Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation
Identifieur interne : 001F74 ( Ncbi/Merge ); précédent : 001F73; suivant : 001F75Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation
Auteurs : Jessica M. Olsen ; Masaaki Sato ; Olof S. Dallner ; Anna L. Sandström ; Didier F. Pisani ; Jean-Claude Chambard ; Ez-Zoubir Amri ; Dana S. Hutchinson ; Tore BengtssonSource :
- The Journal of Cell Biology [ 0021-9525 ] ; 2014.
Descripteurs français
- KwdFr :
- Adipocytes bruns (métabolisme), Agonistes des récepteurs bêta-3 adrénergiques (pharmacologie), Animaux, Cellules cultivées, Cellules souches multipotentes (métabolisme), Complexes multiprotéiques (physiologie), Culture primaire de cellules, Femelle, Glucose (métabolisme), Humains, Insuline (pharmacologie), Insuline (physiologie), Isoprénaline (pharmacologie), Maturation post-traductionnelle des protéines, Morpholines (pharmacologie), Mâle, Phosphorylation, Pyrimidines (pharmacologie), Récepteurs bêta-3 adrénergiques (métabolisme), Sirolimus (pharmacologie), Souris, Sérine-thréonine kinases TOR (antagonistes et inhibiteurs), Sérine-thréonine kinases TOR (métabolisme), Sérine-thréonine kinases TOR (physiologie), Transport de protéines, Transporteur de glucose de type 1 (métabolisme).
- MESH :
- antagonistes et inhibiteurs : Sérine-thréonine kinases TOR.
- métabolisme : Adipocytes bruns, Cellules souches multipotentes, Glucose, Récepteurs bêta-3 adrénergiques, Sérine-thréonine kinases TOR, Transporteur de glucose de type 1.
- pharmacologie : Agonistes des récepteurs bêta-3 adrénergiques, Insuline, Isoprénaline, Morpholines, Pyrimidines, Sirolimus.
- physiologie : Complexes multiprotéiques, Insuline, Sérine-thréonine kinases TOR.
- Animaux, Cellules cultivées, Culture primaire de cellules, Femelle, Humains, Maturation post-traductionnelle des protéines, Mâle, Phosphorylation, Souris, Transport de protéines.
English descriptors
- KwdEn :
- Adipocytes, Brown (metabolism), Adrenergic beta-3 Receptor Agonists (pharmacology), Animals, Cells, Cultured, Female, Glucose (metabolism), Glucose Transporter Type 1 (metabolism), Humans, Insulin (pharmacology), Insulin (physiology), Isoproterenol (pharmacology), Male, Mice, Morpholines (pharmacology), Multipotent Stem Cells (metabolism), Multiprotein Complexes (physiology), Phosphorylation, Primary Cell Culture, Protein Processing, Post-Translational, Protein Transport, Pyrimidines (pharmacology), Receptors, Adrenergic, beta-3 (metabolism), Sirolimus (pharmacology), TOR Serine-Threonine Kinases (antagonists & inhibitors), TOR Serine-Threonine Kinases (metabolism), TOR Serine-Threonine Kinases (physiology).
- MESH :
- chemical , antagonists & inhibitors : TOR Serine-Threonine Kinases.
- chemical , metabolism : Glucose, Glucose Transporter Type 1, Receptors, Adrenergic, beta-3, TOR Serine-Threonine Kinases.
- chemical , pharmacology : Adrenergic beta-3 Receptor Agonists, Insulin, Isoproterenol, Morpholines, Pyrimidines, Sirolimus.
- metabolism : Adipocytes, Brown, Multipotent Stem Cells.
- chemical , physiology : Insulin, Multiprotein Complexes, TOR Serine-Threonine Kinases.
- Animals, Cells, Cultured, Female, Humans, Male, Mice, Phosphorylation, Primary Cell Culture, Protein Processing, Post-Translational, Protein Transport.
Abstract
β3-Adrenoceptors promote glucose uptake in brown adipose tissue via both cAMP-mediated increases in GLUT1 transcription and mTORC2-stimulated translocation of newly synthesized GLUT1 to the plasma membrane.
Url:
DOI: 10.1083/jcb.201403080
PubMed: 25385184
PubMed Central: 4226734
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PMC:4226734Le document en format XML
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Olsen</name><affiliation><nlm:aff id="aff1"><institution>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden</institution></nlm:aff></affiliation></author><author><name sortKey="Sato, Masaaki" sort="Sato, Masaaki" uniqKey="Sato M" first="Masaaki" last="Sato">Masaaki Sato</name><affiliation><nlm:aff id="aff1"><institution>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>Department of Pharmacology</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Dallner, Olof S" sort="Dallner, Olof S" uniqKey="Dallner O" first="Olof S." last="Dallner">Olof S. 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Hutchinson</name><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>Department of Pharmacology</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Bengtsson, Tore" sort="Bengtsson, Tore" uniqKey="Bengtsson T" first="Tore" last="Bengtsson">Tore Bengtsson</name><affiliation><nlm:aff id="aff1"><institution>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden</institution></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Cell Biology</title><idno type="ISSN">0021-9525</idno><idno type="eISSN">1540-8140</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipocytes, Brown (metabolism)</term><term>Adrenergic beta-3 Receptor Agonists (pharmacology)</term><term>Animals</term><term>Cells, Cultured</term><term>Female</term><term>Glucose (metabolism)</term><term>Glucose Transporter Type 1 (metabolism)</term><term>Humans</term><term>Insulin (pharmacology)</term><term>Insulin (physiology)</term><term>Isoproterenol (pharmacology)</term><term>Male</term><term>Mice</term><term>Morpholines (pharmacology)</term><term>Multipotent Stem Cells (metabolism)</term><term>Multiprotein Complexes (physiology)</term><term>Phosphorylation</term><term>Primary Cell Culture</term><term>Protein Processing, Post-Translational</term><term>Protein Transport</term><term>Pyrimidines (pharmacology)</term><term>Receptors, Adrenergic, beta-3 (metabolism)</term><term>Sirolimus (pharmacology)</term><term>TOR Serine-Threonine Kinases (antagonists & inhibitors)</term><term>TOR Serine-Threonine Kinases (metabolism)</term><term>TOR Serine-Threonine Kinases (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adipocytes bruns (métabolisme)</term><term>Agonistes des récepteurs bêta-3 adrénergiques (pharmacologie)</term><term>Animaux</term><term>Cellules cultivées</term><term>Cellules souches multipotentes (métabolisme)</term><term>Complexes multiprotéiques (physiologie)</term><term>Culture primaire de cellules</term><term>Femelle</term><term>Glucose (métabolisme)</term><term>Humains</term><term>Insuline (pharmacologie)</term><term>Insuline (physiologie)</term><term>Isoprénaline (pharmacologie)</term><term>Maturation post-traductionnelle des protéines</term><term>Morpholines (pharmacologie)</term><term>Mâle</term><term>Phosphorylation</term><term>Pyrimidines (pharmacologie)</term><term>Récepteurs bêta-3 adrénergiques (métabolisme)</term><term>Sirolimus (pharmacologie)</term><term>Souris</term><term>Sérine-thréonine kinases TOR (antagonistes et inhibiteurs)</term><term>Sérine-thréonine kinases TOR (métabolisme)</term><term>Sérine-thréonine kinases TOR (physiologie)</term><term>Transport de protéines</term><term>Transporteur de glucose de type 1 (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glucose</term><term>Glucose Transporter Type 1</term><term>Receptors, Adrenergic, beta-3</term><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adrenergic beta-3 Receptor Agonists</term><term>Insulin</term><term>Isoproterenol</term><term>Morpholines</term><term>Pyrimidines</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adipocytes, Brown</term><term>Multipotent Stem Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adipocytes bruns</term><term>Cellules souches multipotentes</term><term>Glucose</term><term>Récepteurs bêta-3 adrénergiques</term><term>Sérine-thréonine kinases TOR</term><term>Transporteur de glucose de type 1</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agonistes des récepteurs bêta-3 adrénergiques</term><term>Insuline</term><term>Isoprénaline</term><term>Morpholines</term><term>Pyrimidines</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Complexes multiprotéiques</term><term>Insuline</term><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Insulin</term><term>Multiprotein Complexes</term><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice</term><term>Phosphorylation</term><term>Primary Cell Culture</term><term>Protein Processing, Post-Translational</term><term>Protein Transport</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Culture primaire de cellules</term><term>Femelle</term><term>Humains</term><term>Maturation post-traductionnelle des protéines</term><term>Mâle</term><term>Phosphorylation</term><term>Souris</term><term>Transport de protéines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>β<sub>3</sub>-Adrenoceptors promote glucose uptake in brown adipose tissue via both cAMP-mediated increases in GLUT1 transcription and mTORC2-stimulated translocation of newly synthesized GLUT1 to the plasma membrane.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Brown, E J" 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Olsen</name><affiliation><nlm:aff id="aff1"><institution>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden</institution></nlm:aff></affiliation></author><author><name sortKey="Sato, Masaaki" sort="Sato, Masaaki" uniqKey="Sato M" first="Masaaki" last="Sato">Masaaki Sato</name><affiliation><nlm:aff id="aff1"><institution>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>Department of Pharmacology</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Dallner, Olof S" sort="Dallner, Olof S" uniqKey="Dallner O" first="Olof S." last="Dallner">Olof S. Dallner</name><affiliation><nlm:aff id="aff1"><institution>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><institution>Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065</institution></nlm:aff></affiliation></author><author><name sortKey="Sandstrom, Anna L" sort="Sandstrom, Anna L" uniqKey="Sandstrom A" first="Anna L." last="Sandström">Anna L. Sandström</name><affiliation><nlm:aff id="aff1"><institution>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden</institution></nlm:aff></affiliation></author><author><name sortKey="Pisani, Didier F" sort="Pisani, Didier F" uniqKey="Pisani D" first="Didier F." last="Pisani">Didier F. Pisani</name><affiliation><nlm:aff id="aff4"><institution>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice, France</institution></nlm:aff></affiliation></author><author><name sortKey="Chambard, Jean Claude" sort="Chambard, Jean Claude" uniqKey="Chambard J" first="Jean-Claude" last="Chambard">Jean-Claude Chambard</name><affiliation><nlm:aff id="aff4"><institution>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice, France</institution></nlm:aff></affiliation></author><author><name sortKey="Amri, Ez Zoubir" sort="Amri, Ez Zoubir" uniqKey="Amri E" first="Ez-Zoubir" last="Amri">Ez-Zoubir Amri</name><affiliation><nlm:aff id="aff4"><institution>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice, France</institution></nlm:aff></affiliation></author><author><name sortKey="Hutchinson, Dana S" sort="Hutchinson, Dana S" uniqKey="Hutchinson D" first="Dana S." last="Hutchinson">Dana S. Hutchinson</name><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>Department of Pharmacology</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Bengtsson, Tore" sort="Bengtsson, Tore" uniqKey="Bengtsson T" first="Tore" last="Bengtsson">Tore Bengtsson</name><affiliation><nlm:aff id="aff1"><institution>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden</institution></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25385184</idno><idno type="pmc">4226734</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226734</idno><idno type="RBID">PMC:4226734</idno><idno type="doi">10.1083/jcb.201403080</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002631</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002631</idno><idno type="wicri:Area/Pmc/Curation">002481</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002481</idno><idno type="wicri:Area/Pmc/Checkpoint">001553</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001553</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation</title><author><name sortKey="Olsen, Jessica M" sort="Olsen, Jessica M" uniqKey="Olsen J" first="Jessica M." last="Olsen">Jessica M. Olsen</name><affiliation><nlm:aff id="aff1"><institution>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden</institution></nlm:aff></affiliation></author><author><name sortKey="Sato, Masaaki" sort="Sato, Masaaki" uniqKey="Sato M" first="Masaaki" last="Sato">Masaaki Sato</name><affiliation><nlm:aff id="aff1"><institution>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden</institution></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>Department of Pharmacology</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Dallner, Olof S" sort="Dallner, Olof S" uniqKey="Dallner O" first="Olof S." last="Dallner">Olof S. 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Hutchinson</name><affiliation><nlm:aff wicri:cut=" and" id="aff3"><institution>Department of Pharmacology</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia</institution></nlm:aff></affiliation></author><author><name sortKey="Bengtsson, Tore" sort="Bengtsson, Tore" uniqKey="Bengtsson T" first="Tore" last="Bengtsson">Tore Bengtsson</name><affiliation><nlm:aff id="aff1"><institution>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden</institution></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Cell Biology</title><idno type="ISSN">0021-9525</idno><idno type="eISSN">1540-8140</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>β<sub>3</sub>-Adrenoceptors promote glucose uptake in brown adipose tissue via both cAMP-mediated increases in GLUT1 transcription and mTORC2-stimulated translocation of newly synthesized GLUT1 to the plasma membrane.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Brown, E J" uniqKey="Brown E">E.J. 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Olsen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm</wicri:regionArea><orgName type="university">Université de Stockholm</orgName><placeName><settlement type="city">Stockholm</settlement><region nuts="1">Svealand</region><region nuts="1">Comté de Stockholm</region></placeName></affiliation></author><author><name sortKey="Sato, Masaaki" sort="Sato, Masaaki" uniqKey="Sato M" first="Masaaki" last="Sato">Masaaki Sato</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052</wicri:regionArea><orgName type="university">Université de Stockholm</orgName><placeName><settlement type="city">Stockholm</settlement><region nuts="1">Svealand</region><region nuts="1">Comté de Stockholm</region></placeName></affiliation></author><author><name sortKey="Dallner, Olof S" sort="Dallner, Olof S" uniqKey="Dallner O" first="Olof S" last="Dallner">Olof S. Dallner</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Sandstrom, Anna L" sort="Sandstrom, Anna L" uniqKey="Sandstrom A" first="Anna L" last="Sandström">Anna L. Sandström</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm</wicri:regionArea><orgName type="university">Université de Stockholm</orgName><placeName><settlement type="city">Stockholm</settlement><region nuts="1">Svealand</region><region nuts="1">Comté de Stockholm</region></placeName></affiliation></author><author><name sortKey="Pisani, Didier F" sort="Pisani, Didier F" uniqKey="Pisani D" first="Didier F" last="Pisani">Didier F. Pisani</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice</wicri:regionArea><wicri:noRegion>06100 Nice</wicri:noRegion><wicri:noRegion>06100 Nice</wicri:noRegion></affiliation></author><author><name sortKey="Chambard, Jean Claude" sort="Chambard, Jean Claude" uniqKey="Chambard J" first="Jean-Claude" last="Chambard">Jean-Claude Chambard</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice</wicri:regionArea><wicri:noRegion>06100 Nice</wicri:noRegion><wicri:noRegion>06100 Nice</wicri:noRegion></affiliation></author><author><name sortKey="Amri, Ez Zoubir" sort="Amri, Ez Zoubir" uniqKey="Amri E" first="Ez-Zoubir" last="Amri">Ez-Zoubir Amri</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice</wicri:regionArea><wicri:noRegion>06100 Nice</wicri:noRegion><wicri:noRegion>06100 Nice</wicri:noRegion></affiliation></author><author><name sortKey="Hutchinson, Dana S" sort="Hutchinson, Dana S" uniqKey="Hutchinson D" first="Dana S" last="Hutchinson">Dana S. Hutchinson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052</wicri:regionArea><wicri:noRegion>Victoria 3052</wicri:noRegion></affiliation></author><author><name sortKey="Bengtsson, Tore" sort="Bengtsson, Tore" uniqKey="Bengtsson T" first="Tore" last="Bengtsson">Tore Bengtsson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden tore.bengtsson@su.se.</nlm:affiliation><country wicri:rule="url">Suède</country><wicri:regionArea>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm</wicri:regionArea><orgName type="university">Université de Stockholm</orgName><placeName><settlement type="city">Stockholm</settlement><region nuts="1">Svealand</region><region nuts="1">Comté de Stockholm</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25385184</idno><idno type="pmid">25385184</idno><idno type="doi">10.1083/jcb.201403080</idno><idno type="wicri:Area/PubMed/Corpus">003283</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003283</idno><idno type="wicri:Area/PubMed/Curation">003173</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003173</idno><idno type="wicri:Area/PubMed/Checkpoint">003173</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003173</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation.</title><author><name sortKey="Olsen, Jessica M" sort="Olsen, Jessica M" uniqKey="Olsen J" first="Jessica M" last="Olsen">Jessica M. Olsen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm</wicri:regionArea><orgName type="university">Université de Stockholm</orgName><placeName><settlement type="city">Stockholm</settlement><region nuts="1">Svealand</region><region nuts="1">Comté de Stockholm</region></placeName></affiliation></author><author><name sortKey="Sato, Masaaki" sort="Sato, Masaaki" uniqKey="Sato M" first="Masaaki" last="Sato">Masaaki Sato</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052</wicri:regionArea><orgName type="university">Université de Stockholm</orgName><placeName><settlement type="city">Stockholm</settlement><region nuts="1">Svealand</region><region nuts="1">Comté de Stockholm</region></placeName></affiliation></author><author><name sortKey="Dallner, Olof S" sort="Dallner, Olof S" uniqKey="Dallner O" first="Olof S" last="Dallner">Olof S. Dallner</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Sandstrom, Anna L" sort="Sandstrom, Anna L" uniqKey="Sandstrom A" first="Anna L" last="Sandström">Anna L. Sandström</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm</wicri:regionArea><orgName type="university">Université de Stockholm</orgName><placeName><settlement type="city">Stockholm</settlement><region nuts="1">Svealand</region><region nuts="1">Comté de Stockholm</region></placeName></affiliation></author><author><name sortKey="Pisani, Didier F" sort="Pisani, Didier F" uniqKey="Pisani D" first="Didier F" last="Pisani">Didier F. Pisani</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice</wicri:regionArea><wicri:noRegion>06100 Nice</wicri:noRegion><wicri:noRegion>06100 Nice</wicri:noRegion></affiliation></author><author><name sortKey="Chambard, Jean Claude" sort="Chambard, Jean Claude" uniqKey="Chambard J" first="Jean-Claude" last="Chambard">Jean-Claude Chambard</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice</wicri:regionArea><wicri:noRegion>06100 Nice</wicri:noRegion><wicri:noRegion>06100 Nice</wicri:noRegion></affiliation></author><author><name sortKey="Amri, Ez Zoubir" sort="Amri, Ez Zoubir" uniqKey="Amri E" first="Ez-Zoubir" last="Amri">Ez-Zoubir Amri</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institute of Biology Valrose, Centre National de la Recherche Scientifique UMR 7277, Institut National de la Santé et de la Recherche Médicale UMR 1091, University of Nice Sophia Antipolis, 06100 Nice</wicri:regionArea><wicri:noRegion>06100 Nice</wicri:noRegion><wicri:noRegion>06100 Nice</wicri:noRegion></affiliation></author><author><name sortKey="Hutchinson, Dana S" sort="Hutchinson, Dana S" uniqKey="Hutchinson D" first="Dana S" last="Hutchinson">Dana S. Hutchinson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia Department of Pharmacology and Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052</wicri:regionArea><wicri:noRegion>Victoria 3052</wicri:noRegion></affiliation></author><author><name sortKey="Bengtsson, Tore" sort="Bengtsson, Tore" uniqKey="Bengtsson T" first="Tore" last="Bengtsson">Tore Bengtsson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm, Sweden tore.bengtsson@su.se.</nlm:affiliation><country wicri:rule="url">Suède</country><wicri:regionArea>Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE -0691 Stockholm</wicri:regionArea><orgName type="university">Université de Stockholm</orgName><placeName><settlement type="city">Stockholm</settlement><region nuts="1">Svealand</region><region nuts="1">Comté de Stockholm</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of cell biology</title><idno type="eISSN">1540-8140</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipocytes, Brown (metabolism)</term><term>Adrenergic beta-3 Receptor Agonists (pharmacology)</term><term>Animals</term><term>Cells, Cultured</term><term>Female</term><term>Glucose 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(pharmacologie)</term><term>Animaux</term><term>Cellules cultivées</term><term>Cellules souches multipotentes (métabolisme)</term><term>Complexes multiprotéiques (physiologie)</term><term>Culture primaire de cellules</term><term>Femelle</term><term>Glucose (métabolisme)</term><term>Humains</term><term>Insuline (pharmacologie)</term><term>Insuline (physiologie)</term><term>Isoprénaline (pharmacologie)</term><term>Maturation post-traductionnelle des protéines</term><term>Morpholines (pharmacologie)</term><term>Mâle</term><term>Phosphorylation</term><term>Pyrimidines (pharmacologie)</term><term>Récepteurs bêta-3 adrénergiques (métabolisme)</term><term>Sirolimus (pharmacologie)</term><term>Souris</term><term>Sérine-thréonine kinases TOR (antagonistes et inhibiteurs)</term><term>Sérine-thréonine kinases TOR (métabolisme)</term><term>Sérine-thréonine kinases TOR (physiologie)</term><term>Transport de protéines</term><term>Transporteur de glucose de type 1 (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glucose</term><term>Glucose Transporter Type 1</term><term>Receptors, Adrenergic, beta-3</term><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adrenergic beta-3 Receptor Agonists</term><term>Insulin</term><term>Isoproterenol</term><term>Morpholines</term><term>Pyrimidines</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adipocytes, Brown</term><term>Multipotent Stem Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adipocytes bruns</term><term>Cellules souches multipotentes</term><term>Glucose</term><term>Récepteurs bêta-3 adrénergiques</term><term>Sérine-thréonine kinases TOR</term><term>Transporteur de glucose de type 1</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Agonistes des récepteurs bêta-3 adrénergiques</term><term>Insuline</term><term>Isoprénaline</term><term>Morpholines</term><term>Pyrimidines</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Complexes multiprotéiques</term><term>Insuline</term><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Insulin</term><term>Multiprotein Complexes</term><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice</term><term>Phosphorylation</term><term>Primary Cell Culture</term><term>Protein Processing, Post-Translational</term><term>Protein Transport</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Culture primaire de cellules</term><term>Femelle</term><term>Humains</term><term>Maturation post-traductionnelle des protéines</term><term>Mâle</term><term>Phosphorylation</term><term>Souris</term><term>Transport de protéines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Brown adipose tissue is the primary site for thermogenesis and can consume, in addition to free fatty acids, a very high amount of glucose from the blood, which can both acutely and chronically affect glucose homeostasis. Here, we show that mechanistic target of rapamycin (mTOR) complex 2 has a novel role in β3-adrenoceptor-stimulated glucose uptake in brown adipose tissue. We show that β3-adrenoceptors stimulate glucose uptake in brown adipose tissue via a signaling pathway that is comprised of two different parts: one part dependent on cAMP-mediated increases in GLUT1 transcription and de novo synthesis of GLUT1 and another part dependent on mTOR complex 2-stimulated translocation of newly synthesized GLUT1 to the plasma membrane, leading to increased glucose uptake. Both parts are essential for β3-adrenoceptor-stimulated glucose uptake. Importantly, the effect of β3-adrenoceptor on mTOR complex 2 is independent of the classical insulin-phosphoinositide 3-kinase-Akt pathway, highlighting a novel mechanism of mTOR complex 2 activation.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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