Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
Identifieur interne : 003800 ( Main/Exploration ); précédent : 003799; suivant : 003801Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
Auteurs : S. Schultz-Cherry ; R. J. Webby ; R. G. Webster ; A. Kelso ; I. G. Barr ; J. W. Mccauley ; R. S. Daniels ; D. Wang ; Y. Shu ; E. Nobusawa ; S. Itamura ; M. Tashiro ; Y. Harada ; S. Watanabe ; T. Odagiri ; Z. Ye ; G. Grohmann ; R. Harvey ; O. Engelhardt ; D. Smith ; K. Hamilton ; F. Claes ; G. DauphinSource :
- mBio [ 2150-7511 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Découverte de médicament (), Grippe chez les oiseaux (transmission), Grippe chez les oiseaux (virologie), Grippe humaine (), Grippe humaine (immunologie), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Pandémies (), Technologie pharmaceutique (), Vaccins antigrippaux (immunologie), Vaccins antigrippaux (isolement et purification), Virus de la grippe A (génétique), Virus de la grippe A (isolement et purification), Virus de la grippe A (pathogénicité), Volaille, Zoonoses (), Zoonoses (immunologie), Zoonoses (virologie), Zoonoses (épidémiologie).
- MESH :
- génétique : Virus de la grippe A.
- immunologie : Grippe humaine, Vaccins antigrippaux, Zoonoses.
- isolement et purification : Vaccins antigrippaux, Virus de la grippe A.
- pathogénicité : Virus de la grippe A.
- virologie : Grippe chez les oiseaux, Grippe humaine, Zoonoses.
- épidémiologie : Grippe chez les oiseaux, Grippe humaine, Zoonoses.
- Animaux, Découverte de médicament, Grippe humaine, Humains, Pandémies, Technologie pharmaceutique, Volaille, Zoonoses.
English descriptors
- KwdEn :
- Animals, Drug Discovery (methods), Humans, Influenza A virus (genetics), Influenza A virus (isolation & purification), Influenza A virus (pathogenicity), Influenza Vaccines (immunology), Influenza Vaccines (isolation & purification), Influenza in Birds (transmission), Influenza in Birds (virology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (prevention & control), Influenza, Human (virology), Pandemics (prevention & control), Poultry, Technology, Pharmaceutical (methods), Zoonoses (epidemiology), Zoonoses (immunology), Zoonoses (prevention & control), Zoonoses (virology).
- MESH :
- chemical , immunology : Influenza Vaccines.
- epidemiology : Influenza, Human, Zoonoses.
- genetics : Influenza A virus.
- immunology : Influenza, Human, Zoonoses.
- isolation & purification : Influenza A virus, Influenza Vaccines.
- methods : Drug Discovery, Technology, Pharmaceutical.
- pathogenicity : Influenza A virus.
- prevention & control : Influenza, Human, Pandemics, Zoonoses.
- transmission : Influenza in Birds.
- virology : Influenza in Birds, Influenza, Human, Zoonoses.
- Animals, Humans, Poultry.
Abstract
In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process—from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process.
Url:
DOI: 10.1128/mBio.02430-14
PubMed: 25505124
PubMed Central: 4278542
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process—from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process.</p>
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