstig">Anders M Larstig</name>
<name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
<name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
<name sortKey="Silveira, Angela" sort="Silveira, Angela" uniqKey="Silveira A" first="Angela" last="Silveira">Angela Silveira</name>
<name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J." last="Strawbridge">Rona J. Strawbridge</name>
</country>
<country name="Italie"><noRegion><name sortKey="Steri, Maristella" sort="Steri, Maristella" uniqKey="Steri M" first="Maristella" last="Steri">Maristella Steri</name>
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<name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name>
<name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name>
<name sortKey="Franzosi, Maria Grazia" sort="Franzosi, Maria Grazia" uniqKey="Franzosi M" first="Maria Grazia" last="Franzosi">Maria Grazia Franzosi</name>
<name sortKey="Masala, Marco" sort="Masala, Marco" uniqKey="Masala M" first="Marco" last="Masala">Marco Masala</name>
<name sortKey="Naitza, Silvia" sort="Naitza, Silvia" uniqKey="Naitza S" first="Silvia" last="Naitza">Silvia Naitza</name>
<name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name>
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<name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name>
<name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J. M." last="De Craen">Anton J. M. De Craen</name>
<name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name>
<name sortKey="De Maat, Moniek P M" sort="De Maat, Moniek P M" uniqKey="De Maat M" first="Moniek P. M." last="De Maat">Moniek P. M. De Maat</name>
<name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name>
<name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name>
<name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name>
<name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name>
<name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P. Eline" last="Slagboom">P. Eline Slagboom</name>
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<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name>
<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name>
<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name>
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<name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C. M." last="Witteman">Jacqueline C. M. Witteman</name>
<name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C. M." last="Witteman">Jacqueline C. M. Witteman</name>
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<name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
<name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
<name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
<name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
<name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name>
<name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name>
<name sortKey="Reiner, Alexander P" sort="Reiner, Alexander P" uniqKey="Reiner A" first="Alexander P." last="Reiner">Alexander P. Reiner</name>
<name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name>
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<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name>
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<name sortKey="Oudot Mellakh, Tiphaine" sort="Oudot Mellakh, Tiphaine" uniqKey="Oudot Mellakh T" first="Tiphaine" last="Oudot-Mellakh">Tiphaine Oudot-Mellakh</name>
<name sortKey="Oudot Mellakh, Tiphaine" sort="Oudot Mellakh, Tiphaine" uniqKey="Oudot Mellakh T" first="Tiphaine" last="Oudot-Mellakh">Tiphaine Oudot-Mellakh</name>
<name sortKey="Oudot Mellakh, Tiphaine" sort="Oudot Mellakh, Tiphaine" uniqKey="Oudot Mellakh T" first="Tiphaine" last="Oudot-Mellakh">Tiphaine Oudot-Mellakh</name>
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<name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Trégouët">David-Alexandre Trégouët</name>
<name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Trégouët">David-Alexandre Trégouët</name>
</country>
<country name="Irlande (pays)"><noRegion><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name>
</noRegion>
</country>
<country name="Croatie"><noRegion><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name>
</noRegion>
<name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name>
</country>
<country name="Nouvelle-Zélande"><noRegion><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name>
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<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Tofler, Geoffrey H" sort="Tofler, Geoffrey H" uniqKey="Tofler G" first="Geoffrey H." last="Tofler">Geoffrey H. Tofler</name>
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</record>
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