A common variant near TGFBR3 is associated with primary open angle glaucoma
Identifieur interne : 003251 ( Main/Exploration ); précédent : 003250; suivant : 003252A common variant near TGFBR3 is associated with primary open angle glaucoma
Auteurs : Zheng Li [Singapour] ; R. Rand Allingham [États-Unis] ; Masakazu Nakano ; Liyun Jia [République populaire de Chine] ; Yuhong Chen ; Yoko Ikeda ; Baskaran Mani [Singapour] ; Li-Jia Chen [République populaire de Chine] ; Changwon Kee ; David F. Garway-Heath [Royaume-Uni] ; Sarangapani Sripriya [Inde] ; Nobuo Fuse [Japon] ; Khaled K. Abu-Amero [Arabie saoudite, États-Unis] ; Chukai Huang [République populaire de Chine] ; Prasanthi Namburi [Inde] ; Kathryn Burdon [Australie] ; Shamira A. Perera [Singapour] ; Puya Gharahkhani [Australie] ; Ying Lin [République populaire de Chine] ; Morio Ueno ; Mineo Ozaki [Japon] ; Takanori Mizoguchi [Japon] ; Subbiah Ramasamy Krishnadas [Inde] ; Essam A. Osman [Arabie saoudite] ; Mei Chin Lee ; Anita S. Y. Chan [Singapour] ; Liza-Sharmini A. Tajudin [Malaisie] ; Tan Do [Viêt Nam] ; Aurelien Goncalves ; Pascal Reynier [France] ; Hong Zhang [République populaire de Chine] ; Rupert Bourne [Royaume-Uni] ; David Goh [Singapour] ; David Broadway [Royaume-Uni] ; Rahat Husain [Singapour] ; Anil K. Negi [Royaume-Uni] ; Daniel H. Su [Singapour] ; Ching-Lin Ho [Singapour] ; Augusto Azuara Blanco [Royaume-Uni] ; Christopher K. S. Leung [République populaire de Chine] ; Tina T. Wong [Singapour] ; Azhany Yakub [Malaisie] ; Yutao Liu [États-Unis, Géorgie (pays)] ; Monisha E. Nongpiur [Singapour] ; Jong Chul Han ; Do Nhu Hon [Viêt Nam] ; Balekudaru Shantha [Inde] ; Bowen Zhao [République populaire de Chine] ; Jinghong Sang [République populaire de Chine] ; Nihong Zhang [République populaire de Chine] ; Ryuichi Sato ; Kengo Yoshii [Japon] ; Songhomita Panda-Jonas [Allemagne] ; Allison E. Ashley Koch [États-Unis] ; Leon W. Herndon [États-Unis] ; Sayoko E. Moroi ; Pratap Challa [États-Unis] ; Jia Nee Foo [Singapour] ; Jin-Xin Bei [République populaire de Chine] ; Yi-Xin Zeng [République populaire de Chine] ; Cameron P. Simmons [Viêt Nam, Royaume-Uni] ; Tran Nguyen Bich Chau [Viêt Nam] ; Philomenadin Ferdinamarie Sharmila [Inde] ; Merwyn Chew ; Blanche Lim ; Pansy O. S. Tam [République populaire de Chine] ; Elaine Chua ; Xiao Yu Ng ; Victor H. K. Yong ; Yaan Fun Chong ; Wee Yang Meah [Singapour] ; Saravanan Vijayan [Inde] ; Sohn Seongsoo ; Wang Xu [Singapour] ; Yik Ying Teo [Singapour] ; Jessica N. Cooke Bailey [États-Unis] ; Jae H. Kang [États-Unis] ; Jonathan L. Haines [États-Unis] ; Ching Yu Cheng [Singapour] ; Seang-Mei Saw [Singapour] ; E-Shyong Tai [Singapour] ; Julia E. Richards [États-Unis] ; Robert Ritch [États-Unis] ; Douglas E. Gaasterland [États-Unis] ; Louis R. Pasquale [États-Unis] ; Jianjun Liu [Singapour] ; Jost B. Jonas [Allemagne] ; Dan Milea [Singapour] ; Ronnie George [Inde] ; Saleh A. Al-Obeidan [Arabie saoudite] ; Kazuhiko Mori ; Stuart Macgregor [Australie] ; Alex W. Hewitt [Australie] ; Christopher A. Girkin [États-Unis] ; Mingzhi Zhang [République populaire de Chine] ; Periasamy Sundaresan [Inde] ; Lingam Vijaya [Inde] ; David A. Mackey [Australie] ; Tien Yin Wong [Singapour] ; Jamie E. Craig [Australie] ; Xinghuai Sun [République populaire de Chine] ; Shigeru Kinoshita ; Janey L. Wiggs [États-Unis] ; Chiea-Chuen Khor [Singapour] ; Zhenglin Yang [République populaire de Chine] ; Chi Pui Pang [République populaire de Chine] ; Ningli Wang [République populaire de Chine] ; Michael A. Hauser [États-Unis] ; Kei Tashiro ; Tin Aung [Singapour] ; Eranga N. Vithana [Singapour]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Proteoglycans, Receptors, Transforming Growth Factor beta.
- genetics : Glaucoma, Open-Angle.
- Aged, Aged, 80 and over, Alleles, Female, Genetic Variation, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide.
Abstract
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at
Url:
DOI: 10.1093/hmg/ddv128
PubMed: 25861811
PubMed Central: 4459396
Affiliations:
- Allemagne, Arabie saoudite, Australie, France, Géorgie (pays), Inde, Japon, Malaisie, Royaume-Uni, République populaire de Chine, Singapour, Viêt Nam, États-Unis
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A common variant near <italic>TGFBR3</italic> is associated with primary open angle glaucoma</title><author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R. Rand" last="Allingham">R. Rand Allingham</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Jia, Liyun" sort="Jia, Liyun" uniqKey="Jia L" first="Liyun" last="Jia">Liyun Jia</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Yuhong" sort="Chen, Yuhong" uniqKey="Chen Y" first="Yuhong" last="Chen">Yuhong Chen</name><affiliation><nlm:aff id="af9"><addr-line>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mani, Baskaran" sort="Mani, Baskaran" uniqKey="Mani B" first="Baskaran" last="Mani">Baskaran Mani</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Li Jia" sort="Chen, Li Jia" uniqKey="Chen L" first="Li-Jia" last="Chen">Li-Jia Chen</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kee, Changwon" sort="Kee, Changwon" uniqKey="Kee C" first="Changwon" last="Kee">Changwon Kee</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Garway Heath, David F" sort="Garway Heath, David F" uniqKey="Garway Heath D" first="David F." last="Garway-Heath">David F. Garway-Heath</name><affiliation wicri:level="1"><nlm:aff id="af16"><institution>National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sripriya, Sarangapani" sort="Sripriya, Sarangapani" uniqKey="Sripriya S" first="Sarangapani" last="Sripriya">Sarangapani Sripriya</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>SNONGC Department of Genetics and Molecular Biology</addr-line>,<institution>Vision Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fuse, Nobuo" sort="Fuse, Nobuo" uniqKey="Fuse N" first="Nobuo" last="Fuse">Nobuo Fuse</name><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Integrative Genomics</addr-line>,<institution>Tohoku Medical Megabank Organization</institution>,<addr-line>Sendai</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K." last="Abu-Amero">Khaled K. Abu-Amero</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>University of Florida</institution>,<addr-line>Jacksonville, FL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Chukai" sort="Huang, Chukai" uniqKey="Huang C" first="Chukai" last="Huang">Chukai Huang</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Chinese University of Hong Kong Joint Shantou International Eye Center</addr-line>,<institution>Shantou University</institution>,<addr-line>Shantou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Namburi, Prasanthi" sort="Namburi, Prasanthi" uniqKey="Namburi P" first="Prasanthi" last="Namburi">Prasanthi Namburi</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burdon, Kathryn" sort="Burdon, Kathryn" uniqKey="Burdon K" first="Kathryn" last="Burdon">Kathryn Burdon</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Department of Ophthalmology</addr-line>,<institution>Flinders University</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A." last="Perera">Shamira A. Perera</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gharahkhani, Puya" sort="Gharahkhani, Puya" uniqKey="Gharahkhani P" first="Puya" last="Gharahkhani">Puya Gharahkhani</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Department of Genetics and Computational Biology, Statistical Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Sichuan Provincial Key Laboratory for Human Disease Gene Study</addr-line>,<institution>Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>School of Medicine</addr-line>,<institution>University of Electronic Science and Technology of China</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name><affiliation wicri:level="1"><nlm:aff id="af28"><institution>Ozaki Eye Hospital</institution>,<addr-line>1–15, Kamezaki, Hyuga, Miyazaki 883-0066</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name><affiliation wicri:level="1"><nlm:aff id="af29"><institution>Mizoguchi Eye Hospital</institution>,<addr-line>6-13 Tawara-machi, Sasebo, Nagasaki 857-0016</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Krishnadas, Subbiah Ramasamy" sort="Krishnadas, Subbiah Ramasamy" uniqKey="Krishnadas S" first="Subbiah Ramasamy" last="Krishnadas">Subbiah Ramasamy Krishnadas</name><affiliation wicri:level="1"><nlm:aff id="af30"><addr-line>Glaucoma Services</addr-line>,<institution>Aravind Eye Hospital</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A." last="Osman">Essam A. Osman</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S. Y." last="Chan">Anita S. Y. Chan</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tajudin, Liza Sharmini A" sort="Tajudin, Liza Sharmini A" uniqKey="Tajudin L" first="Liza-Sharmini A." last="Tajudin">Liza-Sharmini A. Tajudin</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Ophthalmology, School of Medical Sciences</addr-line>,<institution>Universiti Sains Malaysia</institution>,<addr-line>Kota Bharu, Kelantan</addr-line>,<country>Malaysia</country>,</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Do, Tan" sort="Do, Tan" uniqKey="Do T" first="Tan" last="Do">Tan Do</name><affiliation wicri:level="1"><nlm:aff id="af32"><institution>Vietnam National Institute of Ophthalmology</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goncalves, Aurelien" sort="Goncalves, Aurelien" uniqKey="Goncalves A" first="Aurelien" last="Goncalves">Aurelien Goncalves</name><affiliation><nlm:aff id="af33"><addr-line>Ophthalmology Department</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name><affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Biochemistry Department</addr-line>,<institution>Angers University Hospital</institution>,<addr-line>Angers</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Ophthalmology, Tongji Hospital of Tongji Medical College</addr-line>,<institution>Huazhong University of Science and Technology</institution>,<addr-line>Wuhan</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bourne, Rupert" sort="Bourne, Rupert" uniqKey="Bourne R" first="Rupert" last="Bourne">Rupert Bourne</name><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Huntingdon Glaucoma Diagnostic & Research Centre</addr-line>,<institution>Hinchingbrooke Hospital</institution>,<addr-line>Huntingdon</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goh, David" sort="Goh, David" uniqKey="Goh D" first="David" last="Goh">David Goh</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Broadway, David" sort="Broadway, David" uniqKey="Broadway D" first="David" last="Broadway">David Broadway</name><affiliation wicri:level="1"><nlm:aff id="af37"><institution>Norfolk & Norwich University Hospital NHS Trust</institution>,<addr-line>Norwich</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Negi, Anil K" sort="Negi, Anil K" uniqKey="Negi A" first="Anil K." last="Negi">Anil K. Negi</name><affiliation wicri:level="1"><nlm:aff id="af38"><institution>Heart of UK NHS Foundation Trust</institution>,<addr-line>Birmingham</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Su, Daniel H" sort="Su, Daniel H" uniqKey="Su D" first="Daniel H" last="Su">Daniel H. Su</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Ching Lin" sort="Ho, Ching Lin" uniqKey="Ho C" first="Ching-Lin" last="Ho">Ching-Lin Ho</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blanco, Augusto Azuara" sort="Blanco, Augusto Azuara" uniqKey="Blanco A" first="Augusto Azuara" last="Blanco">Augusto Azuara Blanco</name><affiliation wicri:level="1"><nlm:aff id="af39"><addr-line>School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine</addr-line>,<institution>Queen's University Belfast</institution>,<addr-line>Northern Ireland</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leung, Christopher K S" sort="Leung, Christopher K S" uniqKey="Leung C" first="Christopher K. S." last="Leung">Christopher K. S. Leung</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tina T" sort="Wong, Tina T" uniqKey="Wong T" first="Tina T." last="Wong">Tina T. Wong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yakub, Azhany" sort="Yakub, Azhany" uniqKey="Yakub A" first="Azhany" last="Yakub">Azhany Yakub</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Ophthalmology, School of Medical Sciences</addr-line>,<institution>Universiti Sains Malaysia</institution>,<addr-line>Kota Bharu, Kelantan</addr-line>,<country>Malaysia</country>,</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Cellular Biology and Anatomy</addr-line>,<institution>Georgia Regents University</institution>,<addr-line>Augusta</addr-line>,<country>Georgia</country>,</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nongpiur, Monisha E" sort="Nongpiur, Monisha E" uniqKey="Nongpiur M" first="Monisha E." last="Nongpiur">Monisha E. Nongpiur</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Han, Jong Chul" sort="Han, Jong Chul" uniqKey="Han J" first="Jong Chul" last="Han">Jong Chul Han</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Hon, Do Nhu" sort="Hon, Do Nhu" uniqKey="Hon D" first="Do Nhu" last="Hon">Do Nhu Hon</name><affiliation wicri:level="1"><nlm:aff id="af32"><institution>Vietnam National Institute of Ophthalmology</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shantha, Balekudaru" sort="Shantha, Balekudaru" uniqKey="Shantha B" first="Balekudaru" last="Shantha">Balekudaru Shantha</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sato, Ryuichi" sort="Sato, Ryuichi" uniqKey="Sato R" first="Ryuichi" last="Sato">Ryuichi Sato</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yoshii, Kengo" sort="Yoshii, Kengo" uniqKey="Yoshii K" first="Kengo" last="Yoshii">Kengo Yoshii</name><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Medical Statistics</addr-line>,<institution>Kyoto Prefectural University of Medicine</institution>,<addr-line>Kyoto</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Panda Jonas, Songhomita" sort="Panda Jonas, Songhomita" uniqKey="Panda Jonas S" first="Songhomita" last="Panda-Jonas">Songhomita Panda-Jonas</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Ophthalmology</addr-line>,<institution>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E." last="Ashley Koch">Allison E. Ashley Koch</name><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herndon, Leon W" sort="Herndon, Leon W" uniqKey="Herndon L" first="Leon W." last="Herndon">Leon W. Herndon</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E." last="Moroi">Sayoko E. Moroi</name><affiliation><nlm:aff id="af44"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bei, Jin Xin" sort="Bei, Jin Xin" uniqKey="Bei J" first="Jin-Xin" last="Bei">Jin-Xin Bei</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>State Key Laboratory of Oncology in Southern China, Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Experimental Research</addr-line>,<institution>Sun Yat-Sen University Cancer Centre</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeng, Yi Xin" sort="Zeng, Yi Xin" uniqKey="Zeng Y" first="Yi-Xin" last="Zeng">Yi-Xin Zeng</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>State Key Laboratory of Oncology in Southern China, Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Experimental Research</addr-line>,<institution>Sun Yat-Sen University Cancer Centre</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P." last="Simmons">Cameron P. Simmons</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Clinical Research Unit</addr-line>,<institution>Oxford University</institution>,<addr-line>190 Ben Ham Tu, Ho Chi Minh City</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine</addr-line>,<institution>Oxford University</institution>,<addr-line>Oxford OX3 7LJ</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bich Chau, Tran Nguyen" sort="Bich Chau, Tran Nguyen" uniqKey="Bich Chau T" first="Tran Nguyen" last="Bich Chau">Tran Nguyen Bich Chau</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Clinical Research Unit</addr-line>,<institution>Oxford University</institution>,<addr-line>190 Ben Ham Tu, Ho Chi Minh City</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sharmila, Philomenadin Ferdinamarie" sort="Sharmila, Philomenadin Ferdinamarie" uniqKey="Sharmila P" first="Philomenadin Ferdinamarie" last="Sharmila">Philomenadin Ferdinamarie Sharmila</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>SNONGC Department of Genetics and Molecular Biology</addr-line>,<institution>Vision Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chew, Merwyn" sort="Chew, Merwyn" uniqKey="Chew M" first="Merwyn" last="Chew">Merwyn Chew</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lim, Blanche" sort="Lim, Blanche" uniqKey="Lim B" first="Blanche" last="Lim">Blanche Lim</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Tam, Pansy O S" sort="Tam, Pansy O S" uniqKey="Tam P" first="Pansy O. S." last="Tam">Pansy O. S. Tam</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chua, Elaine" sort="Chua, Elaine" uniqKey="Chua E" first="Elaine" last="Chua">Elaine Chua</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ng, Xiao Yu" sort="Ng, Xiao Yu" uniqKey="Ng X" first="Xiao Yu" last="Ng">Xiao Yu Ng</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yong, Victor H K" sort="Yong, Victor H K" uniqKey="Yong V" first="Victor H. K." last="Yong">Victor H. K. Yong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chong, Yaan Fun" sort="Chong, Yaan Fun" uniqKey="Chong Y" first="Yaan Fun" last="Chong">Yaan Fun Chong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seongsoo, Sohn" sort="Seongsoo, Sohn" uniqKey="Seongsoo S" first="Sohn" last="Seongsoo">Sohn Seongsoo</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Wang" sort="Xu, Wang" uniqKey="Xu W" first="Wang" last="Xu">Wang Xu</name><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cooke Bailey, Jessica N" sort="Cooke Bailey, Jessica N" uniqKey="Cooke Bailey J" first="Jessica N." last="Cooke Bailey">Jessica N. Cooke Bailey</name><affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Case Western Reserve University</institution>,<addr-line>Cleveland, OH</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H." last="Kang">Jae H. Kang</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Channing Division of Network Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name><affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Case Western Reserve University</institution>,<addr-line>Cleveland, OH</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Department of Medicine</addr-line>,<institution>National University Health System & National University of Singapore</institution>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E." last="Richards">Julia E. Richards</name><affiliation><nlm:aff id="af44"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name><affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Einhorn Clinical Research Center, Department of Ophthalmology</addr-line>,<institution>New York Eye and Ear Infirmary</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaasterland, Douglas E" sort="Gaasterland, Douglas E" uniqKey="Gaasterland D" first="Douglas E." last="Gaasterland">Douglas E. Gaasterland</name><affiliation wicri:level="1"><nlm:aff id="af54"><institution>Eye Doctors of Washington DC</institution>,<addr-line>Washington, DC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R." last="Pasquale">Louis R. Pasquale</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Channing Division of Network Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af55"><addr-line>Department of Ophthalmology, Harvard Medical School</addr-line>,<institution>Massachusetts Eye and Ear Infirmary</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B." last="Jonas">Jost B. Jonas</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Ophthalmology</addr-line>,<institution>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Milea">Dan Milea</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="George, Ronnie" sort="George, Ronnie" uniqKey="George R" first="Ronnie" last="George">Ronnie George</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A." last="Al-Obeidan">Saleh A. Al-Obeidan</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Department of Genetics and Computational Biology, Statistical Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W." last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af56"><institution>Centre for Eye Research Australia (CERA)</institution>,<institution>University of Melbourne</institution>,<institution>Royal Victorian Eye and Ear Hospital</institution>,<addr-line>Melbourne, VIC</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Girkin, Christopher A" sort="Girkin, Christopher A" uniqKey="Girkin C" first="Christopher A." last="Girkin">Christopher A. Girkin</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Department of Ophthalmology</addr-line>,<institution>University of Alabama at Birmingham</institution>,<addr-line>Birmingham, AL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Mingzhi" sort="Zhang, Mingzhi" uniqKey="Zhang M" first="Mingzhi" last="Zhang">Mingzhi Zhang</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Chinese University of Hong Kong Joint Shantou International Eye Center</addr-line>,<institution>Shantou University</institution>,<addr-line>Shantou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vijaya, Lingam" sort="Vijaya, Lingam" uniqKey="Vijaya L" first="Lingam" last="Vijaya">Lingam Vijaya</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Centre for Ophthalmology and Visual Science</addr-line>,<institution>Lions Eye Institute, University of Western Australia</institution>,<addr-line>Perth, WA</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Department of Ophthalmology</addr-line>,<institution>Flinders University</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Xinghuai" sort="Sun, Xinghuai" uniqKey="Sun X" first="Xinghuai" last="Sun">Xinghuai Sun</name><affiliation><nlm:aff id="af9"><addr-line>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>State Key Laboratory of Medical Neurobiology, Institutes of Brain Science</addr-line>,<institution>Fudan University</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af59"><addr-line>Myopia Key Laboratory of the Ministry of Health of China, Shanghai</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L." last="Wiggs">Janey L. Wiggs</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Department of Ophthalmology</addr-line>,<institution>University of Alabama at Birmingham</institution>,<addr-line>Birmingham, AL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Sichuan Provincial Key Laboratory for Human Disease Gene Study</addr-line>,<institution>Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>School of Medicine</addr-line>,<institution>University of Electronic Science and Technology of China</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Chinese Academy of Sciences</addr-line>,<institution>Sichuan Translational Medicine Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pang, Chi Pui" sort="Pang, Chi Pui" uniqKey="Pang C" first="Chi Pui" last="Pang">Chi Pui Pang</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A." last="Hauser">Michael A. Hauser</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N." last="Vithana">Eranga N. Vithana</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25861811</idno><idno type="pmc">4459396</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459396</idno><idno type="RBID">PMC:4459396</idno><idno type="doi">10.1093/hmg/ddv128</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000276</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000276</idno><idno type="wicri:Area/Pmc/Curation">000276</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000276</idno><idno type="wicri:Area/Pmc/Checkpoint">001225</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001225</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002B73</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B73</idno><idno type="wicri:Area/PubMed/Curation">002B01</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002B01</idno><idno type="wicri:Area/PubMed/Checkpoint">002B01</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002B01</idno><idno type="wicri:Area/Ncbi/Merge">002439</idno><idno type="wicri:Area/Ncbi/Curation">002439</idno><idno type="wicri:Area/Ncbi/Checkpoint">002439</idno><idno type="wicri:doubleKey">0964-6906:2015:Li Z:a:common:variant</idno><idno type="wicri:Area/Main/Merge">003252</idno><idno type="wicri:Area/Main/Curation">003251</idno><idno type="wicri:Area/Main/Exploration">003251</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A common variant near <italic>TGFBR3</italic> is associated with primary open angle glaucoma</title><author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R. Rand" last="Allingham">R. Rand Allingham</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Jia, Liyun" sort="Jia, Liyun" uniqKey="Jia L" first="Liyun" last="Jia">Liyun Jia</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Yuhong" sort="Chen, Yuhong" uniqKey="Chen Y" first="Yuhong" last="Chen">Yuhong Chen</name><affiliation><nlm:aff id="af9"><addr-line>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mani, Baskaran" sort="Mani, Baskaran" uniqKey="Mani B" first="Baskaran" last="Mani">Baskaran Mani</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Li Jia" sort="Chen, Li Jia" uniqKey="Chen L" first="Li-Jia" last="Chen">Li-Jia Chen</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kee, Changwon" sort="Kee, Changwon" uniqKey="Kee C" first="Changwon" last="Kee">Changwon Kee</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Garway Heath, David F" sort="Garway Heath, David F" uniqKey="Garway Heath D" first="David F." last="Garway-Heath">David F. Garway-Heath</name><affiliation wicri:level="1"><nlm:aff id="af16"><institution>National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sripriya, Sarangapani" sort="Sripriya, Sarangapani" uniqKey="Sripriya S" first="Sarangapani" last="Sripriya">Sarangapani Sripriya</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>SNONGC Department of Genetics and Molecular Biology</addr-line>,<institution>Vision Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fuse, Nobuo" sort="Fuse, Nobuo" uniqKey="Fuse N" first="Nobuo" last="Fuse">Nobuo Fuse</name><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Integrative Genomics</addr-line>,<institution>Tohoku Medical Megabank Organization</institution>,<addr-line>Sendai</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K." last="Abu-Amero">Khaled K. Abu-Amero</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>University of Florida</institution>,<addr-line>Jacksonville, FL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Chukai" sort="Huang, Chukai" uniqKey="Huang C" first="Chukai" last="Huang">Chukai Huang</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Chinese University of Hong Kong Joint Shantou International Eye Center</addr-line>,<institution>Shantou University</institution>,<addr-line>Shantou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Namburi, Prasanthi" sort="Namburi, Prasanthi" uniqKey="Namburi P" first="Prasanthi" last="Namburi">Prasanthi Namburi</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burdon, Kathryn" sort="Burdon, Kathryn" uniqKey="Burdon K" first="Kathryn" last="Burdon">Kathryn Burdon</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Department of Ophthalmology</addr-line>,<institution>Flinders University</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A." last="Perera">Shamira A. Perera</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gharahkhani, Puya" sort="Gharahkhani, Puya" uniqKey="Gharahkhani P" first="Puya" last="Gharahkhani">Puya Gharahkhani</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Department of Genetics and Computational Biology, Statistical Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Sichuan Provincial Key Laboratory for Human Disease Gene Study</addr-line>,<institution>Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>School of Medicine</addr-line>,<institution>University of Electronic Science and Technology of China</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name><affiliation wicri:level="1"><nlm:aff id="af28"><institution>Ozaki Eye Hospital</institution>,<addr-line>1–15, Kamezaki, Hyuga, Miyazaki 883-0066</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name><affiliation wicri:level="1"><nlm:aff id="af29"><institution>Mizoguchi Eye Hospital</institution>,<addr-line>6-13 Tawara-machi, Sasebo, Nagasaki 857-0016</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Krishnadas, Subbiah Ramasamy" sort="Krishnadas, Subbiah Ramasamy" uniqKey="Krishnadas S" first="Subbiah Ramasamy" last="Krishnadas">Subbiah Ramasamy Krishnadas</name><affiliation wicri:level="1"><nlm:aff id="af30"><addr-line>Glaucoma Services</addr-line>,<institution>Aravind Eye Hospital</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A." last="Osman">Essam A. Osman</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S. Y." last="Chan">Anita S. Y. Chan</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tajudin, Liza Sharmini A" sort="Tajudin, Liza Sharmini A" uniqKey="Tajudin L" first="Liza-Sharmini A." last="Tajudin">Liza-Sharmini A. Tajudin</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Ophthalmology, School of Medical Sciences</addr-line>,<institution>Universiti Sains Malaysia</institution>,<addr-line>Kota Bharu, Kelantan</addr-line>,<country>Malaysia</country>,</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Do, Tan" sort="Do, Tan" uniqKey="Do T" first="Tan" last="Do">Tan Do</name><affiliation wicri:level="1"><nlm:aff id="af32"><institution>Vietnam National Institute of Ophthalmology</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goncalves, Aurelien" sort="Goncalves, Aurelien" uniqKey="Goncalves A" first="Aurelien" last="Goncalves">Aurelien Goncalves</name><affiliation><nlm:aff id="af33"><addr-line>Ophthalmology Department</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name><affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Biochemistry Department</addr-line>,<institution>Angers University Hospital</institution>,<addr-line>Angers</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Ophthalmology, Tongji Hospital of Tongji Medical College</addr-line>,<institution>Huazhong University of Science and Technology</institution>,<addr-line>Wuhan</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bourne, Rupert" sort="Bourne, Rupert" uniqKey="Bourne R" first="Rupert" last="Bourne">Rupert Bourne</name><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Huntingdon Glaucoma Diagnostic & Research Centre</addr-line>,<institution>Hinchingbrooke Hospital</institution>,<addr-line>Huntingdon</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goh, David" sort="Goh, David" uniqKey="Goh D" first="David" last="Goh">David Goh</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Broadway, David" sort="Broadway, David" uniqKey="Broadway D" first="David" last="Broadway">David Broadway</name><affiliation wicri:level="1"><nlm:aff id="af37"><institution>Norfolk & Norwich University Hospital NHS Trust</institution>,<addr-line>Norwich</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Negi, Anil K" sort="Negi, Anil K" uniqKey="Negi A" first="Anil K." last="Negi">Anil K. Negi</name><affiliation wicri:level="1"><nlm:aff id="af38"><institution>Heart of UK NHS Foundation Trust</institution>,<addr-line>Birmingham</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Su, Daniel H" sort="Su, Daniel H" uniqKey="Su D" first="Daniel H" last="Su">Daniel H. Su</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Ching Lin" sort="Ho, Ching Lin" uniqKey="Ho C" first="Ching-Lin" last="Ho">Ching-Lin Ho</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blanco, Augusto Azuara" sort="Blanco, Augusto Azuara" uniqKey="Blanco A" first="Augusto Azuara" last="Blanco">Augusto Azuara Blanco</name><affiliation wicri:level="1"><nlm:aff id="af39"><addr-line>School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine</addr-line>,<institution>Queen's University Belfast</institution>,<addr-line>Northern Ireland</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leung, Christopher K S" sort="Leung, Christopher K S" uniqKey="Leung C" first="Christopher K. S." last="Leung">Christopher K. S. Leung</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tina T" sort="Wong, Tina T" uniqKey="Wong T" first="Tina T." last="Wong">Tina T. Wong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yakub, Azhany" sort="Yakub, Azhany" uniqKey="Yakub A" first="Azhany" last="Yakub">Azhany Yakub</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Ophthalmology, School of Medical Sciences</addr-line>,<institution>Universiti Sains Malaysia</institution>,<addr-line>Kota Bharu, Kelantan</addr-line>,<country>Malaysia</country>,</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Cellular Biology and Anatomy</addr-line>,<institution>Georgia Regents University</institution>,<addr-line>Augusta</addr-line>,<country>Georgia</country>,</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nongpiur, Monisha E" sort="Nongpiur, Monisha E" uniqKey="Nongpiur M" first="Monisha E." last="Nongpiur">Monisha E. Nongpiur</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Han, Jong Chul" sort="Han, Jong Chul" uniqKey="Han J" first="Jong Chul" last="Han">Jong Chul Han</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Hon, Do Nhu" sort="Hon, Do Nhu" uniqKey="Hon D" first="Do Nhu" last="Hon">Do Nhu Hon</name><affiliation wicri:level="1"><nlm:aff id="af32"><institution>Vietnam National Institute of Ophthalmology</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shantha, Balekudaru" sort="Shantha, Balekudaru" uniqKey="Shantha B" first="Balekudaru" last="Shantha">Balekudaru Shantha</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sato, Ryuichi" sort="Sato, Ryuichi" uniqKey="Sato R" first="Ryuichi" last="Sato">Ryuichi Sato</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yoshii, Kengo" sort="Yoshii, Kengo" uniqKey="Yoshii K" first="Kengo" last="Yoshii">Kengo Yoshii</name><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Medical Statistics</addr-line>,<institution>Kyoto Prefectural University of Medicine</institution>,<addr-line>Kyoto</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Panda Jonas, Songhomita" sort="Panda Jonas, Songhomita" uniqKey="Panda Jonas S" first="Songhomita" last="Panda-Jonas">Songhomita Panda-Jonas</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Ophthalmology</addr-line>,<institution>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E." last="Ashley Koch">Allison E. Ashley Koch</name><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herndon, Leon W" sort="Herndon, Leon W" uniqKey="Herndon L" first="Leon W." last="Herndon">Leon W. Herndon</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E." last="Moroi">Sayoko E. Moroi</name><affiliation><nlm:aff id="af44"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bei, Jin Xin" sort="Bei, Jin Xin" uniqKey="Bei J" first="Jin-Xin" last="Bei">Jin-Xin Bei</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>State Key Laboratory of Oncology in Southern China, Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Experimental Research</addr-line>,<institution>Sun Yat-Sen University Cancer Centre</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeng, Yi Xin" sort="Zeng, Yi Xin" uniqKey="Zeng Y" first="Yi-Xin" last="Zeng">Yi-Xin Zeng</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>State Key Laboratory of Oncology in Southern China, Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Experimental Research</addr-line>,<institution>Sun Yat-Sen University Cancer Centre</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P." last="Simmons">Cameron P. Simmons</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Clinical Research Unit</addr-line>,<institution>Oxford University</institution>,<addr-line>190 Ben Ham Tu, Ho Chi Minh City</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine</addr-line>,<institution>Oxford University</institution>,<addr-line>Oxford OX3 7LJ</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bich Chau, Tran Nguyen" sort="Bich Chau, Tran Nguyen" uniqKey="Bich Chau T" first="Tran Nguyen" last="Bich Chau">Tran Nguyen Bich Chau</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Clinical Research Unit</addr-line>,<institution>Oxford University</institution>,<addr-line>190 Ben Ham Tu, Ho Chi Minh City</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sharmila, Philomenadin Ferdinamarie" sort="Sharmila, Philomenadin Ferdinamarie" uniqKey="Sharmila P" first="Philomenadin Ferdinamarie" last="Sharmila">Philomenadin Ferdinamarie Sharmila</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>SNONGC Department of Genetics and Molecular Biology</addr-line>,<institution>Vision Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chew, Merwyn" sort="Chew, Merwyn" uniqKey="Chew M" first="Merwyn" last="Chew">Merwyn Chew</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lim, Blanche" sort="Lim, Blanche" uniqKey="Lim B" first="Blanche" last="Lim">Blanche Lim</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Tam, Pansy O S" sort="Tam, Pansy O S" uniqKey="Tam P" first="Pansy O. S." last="Tam">Pansy O. S. Tam</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chua, Elaine" sort="Chua, Elaine" uniqKey="Chua E" first="Elaine" last="Chua">Elaine Chua</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ng, Xiao Yu" sort="Ng, Xiao Yu" uniqKey="Ng X" first="Xiao Yu" last="Ng">Xiao Yu Ng</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yong, Victor H K" sort="Yong, Victor H K" uniqKey="Yong V" first="Victor H. K." last="Yong">Victor H. K. Yong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chong, Yaan Fun" sort="Chong, Yaan Fun" uniqKey="Chong Y" first="Yaan Fun" last="Chong">Yaan Fun Chong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seongsoo, Sohn" sort="Seongsoo, Sohn" uniqKey="Seongsoo S" first="Sohn" last="Seongsoo">Sohn Seongsoo</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Wang" sort="Xu, Wang" uniqKey="Xu W" first="Wang" last="Xu">Wang Xu</name><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cooke Bailey, Jessica N" sort="Cooke Bailey, Jessica N" uniqKey="Cooke Bailey J" first="Jessica N." last="Cooke Bailey">Jessica N. Cooke Bailey</name><affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Case Western Reserve University</institution>,<addr-line>Cleveland, OH</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H." last="Kang">Jae H. Kang</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Channing Division of Network Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name><affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Case Western Reserve University</institution>,<addr-line>Cleveland, OH</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Department of Medicine</addr-line>,<institution>National University Health System & National University of Singapore</institution>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E." last="Richards">Julia E. Richards</name><affiliation><nlm:aff id="af44"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name><affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Einhorn Clinical Research Center, Department of Ophthalmology</addr-line>,<institution>New York Eye and Ear Infirmary</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaasterland, Douglas E" sort="Gaasterland, Douglas E" uniqKey="Gaasterland D" first="Douglas E." last="Gaasterland">Douglas E. Gaasterland</name><affiliation wicri:level="1"><nlm:aff id="af54"><institution>Eye Doctors of Washington DC</institution>,<addr-line>Washington, DC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R." last="Pasquale">Louis R. Pasquale</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Channing Division of Network Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af55"><addr-line>Department of Ophthalmology, Harvard Medical School</addr-line>,<institution>Massachusetts Eye and Ear Infirmary</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B." last="Jonas">Jost B. Jonas</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Ophthalmology</addr-line>,<institution>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Milea">Dan Milea</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="George, Ronnie" sort="George, Ronnie" uniqKey="George R" first="Ronnie" last="George">Ronnie George</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A." last="Al-Obeidan">Saleh A. Al-Obeidan</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Department of Genetics and Computational Biology, Statistical Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W." last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af56"><institution>Centre for Eye Research Australia (CERA)</institution>,<institution>University of Melbourne</institution>,<institution>Royal Victorian Eye and Ear Hospital</institution>,<addr-line>Melbourne, VIC</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Girkin, Christopher A" sort="Girkin, Christopher A" uniqKey="Girkin C" first="Christopher A." last="Girkin">Christopher A. Girkin</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Department of Ophthalmology</addr-line>,<institution>University of Alabama at Birmingham</institution>,<addr-line>Birmingham, AL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Mingzhi" sort="Zhang, Mingzhi" uniqKey="Zhang M" first="Mingzhi" last="Zhang">Mingzhi Zhang</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Chinese University of Hong Kong Joint Shantou International Eye Center</addr-line>,<institution>Shantou University</institution>,<addr-line>Shantou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vijaya, Lingam" sort="Vijaya, Lingam" uniqKey="Vijaya L" first="Lingam" last="Vijaya">Lingam Vijaya</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Centre for Ophthalmology and Visual Science</addr-line>,<institution>Lions Eye Institute, University of Western Australia</institution>,<addr-line>Perth, WA</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Department of Ophthalmology</addr-line>,<institution>Flinders University</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Xinghuai" sort="Sun, Xinghuai" uniqKey="Sun X" first="Xinghuai" last="Sun">Xinghuai Sun</name><affiliation><nlm:aff id="af9"><addr-line>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>State Key Laboratory of Medical Neurobiology, Institutes of Brain Science</addr-line>,<institution>Fudan University</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af59"><addr-line>Myopia Key Laboratory of the Ministry of Health of China, Shanghai</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L." last="Wiggs">Janey L. Wiggs</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Department of Ophthalmology</addr-line>,<institution>University of Alabama at Birmingham</institution>,<addr-line>Birmingham, AL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Sichuan Provincial Key Laboratory for Human Disease Gene Study</addr-line>,<institution>Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>School of Medicine</addr-line>,<institution>University of Electronic Science and Technology of China</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Chinese Academy of Sciences</addr-line>,<institution>Sichuan Translational Medicine Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pang, Chi Pui" sort="Pang, Chi Pui" uniqKey="Pang C" first="Chi Pui" last="Pang">Chi Pui Pang</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A." last="Hauser">Michael A. Hauser</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N." last="Vithana">Eranga N. Vithana</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Glaucoma, Open-Angle (genetics)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Proteoglycans (genetics)</term><term>Receptors, Transforming Growth Factor beta (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Allèles</term><term>Femelle</term><term>Glaucome à angle ouvert (génétique)</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Protéoglycanes (génétique)</term><term>Récepteurs TGF-bêta (génétique)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Variation génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proteoglycans</term><term>Receptors, Transforming Growth Factor beta</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Glaucoma, Open-Angle</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glaucome à angle ouvert</term><term>Protéoglycanes</term><term>Récepteurs TGF-bêta</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Allèles</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Variation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at <italic>CDKN2B-AS1</italic> (rs2157719 [G], odds ratio [OR] = 0.71, <italic>P</italic> = 2.81 × 10<sup>−33</sup>), we observed one SNP showing significant association to POAG (<italic>CDC7</italic>–<italic>TGFBR3</italic> rs1192415, OR<sub>G-allele</sub> = 1.13, <italic>P</italic><sub>meta</sub> = 1.60 × 10<sup>−8</sup>). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. 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Plagnol</name></author><author><name sortKey="Hernandez, D G" uniqKey="Hernandez D">D.G. Hernandez</name></author><author><name sortKey="Sharma, M" uniqKey="Sharma M">M. Sharma</name></author><author><name sortKey="Sheerin, U M" uniqKey="Sheerin U">U.M. Sheerin</name></author><author><name sortKey="Saad, M" uniqKey="Saad M">M. Saad</name></author><author><name sortKey="Simon Sanchez, J" uniqKey="Simon Sanchez J">J. Simon-Sanchez</name></author><author><name sortKey="Schulte, C" uniqKey="Schulte C">C. Schulte</name></author><author><name sortKey="Lesage, S" uniqKey="Lesage S">S. Lesage</name></author><author><name sortKey="Sveinbjornsdottir, S" uniqKey="Sveinbjornsdottir S">S. Sveinbjornsdottir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vithana, E N" uniqKey="Vithana E">E.N. Vithana</name></author><author><name sortKey="Aung, T" uniqKey="Aung T">T. Aung</name></author><author><name sortKey="Khor, C C" uniqKey="Khor C">C.C. Khor</name></author><author><name sortKey="Cornes, B K" uniqKey="Cornes B">B.K. Cornes</name></author><author><name sortKey="Tay, W T" uniqKey="Tay W">W.T. Tay</name></author><author><name sortKey="Sim, X" uniqKey="Sim X">X. Sim</name></author><author><name sortKey="Lavanya, R" uniqKey="Lavanya R">R. Lavanya</name></author><author><name sortKey="Wu, R" uniqKey="Wu R">R. Wu</name></author><author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y. Zheng</name></author><author><name sortKey="Hibberd, M L" uniqKey="Hibberd M">M.L. Hibberd</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Arabie saoudite</li><li>Australie</li><li>France</li><li>Géorgie (pays)</li><li>Inde</li><li>Japon</li><li>Malaisie</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Singapour</li><li>Viêt Nam</li><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Chen, Yuhong" sort="Chen, Yuhong" uniqKey="Chen Y" first="Yuhong" last="Chen">Yuhong Chen</name><name sortKey="Chew, Merwyn" sort="Chew, Merwyn" uniqKey="Chew M" first="Merwyn" last="Chew">Merwyn Chew</name><name sortKey="Chong, Yaan Fun" sort="Chong, Yaan Fun" uniqKey="Chong Y" first="Yaan Fun" last="Chong">Yaan Fun Chong</name><name sortKey="Chua, Elaine" sort="Chua, Elaine" uniqKey="Chua E" first="Elaine" last="Chua">Elaine Chua</name><name sortKey="Goncalves, Aurelien" sort="Goncalves, Aurelien" uniqKey="Goncalves A" first="Aurelien" last="Goncalves">Aurelien Goncalves</name><name sortKey="Han, Jong Chul" sort="Han, Jong Chul" uniqKey="Han J" first="Jong Chul" last="Han">Jong Chul Han</name><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name><name sortKey="Kee, Changwon" sort="Kee, Changwon" uniqKey="Kee C" first="Changwon" last="Kee">Changwon Kee</name><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name><name sortKey="Lim, Blanche" sort="Lim, Blanche" uniqKey="Lim B" first="Blanche" last="Lim">Blanche Lim</name><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E." last="Moroi">Sayoko E. Moroi</name><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name><name sortKey="Ng, Xiao Yu" sort="Ng, Xiao Yu" uniqKey="Ng X" first="Xiao Yu" last="Ng">Xiao Yu Ng</name><name sortKey="Sato, Ryuichi" sort="Sato, Ryuichi" uniqKey="Sato R" first="Ryuichi" last="Sato">Ryuichi Sato</name><name sortKey="Seongsoo, Sohn" sort="Seongsoo, Sohn" uniqKey="Seongsoo S" first="Sohn" last="Seongsoo">Sohn Seongsoo</name><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name><name sortKey="Yong, Victor H K" sort="Yong, Victor H K" uniqKey="Yong V" first="Victor H. K." last="Yong">Victor H. K. Yong</name></noCountry><country name="Singapour"><noRegion><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name></noRegion><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S. Y." last="Chan">Anita S. Y. Chan</name><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name><name sortKey="Goh, David" sort="Goh, David" uniqKey="Goh D" first="David" last="Goh">David Goh</name><name sortKey="Ho, Ching Lin" sort="Ho, Ching Lin" uniqKey="Ho C" first="Ching-Lin" last="Ho">Ching-Lin Ho</name><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><name sortKey="Mani, Baskaran" sort="Mani, Baskaran" uniqKey="Mani B" first="Baskaran" last="Mani">Baskaran Mani</name><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Milea">Dan Milea</name><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Milea">Dan Milea</name><name sortKey="Nongpiur, Monisha E" sort="Nongpiur, Monisha E" uniqKey="Nongpiur M" first="Monisha E." last="Nongpiur">Monisha E. Nongpiur</name><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A." last="Perera">Shamira A. Perera</name><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A." last="Perera">Shamira A. Perera</name><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><name sortKey="Su, Daniel H" sort="Su, Daniel H" uniqKey="Su D" first="Daniel H" last="Su">Daniel H. Su</name><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N." last="Vithana">Eranga N. Vithana</name><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><name sortKey="Wong, Tina T" sort="Wong, Tina T" uniqKey="Wong T" first="Tina T." last="Wong">Tina T. Wong</name><name sortKey="Wong, Tina T" sort="Wong, Tina T" uniqKey="Wong T" first="Tina T." last="Wong">Tina T. Wong</name><name sortKey="Xu, Wang" sort="Xu, Wang" uniqKey="Xu W" first="Wang" last="Xu">Wang Xu</name></country><country name="États-Unis"><noRegion><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R. Rand" last="Allingham">R. Rand Allingham</name></noRegion><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K." last="Abu-Amero">Khaled K. Abu-Amero</name><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E." last="Ashley Koch">Allison E. 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Abu-Amero</name></noRegion><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A." last="Al-Obeidan">Saleh A. Al-Obeidan</name><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A." last="Osman">Essam A. Osman</name></country><country name="Australie"><noRegion><name sortKey="Burdon, Kathryn" sort="Burdon, Kathryn" uniqKey="Burdon K" first="Kathryn" last="Burdon">Kathryn Burdon</name></noRegion><name sortKey="Burdon, Kathryn" sort="Burdon, Kathryn" uniqKey="Burdon K" first="Kathryn" last="Burdon">Kathryn Burdon</name><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name><name sortKey="Gharahkhani, Puya" sort="Gharahkhani, Puya" uniqKey="Gharahkhani P" first="Puya" last="Gharahkhani">Puya Gharahkhani</name><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W." last="Hewitt">Alex W. 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Tajudin</name></noRegion><name sortKey="Yakub, Azhany" sort="Yakub, Azhany" uniqKey="Yakub A" first="Azhany" last="Yakub">Azhany Yakub</name></country><country name="Viêt Nam"><noRegion><name sortKey="Do, Tan" sort="Do, Tan" uniqKey="Do T" first="Tan" last="Do">Tan Do</name></noRegion><name sortKey="Bich Chau, Tran Nguyen" sort="Bich Chau, Tran Nguyen" uniqKey="Bich Chau T" first="Tran Nguyen" last="Bich Chau">Tran Nguyen Bich Chau</name><name sortKey="Hon, Do Nhu" sort="Hon, Do Nhu" uniqKey="Hon D" first="Do Nhu" last="Hon">Do Nhu Hon</name><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P." last="Simmons">Cameron P. Simmons</name></country><country name="France"><noRegion><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name></noRegion></country><country name="Géorgie (pays)"><noRegion><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Panda Jonas, Songhomita" sort="Panda Jonas, Songhomita" uniqKey="Panda Jonas S" first="Songhomita" last="Panda-Jonas">Songhomita Panda-Jonas</name></noRegion><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B." last="Jonas">Jost B. Jonas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25861811" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |