Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
Identifieur interne : 001513 ( Pmc/Checkpoint ); précédent : 001512; suivant : 001514Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness
Auteurs : S. Schultz-Cherry ; R. J. Webby ; R. G. Webster ; A. Kelso ; I. G. Barr ; J. W. Mccauley ; R. S. Daniels ; D. Wang ; Y. Shu ; E. Nobusawa ; S. Itamura ; M. Tashiro ; Y. Harada ; S. Watanabe ; T. Odagiri ; Z. Ye ; G. Grohmann ; R. Harvey ; O. Engelhardt ; D. Smith ; K. Hamilton ; F. Claes ; G. DauphinSource :
- mBio [ 2150-7511 ] ; 2014.
Abstract
In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process—from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process.
Url:
DOI: 10.1128/mBio.02430-14
PubMed: 25505124
PubMed Central: 4278542
Affiliations:
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Ye</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Grohmann, G" sort="Grohmann, G" uniqKey="Grohmann G" first="G." last="Grohmann">G. Grohmann</name><affiliation><nlm:aff id="aff7"></nlm:aff></affiliation></author><author><name sortKey="Harvey, R" sort="Harvey, R" uniqKey="Harvey R" first="R." last="Harvey">R. Harvey</name><affiliation><nlm:aff id="aff8"></nlm:aff></affiliation></author><author><name sortKey="Engelhardt, O" sort="Engelhardt, O" uniqKey="Engelhardt O" first="O." last="Engelhardt">O. Engelhardt</name><affiliation><nlm:aff id="aff8"></nlm:aff></affiliation></author><author><name sortKey="Smith, D" sort="Smith, D" uniqKey="Smith D" first="D." last="Smith">D. Smith</name><affiliation><nlm:aff id="aff9"></nlm:aff></affiliation></author><author><name sortKey="Hamilton, K" sort="Hamilton, K" uniqKey="Hamilton K" first="K." last="Hamilton">K. Hamilton</name><affiliation><nlm:aff id="aff10"></nlm:aff></affiliation></author><author><name sortKey="Claes, F" sort="Claes, F" uniqKey="Claes F" first="F." last="Claes">F. Claes</name><affiliation><nlm:aff id="aff11"></nlm:aff></affiliation></author><author><name sortKey="Dauphin, G" sort="Dauphin, G" uniqKey="Dauphin G" first="G." last="Dauphin">G. Dauphin</name><affiliation><nlm:aff id="aff11"></nlm:aff></affiliation></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process—from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Freidl, Gs" uniqKey="Freidl G">GS Freidl</name></author><author><name sortKey="Meijer, A" uniqKey="Meijer A">A Meijer</name></author><author><name sortKey="De Bruin, E" uniqKey="De Bruin E">E de Bruin</name></author><author><name sortKey="De Nardi, M" uniqKey="De Nardi M">M de Nardi</name></author><author><name sortKey="Munoz, O" uniqKey="Munoz O">O Munoz</name></author><author><name sortKey="Capua, I" uniqKey="Capua I">I Capua</name></author><author><name sortKey="Breed, Ac" uniqKey="Breed A">AC Breed</name></author><author><name sortKey="Harris, K" uniqKey="Harris K">K 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sortKey="Kinlaw, K" uniqKey="Kinlaw K">K Kinlaw</name></author><author><name sortKey="Barrett, Dh" uniqKey="Barrett D">DH Barrett</name></author><author><name sortKey="Levine, Rj" uniqKey="Levine R">RJ Levine</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="editorial"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">mBio</journal-id><journal-id journal-id-type="iso-abbrev">MBio</journal-id><journal-id journal-id-type="hwp">mbio</journal-id><journal-id journal-id-type="pmc">mbio</journal-id><journal-id journal-id-type="publisher-id">mBio</journal-id><journal-title-group><journal-title>mBio</journal-title></journal-title-group><issn pub-type="epub">2150-7511</issn><publisher><publisher-name>American Society of Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25505124</article-id><article-id pub-id-type="pmc">4278542</article-id><article-id pub-id-type="publisher-id">mBio02430-14</article-id><article-id pub-id-type="doi">10.1128/mBio.02430-14</article-id><article-categories><subj-group subj-group-type="heading"><subject>Guest Editorial</subject></subj-group></article-categories><title-group><article-title>Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness</article-title><alt-title>Guest Editorial</alt-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Schultz-Cherry</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Webby</surname><given-names>R. J.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Webster</surname><given-names>R. G.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kelso</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Barr</surname><given-names>I. G.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>McCauley</surname><given-names>J. W.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Daniels</surname><given-names>R. S.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shu</surname><given-names>Y.</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nobusawa</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Itamura</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tashiro</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Harada</surname><given-names>Y.</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Watanabe</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Odagiri</surname><given-names>T.</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ye</surname><given-names>Z.</given-names></name><xref ref-type="aff" rid="aff6"><sup>f</sup></xref></contrib><contrib contrib-type="author"><name><surname>Grohmann</surname><given-names>G.</given-names></name><xref ref-type="aff" rid="aff7"><sup>g</sup></xref></contrib><contrib contrib-type="author"><name><surname>Harvey</surname><given-names>R.</given-names></name><xref ref-type="aff" rid="aff8"><sup>h</sup></xref></contrib><contrib contrib-type="author"><name><surname>Engelhardt</surname><given-names>O.</given-names></name><xref ref-type="aff" rid="aff8"><sup>h</sup></xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="aff9"><sup>i</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hamilton</surname><given-names>K.</given-names></name><xref ref-type="aff" rid="aff10"><sup>j</sup></xref></contrib><contrib contrib-type="author"><name><surname>Claes</surname><given-names>F.</given-names></name><xref ref-type="aff" rid="aff11"><sup>k</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dauphin</surname><given-names>G.</given-names></name><xref ref-type="aff" rid="aff11"><sup>k</sup></xref></contrib><aff id="aff1"><label><sup>a</sup></label>WHO Collaborating Center for Studies on the Ecology of Influenza in Animals, Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA</aff><aff id="aff2"><label><sup>b</sup></label>WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia</aff><aff id="aff3"><label><sup>c</sup></label>WHO Collaborating Centre for Reference and Research on Influenza, Division of Virology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom</aff><aff id="aff4"><label><sup>d</sup></label>WHO Collaborating Center for Reference and Research on Influenza, Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention China CDC, Beijing, People’s Republic of China</aff><aff id="aff5"><label><sup>e</sup></label>WHO Collaborating Centre for Reference and Research on Influenza, National Institute of Infectious Diseases, Laboratory of Influenza Virus Surveillance, Influenza Virus Research Center, Tokyo, Japan</aff><aff id="aff6"><label><sup>f</sup></label>Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA</aff><aff id="aff7"><label><sup>g</sup></label>Immunology and Vaccines, Therapeutic Goods Administration Laboratories, Woden, ACT, Australia</aff><aff id="aff8"><label><sup>h</sup></label>National Institute for Biological Standards and Control, Medicines and Healthcare Products Regulatory Agency, Potters Bar, United Kingdom</aff><aff id="aff9"><label><sup>i</sup></label>Center for Pathogen Evolution, Department of Zoology, WHO CC for Modeling Evolution and Control of Emerging Infectious Diseases, University of Cambridge, Cambridge, United Kingdom</aff><aff id="aff10"><label><sup>j</sup></label>OIE Scientific and Technical Department, OIE, Paris, France</aff><aff id="aff11"><label><sup>k</sup></label>OFFLU/EMPRES Laboratory Unit, Animal Health Service, FAO, Rome, Italy</aff></contrib-group><author-notes><corresp id="cor1">Address correspondence to S. Schultz-Cherry, <email>Stacey.schultz-cherry@stjude.org</email>.</corresp></author-notes><pub-date pub-type="epub"><day>12</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="collection"><season>Nov-Dec</season><year>2014</year></pub-date><volume>5</volume><issue>6</issue><elocation-id>e02430-14</elocation-id><permissions><copyright-statement>Copyright © 2014 Schultz-Cherry et al.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>Schultz-Cherry et al.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">Creative Commons Attribution 3.0 Unported license</ext-link>.</license-p></license></permissions><abstract><title>Abstract</title><p>In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process—from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process.</p></abstract><counts><page-count count="7"></page-count></counts><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>November/December 2014</meta-value></custom-meta></custom-meta-group></article-meta><notes notes-type="disclaimer"><p>The views expressed in this article do not necessarily reflect the views of the journal or of ASM.</p></notes></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Barr, I G" sort="Barr, I G" uniqKey="Barr I" first="I. G." last="Barr">I. G. Barr</name><name sortKey="Claes, F" sort="Claes, F" uniqKey="Claes F" first="F." last="Claes">F. Claes</name><name sortKey="Daniels, R S" sort="Daniels, R S" uniqKey="Daniels R" first="R. S." last="Daniels">R. S. Daniels</name><name sortKey="Dauphin, G" sort="Dauphin, G" uniqKey="Dauphin G" first="G." last="Dauphin">G. Dauphin</name><name sortKey="Engelhardt, O" sort="Engelhardt, O" uniqKey="Engelhardt O" first="O." last="Engelhardt">O. Engelhardt</name><name sortKey="Grohmann, G" sort="Grohmann, G" uniqKey="Grohmann G" first="G." last="Grohmann">G. Grohmann</name><name sortKey="Hamilton, K" sort="Hamilton, K" uniqKey="Hamilton K" first="K." last="Hamilton">K. Hamilton</name><name sortKey="Harada, Y" sort="Harada, Y" uniqKey="Harada Y" first="Y." last="Harada">Y. Harada</name><name sortKey="Harvey, R" sort="Harvey, R" uniqKey="Harvey R" first="R." last="Harvey">R. Harvey</name><name sortKey="Itamura, S" sort="Itamura, S" uniqKey="Itamura S" first="S." last="Itamura">S. Itamura</name><name sortKey="Kelso, A" sort="Kelso, A" uniqKey="Kelso A" first="A." last="Kelso">A. Kelso</name><name sortKey="Mccauley, J W" sort="Mccauley, J W" uniqKey="Mccauley J" first="J. W." last="Mccauley">J. W. Mccauley</name><name sortKey="Nobusawa, E" sort="Nobusawa, E" uniqKey="Nobusawa E" first="E." last="Nobusawa">E. Nobusawa</name><name sortKey="Odagiri, T" sort="Odagiri, T" uniqKey="Odagiri T" first="T." last="Odagiri">T. Odagiri</name><name sortKey="Schultz Cherry, S" sort="Schultz Cherry, S" uniqKey="Schultz Cherry S" first="S." last="Schultz-Cherry">S. Schultz-Cherry</name><name sortKey="Shu, Y" sort="Shu, Y" uniqKey="Shu Y" first="Y." last="Shu">Y. Shu</name><name sortKey="Smith, D" sort="Smith, D" uniqKey="Smith D" first="D." last="Smith">D. Smith</name><name sortKey="Tashiro, M" sort="Tashiro, M" uniqKey="Tashiro M" first="M." last="Tashiro">M. Tashiro</name><name sortKey="Wang, D" sort="Wang, D" uniqKey="Wang D" first="D." last="Wang">D. Wang</name><name sortKey="Watanabe, S" sort="Watanabe, S" uniqKey="Watanabe S" first="S." last="Watanabe">S. Watanabe</name><name sortKey="Webby, R J" sort="Webby, R J" uniqKey="Webby R" first="R. J." last="Webby">R. J. Webby</name><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name><name sortKey="Ye, Z" sort="Ye, Z" uniqKey="Ye Z" first="Z." last="Ye">Z. Ye</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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