No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects.
Identifieur interne : 003239 ( PubMed/Corpus ); précédent : 003238; suivant : 003240No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects.
Auteurs : Jens Baumert ; Jie Huang ; Barbara Mcknight ; Maria Sabater-Lleal ; Maristella Steri ; Audrey Y. Chu ; Stella Trompet ; Lorna M. Lopez ; Myriam Fornage ; Alexander Teumer ; Weihong Tang ; Alicja R. Rudnicka ; Anders M Larstig ; Jouke-Jan Hottenga ; Maryam Kavousi ; Jari Lahti ; Toshiko Tanaka ; Caroline Hayward ; Jennifer E. Huffman ; Pierre-Emmanuel Morange ; Lynda M. Rose ; Saonli Basu ; Ann Rumley ; David J. Stott ; Brendan M. Buckley ; Anton J M. De Craen ; Serena Sanna ; Marco Masala ; Reiner Biffar ; Georg Homuth ; Angela Silveira ; Bengt Sennblad ; Anuj Goel ; Hugh Watkins ; Martina Müller-Nurasyid ; Regina Rückerl ; Kent Taylor ; Ming-Huei Chen ; Eco J C. De Geus ; Albert Hofman ; Jacqueline C M. Witteman ; Moniek P M. De Maat ; Aarno Palotie ; Gail Davies ; David S. Siscovick ; Ivana Kolcic ; Sarah H. Wild ; Jaejoon Song ; Wendy L. Mcardle ; Ian Ford ; Naveed Sattar ; David Schlessinger ; Anne Grotevendt ; Maria Grazia Franzosi ; Thomas Illig ; Melanie Waldenberger ; Thomas Lumley ; Geoffrey H. Tofler ; Gonneke Willemsen ; André G. Uitterlinden ; Fernando Rivadeneira ; Katri R Ikkönen ; Daniel I. Chasman ; Aaron R. Folsom ; Gordon D. Lowe ; Rudi G J. Westendorp ; P Eline Slagboom ; Francesco Cucca ; Henri Wallaschofski ; Rona J. Strawbridge ; Udo Seedorf ; Wolfgang Koenig ; Joshua C. Bis ; Kenneth J. Mukamal ; Jenny Van Dongen ; Elisabeth Widen ; Oscar H. Franco ; John M. Starr ; Kiang Liu ; Luigi Ferrucci ; Ozren Polasek ; James F. Wilson ; Tiphaine Oudot-Mellakh ; Harry Campbell ; Pau Navarro ; Stefania Bandinelli ; Johan Eriksson ; Dorret I. Boomsma ; Abbas Dehghan ; Robert Clarke ; Anders Hamsten ; Eric Boerwinkle ; J Wouter Jukema ; Silvia Naitza ; Paul M. Ridker ; Henry Völzke ; Ian J. Deary ; Alexander P. Reiner ; David-Alexandre Trégouët ; Christopher J. O'Donnell ; David P. Strachan ; Annette Peters ; Nicholas L. SmithSource :
- PloS one [ 1932-6203 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Fibrinogen.
- genetics : Alcohol Drinking, Smoking.
- methods : Genomics.
- Body Mass Index, Gene-Environment Interaction, Humans.
Abstract
Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-scale meta-analyses of genome-wide interaction studies to identify possible interactions of genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentration. The present study included 80,607 subjects of European ancestry from 22 studies. Genome-wide interaction analyses were performed separately in each study for about 2.6 million single nucleotide polymorphisms (SNPs) across the 22 autosomal chromosomes. For each SNP and risk factor, we performed a linear regression under an additive genetic model including an interaction term between SNP and risk factor. Interaction estimates were meta-analysed using a fixed-effects model. No genome-wide significant interaction with smoking status, alcohol consumption or BMI was observed in the meta-analyses. The most suggestive interaction was found for smoking and rs10519203, located in the LOC123688 region on chromosome 15, with a p value of 6.2 × 10(-8). This large genome-wide interaction study including 80,607 participants found no strong evidence of interaction between genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentrations. Further studies are needed to yield deeper insight in the interplay between environmental factors and gene variants on the regulation of fibrinogen concentrations.
DOI: 10.1371/journal.pone.0111156
PubMed: 25551457
Links to Exploration step
pubmed:25551457Le document en format XML
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<author><name sortKey="Baumert, Jens" sort="Baumert, Jens" uniqKey="Baumert J" first="Jens" last="Baumert">Jens Baumert</name>
<affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation>
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<author><name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name>
<affiliation><nlm:affiliation>National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; National Heart, Lung and Blood Institute Division of Intramural Research, Bethesda, Maryland, United States of America; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.</nlm:affiliation>
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<author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name>
<affiliation><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, Washington, United States of America.</nlm:affiliation>
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<author><name sortKey="Sabater Lleal, Maria" sort="Sabater Lleal, Maria" uniqKey="Sabater Lleal M" first="Maria" last="Sabater-Lleal">Maria Sabater-Lleal</name>
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<author><name sortKey="Steri, Maristella" sort="Steri, Maristella" uniqKey="Steri M" first="Maristella" last="Steri">Maristella Steri</name>
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<author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y" last="Chu">Audrey Y. Chu</name>
<affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.</nlm:affiliation>
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<author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name>
<affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M" last="Lopez">Lorna M. Lopez</name>
<affiliation><nlm:affiliation>Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation><nlm:affiliation>Brown Foundation Institute of Molecular Medicine, Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.</nlm:affiliation>
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</author>
<author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name>
<affiliation><nlm:affiliation>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.</nlm:affiliation>
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<author><name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name>
<affiliation><nlm:affiliation>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America.</nlm:affiliation>
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</author>
<author><name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R" last="Rudnicka">Alicja R. Rudnicka</name>
<affiliation><nlm:affiliation>Division of Population Health Sciences & Education, St George's, University of London, Cranmer Terrace, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="M Larstig, Anders" sort="M Larstig, Anders" uniqKey="M Larstig A" first="Anders" last="M Larstig">Anders M Larstig</name>
<affiliation><nlm:affiliation>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name>
<affiliation><nlm:affiliation>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name>
<affiliation><nlm:affiliation>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland; Folkhalsan Research Centre, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name>
<affiliation><nlm:affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E" last="Huffman">Jennifer E. Huffman</name>
<affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name>
<affiliation><nlm:affiliation>INSERM UMR_S 1062, Aix-Marseille Université, Marseille, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M" last="Rose">Lynda M. Rose</name>
<affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.</nlm:affiliation>
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</author>
<author><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name>
<affiliation><nlm:affiliation>Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name>
<affiliation><nlm:affiliation>Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J" last="Stott">David J. Stott</name>
<affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M" last="Buckley">Brendan M. Buckley</name>
<affiliation><nlm:affiliation>Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J M" last="De Craen">Anton J M. De Craen</name>
<affiliation><nlm:affiliation>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name>
<affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Masala, Marco" sort="Masala, Marco" uniqKey="Masala M" first="Marco" last="Masala">Marco Masala</name>
<affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name>
<affiliation><nlm:affiliation>Department of Prosthetic Dentistry, Gerostomatology and Dental Materials, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name>
<affiliation><nlm:affiliation>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Silveira, Angela" sort="Silveira, Angela" uniqKey="Silveira A" first="Angela" last="Silveira">Angela Silveira</name>
<affiliation><nlm:affiliation>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
<affiliation><nlm:affiliation>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden; Science for Life Laboratory, Karolinska Insitutet, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name>
<affiliation><nlm:affiliation>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name>
<affiliation><nlm:affiliation>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name>
<affiliation><nlm:affiliation>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ruckerl, Regina" sort="Ruckerl, Regina" uniqKey="Ruckerl R" first="Regina" last="Rückerl">Regina Rückerl</name>
<affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; ESC-Environmental Science Center, University of Augsburg, Augsburg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Taylor, Kent" sort="Taylor, Kent" uniqKey="Taylor K" first="Kent" last="Taylor">Kent Taylor</name>
<affiliation><nlm:affiliation>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<affiliation><nlm:affiliation>Department of Biostatistics, Boston University, Boston, Massachusetts, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J C" last="De Geus">Eco J C. De Geus</name>
<affiliation><nlm:affiliation>Department of Haematology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C M" last="Witteman">Jacqueline C M. Witteman</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Maat, Moniek P M" sort="De Maat, Moniek P M" uniqKey="De Maat M" first="Moniek P M" last="De Maat">Moniek P M. De Maat</name>
<affiliation><nlm:affiliation>Department of Haematology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name>
<affiliation><nlm:affiliation>Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S" last="Siscovick">David S. Siscovick</name>
<affiliation><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name>
<affiliation><nlm:affiliation>Department of Public Health, University of Split Medical School, Split, Croatia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H" last="Wild">Sarah H. Wild</name>
<affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Song, Jaejoon" sort="Song, Jaejoon" uniqKey="Song J" first="Jaejoon" last="Song">Jaejoon Song</name>
<affiliation><nlm:affiliation>Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name>
<affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation><nlm:affiliation>Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<affiliation><nlm:affiliation>BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name>
<affiliation><nlm:affiliation>Intramural Research Program, National Institute on Aging, Baltimore, Maryland, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Grotevendt, Anne" sort="Grotevendt, Anne" uniqKey="Grotevendt A" first="Anne" last="Grotevendt">Anne Grotevendt</name>
<affiliation><nlm:affiliation>Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Franzosi, Maria Grazia" sort="Franzosi, Maria Grazia" uniqKey="Franzosi M" first="Maria Grazia" last="Franzosi">Maria Grazia Franzosi</name>
<affiliation><nlm:affiliation>Department of Cardiovascular Research, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name>
<affiliation><nlm:affiliation>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name>
<affiliation><nlm:affiliation>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name>
<affiliation><nlm:affiliation>Department of Statistics, University of Auckland, Auckland, New Zealand.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tofler, Geoffrey H" sort="Tofler, Geoffrey H" uniqKey="Tofler G" first="Geoffrey H" last="Tofler">Geoffrey H. Tofler</name>
<affiliation><nlm:affiliation>Royal North Shore Hospital, University of Sydney, Sydney, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name>
<affiliation><nlm:affiliation>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation><nlm:affiliation>Division of Preventive Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name>
<affiliation><nlm:affiliation>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name>
<affiliation><nlm:affiliation>Division of Preventive Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R" last="Folsom">Aaron R. Folsom</name>
<affiliation><nlm:affiliation>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lowe, Gordon D" sort="Lowe, Gordon D" uniqKey="Lowe G" first="Gordon D" last="Lowe">Gordon D. Lowe</name>
<affiliation><nlm:affiliation>Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Westendorp, Rudi G J" sort="Westendorp, Rudi G J" uniqKey="Westendorp R" first="Rudi G J" last="Westendorp">Rudi G J. Westendorp</name>
<affiliation><nlm:affiliation>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P Eline" last="Slagboom">P Eline Slagboom</name>
<affiliation><nlm:affiliation>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name>
<affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name>
<affiliation><nlm:affiliation>Intramural Research Program, National Institute on Aging, Baltimore, Maryland, United States of America; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J" last="Strawbridge">Rona J. Strawbridge</name>
<affiliation><nlm:affiliation>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Seedorf, Udo" sort="Seedorf, Udo" uniqKey="Seedorf U" first="Udo" last="Seedorf">Udo Seedorf</name>
<affiliation><nlm:affiliation>Leibniz-Institut für Arterioskleroseforschung an der Universität Münster, Münster, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name>
<affiliation><nlm:affiliation>Department of Internal Medicine II - Cardiology, University of Ulm Medical Center, Ulm, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name>
<affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mukamal, Kenneth J" sort="Mukamal, Kenneth J" uniqKey="Mukamal K" first="Kenneth J" last="Mukamal">Kenneth J. Mukamal</name>
<affiliation><nlm:affiliation>Harvard Medical School, Boston, Massachusetts, United States of America; Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Van Dongen, Jenny" sort="Van Dongen, Jenny" uniqKey="Van Dongen J" first="Jenny" last="Van Dongen">Jenny Van Dongen</name>
<affiliation><nlm:affiliation>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name>
<affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M" last="Starr">John M. Starr</name>
<affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom; Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Kiang" sort="Liu, Kiang" uniqKey="Liu K" first="Kiang" last="Liu">Kiang Liu</name>
<affiliation><nlm:affiliation>Department of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<affiliation><nlm:affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name>
<affiliation><nlm:affiliation>Department of Public Health, University of Split Medical School, Split, Croatia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Oudot Mellakh, Tiphaine" sort="Oudot Mellakh, Tiphaine" uniqKey="Oudot Mellakh T" first="Tiphaine" last="Oudot-Mellakh">Tiphaine Oudot-Mellakh</name>
<affiliation><nlm:affiliation>INSERM, UMR_S 1166, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France; ICAN Institute for Cardiometabolism and Nutrition, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation><nlm:affiliation>Department of Public Health, University of Split Medical School, Split, Croatia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name>
<affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name>
<affiliation><nlm:affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
<affiliation><nlm:affiliation>Folkhalsan Research Centre, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland; Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name>
<affiliation><nlm:affiliation>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
<affiliation><nlm:affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name>
<affiliation><nlm:affiliation>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
<affiliation><nlm:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name>
<affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands; Durrer Center for Cardiogenetic Research, Amsterdam, the Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Naitza, Silvia" sort="Naitza, Silvia" uniqKey="Naitza S" first="Silvia" last="Naitza">Silvia Naitza</name>
<affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
<affiliation><nlm:affiliation>Division of Preventive Medicine, Division of Cardiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J" last="Deary">Ian J. Deary</name>
<affiliation><nlm:affiliation>Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Reiner, Alexander P" sort="Reiner, Alexander P" uniqKey="Reiner A" first="Alexander P" last="Reiner">Alexander P. Reiner</name>
<affiliation><nlm:affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Trégouët">David-Alexandre Trégouët</name>
<affiliation><nlm:affiliation>INSERM, UMR_S 1166, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France; ICAN Institute for Cardiometabolism and Nutrition, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J" last="O'Donnell">Christopher J. O'Donnell</name>
<affiliation><nlm:affiliation>National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; National Heart, Lung and Blood Institute Division of Intramural Research, Bethesda, Maryland, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name>
<affiliation><nlm:affiliation>Division of Population Health Sciences & Education, St George's, University of London, Cranmer Terrace, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name>
<affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich, Munich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L" last="Smith">Nicholas L. Smith</name>
<affiliation><nlm:affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland; Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America; Seattle Epidemiologic Research & Information Center, Veterans Affairs Office of Research & Development, Seattle, Washington, United States of America.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:25551457</idno>
<idno type="pmid">25551457</idno>
<idno type="doi">10.1371/journal.pone.0111156</idno>
<idno type="wicri:Area/PubMed/Corpus">003239</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003239</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects.</title>
<author><name sortKey="Baumert, Jens" sort="Baumert, Jens" uniqKey="Baumert J" first="Jens" last="Baumert">Jens Baumert</name>
<affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name>
<affiliation><nlm:affiliation>National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; National Heart, Lung and Blood Institute Division of Intramural Research, Bethesda, Maryland, United States of America; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name>
<affiliation><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, Washington, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sabater Lleal, Maria" sort="Sabater Lleal, Maria" uniqKey="Sabater Lleal M" first="Maria" last="Sabater-Lleal">Maria Sabater-Lleal</name>
<affiliation><nlm:affiliation>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Steri, Maristella" sort="Steri, Maristella" uniqKey="Steri M" first="Maristella" last="Steri">Maristella Steri</name>
<affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y" last="Chu">Audrey Y. Chu</name>
<affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name>
<affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M" last="Lopez">Lorna M. Lopez</name>
<affiliation><nlm:affiliation>Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation><nlm:affiliation>Brown Foundation Institute of Molecular Medicine, Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name>
<affiliation><nlm:affiliation>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name>
<affiliation><nlm:affiliation>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R" last="Rudnicka">Alicja R. Rudnicka</name>
<affiliation><nlm:affiliation>Division of Population Health Sciences & Education, St George's, University of London, Cranmer Terrace, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="M Larstig, Anders" sort="M Larstig, Anders" uniqKey="M Larstig A" first="Anders" last="M Larstig">Anders M Larstig</name>
<affiliation><nlm:affiliation>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name>
<affiliation><nlm:affiliation>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name>
<affiliation><nlm:affiliation>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland; Folkhalsan Research Centre, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name>
<affiliation><nlm:affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E" last="Huffman">Jennifer E. Huffman</name>
<affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name>
<affiliation><nlm:affiliation>INSERM UMR_S 1062, Aix-Marseille Université, Marseille, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M" last="Rose">Lynda M. Rose</name>
<affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name>
<affiliation><nlm:affiliation>Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name>
<affiliation><nlm:affiliation>Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J" last="Stott">David J. Stott</name>
<affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M" last="Buckley">Brendan M. Buckley</name>
<affiliation><nlm:affiliation>Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J M" last="De Craen">Anton J M. De Craen</name>
<affiliation><nlm:affiliation>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name>
<affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Masala, Marco" sort="Masala, Marco" uniqKey="Masala M" first="Marco" last="Masala">Marco Masala</name>
<affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name>
<affiliation><nlm:affiliation>Department of Prosthetic Dentistry, Gerostomatology and Dental Materials, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name>
<affiliation><nlm:affiliation>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Silveira, Angela" sort="Silveira, Angela" uniqKey="Silveira A" first="Angela" last="Silveira">Angela Silveira</name>
<affiliation><nlm:affiliation>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
<affiliation><nlm:affiliation>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden; Science for Life Laboratory, Karolinska Insitutet, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name>
<affiliation><nlm:affiliation>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name>
<affiliation><nlm:affiliation>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name>
<affiliation><nlm:affiliation>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ruckerl, Regina" sort="Ruckerl, Regina" uniqKey="Ruckerl R" first="Regina" last="Rückerl">Regina Rückerl</name>
<affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; ESC-Environmental Science Center, University of Augsburg, Augsburg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Taylor, Kent" sort="Taylor, Kent" uniqKey="Taylor K" first="Kent" last="Taylor">Kent Taylor</name>
<affiliation><nlm:affiliation>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<affiliation><nlm:affiliation>Department of Biostatistics, Boston University, Boston, Massachusetts, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J C" last="De Geus">Eco J C. De Geus</name>
<affiliation><nlm:affiliation>Department of Haematology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C M" last="Witteman">Jacqueline C M. Witteman</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Maat, Moniek P M" sort="De Maat, Moniek P M" uniqKey="De Maat M" first="Moniek P M" last="De Maat">Moniek P M. De Maat</name>
<affiliation><nlm:affiliation>Department of Haematology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name>
<affiliation><nlm:affiliation>Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S" last="Siscovick">David S. Siscovick</name>
<affiliation><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name>
<affiliation><nlm:affiliation>Department of Public Health, University of Split Medical School, Split, Croatia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H" last="Wild">Sarah H. Wild</name>
<affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Song, Jaejoon" sort="Song, Jaejoon" uniqKey="Song J" first="Jaejoon" last="Song">Jaejoon Song</name>
<affiliation><nlm:affiliation>Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name>
<affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation><nlm:affiliation>Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<affiliation><nlm:affiliation>BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name>
<affiliation><nlm:affiliation>Intramural Research Program, National Institute on Aging, Baltimore, Maryland, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Grotevendt, Anne" sort="Grotevendt, Anne" uniqKey="Grotevendt A" first="Anne" last="Grotevendt">Anne Grotevendt</name>
<affiliation><nlm:affiliation>Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Franzosi, Maria Grazia" sort="Franzosi, Maria Grazia" uniqKey="Franzosi M" first="Maria Grazia" last="Franzosi">Maria Grazia Franzosi</name>
<affiliation><nlm:affiliation>Department of Cardiovascular Research, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name>
<affiliation><nlm:affiliation>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name>
<affiliation><nlm:affiliation>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name>
<affiliation><nlm:affiliation>Department of Statistics, University of Auckland, Auckland, New Zealand.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tofler, Geoffrey H" sort="Tofler, Geoffrey H" uniqKey="Tofler G" first="Geoffrey H" last="Tofler">Geoffrey H. Tofler</name>
<affiliation><nlm:affiliation>Royal North Shore Hospital, University of Sydney, Sydney, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name>
<affiliation><nlm:affiliation>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation><nlm:affiliation>Division of Preventive Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name>
<affiliation><nlm:affiliation>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name>
<affiliation><nlm:affiliation>Division of Preventive Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R" last="Folsom">Aaron R. Folsom</name>
<affiliation><nlm:affiliation>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lowe, Gordon D" sort="Lowe, Gordon D" uniqKey="Lowe G" first="Gordon D" last="Lowe">Gordon D. Lowe</name>
<affiliation><nlm:affiliation>Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Westendorp, Rudi G J" sort="Westendorp, Rudi G J" uniqKey="Westendorp R" first="Rudi G J" last="Westendorp">Rudi G J. Westendorp</name>
<affiliation><nlm:affiliation>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P Eline" last="Slagboom">P Eline Slagboom</name>
<affiliation><nlm:affiliation>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name>
<affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name>
<affiliation><nlm:affiliation>Intramural Research Program, National Institute on Aging, Baltimore, Maryland, United States of America; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Strawbridge, Rona J" sort="Strawbridge, Rona J" uniqKey="Strawbridge R" first="Rona J" last="Strawbridge">Rona J. Strawbridge</name>
<affiliation><nlm:affiliation>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Seedorf, Udo" sort="Seedorf, Udo" uniqKey="Seedorf U" first="Udo" last="Seedorf">Udo Seedorf</name>
<affiliation><nlm:affiliation>Leibniz-Institut für Arterioskleroseforschung an der Universität Münster, Münster, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name>
<affiliation><nlm:affiliation>Department of Internal Medicine II - Cardiology, University of Ulm Medical Center, Ulm, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name>
<affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mukamal, Kenneth J" sort="Mukamal, Kenneth J" uniqKey="Mukamal K" first="Kenneth J" last="Mukamal">Kenneth J. Mukamal</name>
<affiliation><nlm:affiliation>Harvard Medical School, Boston, Massachusetts, United States of America; Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Van Dongen, Jenny" sort="Van Dongen, Jenny" uniqKey="Van Dongen J" first="Jenny" last="Van Dongen">Jenny Van Dongen</name>
<affiliation><nlm:affiliation>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Widen, Elisabeth" sort="Widen, Elisabeth" uniqKey="Widen E" first="Elisabeth" last="Widen">Elisabeth Widen</name>
<affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M" last="Starr">John M. Starr</name>
<affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom; Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Kiang" sort="Liu, Kiang" uniqKey="Liu K" first="Kiang" last="Liu">Kiang Liu</name>
<affiliation><nlm:affiliation>Department of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<affiliation><nlm:affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name>
<affiliation><nlm:affiliation>Department of Public Health, University of Split Medical School, Split, Croatia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Oudot Mellakh, Tiphaine" sort="Oudot Mellakh, Tiphaine" uniqKey="Oudot Mellakh T" first="Tiphaine" last="Oudot-Mellakh">Tiphaine Oudot-Mellakh</name>
<affiliation><nlm:affiliation>INSERM, UMR_S 1166, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France; ICAN Institute for Cardiometabolism and Nutrition, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation><nlm:affiliation>Department of Public Health, University of Split Medical School, Split, Croatia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name>
<affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name>
<affiliation><nlm:affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Eriksson, Johan" sort="Eriksson, Johan" uniqKey="Eriksson J" first="Johan" last="Eriksson">Johan Eriksson</name>
<affiliation><nlm:affiliation>Folkhalsan Research Centre, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland; Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name>
<affiliation><nlm:affiliation>Department of Biological Psychology, VU University & EMGO+ institute, VU Medical Centre, Amsterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Netherlands Genomics Initiative (NGI)-Sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name>
<affiliation><nlm:affiliation>Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name>
<affiliation><nlm:affiliation>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
<affiliation><nlm:affiliation>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name>
<affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands; Durrer Center for Cardiogenetic Research, Amsterdam, the Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Naitza, Silvia" sort="Naitza, Silvia" uniqKey="Naitza S" first="Silvia" last="Naitza">Silvia Naitza</name>
<affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
<affiliation><nlm:affiliation>Division of Preventive Medicine, Division of Cardiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J" last="Deary">Ian J. Deary</name>
<affiliation><nlm:affiliation>Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Reiner, Alexander P" sort="Reiner, Alexander P" uniqKey="Reiner A" first="Alexander P" last="Reiner">Alexander P. Reiner</name>
<affiliation><nlm:affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Trégouët">David-Alexandre Trégouët</name>
<affiliation><nlm:affiliation>INSERM, UMR_S 1166, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris, France; ICAN Institute for Cardiometabolism and Nutrition, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J" last="O'Donnell">Christopher J. O'Donnell</name>
<affiliation><nlm:affiliation>National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America; National Heart, Lung and Blood Institute Division of Intramural Research, Bethesda, Maryland, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name>
<affiliation><nlm:affiliation>Division of Population Health Sciences & Education, St George's, University of London, Cranmer Terrace, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name>
<affiliation><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich, Munich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L" last="Smith">Nicholas L. Smith</name>
<affiliation><nlm:affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland; Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America; Seattle Epidemiologic Research & Information Center, Veterans Affairs Office of Research & Development, Seattle, Washington, United States of America.</nlm:affiliation>
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<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2014" type="published">2014</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcohol Drinking (genetics)</term>
<term>Body Mass Index</term>
<term>Fibrinogen (metabolism)</term>
<term>Gene-Environment Interaction</term>
<term>Genomics (methods)</term>
<term>Humans</term>
<term>Smoking (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fibrinogen</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alcohol Drinking</term>
<term>Smoking</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genomics</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Body Mass Index</term>
<term>Gene-Environment Interaction</term>
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<front><div type="abstract" xml:lang="en">Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-scale meta-analyses of genome-wide interaction studies to identify possible interactions of genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentration. The present study included 80,607 subjects of European ancestry from 22 studies. Genome-wide interaction analyses were performed separately in each study for about 2.6 million single nucleotide polymorphisms (SNPs) across the 22 autosomal chromosomes. For each SNP and risk factor, we performed a linear regression under an additive genetic model including an interaction term between SNP and risk factor. Interaction estimates were meta-analysed using a fixed-effects model. No genome-wide significant interaction with smoking status, alcohol consumption or BMI was observed in the meta-analyses. The most suggestive interaction was found for smoking and rs10519203, located in the LOC123688 region on chromosome 15, with a p value of 6.2 × 10(-8). This large genome-wide interaction study including 80,607 participants found no strong evidence of interaction between genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentrations. Further studies are needed to yield deeper insight in the interplay between environmental factors and gene variants on the regulation of fibrinogen concentrations.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25551457</PMID>
<DateCreated><Year>2015</Year>
<Month>01</Month>
<Day>01</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>09</Month>
<Day>02</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>9</Volume>
<Issue>12</Issue>
<PubDate><Year>2014</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects.</ArticleTitle>
<Pagination><MedlinePgn>e111156</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0111156</ELocationID>
<Abstract><AbstractText>Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-scale meta-analyses of genome-wide interaction studies to identify possible interactions of genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentration. The present study included 80,607 subjects of European ancestry from 22 studies. Genome-wide interaction analyses were performed separately in each study for about 2.6 million single nucleotide polymorphisms (SNPs) across the 22 autosomal chromosomes. For each SNP and risk factor, we performed a linear regression under an additive genetic model including an interaction term between SNP and risk factor. Interaction estimates were meta-analysed using a fixed-effects model. No genome-wide significant interaction with smoking status, alcohol consumption or BMI was observed in the meta-analyses. The most suggestive interaction was found for smoking and rs10519203, located in the LOC123688 region on chromosome 15, with a p value of 6.2 × 10(-8). This large genome-wide interaction study including 80,607 participants found no strong evidence of interaction between genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentrations. Further studies are needed to yield deeper insight in the interplay between environmental factors and gene variants on the regulation of fibrinogen concentrations.</AbstractText>
</Abstract>
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