Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation
Identifieur interne : 003892 ( Main/Exploration ); précédent : 003891; suivant : 003893Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation
Auteurs : Jessica M. Olsen ; Masaaki Sato ; Olof S. Dallner ; Anna L. Sandström ; Didier F. Pisani ; Jean-Claude Chambard ; Ez-Zoubir Amri ; Dana S. Hutchinson ; Tore BengtssonSource :
- The Journal of Cell Biology [ 0021-9525 ] ; 2014.
Descripteurs français
- KwdFr :
- Adipocytes bruns (métabolisme), Agonistes des récepteurs bêta-3 adrénergiques (pharmacologie), Animaux, Cellules cultivées, Cellules souches multipotentes (métabolisme), Complexes multiprotéiques (physiologie), Culture primaire de cellules, Femelle, Glucose (métabolisme), Humains, Insuline (pharmacologie), Insuline (physiologie), Isoprénaline (pharmacologie), Maturation post-traductionnelle des protéines, Morpholines (pharmacologie), Mâle, Phosphorylation, Pyrimidines (pharmacologie), Récepteurs bêta-3 adrénergiques (métabolisme), Sirolimus (pharmacologie), Souris, Sérine-thréonine kinases TOR (antagonistes et inhibiteurs), Sérine-thréonine kinases TOR (métabolisme), Sérine-thréonine kinases TOR (physiologie), Transport de protéines, Transporteur de glucose de type 1 (métabolisme).
- MESH :
- antagonistes et inhibiteurs : Sérine-thréonine kinases TOR.
- métabolisme : Adipocytes bruns, Cellules souches multipotentes, Glucose, Récepteurs bêta-3 adrénergiques, Sérine-thréonine kinases TOR, Transporteur de glucose de type 1.
- pharmacologie : Agonistes des récepteurs bêta-3 adrénergiques, Insuline, Isoprénaline, Morpholines, Pyrimidines, Sirolimus.
- physiologie : Complexes multiprotéiques, Insuline, Sérine-thréonine kinases TOR.
- Animaux, Cellules cultivées, Culture primaire de cellules, Femelle, Humains, Maturation post-traductionnelle des protéines, Mâle, Phosphorylation, Souris, Transport de protéines.
English descriptors
- KwdEn :
- Adipocytes, Brown (metabolism), Adrenergic beta-3 Receptor Agonists (pharmacology), Animals, Cells, Cultured, Female, Glucose (metabolism), Glucose Transporter Type 1 (metabolism), Humans, Insulin (pharmacology), Insulin (physiology), Isoproterenol (pharmacology), Male, Mice, Morpholines (pharmacology), Multipotent Stem Cells (metabolism), Multiprotein Complexes (physiology), Phosphorylation, Primary Cell Culture, Protein Processing, Post-Translational, Protein Transport, Pyrimidines (pharmacology), Receptors, Adrenergic, beta-3 (metabolism), Sirolimus (pharmacology), TOR Serine-Threonine Kinases (antagonists & inhibitors), TOR Serine-Threonine Kinases (metabolism), TOR Serine-Threonine Kinases (physiology).
- MESH :
- chemical , antagonists & inhibitors : TOR Serine-Threonine Kinases.
- chemical , metabolism : Glucose, Glucose Transporter Type 1, Receptors, Adrenergic, beta-3, TOR Serine-Threonine Kinases.
- chemical , pharmacology : Adrenergic beta-3 Receptor Agonists, Insulin, Isoproterenol, Morpholines, Pyrimidines, Sirolimus.
- metabolism : Adipocytes, Brown, Multipotent Stem Cells.
- chemical , physiology : Insulin, Multiprotein Complexes, TOR Serine-Threonine Kinases.
- Animals, Cells, Cultured, Female, Humans, Male, Mice, Phosphorylation, Primary Cell Culture, Protein Processing, Post-Translational, Protein Transport.
Abstract
β3-Adrenoceptors promote glucose uptake in brown adipose tissue via both cAMP-mediated increases in GLUT1 transcription and mTORC2-stimulated translocation of newly synthesized GLUT1 to the plasma membrane.
Url:
DOI: 10.1083/jcb.201403080
PubMed: 25385184
PubMed Central: 4226734
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipocytes, Brown (metabolism)</term>
<term>Adrenergic beta-3 Receptor Agonists (pharmacology)</term>
<term>Animals</term>
<term>Cells, Cultured</term>
<term>Female</term>
<term>Glucose (metabolism)</term>
<term>Glucose Transporter Type 1 (metabolism)</term>
<term>Humans</term>
<term>Insulin (pharmacology)</term>
<term>Insulin (physiology)</term>
<term>Isoproterenol (pharmacology)</term>
<term>Male</term>
<term>Mice</term>
<term>Morpholines (pharmacology)</term>
<term>Multipotent Stem Cells (metabolism)</term>
<term>Multiprotein Complexes (physiology)</term>
<term>Phosphorylation</term>
<term>Primary Cell Culture</term>
<term>Protein Processing, Post-Translational</term>
<term>Protein Transport</term>
<term>Pyrimidines (pharmacology)</term>
<term>Receptors, Adrenergic, beta-3 (metabolism)</term>
<term>Sirolimus (pharmacology)</term>
<term>TOR Serine-Threonine Kinases (antagonists & inhibitors)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
<term>TOR Serine-Threonine Kinases (physiology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adipocytes bruns (métabolisme)</term>
<term>Agonistes des récepteurs bêta-3 adrénergiques (pharmacologie)</term>
<term>Animaux</term>
<term>Cellules cultivées</term>
<term>Cellules souches multipotentes (métabolisme)</term>
<term>Complexes multiprotéiques (physiologie)</term>
<term>Culture primaire de cellules</term>
<term>Femelle</term>
<term>Glucose (métabolisme)</term>
<term>Humains</term>
<term>Insuline (pharmacologie)</term>
<term>Insuline (physiologie)</term>
<term>Isoprénaline (pharmacologie)</term>
<term>Maturation post-traductionnelle des protéines</term>
<term>Morpholines (pharmacologie)</term>
<term>Mâle</term>
<term>Phosphorylation</term>
<term>Pyrimidines (pharmacologie)</term>
<term>Récepteurs bêta-3 adrénergiques (métabolisme)</term>
<term>Sirolimus (pharmacologie)</term>
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<term>Sérine-thréonine kinases TOR (antagonistes et inhibiteurs)</term>
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<term>Transport de protéines</term>
<term>Transporteur de glucose de type 1 (métabolisme)</term>
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<term>Receptors, Adrenergic, beta-3</term>
<term>TOR Serine-Threonine Kinases</term>
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<term>Morpholines</term>
<term>Pyrimidines</term>
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<term>Multipotent Stem Cells</term>
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<term>Cellules souches multipotentes</term>
<term>Glucose</term>
<term>Récepteurs bêta-3 adrénergiques</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Transporteur de glucose de type 1</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agonistes des récepteurs bêta-3 adrénergiques</term>
<term>Insuline</term>
<term>Isoprénaline</term>
<term>Morpholines</term>
<term>Pyrimidines</term>
<term>Sirolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Complexes multiprotéiques</term>
<term>Insuline</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Insulin</term>
<term>Multiprotein Complexes</term>
<term>TOR Serine-Threonine Kinases</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mice</term>
<term>Phosphorylation</term>
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<term>Maturation post-traductionnelle des protéines</term>
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<front><div type="abstract" xml:lang="en"><p>β<sub>3</sub>
-Adrenoceptors promote glucose uptake in brown adipose tissue via both cAMP-mediated increases in GLUT1 transcription and mTORC2-stimulated translocation of newly synthesized GLUT1 to the plasma membrane.</p>
</div>
</front>
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<name sortKey="Dallner, Olof S" sort="Dallner, Olof S" uniqKey="Dallner O" first="Olof S." last="Dallner">Olof S. Dallner</name>
<name sortKey="Hutchinson, Dana S" sort="Hutchinson, Dana S" uniqKey="Hutchinson D" first="Dana S." last="Hutchinson">Dana S. Hutchinson</name>
<name sortKey="Olsen, Jessica M" sort="Olsen, Jessica M" uniqKey="Olsen J" first="Jessica M." last="Olsen">Jessica M. Olsen</name>
<name sortKey="Pisani, Didier F" sort="Pisani, Didier F" uniqKey="Pisani D" first="Didier F." last="Pisani">Didier F. Pisani</name>
<name sortKey="Sandstrom, Anna L" sort="Sandstrom, Anna L" uniqKey="Sandstrom A" first="Anna L." last="Sandström">Anna L. Sandström</name>
<name sortKey="Sato, Masaaki" sort="Sato, Masaaki" uniqKey="Sato M" first="Masaaki" last="Sato">Masaaki Sato</name>
</noCountry>
</tree>
</affiliations>
</record>
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