Real-Time Whole-Body Visualization of Chikungunya Virus Infection and Host Interferon Response in Zebrafish
Identifieur interne : 004516 ( Main/Exploration ); précédent : 004515; suivant : 004517Real-Time Whole-Body Visualization of Chikungunya Virus Infection and Host Interferon Response in Zebrafish
Auteurs : Nuno Palha [France] ; Florence Guivel-Benhassine [France] ; Valérie Briolat [France] ; Georges Lutfalla [France] ; Marion Sourisseau [France] ; Felix Ellett [Australie] ; Chieh-Huei Wang [Australie] ; Graham J. Lieschke [Australie] ; Philippe Herbomel [France] ; Olivier Schwartz [France] ; Jean-Pierre Levraud [France]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2013.
Abstract
Chikungunya Virus (CHIKV), a re-emerging arbovirus that may cause severe disease, constitutes an important public health problem. Herein we describe a novel CHIKV infection model in zebrafish, where viral spread was live-imaged in the whole body up to cellular resolution. Infected cells emerged in various organs in one principal wave with a median appearance time of ∼14 hours post infection. Timing of infected cell death was organ dependent, leading to a shift of CHIKV localization towards the brain. As in mammals, CHIKV infection triggered a strong type-I interferon (IFN) response, critical for survival. IFN was mainly expressed by neutrophils and hepatocytes. Cell type specific ablation experiments further demonstrated that neutrophils play a crucial, unexpected role in CHIKV containment. Altogether, our results show that the zebrafish represents a novel valuable model to dynamically visualize replication, pathogenesis and host responses to a human virus.
Url:
DOI: 10.1371/journal.ppat.1003619
PubMed: 24039582
PubMed Central: 3764224
Affiliations:
- Australie, France
- Languedoc-Roussillon, Occitanie (région administrative), Île-de-France
- Montpellier, Paris
- Université Montpellier 2, Université Pierre-et-Marie-Curie
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Le document en format XML
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<affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CNRS URA2578, Paris, France</addr-line>
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<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS URA2578, Paris</wicri:regionArea>
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<region type="old region">Île-de-France</region>
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<author><name sortKey="Schwartz, Olivier" sort="Schwartz, Olivier" uniqKey="Schwartz O" first="Olivier" last="Schwartz">Olivier Schwartz</name>
<affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur, Virus et Immunité, Department of Virology, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur, Virus et Immunité, Department of Virology, Paris</wicri:regionArea>
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<affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>CNRS URA3015, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS URA3015, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<author><name sortKey="Levraud, Jean Pierre" sort="Levraud, Jean Pierre" uniqKey="Levraud J" first="Jean-Pierre" last="Levraud">Jean-Pierre Levraud</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>CNRS URA2578, Paris, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS URA2578, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
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</analytic>
<series><title level="j">PLoS Pathogens</title>
<idno type="ISSN">1553-7366</idno>
<idno type="eISSN">1553-7374</idno>
<imprint><date when="2013">2013</date>
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<front><div type="abstract" xml:lang="en"><p>Chikungunya Virus (CHIKV), a re-emerging arbovirus that may cause severe disease, constitutes an important public health problem. Herein we describe a novel CHIKV infection model in zebrafish, where viral spread was live-imaged in the whole body up to cellular resolution. Infected cells emerged in various organs in one principal wave with a median appearance time of ∼14 hours post infection. Timing of infected cell death was organ dependent, leading to a shift of CHIKV localization towards the brain. As in mammals, CHIKV infection triggered a strong type-I interferon (IFN) response, critical for survival. IFN was mainly expressed by neutrophils and hepatocytes. Cell type specific ablation experiments further demonstrated that neutrophils play a crucial, unexpected role in CHIKV containment. Altogether, our results show that the zebrafish represents a novel valuable model to dynamically visualize replication, pathogenesis and host responses to a human virus.</p>
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<li>France</li>
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<li>Occitanie (région administrative)</li>
<li>Île-de-France</li>
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<name sortKey="Schwartz, Olivier" sort="Schwartz, Olivier" uniqKey="Schwartz O" first="Olivier" last="Schwartz">Olivier Schwartz</name>
<name sortKey="Sourisseau, Marion" sort="Sourisseau, Marion" uniqKey="Sourisseau M" first="Marion" last="Sourisseau">Marion Sourisseau</name>
<name sortKey="Sourisseau, Marion" sort="Sourisseau, Marion" uniqKey="Sourisseau M" first="Marion" last="Sourisseau">Marion Sourisseau</name>
</country>
<country name="Australie"><noRegion><name sortKey="Ellett, Felix" sort="Ellett, Felix" uniqKey="Ellett F" first="Felix" last="Ellett">Felix Ellett</name>
</noRegion>
<name sortKey="Lieschke, Graham J" sort="Lieschke, Graham J" uniqKey="Lieschke G" first="Graham J." last="Lieschke">Graham J. Lieschke</name>
<name sortKey="Wang, Chieh Huei" sort="Wang, Chieh Huei" uniqKey="Wang C" first="Chieh-Huei" last="Wang">Chieh-Huei Wang</name>
</country>
</tree>
</affiliations>
</record>
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