Origins of the glycinergic inputs to the rat locus coeruleus and dorsal raphe nuclei: a study combining retrograde tracing with glycine immunohistochemistry
Identifieur interne : 00C496 ( Main/Exploration ); précédent : 00C495; suivant : 00C497Origins of the glycinergic inputs to the rat locus coeruleus and dorsal raphe nuclei: a study combining retrograde tracing with glycine immunohistochemistry
Auteurs : Claire Rampon [France] ; Christelle Peyron [France] ; Damien Gervasoni [France] ; David V. Pow [France, Australie] ; Pierre-Hervé Luppi [France] ; Patrice Fort [France]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 1999-03.
English descriptors
- KwdEn :
- Aghajanian, Anaesthetized rats, Brainstem, Cell bodies, Coeruleus, Contralateral, Dorsal, Dorsal raphe, Dorsal raphe nuclei, Dorsal raphe nucleus, Dpgi, Dpme, Electrophysiological, Ennis, European journal, European neuroscience association, Gaba, Gabaergic, Gigantocellular, Glutamate, Glycine, Glycine immunohistochemistry, Glycinergic, Glycinergic innervation, Glycinergic inputs, Glycinergic neurons, Immunocytochemical, Immunohistochemistry, Injection cases, Injection sites, Innervation, Ipsilateral, Large number, Largest number, Lateral, Lateral paragigantocellular nucleus, Lesser degree, Locus, Locus coeruleus, Locus coeruleus neurones, Lpgi, Luppi, Medulla, Medullary, Mesencephalic, Mesencephalic reticular nucleus, Moderate proportion, Monoaminergic, Monoaminergic neurons, Monoaminergic nuclei, More caudally, Neuron, Neurones, Neuroscience, Neurotransmitter, Noradrenergic, Nucleus, Oral part, Paragigantocellular, Pbst, Periaqueductal, Peyron, Pontine, Primary antiserum, Proximal dendrites, Rampon, Raphe, Raphe magnus, Reticular, Retrograde transport, Retrogradely, Room temperature, Rostral, Rostral ventromedial medullary reticular formation, Saint marie, Serotonergic, Serotonergic neurons, Small number, Solitary tract, Spinal, Spinal motoneurons, Substantial number, Superior olivary, Tracer, Trigeminal, Vector labs, Ventral, Ventral part, Ventrolateral, Ventrolateral parts, Ventromedial.
- Teeft :
- Aghajanian, Anaesthetized rats, Brainstem, Cell bodies, Coeruleus, Contralateral, Dorsal, Dorsal raphe, Dorsal raphe nuclei, Dorsal raphe nucleus, Dpgi, Dpme, Electrophysiological, Ennis, European journal, European neuroscience association, Gaba, Gabaergic, Gigantocellular, Glutamate, Glycine, Glycine immunohistochemistry, Glycinergic, Glycinergic innervation, Glycinergic inputs, Glycinergic neurons, Immunocytochemical, Immunohistochemistry, Injection cases, Injection sites, Innervation, Ipsilateral, Large number, Largest number, Lateral, Lateral paragigantocellular nucleus, Lesser degree, Locus, Locus coeruleus, Locus coeruleus neurones, Lpgi, Luppi, Medulla, Medullary, Mesencephalic, Mesencephalic reticular nucleus, Moderate proportion, Monoaminergic, Monoaminergic neurons, Monoaminergic nuclei, More caudally, Neuron, Neurones, Neuroscience, Neurotransmitter, Noradrenergic, Nucleus, Oral part, Paragigantocellular, Pbst, Periaqueductal, Peyron, Pontine, Primary antiserum, Proximal dendrites, Rampon, Raphe, Raphe magnus, Reticular, Retrograde transport, Retrogradely, Room temperature, Rostral, Rostral ventromedial medullary reticular formation, Saint marie, Serotonergic, Serotonergic neurons, Small number, Solitary tract, Spinal, Spinal motoneurons, Substantial number, Superior olivary, Tracer, Trigeminal, Vector labs, Ventral, Ventral part, Ventrolateral, Ventrolateral parts, Ventromedial.
Abstract
The amino acid glycine is a major inhibitory neurotransmitter in the brainstem and is likely involved in the tonic inhibition of the monoaminergic neurons during all sleep‐waking stages. In order to determine the neurons at the origin of the glycinergic innervation of the two principal monoaminergic nuclei, the locus coeruleus and the dorsal raphe of the rat, we applied a double‐labelling technique, combining retrograde transport of cholera‐toxin B subunit with glycine immunohistochemistry. Using this technique, we found that the locus coeruleus and dorsal raphe nuclei receive a common glycinergic innervation from the ventral and ventrolateral periaqueductal grey, including the adjacent deep mesencephalic reticular nucleus. Small additional glycinergic inputs to these nuclei originated from the lateral paragigantocellular nucleus and the rostral ventromedial medullary reticular formation. The potential role of these glycinergic inputs in the control of the excitability of the monoaminergic neurons of the locus coeruleus and dorsal raphe nuclei is discussed.
Url:
DOI: 10.1046/j.1460-9568.1999.00511.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000504
- to stream Istex, to step Curation: 000504
- to stream Istex, to step Checkpoint: 002159
- to stream Main, to step Merge: 00D469
- to stream Main, to step Curation: 00C496
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Origins of the glycinergic inputs to the rat locus coeruleus and dorsal raphe nuclei: a study combining retrograde tracing with glycine immunohistochemistry</title>
<author><name sortKey="Rampon, Claire" sort="Rampon, Claire" uniqKey="Rampon C" first="Claire" last="Rampon">Claire Rampon</name>
</author>
<author><name sortKey="Peyron, Christelle" sort="Peyron, Christelle" uniqKey="Peyron C" first="Christelle" last="Peyron">Christelle Peyron</name>
</author>
<author><name sortKey="Gervasoni, Damien" sort="Gervasoni, Damien" uniqKey="Gervasoni D" first="Damien" last="Gervasoni">Damien Gervasoni</name>
</author>
<author><name sortKey="Pow, David V" sort="Pow, David V" uniqKey="Pow D" first="David V." last="Pow">David V. Pow</name>
</author>
<author><name sortKey="Luppi, Pierre Erve" sort="Luppi, Pierre Erve" uniqKey="Luppi P" first="Pierre-Hervé" last="Luppi">Pierre-Hervé Luppi</name>
</author>
<author><name sortKey="Fort, Patrice" sort="Fort, Patrice" uniqKey="Fort P" first="Patrice" last="Fort">Patrice Fort</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:1A74E7E0146DD78C5305A1848EB37FA363EC7C7E</idno>
<date when="1999" year="1999">1999</date>
<idno type="doi">10.1046/j.1460-9568.1999.00511.x</idno>
<idno type="url">https://api.istex.fr/document/1A74E7E0146DD78C5305A1848EB37FA363EC7C7E/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000504</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000504</idno>
<idno type="wicri:Area/Istex/Curation">000504</idno>
<idno type="wicri:Area/Istex/Checkpoint">002159</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002159</idno>
<idno type="wicri:doubleKey">0953-816X:1999:Rampon C:origins:of:the</idno>
<idno type="wicri:Area/Main/Merge">00D469</idno>
<idno type="wicri:Area/Main/Curation">00C496</idno>
<idno type="wicri:Area/Main/Exploration">00C496</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Origins of the glycinergic inputs to the rat locus coeruleus and dorsal raphe nuclei: a study combining retrograde tracing with glycine immunohistochemistry</title>
<author><name sortKey="Rampon, Claire" sort="Rampon, Claire" uniqKey="Rampon C" first="Claire" last="Rampon">Claire Rampon</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Neurobiologie des Etats de Sommeil et d'Eveil, INSERM U480, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peyron, Christelle" sort="Peyron, Christelle" uniqKey="Peyron C" first="Christelle" last="Peyron">Christelle Peyron</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Neurobiologie des Etats de Sommeil et d'Eveil, INSERM U480, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gervasoni, Damien" sort="Gervasoni, Damien" uniqKey="Gervasoni D" first="Damien" last="Gervasoni">Damien Gervasoni</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Neurobiologie des Etats de Sommeil et d'Eveil, INSERM U480, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pow, David V" sort="Pow, David V" uniqKey="Pow D" first="David V." last="Pow">David V. Pow</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Neurobiologie des Etats de Sommeil et d'Eveil, INSERM U480, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Vision, Touch and Hearing Research Center, University of Queensland, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Luppi, Pierre Erve" sort="Luppi, Pierre Erve" uniqKey="Luppi P" first="Pierre-Hervé" last="Luppi">Pierre-Hervé Luppi</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Neurobiologie des Etats de Sommeil et d'Eveil, INSERM U480, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fort, Patrice" sort="Fort, Patrice" uniqKey="Fort P" first="Patrice" last="Fort">Patrice Fort</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Neurobiologie des Etats de Sommeil et d'Eveil, INSERM U480, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">European Journal of Neuroscience</title>
<title level="j" type="alt">EUROPEAN JOURNAL OF NEUROSCIENCE</title>
<idno type="ISSN">0953-816X</idno>
<idno type="eISSN">1460-9568</idno>
<imprint><biblScope unit="vol">11</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="1058">1058</biblScope>
<biblScope unit="page" to="1066">1066</biblScope>
<biblScope unit="page-count">9</biblScope>
<publisher>Blackwell Science Ltd</publisher>
<pubPlace>Oxford, UK</pubPlace>
<date type="published" when="1999-03">1999-03</date>
</imprint>
<idno type="ISSN">0953-816X</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0953-816X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aghajanian</term>
<term>Anaesthetized rats</term>
<term>Brainstem</term>
<term>Cell bodies</term>
<term>Coeruleus</term>
<term>Contralateral</term>
<term>Dorsal</term>
<term>Dorsal raphe</term>
<term>Dorsal raphe nuclei</term>
<term>Dorsal raphe nucleus</term>
<term>Dpgi</term>
<term>Dpme</term>
<term>Electrophysiological</term>
<term>Ennis</term>
<term>European journal</term>
<term>European neuroscience association</term>
<term>Gaba</term>
<term>Gabaergic</term>
<term>Gigantocellular</term>
<term>Glutamate</term>
<term>Glycine</term>
<term>Glycine immunohistochemistry</term>
<term>Glycinergic</term>
<term>Glycinergic innervation</term>
<term>Glycinergic inputs</term>
<term>Glycinergic neurons</term>
<term>Immunocytochemical</term>
<term>Immunohistochemistry</term>
<term>Injection cases</term>
<term>Injection sites</term>
<term>Innervation</term>
<term>Ipsilateral</term>
<term>Large number</term>
<term>Largest number</term>
<term>Lateral</term>
<term>Lateral paragigantocellular nucleus</term>
<term>Lesser degree</term>
<term>Locus</term>
<term>Locus coeruleus</term>
<term>Locus coeruleus neurones</term>
<term>Lpgi</term>
<term>Luppi</term>
<term>Medulla</term>
<term>Medullary</term>
<term>Mesencephalic</term>
<term>Mesencephalic reticular nucleus</term>
<term>Moderate proportion</term>
<term>Monoaminergic</term>
<term>Monoaminergic neurons</term>
<term>Monoaminergic nuclei</term>
<term>More caudally</term>
<term>Neuron</term>
<term>Neurones</term>
<term>Neuroscience</term>
<term>Neurotransmitter</term>
<term>Noradrenergic</term>
<term>Nucleus</term>
<term>Oral part</term>
<term>Paragigantocellular</term>
<term>Pbst</term>
<term>Periaqueductal</term>
<term>Peyron</term>
<term>Pontine</term>
<term>Primary antiserum</term>
<term>Proximal dendrites</term>
<term>Rampon</term>
<term>Raphe</term>
<term>Raphe magnus</term>
<term>Reticular</term>
<term>Retrograde transport</term>
<term>Retrogradely</term>
<term>Room temperature</term>
<term>Rostral</term>
<term>Rostral ventromedial medullary reticular formation</term>
<term>Saint marie</term>
<term>Serotonergic</term>
<term>Serotonergic neurons</term>
<term>Small number</term>
<term>Solitary tract</term>
<term>Spinal</term>
<term>Spinal motoneurons</term>
<term>Substantial number</term>
<term>Superior olivary</term>
<term>Tracer</term>
<term>Trigeminal</term>
<term>Vector labs</term>
<term>Ventral</term>
<term>Ventral part</term>
<term>Ventrolateral</term>
<term>Ventrolateral parts</term>
<term>Ventromedial</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Aghajanian</term>
<term>Anaesthetized rats</term>
<term>Brainstem</term>
<term>Cell bodies</term>
<term>Coeruleus</term>
<term>Contralateral</term>
<term>Dorsal</term>
<term>Dorsal raphe</term>
<term>Dorsal raphe nuclei</term>
<term>Dorsal raphe nucleus</term>
<term>Dpgi</term>
<term>Dpme</term>
<term>Electrophysiological</term>
<term>Ennis</term>
<term>European journal</term>
<term>European neuroscience association</term>
<term>Gaba</term>
<term>Gabaergic</term>
<term>Gigantocellular</term>
<term>Glutamate</term>
<term>Glycine</term>
<term>Glycine immunohistochemistry</term>
<term>Glycinergic</term>
<term>Glycinergic innervation</term>
<term>Glycinergic inputs</term>
<term>Glycinergic neurons</term>
<term>Immunocytochemical</term>
<term>Immunohistochemistry</term>
<term>Injection cases</term>
<term>Injection sites</term>
<term>Innervation</term>
<term>Ipsilateral</term>
<term>Large number</term>
<term>Largest number</term>
<term>Lateral</term>
<term>Lateral paragigantocellular nucleus</term>
<term>Lesser degree</term>
<term>Locus</term>
<term>Locus coeruleus</term>
<term>Locus coeruleus neurones</term>
<term>Lpgi</term>
<term>Luppi</term>
<term>Medulla</term>
<term>Medullary</term>
<term>Mesencephalic</term>
<term>Mesencephalic reticular nucleus</term>
<term>Moderate proportion</term>
<term>Monoaminergic</term>
<term>Monoaminergic neurons</term>
<term>Monoaminergic nuclei</term>
<term>More caudally</term>
<term>Neuron</term>
<term>Neurones</term>
<term>Neuroscience</term>
<term>Neurotransmitter</term>
<term>Noradrenergic</term>
<term>Nucleus</term>
<term>Oral part</term>
<term>Paragigantocellular</term>
<term>Pbst</term>
<term>Periaqueductal</term>
<term>Peyron</term>
<term>Pontine</term>
<term>Primary antiserum</term>
<term>Proximal dendrites</term>
<term>Rampon</term>
<term>Raphe</term>
<term>Raphe magnus</term>
<term>Reticular</term>
<term>Retrograde transport</term>
<term>Retrogradely</term>
<term>Room temperature</term>
<term>Rostral</term>
<term>Rostral ventromedial medullary reticular formation</term>
<term>Saint marie</term>
<term>Serotonergic</term>
<term>Serotonergic neurons</term>
<term>Small number</term>
<term>Solitary tract</term>
<term>Spinal</term>
<term>Spinal motoneurons</term>
<term>Substantial number</term>
<term>Superior olivary</term>
<term>Tracer</term>
<term>Trigeminal</term>
<term>Vector labs</term>
<term>Ventral</term>
<term>Ventral part</term>
<term>Ventrolateral</term>
<term>Ventrolateral parts</term>
<term>Ventromedial</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The amino acid glycine is a major inhibitory neurotransmitter in the brainstem and is likely involved in the tonic inhibition of the monoaminergic neurons during all sleep‐waking stages. In order to determine the neurons at the origin of the glycinergic innervation of the two principal monoaminergic nuclei, the locus coeruleus and the dorsal raphe of the rat, we applied a double‐labelling technique, combining retrograde transport of cholera‐toxin B subunit with glycine immunohistochemistry. Using this technique, we found that the locus coeruleus and dorsal raphe nuclei receive a common glycinergic innervation from the ventral and ventrolateral periaqueductal grey, including the adjacent deep mesencephalic reticular nucleus. Small additional glycinergic inputs to these nuclei originated from the lateral paragigantocellular nucleus and the rostral ventromedial medullary reticular formation. The potential role of these glycinergic inputs in the control of the excitability of the monoaminergic neurons of the locus coeruleus and dorsal raphe nuclei is discussed.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Lyon</li>
</settlement>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Rampon, Claire" sort="Rampon, Claire" uniqKey="Rampon C" first="Claire" last="Rampon">Claire Rampon</name>
</region>
<name sortKey="Fort, Patrice" sort="Fort, Patrice" uniqKey="Fort P" first="Patrice" last="Fort">Patrice Fort</name>
<name sortKey="Gervasoni, Damien" sort="Gervasoni, Damien" uniqKey="Gervasoni D" first="Damien" last="Gervasoni">Damien Gervasoni</name>
<name sortKey="Luppi, Pierre Erve" sort="Luppi, Pierre Erve" uniqKey="Luppi P" first="Pierre-Hervé" last="Luppi">Pierre-Hervé Luppi</name>
<name sortKey="Peyron, Christelle" sort="Peyron, Christelle" uniqKey="Peyron C" first="Christelle" last="Peyron">Christelle Peyron</name>
<name sortKey="Pow, David V" sort="Pow, David V" uniqKey="Pow D" first="David V." last="Pow">David V. Pow</name>
</country>
<country name="Australie"><noRegion><name sortKey="Pow, David V" sort="Pow, David V" uniqKey="Pow D" first="David V." last="Pow">David V. Pow</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00C496 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00C496 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:1A74E7E0146DD78C5305A1848EB37FA363EC7C7E |texte= Origins of the glycinergic inputs to the rat locus coeruleus and dorsal raphe nuclei: a study combining retrograde tracing with glycine immunohistochemistry }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |