A common variant near TGFBR3 is associated with primary open angle glaucoma
Identifieur interne : 002439 ( Ncbi/Merge ); précédent : 002438; suivant : 002440A common variant near TGFBR3 is associated with primary open angle glaucoma
Auteurs : Zheng Li [Singapour] ; R. Rand Allingham [États-Unis] ; Masakazu Nakano ; Liyun Jia [République populaire de Chine] ; Yuhong Chen ; Yoko Ikeda ; Baskaran Mani [Singapour] ; Li-Jia Chen [République populaire de Chine] ; Changwon Kee ; David F. Garway-Heath [Royaume-Uni] ; Sarangapani Sripriya [Inde] ; Nobuo Fuse [Japon] ; Khaled K. Abu-Amero [Arabie saoudite, États-Unis] ; Chukai Huang [République populaire de Chine] ; Prasanthi Namburi [Inde] ; Kathryn Burdon [Australie] ; Shamira A. Perera [Singapour] ; Puya Gharahkhani [Australie] ; Ying Lin [République populaire de Chine] ; Morio Ueno ; Mineo Ozaki [Japon] ; Takanori Mizoguchi [Japon] ; Subbiah Ramasamy Krishnadas [Inde] ; Essam A. Osman [Arabie saoudite] ; Mei Chin Lee ; Anita S. Y. Chan [Singapour] ; Liza-Sharmini A. Tajudin [Malaisie] ; Tan Do [Viêt Nam] ; Aurelien Goncalves ; Pascal Reynier [France] ; Hong Zhang [République populaire de Chine] ; Rupert Bourne [Royaume-Uni] ; David Goh [Singapour] ; David Broadway [Royaume-Uni] ; Rahat Husain [Singapour] ; Anil K. Negi [Royaume-Uni] ; Daniel H. Su [Singapour] ; Ching-Lin Ho [Singapour] ; Augusto Azuara Blanco [Royaume-Uni] ; Christopher K. S. Leung [République populaire de Chine] ; Tina T. Wong [Singapour] ; Azhany Yakub [Malaisie] ; Yutao Liu [États-Unis, Géorgie (pays)] ; Monisha E. Nongpiur [Singapour] ; Jong Chul Han ; Do Nhu Hon [Viêt Nam] ; Balekudaru Shantha [Inde] ; Bowen Zhao [République populaire de Chine] ; Jinghong Sang [République populaire de Chine] ; Nihong Zhang [République populaire de Chine] ; Ryuichi Sato ; Kengo Yoshii [Japon] ; Songhomita Panda-Jonas [Allemagne] ; Allison E. Ashley Koch [États-Unis] ; Leon W. Herndon [États-Unis] ; Sayoko E. Moroi ; Pratap Challa [États-Unis] ; Jia Nee Foo [Singapour] ; Jin-Xin Bei [République populaire de Chine] ; Yi-Xin Zeng [République populaire de Chine] ; Cameron P. Simmons [Viêt Nam, Royaume-Uni] ; Tran Nguyen Bich Chau [Viêt Nam] ; Philomenadin Ferdinamarie Sharmila [Inde] ; Merwyn Chew ; Blanche Lim ; Pansy O. S. Tam [République populaire de Chine] ; Elaine Chua ; Xiao Yu Ng ; Victor H. K. Yong ; Yaan Fun Chong ; Wee Yang Meah [Singapour] ; Saravanan Vijayan [Inde] ; Sohn Seongsoo ; Wang Xu [Singapour] ; Yik Ying Teo [Singapour] ; Jessica N. Cooke Bailey [États-Unis] ; Jae H. Kang [États-Unis] ; Jonathan L. Haines [États-Unis] ; Ching Yu Cheng [Singapour] ; Seang-Mei Saw [Singapour] ; E-Shyong Tai [Singapour] ; Julia E. Richards [États-Unis] ; Robert Ritch [États-Unis] ; Douglas E. Gaasterland [États-Unis] ; Louis R. Pasquale [États-Unis] ; Jianjun Liu [Singapour] ; Jost B. Jonas [Allemagne] ; Dan Milea [Singapour] ; Ronnie George [Inde] ; Saleh A. Al-Obeidan [Arabie saoudite] ; Kazuhiko Mori ; Stuart Macgregor [Australie] ; Alex W. Hewitt [Australie] ; Christopher A. Girkin [États-Unis] ; Mingzhi Zhang [République populaire de Chine] ; Periasamy Sundaresan [Inde] ; Lingam Vijaya [Inde] ; David A. Mackey [Australie] ; Tien Yin Wong [Singapour] ; Jamie E. Craig [Australie] ; Xinghuai Sun [République populaire de Chine] ; Shigeru Kinoshita ; Janey L. Wiggs [États-Unis] ; Chiea-Chuen Khor [Singapour] ; Zhenglin Yang [République populaire de Chine] ; Chi Pui Pang [République populaire de Chine] ; Ningli Wang [République populaire de Chine] ; Michael A. Hauser [États-Unis] ; Kei Tashiro ; Tin Aung [Singapour] ; Eranga N. Vithana [Singapour]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Proteoglycans, Receptors, Transforming Growth Factor beta.
- genetics : Glaucoma, Open-Angle.
- Aged, Aged, 80 and over, Alleles, Female, Genetic Variation, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide.
Abstract
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at
Url:
DOI: 10.1093/hmg/ddv128
PubMed: 25861811
PubMed Central: 4459396
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PMC:4459396Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A common variant near <italic>TGFBR3</italic> is associated with primary open angle glaucoma</title><author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R. Rand" last="Allingham">R. Rand Allingham</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Jia, Liyun" sort="Jia, Liyun" uniqKey="Jia L" first="Liyun" last="Jia">Liyun Jia</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Yuhong" sort="Chen, Yuhong" uniqKey="Chen Y" first="Yuhong" last="Chen">Yuhong Chen</name><affiliation><nlm:aff id="af9"><addr-line>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mani, Baskaran" sort="Mani, Baskaran" uniqKey="Mani B" first="Baskaran" last="Mani">Baskaran Mani</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Li Jia" sort="Chen, Li Jia" uniqKey="Chen L" first="Li-Jia" last="Chen">Li-Jia Chen</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kee, Changwon" sort="Kee, Changwon" uniqKey="Kee C" first="Changwon" last="Kee">Changwon Kee</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Garway Heath, David F" sort="Garway Heath, David F" uniqKey="Garway Heath D" first="David F." last="Garway-Heath">David F. Garway-Heath</name><affiliation wicri:level="1"><nlm:aff id="af16"><institution>National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sripriya, Sarangapani" sort="Sripriya, Sarangapani" uniqKey="Sripriya S" first="Sarangapani" last="Sripriya">Sarangapani Sripriya</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>SNONGC Department of Genetics and Molecular Biology</addr-line>,<institution>Vision Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fuse, Nobuo" sort="Fuse, Nobuo" uniqKey="Fuse N" first="Nobuo" last="Fuse">Nobuo Fuse</name><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Integrative Genomics</addr-line>,<institution>Tohoku Medical Megabank Organization</institution>,<addr-line>Sendai</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K." last="Abu-Amero">Khaled K. Abu-Amero</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>University of Florida</institution>,<addr-line>Jacksonville, FL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Chukai" sort="Huang, Chukai" uniqKey="Huang C" first="Chukai" last="Huang">Chukai Huang</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Chinese University of Hong Kong Joint Shantou International Eye Center</addr-line>,<institution>Shantou University</institution>,<addr-line>Shantou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Namburi, Prasanthi" sort="Namburi, Prasanthi" uniqKey="Namburi P" first="Prasanthi" last="Namburi">Prasanthi Namburi</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burdon, Kathryn" sort="Burdon, Kathryn" uniqKey="Burdon K" first="Kathryn" last="Burdon">Kathryn Burdon</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Department of Ophthalmology</addr-line>,<institution>Flinders University</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A." last="Perera">Shamira A. Perera</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gharahkhani, Puya" sort="Gharahkhani, Puya" uniqKey="Gharahkhani P" first="Puya" last="Gharahkhani">Puya Gharahkhani</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Department of Genetics and Computational Biology, Statistical Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Sichuan Provincial Key Laboratory for Human Disease Gene Study</addr-line>,<institution>Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>School of Medicine</addr-line>,<institution>University of Electronic Science and Technology of China</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name><affiliation wicri:level="1"><nlm:aff id="af28"><institution>Ozaki Eye Hospital</institution>,<addr-line>1–15, Kamezaki, Hyuga, Miyazaki 883-0066</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name><affiliation wicri:level="1"><nlm:aff id="af29"><institution>Mizoguchi Eye Hospital</institution>,<addr-line>6-13 Tawara-machi, Sasebo, Nagasaki 857-0016</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Krishnadas, Subbiah Ramasamy" sort="Krishnadas, Subbiah Ramasamy" uniqKey="Krishnadas S" first="Subbiah Ramasamy" last="Krishnadas">Subbiah Ramasamy Krishnadas</name><affiliation wicri:level="1"><nlm:aff id="af30"><addr-line>Glaucoma Services</addr-line>,<institution>Aravind Eye Hospital</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A." last="Osman">Essam A. Osman</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S. Y." last="Chan">Anita S. Y. Chan</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tajudin, Liza Sharmini A" sort="Tajudin, Liza Sharmini A" uniqKey="Tajudin L" first="Liza-Sharmini A." last="Tajudin">Liza-Sharmini A. Tajudin</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Ophthalmology, School of Medical Sciences</addr-line>,<institution>Universiti Sains Malaysia</institution>,<addr-line>Kota Bharu, Kelantan</addr-line>,<country>Malaysia</country>,</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Do, Tan" sort="Do, Tan" uniqKey="Do T" first="Tan" last="Do">Tan Do</name><affiliation wicri:level="1"><nlm:aff id="af32"><institution>Vietnam National Institute of Ophthalmology</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goncalves, Aurelien" sort="Goncalves, Aurelien" uniqKey="Goncalves A" first="Aurelien" last="Goncalves">Aurelien Goncalves</name><affiliation><nlm:aff id="af33"><addr-line>Ophthalmology Department</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name><affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Biochemistry Department</addr-line>,<institution>Angers University Hospital</institution>,<addr-line>Angers</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Ophthalmology, Tongji Hospital of Tongji Medical College</addr-line>,<institution>Huazhong University of Science and Technology</institution>,<addr-line>Wuhan</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bourne, Rupert" sort="Bourne, Rupert" uniqKey="Bourne R" first="Rupert" last="Bourne">Rupert Bourne</name><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Huntingdon Glaucoma Diagnostic & Research Centre</addr-line>,<institution>Hinchingbrooke Hospital</institution>,<addr-line>Huntingdon</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goh, David" sort="Goh, David" uniqKey="Goh D" first="David" last="Goh">David Goh</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Broadway, David" sort="Broadway, David" uniqKey="Broadway D" first="David" last="Broadway">David Broadway</name><affiliation wicri:level="1"><nlm:aff id="af37"><institution>Norfolk & Norwich University Hospital NHS Trust</institution>,<addr-line>Norwich</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Negi, Anil K" sort="Negi, Anil K" uniqKey="Negi A" first="Anil K." last="Negi">Anil K. Negi</name><affiliation wicri:level="1"><nlm:aff id="af38"><institution>Heart of UK NHS Foundation Trust</institution>,<addr-line>Birmingham</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Su, Daniel H" sort="Su, Daniel H" uniqKey="Su D" first="Daniel H" last="Su">Daniel H. Su</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Ching Lin" sort="Ho, Ching Lin" uniqKey="Ho C" first="Ching-Lin" last="Ho">Ching-Lin Ho</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blanco, Augusto Azuara" sort="Blanco, Augusto Azuara" uniqKey="Blanco A" first="Augusto Azuara" last="Blanco">Augusto Azuara Blanco</name><affiliation wicri:level="1"><nlm:aff id="af39"><addr-line>School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine</addr-line>,<institution>Queen's University Belfast</institution>,<addr-line>Northern Ireland</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leung, Christopher K S" sort="Leung, Christopher K S" uniqKey="Leung C" first="Christopher K. S." last="Leung">Christopher K. S. Leung</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tina T" sort="Wong, Tina T" uniqKey="Wong T" first="Tina T." last="Wong">Tina T. Wong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yakub, Azhany" sort="Yakub, Azhany" uniqKey="Yakub A" first="Azhany" last="Yakub">Azhany Yakub</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Ophthalmology, School of Medical Sciences</addr-line>,<institution>Universiti Sains Malaysia</institution>,<addr-line>Kota Bharu, Kelantan</addr-line>,<country>Malaysia</country>,</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Cellular Biology and Anatomy</addr-line>,<institution>Georgia Regents University</institution>,<addr-line>Augusta</addr-line>,<country>Georgia</country>,</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nongpiur, Monisha E" sort="Nongpiur, Monisha E" uniqKey="Nongpiur M" first="Monisha E." last="Nongpiur">Monisha E. Nongpiur</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Han, Jong Chul" sort="Han, Jong Chul" uniqKey="Han J" first="Jong Chul" last="Han">Jong Chul Han</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Hon, Do Nhu" sort="Hon, Do Nhu" uniqKey="Hon D" first="Do Nhu" last="Hon">Do Nhu Hon</name><affiliation wicri:level="1"><nlm:aff id="af32"><institution>Vietnam National Institute of Ophthalmology</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shantha, Balekudaru" sort="Shantha, Balekudaru" uniqKey="Shantha B" first="Balekudaru" last="Shantha">Balekudaru Shantha</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sato, Ryuichi" sort="Sato, Ryuichi" uniqKey="Sato R" first="Ryuichi" last="Sato">Ryuichi Sato</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yoshii, Kengo" sort="Yoshii, Kengo" uniqKey="Yoshii K" first="Kengo" last="Yoshii">Kengo Yoshii</name><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Medical Statistics</addr-line>,<institution>Kyoto Prefectural University of Medicine</institution>,<addr-line>Kyoto</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Panda Jonas, Songhomita" sort="Panda Jonas, Songhomita" uniqKey="Panda Jonas S" first="Songhomita" last="Panda-Jonas">Songhomita Panda-Jonas</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Ophthalmology</addr-line>,<institution>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E." last="Ashley Koch">Allison E. Ashley Koch</name><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herndon, Leon W" sort="Herndon, Leon W" uniqKey="Herndon L" first="Leon W." last="Herndon">Leon W. Herndon</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E." last="Moroi">Sayoko E. Moroi</name><affiliation><nlm:aff id="af44"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bei, Jin Xin" sort="Bei, Jin Xin" uniqKey="Bei J" first="Jin-Xin" last="Bei">Jin-Xin Bei</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>State Key Laboratory of Oncology in Southern China, Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Experimental Research</addr-line>,<institution>Sun Yat-Sen University Cancer Centre</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeng, Yi Xin" sort="Zeng, Yi Xin" uniqKey="Zeng Y" first="Yi-Xin" last="Zeng">Yi-Xin Zeng</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>State Key Laboratory of Oncology in Southern China, Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Experimental Research</addr-line>,<institution>Sun Yat-Sen University Cancer Centre</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P." last="Simmons">Cameron P. Simmons</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Clinical Research Unit</addr-line>,<institution>Oxford University</institution>,<addr-line>190 Ben Ham Tu, Ho Chi Minh City</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine</addr-line>,<institution>Oxford University</institution>,<addr-line>Oxford OX3 7LJ</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bich Chau, Tran Nguyen" sort="Bich Chau, Tran Nguyen" uniqKey="Bich Chau T" first="Tran Nguyen" last="Bich Chau">Tran Nguyen Bich Chau</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Clinical Research Unit</addr-line>,<institution>Oxford University</institution>,<addr-line>190 Ben Ham Tu, Ho Chi Minh City</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sharmila, Philomenadin Ferdinamarie" sort="Sharmila, Philomenadin Ferdinamarie" uniqKey="Sharmila P" first="Philomenadin Ferdinamarie" last="Sharmila">Philomenadin Ferdinamarie Sharmila</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>SNONGC Department of Genetics and Molecular Biology</addr-line>,<institution>Vision Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chew, Merwyn" sort="Chew, Merwyn" uniqKey="Chew M" first="Merwyn" last="Chew">Merwyn Chew</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lim, Blanche" sort="Lim, Blanche" uniqKey="Lim B" first="Blanche" last="Lim">Blanche Lim</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Tam, Pansy O S" sort="Tam, Pansy O S" uniqKey="Tam P" first="Pansy O. S." last="Tam">Pansy O. S. Tam</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chua, Elaine" sort="Chua, Elaine" uniqKey="Chua E" first="Elaine" last="Chua">Elaine Chua</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ng, Xiao Yu" sort="Ng, Xiao Yu" uniqKey="Ng X" first="Xiao Yu" last="Ng">Xiao Yu Ng</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yong, Victor H K" sort="Yong, Victor H K" uniqKey="Yong V" first="Victor H. K." last="Yong">Victor H. K. Yong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chong, Yaan Fun" sort="Chong, Yaan Fun" uniqKey="Chong Y" first="Yaan Fun" last="Chong">Yaan Fun Chong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seongsoo, Sohn" sort="Seongsoo, Sohn" uniqKey="Seongsoo S" first="Sohn" last="Seongsoo">Sohn Seongsoo</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Wang" sort="Xu, Wang" uniqKey="Xu W" first="Wang" last="Xu">Wang Xu</name><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cooke Bailey, Jessica N" sort="Cooke Bailey, Jessica N" uniqKey="Cooke Bailey J" first="Jessica N." last="Cooke Bailey">Jessica N. Cooke Bailey</name><affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Case Western Reserve University</institution>,<addr-line>Cleveland, OH</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H." last="Kang">Jae H. Kang</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Channing Division of Network Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name><affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Case Western Reserve University</institution>,<addr-line>Cleveland, OH</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Department of Medicine</addr-line>,<institution>National University Health System & National University of Singapore</institution>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E." last="Richards">Julia E. Richards</name><affiliation><nlm:aff id="af44"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name><affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Einhorn Clinical Research Center, Department of Ophthalmology</addr-line>,<institution>New York Eye and Ear Infirmary</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaasterland, Douglas E" sort="Gaasterland, Douglas E" uniqKey="Gaasterland D" first="Douglas E." last="Gaasterland">Douglas E. Gaasterland</name><affiliation wicri:level="1"><nlm:aff id="af54"><institution>Eye Doctors of Washington DC</institution>,<addr-line>Washington, DC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R." last="Pasquale">Louis R. Pasquale</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Channing Division of Network Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af55"><addr-line>Department of Ophthalmology, Harvard Medical School</addr-line>,<institution>Massachusetts Eye and Ear Infirmary</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B." last="Jonas">Jost B. Jonas</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Ophthalmology</addr-line>,<institution>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Milea">Dan Milea</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="George, Ronnie" sort="George, Ronnie" uniqKey="George R" first="Ronnie" last="George">Ronnie George</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A." last="Al-Obeidan">Saleh A. Al-Obeidan</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Department of Genetics and Computational Biology, Statistical Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W." last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af56"><institution>Centre for Eye Research Australia (CERA)</institution>,<institution>University of Melbourne</institution>,<institution>Royal Victorian Eye and Ear Hospital</institution>,<addr-line>Melbourne, VIC</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Girkin, Christopher A" sort="Girkin, Christopher A" uniqKey="Girkin C" first="Christopher A." last="Girkin">Christopher A. Girkin</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Department of Ophthalmology</addr-line>,<institution>University of Alabama at Birmingham</institution>,<addr-line>Birmingham, AL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Mingzhi" sort="Zhang, Mingzhi" uniqKey="Zhang M" first="Mingzhi" last="Zhang">Mingzhi Zhang</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Chinese University of Hong Kong Joint Shantou International Eye Center</addr-line>,<institution>Shantou University</institution>,<addr-line>Shantou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vijaya, Lingam" sort="Vijaya, Lingam" uniqKey="Vijaya L" first="Lingam" last="Vijaya">Lingam Vijaya</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Centre for Ophthalmology and Visual Science</addr-line>,<institution>Lions Eye Institute, University of Western Australia</institution>,<addr-line>Perth, WA</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Department of Ophthalmology</addr-line>,<institution>Flinders University</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Xinghuai" sort="Sun, Xinghuai" uniqKey="Sun X" first="Xinghuai" last="Sun">Xinghuai Sun</name><affiliation><nlm:aff id="af9"><addr-line>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>State Key Laboratory of Medical Neurobiology, Institutes of Brain Science</addr-line>,<institution>Fudan University</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af59"><addr-line>Myopia Key Laboratory of the Ministry of Health of China, Shanghai</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L." last="Wiggs">Janey L. Wiggs</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Department of Ophthalmology</addr-line>,<institution>University of Alabama at Birmingham</institution>,<addr-line>Birmingham, AL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Sichuan Provincial Key Laboratory for Human Disease Gene Study</addr-line>,<institution>Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>School of Medicine</addr-line>,<institution>University of Electronic Science and Technology of China</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Chinese Academy of Sciences</addr-line>,<institution>Sichuan Translational Medicine Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pang, Chi Pui" sort="Pang, Chi Pui" uniqKey="Pang C" first="Chi Pui" last="Pang">Chi Pui Pang</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A." last="Hauser">Michael A. Hauser</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N." last="Vithana">Eranga N. Vithana</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25861811</idno><idno type="pmc">4459396</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459396</idno><idno type="RBID">PMC:4459396</idno><idno type="doi">10.1093/hmg/ddv128</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000276</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000276</idno><idno type="wicri:Area/Pmc/Curation">000276</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000276</idno><idno type="wicri:Area/Pmc/Checkpoint">001225</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001225</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002B73</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B73</idno><idno type="wicri:Area/PubMed/Curation">002B01</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002B01</idno><idno type="wicri:Area/PubMed/Checkpoint">002B01</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002B01</idno><idno type="wicri:Area/Ncbi/Merge">002439</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A common variant near <italic>TGFBR3</italic> is associated with primary open angle glaucoma</title><author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R. Rand" last="Allingham">R. Rand Allingham</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Jia, Liyun" sort="Jia, Liyun" uniqKey="Jia L" first="Liyun" last="Jia">Liyun Jia</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Yuhong" sort="Chen, Yuhong" uniqKey="Chen Y" first="Yuhong" last="Chen">Yuhong Chen</name><affiliation><nlm:aff id="af9"><addr-line>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mani, Baskaran" sort="Mani, Baskaran" uniqKey="Mani B" first="Baskaran" last="Mani">Baskaran Mani</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Li Jia" sort="Chen, Li Jia" uniqKey="Chen L" first="Li-Jia" last="Chen">Li-Jia Chen</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kee, Changwon" sort="Kee, Changwon" uniqKey="Kee C" first="Changwon" last="Kee">Changwon Kee</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Garway Heath, David F" sort="Garway Heath, David F" uniqKey="Garway Heath D" first="David F." last="Garway-Heath">David F. Garway-Heath</name><affiliation wicri:level="1"><nlm:aff id="af16"><institution>National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sripriya, Sarangapani" sort="Sripriya, Sarangapani" uniqKey="Sripriya S" first="Sarangapani" last="Sripriya">Sarangapani Sripriya</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>SNONGC Department of Genetics and Molecular Biology</addr-line>,<institution>Vision Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fuse, Nobuo" sort="Fuse, Nobuo" uniqKey="Fuse N" first="Nobuo" last="Fuse">Nobuo Fuse</name><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Integrative Genomics</addr-line>,<institution>Tohoku Medical Megabank Organization</institution>,<addr-line>Sendai</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K." last="Abu-Amero">Khaled K. Abu-Amero</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>University of Florida</institution>,<addr-line>Jacksonville, FL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Chukai" sort="Huang, Chukai" uniqKey="Huang C" first="Chukai" last="Huang">Chukai Huang</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Chinese University of Hong Kong Joint Shantou International Eye Center</addr-line>,<institution>Shantou University</institution>,<addr-line>Shantou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Namburi, Prasanthi" sort="Namburi, Prasanthi" uniqKey="Namburi P" first="Prasanthi" last="Namburi">Prasanthi Namburi</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burdon, Kathryn" sort="Burdon, Kathryn" uniqKey="Burdon K" first="Kathryn" last="Burdon">Kathryn Burdon</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Department of Ophthalmology</addr-line>,<institution>Flinders University</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A." last="Perera">Shamira A. Perera</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gharahkhani, Puya" sort="Gharahkhani, Puya" uniqKey="Gharahkhani P" first="Puya" last="Gharahkhani">Puya Gharahkhani</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Department of Genetics and Computational Biology, Statistical Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Sichuan Provincial Key Laboratory for Human Disease Gene Study</addr-line>,<institution>Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>School of Medicine</addr-line>,<institution>University of Electronic Science and Technology of China</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name><affiliation wicri:level="1"><nlm:aff id="af28"><institution>Ozaki Eye Hospital</institution>,<addr-line>1–15, Kamezaki, Hyuga, Miyazaki 883-0066</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name><affiliation wicri:level="1"><nlm:aff id="af29"><institution>Mizoguchi Eye Hospital</institution>,<addr-line>6-13 Tawara-machi, Sasebo, Nagasaki 857-0016</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Krishnadas, Subbiah Ramasamy" sort="Krishnadas, Subbiah Ramasamy" uniqKey="Krishnadas S" first="Subbiah Ramasamy" last="Krishnadas">Subbiah Ramasamy Krishnadas</name><affiliation wicri:level="1"><nlm:aff id="af30"><addr-line>Glaucoma Services</addr-line>,<institution>Aravind Eye Hospital</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A." last="Osman">Essam A. Osman</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S. Y." last="Chan">Anita S. Y. Chan</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tajudin, Liza Sharmini A" sort="Tajudin, Liza Sharmini A" uniqKey="Tajudin L" first="Liza-Sharmini A." last="Tajudin">Liza-Sharmini A. Tajudin</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Ophthalmology, School of Medical Sciences</addr-line>,<institution>Universiti Sains Malaysia</institution>,<addr-line>Kota Bharu, Kelantan</addr-line>,<country>Malaysia</country>,</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Do, Tan" sort="Do, Tan" uniqKey="Do T" first="Tan" last="Do">Tan Do</name><affiliation wicri:level="1"><nlm:aff id="af32"><institution>Vietnam National Institute of Ophthalmology</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goncalves, Aurelien" sort="Goncalves, Aurelien" uniqKey="Goncalves A" first="Aurelien" last="Goncalves">Aurelien Goncalves</name><affiliation><nlm:aff id="af33"><addr-line>Ophthalmology Department</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name><affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Biochemistry Department</addr-line>,<institution>Angers University Hospital</institution>,<addr-line>Angers</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Ophthalmology, Tongji Hospital of Tongji Medical College</addr-line>,<institution>Huazhong University of Science and Technology</institution>,<addr-line>Wuhan</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bourne, Rupert" sort="Bourne, Rupert" uniqKey="Bourne R" first="Rupert" last="Bourne">Rupert Bourne</name><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Huntingdon Glaucoma Diagnostic & Research Centre</addr-line>,<institution>Hinchingbrooke Hospital</institution>,<addr-line>Huntingdon</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goh, David" sort="Goh, David" uniqKey="Goh D" first="David" last="Goh">David Goh</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Broadway, David" sort="Broadway, David" uniqKey="Broadway D" first="David" last="Broadway">David Broadway</name><affiliation wicri:level="1"><nlm:aff id="af37"><institution>Norfolk & Norwich University Hospital NHS Trust</institution>,<addr-line>Norwich</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Negi, Anil K" sort="Negi, Anil K" uniqKey="Negi A" first="Anil K." last="Negi">Anil K. Negi</name><affiliation wicri:level="1"><nlm:aff id="af38"><institution>Heart of UK NHS Foundation Trust</institution>,<addr-line>Birmingham</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Su, Daniel H" sort="Su, Daniel H" uniqKey="Su D" first="Daniel H" last="Su">Daniel H. Su</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Ching Lin" sort="Ho, Ching Lin" uniqKey="Ho C" first="Ching-Lin" last="Ho">Ching-Lin Ho</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blanco, Augusto Azuara" sort="Blanco, Augusto Azuara" uniqKey="Blanco A" first="Augusto Azuara" last="Blanco">Augusto Azuara Blanco</name><affiliation wicri:level="1"><nlm:aff id="af39"><addr-line>School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine</addr-line>,<institution>Queen's University Belfast</institution>,<addr-line>Northern Ireland</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leung, Christopher K S" sort="Leung, Christopher K S" uniqKey="Leung C" first="Christopher K. S." last="Leung">Christopher K. S. Leung</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tina T" sort="Wong, Tina T" uniqKey="Wong T" first="Tina T." last="Wong">Tina T. Wong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yakub, Azhany" sort="Yakub, Azhany" uniqKey="Yakub A" first="Azhany" last="Yakub">Azhany Yakub</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Ophthalmology, School of Medical Sciences</addr-line>,<institution>Universiti Sains Malaysia</institution>,<addr-line>Kota Bharu, Kelantan</addr-line>,<country>Malaysia</country>,</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Cellular Biology and Anatomy</addr-line>,<institution>Georgia Regents University</institution>,<addr-line>Augusta</addr-line>,<country>Georgia</country>,</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nongpiur, Monisha E" sort="Nongpiur, Monisha E" uniqKey="Nongpiur M" first="Monisha E." last="Nongpiur">Monisha E. Nongpiur</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Han, Jong Chul" sort="Han, Jong Chul" uniqKey="Han J" first="Jong Chul" last="Han">Jong Chul Han</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Hon, Do Nhu" sort="Hon, Do Nhu" uniqKey="Hon D" first="Do Nhu" last="Hon">Do Nhu Hon</name><affiliation wicri:level="1"><nlm:aff id="af32"><institution>Vietnam National Institute of Ophthalmology</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shantha, Balekudaru" sort="Shantha, Balekudaru" uniqKey="Shantha B" first="Balekudaru" last="Shantha">Balekudaru Shantha</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sato, Ryuichi" sort="Sato, Ryuichi" uniqKey="Sato R" first="Ryuichi" last="Sato">Ryuichi Sato</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yoshii, Kengo" sort="Yoshii, Kengo" uniqKey="Yoshii K" first="Kengo" last="Yoshii">Kengo Yoshii</name><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Medical Statistics</addr-line>,<institution>Kyoto Prefectural University of Medicine</institution>,<addr-line>Kyoto</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Panda Jonas, Songhomita" sort="Panda Jonas, Songhomita" uniqKey="Panda Jonas S" first="Songhomita" last="Panda-Jonas">Songhomita Panda-Jonas</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Ophthalmology</addr-line>,<institution>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E." last="Ashley Koch">Allison E. Ashley Koch</name><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herndon, Leon W" sort="Herndon, Leon W" uniqKey="Herndon L" first="Leon W." last="Herndon">Leon W. Herndon</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E." last="Moroi">Sayoko E. Moroi</name><affiliation><nlm:aff id="af44"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bei, Jin Xin" sort="Bei, Jin Xin" uniqKey="Bei J" first="Jin-Xin" last="Bei">Jin-Xin Bei</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>State Key Laboratory of Oncology in Southern China, Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Experimental Research</addr-line>,<institution>Sun Yat-Sen University Cancer Centre</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeng, Yi Xin" sort="Zeng, Yi Xin" uniqKey="Zeng Y" first="Yi-Xin" last="Zeng">Yi-Xin Zeng</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>State Key Laboratory of Oncology in Southern China, Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Experimental Research</addr-line>,<institution>Sun Yat-Sen University Cancer Centre</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P." last="Simmons">Cameron P. Simmons</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Clinical Research Unit</addr-line>,<institution>Oxford University</institution>,<addr-line>190 Ben Ham Tu, Ho Chi Minh City</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine</addr-line>,<institution>Oxford University</institution>,<addr-line>Oxford OX3 7LJ</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bich Chau, Tran Nguyen" sort="Bich Chau, Tran Nguyen" uniqKey="Bich Chau T" first="Tran Nguyen" last="Bich Chau">Tran Nguyen Bich Chau</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Clinical Research Unit</addr-line>,<institution>Oxford University</institution>,<addr-line>190 Ben Ham Tu, Ho Chi Minh City</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sharmila, Philomenadin Ferdinamarie" sort="Sharmila, Philomenadin Ferdinamarie" uniqKey="Sharmila P" first="Philomenadin Ferdinamarie" last="Sharmila">Philomenadin Ferdinamarie Sharmila</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>SNONGC Department of Genetics and Molecular Biology</addr-line>,<institution>Vision Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chew, Merwyn" sort="Chew, Merwyn" uniqKey="Chew M" first="Merwyn" last="Chew">Merwyn Chew</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lim, Blanche" sort="Lim, Blanche" uniqKey="Lim B" first="Blanche" last="Lim">Blanche Lim</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Tam, Pansy O S" sort="Tam, Pansy O S" uniqKey="Tam P" first="Pansy O. S." last="Tam">Pansy O. S. Tam</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chua, Elaine" sort="Chua, Elaine" uniqKey="Chua E" first="Elaine" last="Chua">Elaine Chua</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ng, Xiao Yu" sort="Ng, Xiao Yu" uniqKey="Ng X" first="Xiao Yu" last="Ng">Xiao Yu Ng</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yong, Victor H K" sort="Yong, Victor H K" uniqKey="Yong V" first="Victor H. K." last="Yong">Victor H. K. Yong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chong, Yaan Fun" sort="Chong, Yaan Fun" uniqKey="Chong Y" first="Yaan Fun" last="Chong">Yaan Fun Chong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seongsoo, Sohn" sort="Seongsoo, Sohn" uniqKey="Seongsoo S" first="Sohn" last="Seongsoo">Sohn Seongsoo</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Wang" sort="Xu, Wang" uniqKey="Xu W" first="Wang" last="Xu">Wang Xu</name><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cooke Bailey, Jessica N" sort="Cooke Bailey, Jessica N" uniqKey="Cooke Bailey J" first="Jessica N." last="Cooke Bailey">Jessica N. Cooke Bailey</name><affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Case Western Reserve University</institution>,<addr-line>Cleveland, OH</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H." last="Kang">Jae H. Kang</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Channing Division of Network Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name><affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Case Western Reserve University</institution>,<addr-line>Cleveland, OH</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Department of Medicine</addr-line>,<institution>National University Health System & National University of Singapore</institution>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E." last="Richards">Julia E. Richards</name><affiliation><nlm:aff id="af44"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name><affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Einhorn Clinical Research Center, Department of Ophthalmology</addr-line>,<institution>New York Eye and Ear Infirmary</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaasterland, Douglas E" sort="Gaasterland, Douglas E" uniqKey="Gaasterland D" first="Douglas E." last="Gaasterland">Douglas E. Gaasterland</name><affiliation wicri:level="1"><nlm:aff id="af54"><institution>Eye Doctors of Washington DC</institution>,<addr-line>Washington, DC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R." last="Pasquale">Louis R. Pasquale</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Channing Division of Network Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af55"><addr-line>Department of Ophthalmology, Harvard Medical School</addr-line>,<institution>Massachusetts Eye and Ear Infirmary</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B." last="Jonas">Jost B. Jonas</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Ophthalmology</addr-line>,<institution>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Milea">Dan Milea</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="George, Ronnie" sort="George, Ronnie" uniqKey="George R" first="Ronnie" last="George">Ronnie George</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A." last="Al-Obeidan">Saleh A. Al-Obeidan</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Department of Genetics and Computational Biology, Statistical Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W." last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af56"><institution>Centre for Eye Research Australia (CERA)</institution>,<institution>University of Melbourne</institution>,<institution>Royal Victorian Eye and Ear Hospital</institution>,<addr-line>Melbourne, VIC</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Girkin, Christopher A" sort="Girkin, Christopher A" uniqKey="Girkin C" first="Christopher A." last="Girkin">Christopher A. Girkin</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Department of Ophthalmology</addr-line>,<institution>University of Alabama at Birmingham</institution>,<addr-line>Birmingham, AL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Mingzhi" sort="Zhang, Mingzhi" uniqKey="Zhang M" first="Mingzhi" last="Zhang">Mingzhi Zhang</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Chinese University of Hong Kong Joint Shantou International Eye Center</addr-line>,<institution>Shantou University</institution>,<addr-line>Shantou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vijaya, Lingam" sort="Vijaya, Lingam" uniqKey="Vijaya L" first="Lingam" last="Vijaya">Lingam Vijaya</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Centre for Ophthalmology and Visual Science</addr-line>,<institution>Lions Eye Institute, University of Western Australia</institution>,<addr-line>Perth, WA</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Department of Ophthalmology</addr-line>,<institution>Flinders University</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Xinghuai" sort="Sun, Xinghuai" uniqKey="Sun X" first="Xinghuai" last="Sun">Xinghuai Sun</name><affiliation><nlm:aff id="af9"><addr-line>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>State Key Laboratory of Medical Neurobiology, Institutes of Brain Science</addr-line>,<institution>Fudan University</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af59"><addr-line>Myopia Key Laboratory of the Ministry of Health of China, Shanghai</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L." last="Wiggs">Janey L. Wiggs</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Department of Ophthalmology</addr-line>,<institution>University of Alabama at Birmingham</institution>,<addr-line>Birmingham, AL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Sichuan Provincial Key Laboratory for Human Disease Gene Study</addr-line>,<institution>Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>School of Medicine</addr-line>,<institution>University of Electronic Science and Technology of China</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Chinese Academy of Sciences</addr-line>,<institution>Sichuan Translational Medicine Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pang, Chi Pui" sort="Pang, Chi Pui" uniqKey="Pang C" first="Chi Pui" last="Pang">Chi Pui Pang</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A." last="Hauser">Michael A. Hauser</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N." last="Vithana">Eranga N. Vithana</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Glaucoma, Open-Angle (genetics)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Proteoglycans (genetics)</term><term>Receptors, Transforming Growth Factor beta (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Allèles</term><term>Femelle</term><term>Glaucome à angle ouvert (génétique)</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Protéoglycanes (génétique)</term><term>Récepteurs TGF-bêta (génétique)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Variation génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proteoglycans</term><term>Receptors, Transforming Growth Factor beta</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Glaucoma, Open-Angle</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glaucome à angle ouvert</term><term>Protéoglycanes</term><term>Récepteurs TGF-bêta</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Allèles</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Variation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at <italic>CDKN2B-AS1</italic> (rs2157719 [G], odds ratio [OR] = 0.71, <italic>P</italic> = 2.81 × 10<sup>−33</sup>), we observed one SNP showing significant association to POAG (<italic>CDC7</italic>–<italic>TGFBR3</italic> rs1192415, OR<sub>G-allele</sub> = 1.13, <italic>P</italic><sub>meta</sub> = 1.60 × 10<sup>−8</sup>). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. 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Hibberd</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="25861811"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A common variant near <italic>TGFBR3</italic> is associated with primary open angle glaucoma</title><author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R. Rand" last="Allingham">R. Rand Allingham</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Jia, Liyun" sort="Jia, Liyun" uniqKey="Jia L" first="Liyun" last="Jia">Liyun Jia</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Yuhong" sort="Chen, Yuhong" uniqKey="Chen Y" first="Yuhong" last="Chen">Yuhong Chen</name><affiliation><nlm:aff id="af9"><addr-line>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mani, Baskaran" sort="Mani, Baskaran" uniqKey="Mani B" first="Baskaran" last="Mani">Baskaran Mani</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Li Jia" sort="Chen, Li Jia" uniqKey="Chen L" first="Li-Jia" last="Chen">Li-Jia Chen</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kee, Changwon" sort="Kee, Changwon" uniqKey="Kee C" first="Changwon" last="Kee">Changwon Kee</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Garway Heath, David F" sort="Garway Heath, David F" uniqKey="Garway Heath D" first="David F." last="Garway-Heath">David F. Garway-Heath</name><affiliation wicri:level="1"><nlm:aff id="af16"><institution>National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sripriya, Sarangapani" sort="Sripriya, Sarangapani" uniqKey="Sripriya S" first="Sarangapani" last="Sripriya">Sarangapani Sripriya</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>SNONGC Department of Genetics and Molecular Biology</addr-line>,<institution>Vision Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fuse, Nobuo" sort="Fuse, Nobuo" uniqKey="Fuse N" first="Nobuo" last="Fuse">Nobuo Fuse</name><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Integrative Genomics</addr-line>,<institution>Tohoku Medical Megabank Organization</institution>,<addr-line>Sendai</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K." last="Abu-Amero">Khaled K. Abu-Amero</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>University of Florida</institution>,<addr-line>Jacksonville, FL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Chukai" sort="Huang, Chukai" uniqKey="Huang C" first="Chukai" last="Huang">Chukai Huang</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Chinese University of Hong Kong Joint Shantou International Eye Center</addr-line>,<institution>Shantou University</institution>,<addr-line>Shantou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Namburi, Prasanthi" sort="Namburi, Prasanthi" uniqKey="Namburi P" first="Prasanthi" last="Namburi">Prasanthi Namburi</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burdon, Kathryn" sort="Burdon, Kathryn" uniqKey="Burdon K" first="Kathryn" last="Burdon">Kathryn Burdon</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Department of Ophthalmology</addr-line>,<institution>Flinders University</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A." last="Perera">Shamira A. Perera</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gharahkhani, Puya" sort="Gharahkhani, Puya" uniqKey="Gharahkhani P" first="Puya" last="Gharahkhani">Puya Gharahkhani</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Department of Genetics and Computational Biology, Statistical Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Sichuan Provincial Key Laboratory for Human Disease Gene Study</addr-line>,<institution>Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>School of Medicine</addr-line>,<institution>University of Electronic Science and Technology of China</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name><affiliation wicri:level="1"><nlm:aff id="af28"><institution>Ozaki Eye Hospital</institution>,<addr-line>1–15, Kamezaki, Hyuga, Miyazaki 883-0066</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name><affiliation wicri:level="1"><nlm:aff id="af29"><institution>Mizoguchi Eye Hospital</institution>,<addr-line>6-13 Tawara-machi, Sasebo, Nagasaki 857-0016</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Krishnadas, Subbiah Ramasamy" sort="Krishnadas, Subbiah Ramasamy" uniqKey="Krishnadas S" first="Subbiah Ramasamy" last="Krishnadas">Subbiah Ramasamy Krishnadas</name><affiliation wicri:level="1"><nlm:aff id="af30"><addr-line>Glaucoma Services</addr-line>,<institution>Aravind Eye Hospital</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A." last="Osman">Essam A. Osman</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S. Y." last="Chan">Anita S. Y. Chan</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tajudin, Liza Sharmini A" sort="Tajudin, Liza Sharmini A" uniqKey="Tajudin L" first="Liza-Sharmini A." last="Tajudin">Liza-Sharmini A. Tajudin</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Ophthalmology, School of Medical Sciences</addr-line>,<institution>Universiti Sains Malaysia</institution>,<addr-line>Kota Bharu, Kelantan</addr-line>,<country>Malaysia</country>,</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Do, Tan" sort="Do, Tan" uniqKey="Do T" first="Tan" last="Do">Tan Do</name><affiliation wicri:level="1"><nlm:aff id="af32"><institution>Vietnam National Institute of Ophthalmology</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goncalves, Aurelien" sort="Goncalves, Aurelien" uniqKey="Goncalves A" first="Aurelien" last="Goncalves">Aurelien Goncalves</name><affiliation><nlm:aff id="af33"><addr-line>Ophthalmology Department</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name><affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Biochemistry Department</addr-line>,<institution>Angers University Hospital</institution>,<addr-line>Angers</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Ophthalmology, Tongji Hospital of Tongji Medical College</addr-line>,<institution>Huazhong University of Science and Technology</institution>,<addr-line>Wuhan</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bourne, Rupert" sort="Bourne, Rupert" uniqKey="Bourne R" first="Rupert" last="Bourne">Rupert Bourne</name><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Huntingdon Glaucoma Diagnostic & Research Centre</addr-line>,<institution>Hinchingbrooke Hospital</institution>,<addr-line>Huntingdon</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goh, David" sort="Goh, David" uniqKey="Goh D" first="David" last="Goh">David Goh</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Broadway, David" sort="Broadway, David" uniqKey="Broadway D" first="David" last="Broadway">David Broadway</name><affiliation wicri:level="1"><nlm:aff id="af37"><institution>Norfolk & Norwich University Hospital NHS Trust</institution>,<addr-line>Norwich</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Negi, Anil K" sort="Negi, Anil K" uniqKey="Negi A" first="Anil K." last="Negi">Anil K. Negi</name><affiliation wicri:level="1"><nlm:aff id="af38"><institution>Heart of UK NHS Foundation Trust</institution>,<addr-line>Birmingham</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Su, Daniel H" sort="Su, Daniel H" uniqKey="Su D" first="Daniel H" last="Su">Daniel H. Su</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Ching Lin" sort="Ho, Ching Lin" uniqKey="Ho C" first="Ching-Lin" last="Ho">Ching-Lin Ho</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blanco, Augusto Azuara" sort="Blanco, Augusto Azuara" uniqKey="Blanco A" first="Augusto Azuara" last="Blanco">Augusto Azuara Blanco</name><affiliation wicri:level="1"><nlm:aff id="af39"><addr-line>School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine</addr-line>,<institution>Queen's University Belfast</institution>,<addr-line>Northern Ireland</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leung, Christopher K S" sort="Leung, Christopher K S" uniqKey="Leung C" first="Christopher K. S." last="Leung">Christopher K. S. Leung</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tina T" sort="Wong, Tina T" uniqKey="Wong T" first="Tina T." last="Wong">Tina T. Wong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yakub, Azhany" sort="Yakub, Azhany" uniqKey="Yakub A" first="Azhany" last="Yakub">Azhany Yakub</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Ophthalmology, School of Medical Sciences</addr-line>,<institution>Universiti Sains Malaysia</institution>,<addr-line>Kota Bharu, Kelantan</addr-line>,<country>Malaysia</country>,</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Cellular Biology and Anatomy</addr-line>,<institution>Georgia Regents University</institution>,<addr-line>Augusta</addr-line>,<country>Georgia</country>,</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nongpiur, Monisha E" sort="Nongpiur, Monisha E" uniqKey="Nongpiur M" first="Monisha E." last="Nongpiur">Monisha E. Nongpiur</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Han, Jong Chul" sort="Han, Jong Chul" uniqKey="Han J" first="Jong Chul" last="Han">Jong Chul Han</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Hon, Do Nhu" sort="Hon, Do Nhu" uniqKey="Hon D" first="Do Nhu" last="Hon">Do Nhu Hon</name><affiliation wicri:level="1"><nlm:aff id="af32"><institution>Vietnam National Institute of Ophthalmology</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shantha, Balekudaru" sort="Shantha, Balekudaru" uniqKey="Shantha B" first="Balekudaru" last="Shantha">Balekudaru Shantha</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sato, Ryuichi" sort="Sato, Ryuichi" uniqKey="Sato R" first="Ryuichi" last="Sato">Ryuichi Sato</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yoshii, Kengo" sort="Yoshii, Kengo" uniqKey="Yoshii K" first="Kengo" last="Yoshii">Kengo Yoshii</name><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Medical Statistics</addr-line>,<institution>Kyoto Prefectural University of Medicine</institution>,<addr-line>Kyoto</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Panda Jonas, Songhomita" sort="Panda Jonas, Songhomita" uniqKey="Panda Jonas S" first="Songhomita" last="Panda-Jonas">Songhomita Panda-Jonas</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Ophthalmology</addr-line>,<institution>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E." last="Ashley Koch">Allison E. Ashley Koch</name><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herndon, Leon W" sort="Herndon, Leon W" uniqKey="Herndon L" first="Leon W." last="Herndon">Leon W. Herndon</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E." last="Moroi">Sayoko E. Moroi</name><affiliation><nlm:aff id="af44"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bei, Jin Xin" sort="Bei, Jin Xin" uniqKey="Bei J" first="Jin-Xin" last="Bei">Jin-Xin Bei</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>State Key Laboratory of Oncology in Southern China, Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Experimental Research</addr-line>,<institution>Sun Yat-Sen University Cancer Centre</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeng, Yi Xin" sort="Zeng, Yi Xin" uniqKey="Zeng Y" first="Yi-Xin" last="Zeng">Yi-Xin Zeng</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>State Key Laboratory of Oncology in Southern China, Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Experimental Research</addr-line>,<institution>Sun Yat-Sen University Cancer Centre</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P." last="Simmons">Cameron P. Simmons</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Clinical Research Unit</addr-line>,<institution>Oxford University</institution>,<addr-line>190 Ben Ham Tu, Ho Chi Minh City</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine</addr-line>,<institution>Oxford University</institution>,<addr-line>Oxford OX3 7LJ</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bich Chau, Tran Nguyen" sort="Bich Chau, Tran Nguyen" uniqKey="Bich Chau T" first="Tran Nguyen" last="Bich Chau">Tran Nguyen Bich Chau</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Clinical Research Unit</addr-line>,<institution>Oxford University</institution>,<addr-line>190 Ben Ham Tu, Ho Chi Minh City</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sharmila, Philomenadin Ferdinamarie" sort="Sharmila, Philomenadin Ferdinamarie" uniqKey="Sharmila P" first="Philomenadin Ferdinamarie" last="Sharmila">Philomenadin Ferdinamarie Sharmila</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>SNONGC Department of Genetics and Molecular Biology</addr-line>,<institution>Vision Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chew, Merwyn" sort="Chew, Merwyn" uniqKey="Chew M" first="Merwyn" last="Chew">Merwyn Chew</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lim, Blanche" sort="Lim, Blanche" uniqKey="Lim B" first="Blanche" last="Lim">Blanche Lim</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Tam, Pansy O S" sort="Tam, Pansy O S" uniqKey="Tam P" first="Pansy O. S." last="Tam">Pansy O. S. Tam</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chua, Elaine" sort="Chua, Elaine" uniqKey="Chua E" first="Elaine" last="Chua">Elaine Chua</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ng, Xiao Yu" sort="Ng, Xiao Yu" uniqKey="Ng X" first="Xiao Yu" last="Ng">Xiao Yu Ng</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yong, Victor H K" sort="Yong, Victor H K" uniqKey="Yong V" first="Victor H. K." last="Yong">Victor H. K. Yong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chong, Yaan Fun" sort="Chong, Yaan Fun" uniqKey="Chong Y" first="Yaan Fun" last="Chong">Yaan Fun Chong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seongsoo, Sohn" sort="Seongsoo, Sohn" uniqKey="Seongsoo S" first="Sohn" last="Seongsoo">Sohn Seongsoo</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Wang" sort="Xu, Wang" uniqKey="Xu W" first="Wang" last="Xu">Wang Xu</name><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cooke Bailey, Jessica N" sort="Cooke Bailey, Jessica N" uniqKey="Cooke Bailey J" first="Jessica N." last="Cooke Bailey">Jessica N. Cooke Bailey</name><affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Case Western Reserve University</institution>,<addr-line>Cleveland, OH</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H." last="Kang">Jae H. Kang</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Channing Division of Network Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name><affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Case Western Reserve University</institution>,<addr-line>Cleveland, OH</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Department of Medicine</addr-line>,<institution>National University Health System & National University of Singapore</institution>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E." last="Richards">Julia E. Richards</name><affiliation><nlm:aff id="af44"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name><affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Einhorn Clinical Research Center, Department of Ophthalmology</addr-line>,<institution>New York Eye and Ear Infirmary</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaasterland, Douglas E" sort="Gaasterland, Douglas E" uniqKey="Gaasterland D" first="Douglas E." last="Gaasterland">Douglas E. Gaasterland</name><affiliation wicri:level="1"><nlm:aff id="af54"><institution>Eye Doctors of Washington DC</institution>,<addr-line>Washington, DC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R." last="Pasquale">Louis R. Pasquale</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Channing Division of Network Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af55"><addr-line>Department of Ophthalmology, Harvard Medical School</addr-line>,<institution>Massachusetts Eye and Ear Infirmary</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B." last="Jonas">Jost B. Jonas</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Ophthalmology</addr-line>,<institution>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Milea">Dan Milea</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="George, Ronnie" sort="George, Ronnie" uniqKey="George R" first="Ronnie" last="George">Ronnie George</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A." last="Al-Obeidan">Saleh A. Al-Obeidan</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Department of Genetics and Computational Biology, Statistical Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W." last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af56"><institution>Centre for Eye Research Australia (CERA)</institution>,<institution>University of Melbourne</institution>,<institution>Royal Victorian Eye and Ear Hospital</institution>,<addr-line>Melbourne, VIC</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Girkin, Christopher A" sort="Girkin, Christopher A" uniqKey="Girkin C" first="Christopher A." last="Girkin">Christopher A. Girkin</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Department of Ophthalmology</addr-line>,<institution>University of Alabama at Birmingham</institution>,<addr-line>Birmingham, AL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Mingzhi" sort="Zhang, Mingzhi" uniqKey="Zhang M" first="Mingzhi" last="Zhang">Mingzhi Zhang</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Chinese University of Hong Kong Joint Shantou International Eye Center</addr-line>,<institution>Shantou University</institution>,<addr-line>Shantou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vijaya, Lingam" sort="Vijaya, Lingam" uniqKey="Vijaya L" first="Lingam" last="Vijaya">Lingam Vijaya</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Centre for Ophthalmology and Visual Science</addr-line>,<institution>Lions Eye Institute, University of Western Australia</institution>,<addr-line>Perth, WA</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Department of Ophthalmology</addr-line>,<institution>Flinders University</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Xinghuai" sort="Sun, Xinghuai" uniqKey="Sun X" first="Xinghuai" last="Sun">Xinghuai Sun</name><affiliation><nlm:aff id="af9"><addr-line>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>State Key Laboratory of Medical Neurobiology, Institutes of Brain Science</addr-line>,<institution>Fudan University</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af59"><addr-line>Myopia Key Laboratory of the Ministry of Health of China, Shanghai</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L." last="Wiggs">Janey L. Wiggs</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Department of Ophthalmology</addr-line>,<institution>University of Alabama at Birmingham</institution>,<addr-line>Birmingham, AL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Sichuan Provincial Key Laboratory for Human Disease Gene Study</addr-line>,<institution>Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>School of Medicine</addr-line>,<institution>University of Electronic Science and Technology of China</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Chinese Academy of Sciences</addr-line>,<institution>Sichuan Translational Medicine Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pang, Chi Pui" sort="Pang, Chi Pui" uniqKey="Pang C" first="Chi Pui" last="Pang">Chi Pui Pang</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A." last="Hauser">Michael A. Hauser</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N." last="Vithana">Eranga N. Vithana</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25861811</idno><idno type="pmc">4459396</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459396</idno><idno type="RBID">PMC:4459396</idno><idno type="doi">10.1093/hmg/ddv128</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000276</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000276</idno><idno type="wicri:Area/Pmc/Curation">000276</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000276</idno><idno type="wicri:Area/Pmc/Checkpoint">001225</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001225</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A common variant near <italic>TGFBR3</italic> is associated with primary open angle glaucoma</title><author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R. Rand" last="Allingham">R. Rand Allingham</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Jia, Liyun" sort="Jia, Liyun" uniqKey="Jia L" first="Liyun" last="Jia">Liyun Jia</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Yuhong" sort="Chen, Yuhong" uniqKey="Chen Y" first="Yuhong" last="Chen">Yuhong Chen</name><affiliation><nlm:aff id="af9"><addr-line>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Mani, Baskaran" sort="Mani, Baskaran" uniqKey="Mani B" first="Baskaran" last="Mani">Baskaran Mani</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Li Jia" sort="Chen, Li Jia" uniqKey="Chen L" first="Li-Jia" last="Chen">Li-Jia Chen</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kee, Changwon" sort="Kee, Changwon" uniqKey="Kee C" first="Changwon" last="Kee">Changwon Kee</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Garway Heath, David F" sort="Garway Heath, David F" uniqKey="Garway Heath D" first="David F." last="Garway-Heath">David F. Garway-Heath</name><affiliation wicri:level="1"><nlm:aff id="af16"><institution>National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology</institution>,<addr-line>London</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sripriya, Sarangapani" sort="Sripriya, Sarangapani" uniqKey="Sripriya S" first="Sarangapani" last="Sripriya">Sarangapani Sripriya</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>SNONGC Department of Genetics and Molecular Biology</addr-line>,<institution>Vision Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fuse, Nobuo" sort="Fuse, Nobuo" uniqKey="Fuse N" first="Nobuo" last="Fuse">Nobuo Fuse</name><affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Integrative Genomics</addr-line>,<institution>Tohoku Medical Megabank Organization</institution>,<addr-line>Sendai</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K." last="Abu-Amero">Khaled K. Abu-Amero</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>University of Florida</institution>,<addr-line>Jacksonville, FL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Chukai" sort="Huang, Chukai" uniqKey="Huang C" first="Chukai" last="Huang">Chukai Huang</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Chinese University of Hong Kong Joint Shantou International Eye Center</addr-line>,<institution>Shantou University</institution>,<addr-line>Shantou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Namburi, Prasanthi" sort="Namburi, Prasanthi" uniqKey="Namburi P" first="Prasanthi" last="Namburi">Prasanthi Namburi</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burdon, Kathryn" sort="Burdon, Kathryn" uniqKey="Burdon K" first="Kathryn" last="Burdon">Kathryn Burdon</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Department of Ophthalmology</addr-line>,<institution>Flinders University</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A." last="Perera">Shamira A. Perera</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gharahkhani, Puya" sort="Gharahkhani, Puya" uniqKey="Gharahkhani P" first="Puya" last="Gharahkhani">Puya Gharahkhani</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Department of Genetics and Computational Biology, Statistical Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Sichuan Provincial Key Laboratory for Human Disease Gene Study</addr-line>,<institution>Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>School of Medicine</addr-line>,<institution>University of Electronic Science and Technology of China</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name><affiliation wicri:level="1"><nlm:aff id="af28"><institution>Ozaki Eye Hospital</institution>,<addr-line>1–15, Kamezaki, Hyuga, Miyazaki 883-0066</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name><affiliation wicri:level="1"><nlm:aff id="af29"><institution>Mizoguchi Eye Hospital</institution>,<addr-line>6-13 Tawara-machi, Sasebo, Nagasaki 857-0016</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Krishnadas, Subbiah Ramasamy" sort="Krishnadas, Subbiah Ramasamy" uniqKey="Krishnadas S" first="Subbiah Ramasamy" last="Krishnadas">Subbiah Ramasamy Krishnadas</name><affiliation wicri:level="1"><nlm:aff id="af30"><addr-line>Glaucoma Services</addr-line>,<institution>Aravind Eye Hospital</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A." last="Osman">Essam A. Osman</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S. Y." last="Chan">Anita S. Y. Chan</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tajudin, Liza Sharmini A" sort="Tajudin, Liza Sharmini A" uniqKey="Tajudin L" first="Liza-Sharmini A." last="Tajudin">Liza-Sharmini A. Tajudin</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Ophthalmology, School of Medical Sciences</addr-line>,<institution>Universiti Sains Malaysia</institution>,<addr-line>Kota Bharu, Kelantan</addr-line>,<country>Malaysia</country>,</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Do, Tan" sort="Do, Tan" uniqKey="Do T" first="Tan" last="Do">Tan Do</name><affiliation wicri:level="1"><nlm:aff id="af32"><institution>Vietnam National Institute of Ophthalmology</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goncalves, Aurelien" sort="Goncalves, Aurelien" uniqKey="Goncalves A" first="Aurelien" last="Goncalves">Aurelien Goncalves</name><affiliation><nlm:aff id="af33"><addr-line>Ophthalmology Department</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name><affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Biochemistry Department</addr-line>,<institution>Angers University Hospital</institution>,<addr-line>Angers</addr-line>,<country>France</country>,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Ophthalmology, Tongji Hospital of Tongji Medical College</addr-line>,<institution>Huazhong University of Science and Technology</institution>,<addr-line>Wuhan</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bourne, Rupert" sort="Bourne, Rupert" uniqKey="Bourne R" first="Rupert" last="Bourne">Rupert Bourne</name><affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Huntingdon Glaucoma Diagnostic & Research Centre</addr-line>,<institution>Hinchingbrooke Hospital</institution>,<addr-line>Huntingdon</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goh, David" sort="Goh, David" uniqKey="Goh D" first="David" last="Goh">David Goh</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Broadway, David" sort="Broadway, David" uniqKey="Broadway D" first="David" last="Broadway">David Broadway</name><affiliation wicri:level="1"><nlm:aff id="af37"><institution>Norfolk & Norwich University Hospital NHS Trust</institution>,<addr-line>Norwich</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Negi, Anil K" sort="Negi, Anil K" uniqKey="Negi A" first="Anil K." last="Negi">Anil K. Negi</name><affiliation wicri:level="1"><nlm:aff id="af38"><institution>Heart of UK NHS Foundation Trust</institution>,<addr-line>Birmingham</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Su, Daniel H" sort="Su, Daniel H" uniqKey="Su D" first="Daniel H" last="Su">Daniel H. Su</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ho, Ching Lin" sort="Ho, Ching Lin" uniqKey="Ho C" first="Ching-Lin" last="Ho">Ching-Lin Ho</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blanco, Augusto Azuara" sort="Blanco, Augusto Azuara" uniqKey="Blanco A" first="Augusto Azuara" last="Blanco">Augusto Azuara Blanco</name><affiliation wicri:level="1"><nlm:aff id="af39"><addr-line>School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine</addr-line>,<institution>Queen's University Belfast</institution>,<addr-line>Northern Ireland</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leung, Christopher K S" sort="Leung, Christopher K S" uniqKey="Leung C" first="Christopher K. S." last="Leung">Christopher K. S. Leung</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tina T" sort="Wong, Tina T" uniqKey="Wong T" first="Tina T." last="Wong">Tina T. Wong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yakub, Azhany" sort="Yakub, Azhany" uniqKey="Yakub A" first="Azhany" last="Yakub">Azhany Yakub</name><affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Ophthalmology, School of Medical Sciences</addr-line>,<institution>Universiti Sains Malaysia</institution>,<addr-line>Kota Bharu, Kelantan</addr-line>,<country>Malaysia</country>,</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Cellular Biology and Anatomy</addr-line>,<institution>Georgia Regents University</institution>,<addr-line>Augusta</addr-line>,<country>Georgia</country>,</nlm:aff><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nongpiur, Monisha E" sort="Nongpiur, Monisha E" uniqKey="Nongpiur M" first="Monisha E." last="Nongpiur">Monisha E. Nongpiur</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Han, Jong Chul" sort="Han, Jong Chul" uniqKey="Han J" first="Jong Chul" last="Han">Jong Chul Han</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Hon, Do Nhu" sort="Hon, Do Nhu" uniqKey="Hon D" first="Do Nhu" last="Hon">Do Nhu Hon</name><affiliation wicri:level="1"><nlm:aff id="af32"><institution>Vietnam National Institute of Ophthalmology</institution>,<addr-line>Hanoi</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shantha, Balekudaru" sort="Shantha, Balekudaru" uniqKey="Shantha B" first="Balekudaru" last="Shantha">Balekudaru Shantha</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sato, Ryuichi" sort="Sato, Ryuichi" uniqKey="Sato R" first="Ryuichi" last="Sato">Ryuichi Sato</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yoshii, Kengo" sort="Yoshii, Kengo" uniqKey="Yoshii K" first="Kengo" last="Yoshii">Kengo Yoshii</name><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Medical Statistics</addr-line>,<institution>Kyoto Prefectural University of Medicine</institution>,<addr-line>Kyoto</addr-line>,<country>Japan</country>,</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Panda Jonas, Songhomita" sort="Panda Jonas, Songhomita" uniqKey="Panda Jonas S" first="Songhomita" last="Panda-Jonas">Songhomita Panda-Jonas</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Ophthalmology</addr-line>,<institution>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E." last="Ashley Koch">Allison E. Ashley Koch</name><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herndon, Leon W" sort="Herndon, Leon W" uniqKey="Herndon L" first="Leon W." last="Herndon">Leon W. Herndon</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E." last="Moroi">Sayoko E. Moroi</name><affiliation><nlm:aff id="af44"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bei, Jin Xin" sort="Bei, Jin Xin" uniqKey="Bei J" first="Jin-Xin" last="Bei">Jin-Xin Bei</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>State Key Laboratory of Oncology in Southern China, Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Experimental Research</addr-line>,<institution>Sun Yat-Sen University Cancer Centre</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeng, Yi Xin" sort="Zeng, Yi Xin" uniqKey="Zeng Y" first="Yi-Xin" last="Zeng">Yi-Xin Zeng</name><affiliation wicri:level="1"><nlm:aff id="af46"><addr-line>State Key Laboratory of Oncology in Southern China, Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af47"><addr-line>Department of Experimental Research</addr-line>,<institution>Sun Yat-Sen University Cancer Centre</institution>,<addr-line>Guangzhou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P." last="Simmons">Cameron P. Simmons</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Clinical Research Unit</addr-line>,<institution>Oxford University</institution>,<addr-line>190 Ben Ham Tu, Ho Chi Minh City</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine</addr-line>,<institution>Oxford University</institution>,<addr-line>Oxford OX3 7LJ</addr-line>,<country>UK</country>,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bich Chau, Tran Nguyen" sort="Bich Chau, Tran Nguyen" uniqKey="Bich Chau T" first="Tran Nguyen" last="Bich Chau">Tran Nguyen Bich Chau</name><affiliation wicri:level="1"><nlm:aff id="af48"><addr-line>Clinical Research Unit</addr-line>,<institution>Oxford University</institution>,<addr-line>190 Ben Ham Tu, Ho Chi Minh City</addr-line>,<country>Vietnam</country>,</nlm:aff><country xml:lang="fr">Viêt Nam</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sharmila, Philomenadin Ferdinamarie" sort="Sharmila, Philomenadin Ferdinamarie" uniqKey="Sharmila P" first="Philomenadin Ferdinamarie" last="Sharmila">Philomenadin Ferdinamarie Sharmila</name><affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>SNONGC Department of Genetics and Molecular Biology</addr-line>,<institution>Vision Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chew, Merwyn" sort="Chew, Merwyn" uniqKey="Chew M" first="Merwyn" last="Chew">Merwyn Chew</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Lim, Blanche" sort="Lim, Blanche" uniqKey="Lim B" first="Blanche" last="Lim">Blanche Lim</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Tam, Pansy O S" sort="Tam, Pansy O S" uniqKey="Tam P" first="Pansy O. S." last="Tam">Pansy O. S. Tam</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chua, Elaine" sort="Chua, Elaine" uniqKey="Chua E" first="Elaine" last="Chua">Elaine Chua</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Ng, Xiao Yu" sort="Ng, Xiao Yu" uniqKey="Ng X" first="Xiao Yu" last="Ng">Xiao Yu Ng</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yong, Victor H K" sort="Yong, Victor H K" uniqKey="Yong V" first="Victor H. K." last="Yong">Victor H. K. Yong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Chong, Yaan Fun" sort="Chong, Yaan Fun" uniqKey="Chong Y" first="Yaan Fun" last="Chong">Yaan Fun Chong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seongsoo, Sohn" sort="Seongsoo, Sohn" uniqKey="Seongsoo S" first="Sohn" last="Seongsoo">Sohn Seongsoo</name><affiliation><nlm:aff id="af15"><addr-line>Department of Ophthalmology, Samsung Medical Center</addr-line>,<institution>Sungkyunkwan University, School of Medicine</institution>,<addr-line>Seoul</addr-line>,<country>Seoul Korea</country>,</nlm:aff><wicri:noCountry code="nlm country">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Wang" sort="Xu, Wang" uniqKey="Xu W" first="Wang" last="Xu">Wang Xu</name><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cooke Bailey, Jessica N" sort="Cooke Bailey, Jessica N" uniqKey="Cooke Bailey J" first="Jessica N." last="Cooke Bailey">Jessica N. Cooke Bailey</name><affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Case Western Reserve University</institution>,<addr-line>Cleveland, OH</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H." last="Kang">Jae H. Kang</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Channing Division of Network Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name><affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Biostatistics</addr-line>,<institution>Case Western Reserve University</institution>,<addr-line>Cleveland, OH</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Saw Swee Hock School of Public Health</addr-line>,<institution>National University of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Department of Medicine</addr-line>,<institution>National University Health System & National University of Singapore</institution>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E." last="Richards">Julia E. Richards</name><affiliation><nlm:aff id="af44"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Department of Epidemiology</addr-line>,<institution>University of Michigan</institution>,<addr-line>Ann Arbor, MI</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name><affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Einhorn Clinical Research Center, Department of Ophthalmology</addr-line>,<institution>New York Eye and Ear Infirmary</institution>,<addr-line>New York, NY</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaasterland, Douglas E" sort="Gaasterland, Douglas E" uniqKey="Gaasterland D" first="Douglas E." last="Gaasterland">Douglas E. Gaasterland</name><affiliation wicri:level="1"><nlm:aff id="af54"><institution>Eye Doctors of Washington DC</institution>,<addr-line>Washington, DC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R." last="Pasquale">Louis R. Pasquale</name><affiliation wicri:level="1"><nlm:aff id="af51"><addr-line>Channing Division of Network Medicine</addr-line>,<institution>Brigham and Women's Hospital</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af55"><addr-line>Department of Ophthalmology, Harvard Medical School</addr-line>,<institution>Massachusetts Eye and Ear Infirmary</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B." last="Jonas">Jost B. Jonas</name><affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Ophthalmology</addr-line>,<institution>Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg</institution>,<addr-line>Heidelberg</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Milea">Dan Milea</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="George, Ronnie" sort="George, Ronnie" uniqKey="George R" first="Ronnie" last="George">Ronnie George</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A." last="Al-Obeidan">Saleh A. Al-Obeidan</name><affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Department of Ophthalmology</addr-line>,<institution>College of Medicine</institution>,<institution>King Saud University</institution>,<addr-line>Riyadh</addr-line>,<country>Saudi Arabia</country>,</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Department of Genetics and Computational Biology, Statistical Genetics</addr-line>,<institution>QIMR Berghofer Medical Research Institute</institution>,<addr-line>Brisbane, QLD</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W." last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af56"><institution>Centre for Eye Research Australia (CERA)</institution>,<institution>University of Melbourne</institution>,<institution>Royal Victorian Eye and Ear Hospital</institution>,<addr-line>Melbourne, VIC</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Girkin, Christopher A" sort="Girkin, Christopher A" uniqKey="Girkin C" first="Christopher A." last="Girkin">Christopher A. Girkin</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Department of Ophthalmology</addr-line>,<institution>University of Alabama at Birmingham</institution>,<addr-line>Birmingham, AL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Mingzhi" sort="Zhang, Mingzhi" uniqKey="Zhang M" first="Mingzhi" last="Zhang">Mingzhi Zhang</name><affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>Chinese University of Hong Kong Joint Shantou International Eye Center</addr-line>,<institution>Shantou University</institution>,<addr-line>Shantou</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><affiliation wicri:level="1"><nlm:aff id="af22"><addr-line>Department of Genetics</addr-line>,<institution>Aravind Medical Research Foundation</institution>,<addr-line>Madurai, Tamilnadu</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vijaya, Lingam" sort="Vijaya, Lingam" uniqKey="Vijaya L" first="Lingam" last="Vijaya">Lingam Vijaya</name><affiliation wicri:level="1"><nlm:aff id="af42"><institution>Medical Research Foundation, Sankara Nethralaya</institution>,<addr-line>Chennai</addr-line>,<country>India</country>,</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A." last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:aff id="af23"><institution>Menzies Institute for Medical Research</institution>,<institution>University of Tasmania</institution>,<addr-line>Hobart</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af58"><addr-line>Centre for Ophthalmology and Visual Science</addr-line>,<institution>Lions Eye Institute, University of Western Australia</institution>,<addr-line>Perth, WA</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E." last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Department of Ophthalmology</addr-line>,<institution>Flinders University</institution>,<addr-line>Adelaide</addr-line>,<country>Australia</country>,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Xinghuai" sort="Sun, Xinghuai" uniqKey="Sun X" first="Xinghuai" last="Sun">Xinghuai Sun</name><affiliation><nlm:aff id="af9"><addr-line>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>State Key Laboratory of Medical Neurobiology, Institutes of Brain Science</addr-line>,<institution>Fudan University</institution>,<addr-line>Shanghai</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af59"><addr-line>Myopia Key Laboratory of the Ministry of Health of China, Shanghai</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name><affiliation><nlm:aff id="af6"><addr-line>Department of Ophthalmology</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L." last="Wiggs">Janey L. Wiggs</name><affiliation wicri:level="1"><nlm:aff id="af57"><addr-line>Department of Ophthalmology</addr-line>,<institution>University of Alabama at Birmingham</institution>,<addr-line>Birmingham, AL</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Division of Human Genetics</addr-line>,<institution>Genome Institute of Singapore</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Sichuan Provincial Key Laboratory for Human Disease Gene Study</addr-line>,<institution>Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af27"><addr-line>School of Medicine</addr-line>,<institution>University of Electronic Science and Technology of China</institution>,<addr-line>Chengdu</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Chinese Academy of Sciences</addr-line>,<institution>Sichuan Translational Medicine Hospital</institution>,<addr-line>Chengdu</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pang, Chi Pui" sort="Pang, Chi Pui" uniqKey="Pang C" first="Chi Pui" last="Pang">Chi Pui Pang</name><affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Department of Ophthalmology and Visual Sciences</addr-line>,<institution>The Chinese Uuniversity of Hong Kong Eye Hospital</institution>,<addr-line>Hong Kong</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name><affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital</addr-line>,<institution>Capital Medical University</institution>,<addr-line>Beijing</addr-line>,<country>China</country>,</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A." last="Hauser">Michael A. Hauser</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Ophthalmology</addr-line>,<institution>Duke University Eye Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af40"><addr-line>Department of Medicine</addr-line>,<institution>Duke University Medical Center</institution>,<addr-line>Durham, NC</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name><affiliation><nlm:aff id="af5"><addr-line>Department of Genomic Medical Sciences</addr-line>,</nlm:aff></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Singapore National Eye Center</addr-line>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N." last="Vithana">Eranga N. Vithana</name><affiliation><nlm:aff id="af1"><addr-line>Singapore Eye Research Institute</addr-line>,</nlm:aff></affiliation><affiliation><nlm:aff id="af11"><addr-line>Department of Ophthalmology, Yong Loo Lin School of Medicine</addr-line>,</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af13"><institution>Duke-NUS Graduate Medical School</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country>,</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at <italic>CDKN2B-AS1</italic> (rs2157719 [G], odds ratio [OR] = 0.71, <italic>P</italic> = 2.81 × 10<sup>−33</sup>), we observed one SNP showing significant association to POAG (<italic>CDC7</italic>–<italic>TGFBR3</italic> rs1192415, OR<sub>G-allele</sub> = 1.13, <italic>P</italic><sub>meta</sub> = 1.60 × 10<sup>−8</sup>). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. 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Garway-Heath</name><affiliation wicri:level="3"><nlm:affiliation>National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sripriya, Sarangapani" sort="Sripriya, Sarangapani" uniqKey="Sripriya S" first="Sarangapani" last="Sripriya">Sarangapani Sripriya</name><affiliation wicri:level="1"><nlm:affiliation>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai</wicri:regionArea><wicri:noRegion>Chennai</wicri:noRegion></affiliation></author><author><name sortKey="Fuse, Nobuo" sort="Fuse, Nobuo" uniqKey="Fuse N" first="Nobuo" last="Fuse">Nobuo Fuse</name><affiliation wicri:level="1"><nlm:affiliation>Department of Integrative Genomics, Tohoku Medical Megabank Organization, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Integrative Genomics, Tohoku Medical Megabank Organization, Sendai</wicri:regionArea><wicri:noRegion>Sendai</wicri:noRegion></affiliation></author><author><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K" last="Abu-Amero">Khaled K. Abu-Amero</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Huang, Chukai" sort="Huang, Chukai" uniqKey="Huang C" first="Chukai" last="Huang">Chukai Huang</name><affiliation wicri:level="1"><nlm:affiliation>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou</wicri:regionArea><wicri:noRegion>Shantou</wicri:noRegion></affiliation></author><author><name sortKey="Namburi, Prasanthi" sort="Namburi, Prasanthi" uniqKey="Namburi P" first="Prasanthi" last="Namburi">Prasanthi Namburi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu</wicri:regionArea><wicri:noRegion>Tamilnadu</wicri:noRegion></affiliation></author><author><name sortKey="Burdon, Kathryn" sort="Burdon, Kathryn" uniqKey="Burdon K" first="Kathryn" last="Burdon">Kathryn Burdon</name><affiliation wicri:level="1"><nlm:affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A" last="Perera">Shamira A. Perera</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Gharahkhani, Puya" sort="Gharahkhani, Puya" uniqKey="Gharahkhani P" first="Puya" last="Gharahkhani">Puya Gharahkhani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><affiliation wicri:level="1"><nlm:affiliation>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Ophthalmology.</wicri:noCountry></affiliation></author><author><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name><affiliation wicri:level="1"><nlm:affiliation>Ozaki Eye Hospital, 1-15, Kamezaki, Hyuga, Miyazaki 883-0066, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Ozaki Eye Hospital, 1-15, Kamezaki, Hyuga, Miyazaki 883-0066</wicri:regionArea><wicri:noRegion>Miyazaki 883-0066</wicri:noRegion></affiliation></author><author><name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name><affiliation wicri:level="1"><nlm:affiliation>Mizoguchi Eye Hospital, 6-13 Tawara-machi, Sasebo, Nagasaki 857-0016, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Mizoguchi Eye Hospital, 6-13 Tawara-machi, Sasebo, Nagasaki 857-0016</wicri:regionArea><wicri:noRegion>Nagasaki 857-0016</wicri:noRegion></affiliation></author><author><name sortKey="Krishnadas, Subbiah Ramasamy" sort="Krishnadas, Subbiah Ramasamy" uniqKey="Krishnadas S" first="Subbiah Ramasamy" last="Krishnadas">Subbiah Ramasamy Krishnadas</name><affiliation wicri:level="1"><nlm:affiliation>Glaucoma Services, Aravind Eye Hospital, Madurai, Tamilnadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Glaucoma Services, Aravind Eye Hospital, Madurai, Tamilnadu</wicri:regionArea><wicri:noRegion>Tamilnadu</wicri:noRegion></affiliation></author><author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A" last="Osman">Essam A. Osman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S Y" last="Chan">Anita S Y. Chan</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Tajudin, Liza Sharmini A" sort="Tajudin, Liza Sharmini A" uniqKey="Tajudin L" first="Liza-Sharmini A" last="Tajudin">Liza-Sharmini A. Tajudin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan</wicri:regionArea><wicri:noRegion>Kelantan</wicri:noRegion></affiliation></author><author><name sortKey="Do, Tan" sort="Do, Tan" uniqKey="Do T" first="Tan" last="Do">Tan Do</name><affiliation wicri:level="1"><nlm:affiliation>Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Vietnam National Institute of Ophthalmology, Hanoi</wicri:regionArea><wicri:noRegion>Hanoi</wicri:noRegion></affiliation></author><author><name sortKey="Goncalves, Aurelien" sort="Goncalves, Aurelien" uniqKey="Goncalves A" first="Aurelien" last="Goncalves">Aurelien Goncalves</name><affiliation><nlm:affiliation>Ophthalmology Department.</nlm:affiliation><wicri:noCountry code="no comma">Ophthalmology Department.</wicri:noCountry></affiliation></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name><affiliation wicri:level="3"><nlm:affiliation>Biochemistry Department, Angers University Hospital, Angers, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biochemistry Department, Angers University Hospital, Angers</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Angers</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Ophthalmology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan</wicri:regionArea><wicri:noRegion>Wuhan</wicri:noRegion></affiliation></author><author><name sortKey="Bourne, Rupert" sort="Bourne, Rupert" uniqKey="Bourne R" first="Rupert" last="Bourne">Rupert Bourne</name><affiliation wicri:level="1"><nlm:affiliation>Huntingdon Glaucoma Diagnostic & Research Centre, Hinchingbrooke Hospital, Huntingdon, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Huntingdon Glaucoma Diagnostic & Research Centre, Hinchingbrooke Hospital, Huntingdon</wicri:regionArea><wicri:noRegion>Huntingdon</wicri:noRegion></affiliation></author><author><name sortKey="Goh, David" sort="Goh, David" uniqKey="Goh D" first="David" last="Goh">David Goh</name><affiliation wicri:level="1"><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Broadway, David" sort="Broadway, David" uniqKey="Broadway D" first="David" last="Broadway">David Broadway</name><affiliation wicri:level="1"><nlm:affiliation>Norfolk & Norwich University Hospital NHS Trust, Norwich, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Norfolk & Norwich University Hospital NHS Trust, Norwich</wicri:regionArea><wicri:noRegion>Norwich</wicri:noRegion></affiliation></author><author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name><affiliation wicri:level="1"><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Negi, Anil K" sort="Negi, Anil K" uniqKey="Negi A" first="Anil K" last="Negi">Anil K. Negi</name><affiliation wicri:level="3"><nlm:affiliation>Heart of UK NHS Foundation Trust, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Heart of UK NHS Foundation Trust, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Su, Daniel H" sort="Su, Daniel H" uniqKey="Su D" first="Daniel H" last="Su">Daniel H. Su</name><affiliation wicri:level="1"><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Ho, Ching Lin" sort="Ho, Ching Lin" uniqKey="Ho C" first="Ching-Lin" last="Ho">Ching-Lin Ho</name><affiliation wicri:level="1"><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Blanco, Augusto Azuara" sort="Blanco, Augusto Azuara" uniqKey="Blanco A" first="Augusto Azuara" last="Blanco">Augusto Azuara Blanco</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, Queen's University Belfast, Northern Ireland, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, Queen's University Belfast, Northern Ireland</wicri:regionArea><wicri:noRegion>Northern Ireland</wicri:noRegion></affiliation></author><author><name sortKey="Leung, Christopher K S" sort="Leung, Christopher K S" uniqKey="Leung C" first="Christopher K S" last="Leung">Christopher K S. Leung</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Tina T" sort="Wong, Tina T" uniqKey="Wong T" first="Tina T" last="Wong">Tina T. Wong</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Yakub, Azhany" sort="Yakub, Azhany" uniqKey="Yakub A" first="Azhany" last="Yakub">Azhany Yakub</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan</wicri:regionArea><wicri:noRegion>Kelantan</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Duke University Medical Center, Durham, NC, USA, Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Department of Medicine, Duke University Medical Center, Durham, NC, USA, Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta</wicri:regionArea><wicri:noRegion>Augusta</wicri:noRegion></affiliation></author><author><name sortKey="Nongpiur, Monisha E" sort="Nongpiur, Monisha E" uniqKey="Nongpiur M" first="Monisha E" last="Nongpiur">Monisha E. Nongpiur</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Han, Jong Chul" sort="Han, Jong Chul" uniqKey="Han J" first="Jong Chul" last="Han">Jong Chul Han</name><affiliation><nlm:affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</nlm:affiliation><wicri:noCountry code="subField">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Hon, Do Nhu" sort="Hon, Do Nhu" uniqKey="Hon D" first="Do Nhu" last="Hon">Do Nhu Hon</name><affiliation wicri:level="1"><nlm:affiliation>Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Vietnam National Institute of Ophthalmology, Hanoi</wicri:regionArea><wicri:noRegion>Hanoi</wicri:noRegion></affiliation></author><author><name sortKey="Shantha, Balekudaru" sort="Shantha, Balekudaru" uniqKey="Shantha B" first="Balekudaru" last="Shantha">Balekudaru Shantha</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Medical Research Foundation, Sankara Nethralaya, Chennai</wicri:regionArea><wicri:noRegion>Chennai</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Sato, Ryuichi" sort="Sato, Ryuichi" uniqKey="Sato R" first="Ryuichi" last="Sato">Ryuichi Sato</name><affiliation><nlm:affiliation>Department of Genomic Medical Sciences.</nlm:affiliation><wicri:noCountry code="no comma">Department of Genomic Medical Sciences.</wicri:noCountry></affiliation></author><author><name sortKey="Yoshii, Kengo" sort="Yoshii, Kengo" uniqKey="Yoshii K" first="Kengo" last="Yoshii">Kengo Yoshii</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Statistics, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medical Statistics, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Panda Jonas, Songhomita" sort="Panda Jonas, Songhomita" uniqKey="Panda Jonas S" first="Songhomita" last="Panda-Jonas">Songhomita Panda-Jonas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E" last="Ashley Koch">Allison E. Ashley Koch</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Duke University Medical Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Herndon, Leon W" sort="Herndon, Leon W" uniqKey="Herndon L" first="Leon W" last="Herndon">Leon W. Herndon</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Eye Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E" last="Moroi">Sayoko E. Moroi</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences.</nlm:affiliation><wicri:noCountry code="no comma">Department of Ophthalmology and Visual Sciences.</wicri:noCountry></affiliation></author><author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Eye Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Human Genetics, Genome Institute of Singapore, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Bei, Jin Xin" sort="Bei, Jin Xin" uniqKey="Bei J" first="Jin-Xin" last="Bei">Jin-Xin Bei</name><affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zeng, Yi Xin" sort="Zeng, Yi Xin" uniqKey="Zeng Y" first="Yi-Xin" last="Zeng">Yi-Xin Zeng</name><affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P" last="Simmons">Cameron P. Simmons</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7LJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7LJ</wicri:regionArea><wicri:noRegion>Oxford OX3 7LJ</wicri:noRegion></affiliation></author><author><name sortKey="Bich Chau, Tran Nguyen" sort="Bich Chau, Tran Nguyen" uniqKey="Bich Chau T" first="Tran Nguyen" last="Bich Chau">Tran Nguyen Bich Chau</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Sharmila, Philomenadin Ferdinamarie" sort="Sharmila, Philomenadin Ferdinamarie" uniqKey="Sharmila P" first="Philomenadin Ferdinamarie" last="Sharmila">Philomenadin Ferdinamarie Sharmila</name><affiliation wicri:level="1"><nlm:affiliation>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai</wicri:regionArea><wicri:noRegion>Chennai</wicri:noRegion></affiliation></author><author><name sortKey="Chew, Merwyn" sort="Chew, Merwyn" uniqKey="Chew M" first="Merwyn" last="Chew">Merwyn Chew</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Lim, Blanche" sort="Lim, Blanche" uniqKey="Lim B" first="Blanche" last="Lim">Blanche Lim</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Tam, Pansy O S" sort="Tam, Pansy O S" uniqKey="Tam P" first="Pansy O S" last="Tam">Pansy O S. Tam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Chua, Elaine" sort="Chua, Elaine" uniqKey="Chua E" first="Elaine" last="Chua">Elaine Chua</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Ng, Xiao Yu" sort="Ng, Xiao Yu" uniqKey="Ng X" first="Xiao Yu" last="Ng">Xiao Yu Ng</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Yong, Victor H K" sort="Yong, Victor H K" uniqKey="Yong V" first="Victor H K" last="Yong">Victor H K. Yong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Chong, Yaan Fun" sort="Chong, Yaan Fun" uniqKey="Chong Y" first="Yaan Fun" last="Chong">Yaan Fun Chong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Human Genetics, Genome Institute of Singapore, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu</wicri:regionArea><wicri:noRegion>Tamilnadu</wicri:noRegion></affiliation></author><author><name sortKey="Seongsoo, Sohn" sort="Seongsoo, Sohn" uniqKey="Seongsoo S" first="Sohn" last="Seongsoo">Sohn Seongsoo</name><affiliation><nlm:affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</nlm:affiliation><wicri:noCountry code="subField">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Wang" sort="Xu, Wang" uniqKey="Xu W" first="Wang" last="Xu">Wang Xu</name><affiliation wicri:level="4"><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore, Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><affiliation wicri:level="4"><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Cooke Bailey, Jessica N" sort="Cooke Bailey, Jessica N" uniqKey="Cooke Bailey J" first="Jessica N" last="Cooke Bailey">Jessica N. Cooke Bailey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H" last="Kang">Jae H. Kang</name><affiliation wicri:level="2"><nlm:affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation wicri:level="4"><nlm:affiliation>Singapore Eye Research Institute, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Saw Swee Hock School of Public Health, National University of Singapore, Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, National University Health System & National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medicine, National University Health System & National University of Singapore</wicri:regionArea><wicri:noRegion>National University Health System & National University of Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E" last="Richards">Julia E. Richards</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Department of Epidemiology, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name><affiliation wicri:level="2"><nlm:affiliation>Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Gaasterland, Douglas E" sort="Gaasterland, Douglas E" uniqKey="Gaasterland D" first="Douglas E" last="Gaasterland">Douglas E. Gaasterland</name><affiliation wicri:level="2"><nlm:affiliation>Eye Doctors of Washington DC, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eye Doctors of Washington DC, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R" last="Pasquale">Louis R. Pasquale</name><affiliation wicri:level="2"><nlm:affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Human Genetics, Genome Institute of Singapore, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B" last="Jonas">Jost B. Jonas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Milea">Dan Milea</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="George, Ronnie" sort="George, Ronnie" uniqKey="George R" first="Ronnie" last="George">Ronnie George</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Medical Research Foundation, Sankara Nethralaya, Chennai</wicri:regionArea><wicri:noRegion>Chennai</wicri:noRegion></affiliation></author><author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A" last="Al-Obeidan">Saleh A. Al-Obeidan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Ophthalmology.</wicri:noCountry></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="1"><nlm:affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Girkin, Christopher A" sort="Girkin, Christopher A" uniqKey="Girkin C" first="Christopher A" last="Girkin">Christopher A. Girkin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Zhang, Mingzhi" sort="Zhang, Mingzhi" uniqKey="Zhang M" first="Mingzhi" last="Zhang">Mingzhi Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou</wicri:regionArea><wicri:noRegion>Shantou</wicri:noRegion></affiliation></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu</wicri:regionArea><wicri:noRegion>Tamilnadu</wicri:noRegion></affiliation></author><author><name sortKey="Vijaya, Lingam" sort="Vijaya, Lingam" uniqKey="Vijaya L" first="Lingam" last="Vijaya">Lingam Vijaya</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Medical Research Foundation, Sankara Nethralaya, Chennai</wicri:regionArea><wicri:noRegion>Chennai</wicri:noRegion></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine.</nlm:affiliation><wicri:noCountry code="subField">Yong Loo Lin School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Xinghuai" sort="Sun, Xinghuai" uniqKey="Sun X" first="Xinghuai" last="Sun">Xinghuai Sun</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China, Myopia Key Laboratory of the Ministry of Health of China, Shanghai, China and.</nlm:affiliation><wicri:noCountry code="subField">China and</wicri:noCountry></affiliation></author><author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Ophthalmology.</wicri:noCountry></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L" last="Wiggs">Janey L. Wiggs</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, eranga.n.v@sericom.sg khorcc@gis.a-star.edu.sg.</nlm:affiliation><country wicri:rule="url">Singapour</country><wicri:regionArea>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine</wicri:regionArea><wicri:noRegion>Yong Loo Lin School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation wicri:level="1"><nlm:affiliation>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Chinese Academy of Sciences, Sichuan Translational Medicine Hospital, Chengdu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Chinese Academy of Sciences, Sichuan Translational Medicine Hospital, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Pang, Chi Pui" sort="Pang, Chi Pui" uniqKey="Pang C" first="Chi Pui" last="Pang">Chi Pui Pang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA, Department of Medicine, Duke University Medical Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA, Department of Medicine, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name><affiliation><nlm:affiliation>Department of Genomic Medical Sciences.</nlm:affiliation><wicri:noCountry code="no comma">Department of Genomic Medical Sciences.</wicri:noCountry></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N" last="Vithana">Eranga N. Vithana</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, eranga.n.v@sericom.sg khorcc@gis.a-star.edu.sg.</nlm:affiliation><country wicri:rule="url">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25861811</idno><idno type="pmid">25861811</idno><idno type="doi">10.1093/hmg/ddv128</idno><idno type="wicri:Area/PubMed/Corpus">002B73</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B73</idno><idno type="wicri:Area/PubMed/Curation">002B01</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002B01</idno><idno type="wicri:Area/PubMed/Checkpoint">002B01</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002B01</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A common variant near TGFBR3 is associated with primary open angle glaucoma.</title><author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Division of Human Genetics, Genome Institute of Singapore, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Eye Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name><affiliation><nlm:affiliation>Department of Genomic Medical Sciences.</nlm:affiliation><wicri:noCountry code="no comma">Department of Genomic Medical Sciences.</wicri:noCountry></affiliation></author><author><name sortKey="Jia, Liyun" sort="Jia, Liyun" uniqKey="Jia L" first="Liyun" last="Jia">Liyun Jia</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chen, Yuhong" sort="Chen, Yuhong" uniqKey="Chen Y" first="Yuhong" last="Chen">Yuhong Chen</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School.</nlm:affiliation><wicri:noCountry code="subField">Shanghai Medical School</wicri:noCountry></affiliation></author><author><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Ophthalmology.</wicri:noCountry></affiliation></author><author><name sortKey="Mani, Baskaran" sort="Mani, Baskaran" uniqKey="Mani B" first="Baskaran" last="Mani">Baskaran Mani</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Li Jia" sort="Chen, Li Jia" uniqKey="Chen L" first="Li-Jia" last="Chen">Li-Jia Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Kee, Changwon" sort="Kee, Changwon" uniqKey="Kee C" first="Changwon" last="Kee">Changwon Kee</name><affiliation><nlm:affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</nlm:affiliation><wicri:noCountry code="subField">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Garway Heath, David F" sort="Garway Heath, David F" uniqKey="Garway Heath D" first="David F" last="Garway-Heath">David F. Garway-Heath</name><affiliation wicri:level="3"><nlm:affiliation>National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sripriya, Sarangapani" sort="Sripriya, Sarangapani" uniqKey="Sripriya S" first="Sarangapani" last="Sripriya">Sarangapani Sripriya</name><affiliation wicri:level="1"><nlm:affiliation>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai</wicri:regionArea><wicri:noRegion>Chennai</wicri:noRegion></affiliation></author><author><name sortKey="Fuse, Nobuo" sort="Fuse, Nobuo" uniqKey="Fuse N" first="Nobuo" last="Fuse">Nobuo Fuse</name><affiliation wicri:level="1"><nlm:affiliation>Department of Integrative Genomics, Tohoku Medical Megabank Organization, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Integrative Genomics, Tohoku Medical Megabank Organization, Sendai</wicri:regionArea><wicri:noRegion>Sendai</wicri:noRegion></affiliation></author><author><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K" last="Abu-Amero">Khaled K. Abu-Amero</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Huang, Chukai" sort="Huang, Chukai" uniqKey="Huang C" first="Chukai" last="Huang">Chukai Huang</name><affiliation wicri:level="1"><nlm:affiliation>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou</wicri:regionArea><wicri:noRegion>Shantou</wicri:noRegion></affiliation></author><author><name sortKey="Namburi, Prasanthi" sort="Namburi, Prasanthi" uniqKey="Namburi P" first="Prasanthi" last="Namburi">Prasanthi Namburi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu</wicri:regionArea><wicri:noRegion>Tamilnadu</wicri:noRegion></affiliation></author><author><name sortKey="Burdon, Kathryn" sort="Burdon, Kathryn" uniqKey="Burdon K" first="Kathryn" last="Burdon">Kathryn Burdon</name><affiliation wicri:level="1"><nlm:affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A" last="Perera">Shamira A. Perera</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Gharahkhani, Puya" sort="Gharahkhani, Puya" uniqKey="Gharahkhani P" first="Puya" last="Gharahkhani">Puya Gharahkhani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><affiliation wicri:level="1"><nlm:affiliation>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Ophthalmology.</wicri:noCountry></affiliation></author><author><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name><affiliation wicri:level="1"><nlm:affiliation>Ozaki Eye Hospital, 1-15, Kamezaki, Hyuga, Miyazaki 883-0066, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Ozaki Eye Hospital, 1-15, Kamezaki, Hyuga, Miyazaki 883-0066</wicri:regionArea><wicri:noRegion>Miyazaki 883-0066</wicri:noRegion></affiliation></author><author><name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name><affiliation wicri:level="1"><nlm:affiliation>Mizoguchi Eye Hospital, 6-13 Tawara-machi, Sasebo, Nagasaki 857-0016, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Mizoguchi Eye Hospital, 6-13 Tawara-machi, Sasebo, Nagasaki 857-0016</wicri:regionArea><wicri:noRegion>Nagasaki 857-0016</wicri:noRegion></affiliation></author><author><name sortKey="Krishnadas, Subbiah Ramasamy" sort="Krishnadas, Subbiah Ramasamy" uniqKey="Krishnadas S" first="Subbiah Ramasamy" last="Krishnadas">Subbiah Ramasamy Krishnadas</name><affiliation wicri:level="1"><nlm:affiliation>Glaucoma Services, Aravind Eye Hospital, Madurai, Tamilnadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Glaucoma Services, Aravind Eye Hospital, Madurai, Tamilnadu</wicri:regionArea><wicri:noRegion>Tamilnadu</wicri:noRegion></affiliation></author><author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A" last="Osman">Essam A. Osman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S Y" last="Chan">Anita S Y. Chan</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Tajudin, Liza Sharmini A" sort="Tajudin, Liza Sharmini A" uniqKey="Tajudin L" first="Liza-Sharmini A" last="Tajudin">Liza-Sharmini A. Tajudin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan</wicri:regionArea><wicri:noRegion>Kelantan</wicri:noRegion></affiliation></author><author><name sortKey="Do, Tan" sort="Do, Tan" uniqKey="Do T" first="Tan" last="Do">Tan Do</name><affiliation wicri:level="1"><nlm:affiliation>Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Vietnam National Institute of Ophthalmology, Hanoi</wicri:regionArea><wicri:noRegion>Hanoi</wicri:noRegion></affiliation></author><author><name sortKey="Goncalves, Aurelien" sort="Goncalves, Aurelien" uniqKey="Goncalves A" first="Aurelien" last="Goncalves">Aurelien Goncalves</name><affiliation><nlm:affiliation>Ophthalmology Department.</nlm:affiliation><wicri:noCountry code="no comma">Ophthalmology Department.</wicri:noCountry></affiliation></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name><affiliation wicri:level="3"><nlm:affiliation>Biochemistry Department, Angers University Hospital, Angers, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Biochemistry Department, Angers University Hospital, Angers</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Angers</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Ophthalmology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan</wicri:regionArea><wicri:noRegion>Wuhan</wicri:noRegion></affiliation></author><author><name sortKey="Bourne, Rupert" sort="Bourne, Rupert" uniqKey="Bourne R" first="Rupert" last="Bourne">Rupert Bourne</name><affiliation wicri:level="1"><nlm:affiliation>Huntingdon Glaucoma Diagnostic & Research Centre, Hinchingbrooke Hospital, Huntingdon, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Huntingdon Glaucoma Diagnostic & Research Centre, Hinchingbrooke Hospital, Huntingdon</wicri:regionArea><wicri:noRegion>Huntingdon</wicri:noRegion></affiliation></author><author><name sortKey="Goh, David" sort="Goh, David" uniqKey="Goh D" first="David" last="Goh">David Goh</name><affiliation wicri:level="1"><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Broadway, David" sort="Broadway, David" uniqKey="Broadway D" first="David" last="Broadway">David Broadway</name><affiliation wicri:level="1"><nlm:affiliation>Norfolk & Norwich University Hospital NHS Trust, Norwich, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Norfolk & Norwich University Hospital NHS Trust, Norwich</wicri:regionArea><wicri:noRegion>Norwich</wicri:noRegion></affiliation></author><author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name><affiliation wicri:level="1"><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Negi, Anil K" sort="Negi, Anil K" uniqKey="Negi A" first="Anil K" last="Negi">Anil K. Negi</name><affiliation wicri:level="3"><nlm:affiliation>Heart of UK NHS Foundation Trust, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Heart of UK NHS Foundation Trust, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Su, Daniel H" sort="Su, Daniel H" uniqKey="Su D" first="Daniel H" last="Su">Daniel H. Su</name><affiliation wicri:level="1"><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Ho, Ching Lin" sort="Ho, Ching Lin" uniqKey="Ho C" first="Ching-Lin" last="Ho">Ching-Lin Ho</name><affiliation wicri:level="1"><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Blanco, Augusto Azuara" sort="Blanco, Augusto Azuara" uniqKey="Blanco A" first="Augusto Azuara" last="Blanco">Augusto Azuara Blanco</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, Queen's University Belfast, Northern Ireland, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, Queen's University Belfast, Northern Ireland</wicri:regionArea><wicri:noRegion>Northern Ireland</wicri:noRegion></affiliation></author><author><name sortKey="Leung, Christopher K S" sort="Leung, Christopher K S" uniqKey="Leung C" first="Christopher K S" last="Leung">Christopher K S. Leung</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Tina T" sort="Wong, Tina T" uniqKey="Wong T" first="Tina T" last="Wong">Tina T. Wong</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Yakub, Azhany" sort="Yakub, Azhany" uniqKey="Yakub A" first="Azhany" last="Yakub">Azhany Yakub</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan</wicri:regionArea><wicri:noRegion>Kelantan</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Duke University Medical Center, Durham, NC, USA, Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Department of Medicine, Duke University Medical Center, Durham, NC, USA, Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta</wicri:regionArea><wicri:noRegion>Augusta</wicri:noRegion></affiliation></author><author><name sortKey="Nongpiur, Monisha E" sort="Nongpiur, Monisha E" uniqKey="Nongpiur M" first="Monisha E" last="Nongpiur">Monisha E. Nongpiur</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Han, Jong Chul" sort="Han, Jong Chul" uniqKey="Han J" first="Jong Chul" last="Han">Jong Chul Han</name><affiliation><nlm:affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</nlm:affiliation><wicri:noCountry code="subField">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Hon, Do Nhu" sort="Hon, Do Nhu" uniqKey="Hon D" first="Do Nhu" last="Hon">Do Nhu Hon</name><affiliation wicri:level="1"><nlm:affiliation>Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Vietnam National Institute of Ophthalmology, Hanoi</wicri:regionArea><wicri:noRegion>Hanoi</wicri:noRegion></affiliation></author><author><name sortKey="Shantha, Balekudaru" sort="Shantha, Balekudaru" uniqKey="Shantha B" first="Balekudaru" last="Shantha">Balekudaru Shantha</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Medical Research Foundation, Sankara Nethralaya, Chennai</wicri:regionArea><wicri:noRegion>Chennai</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Sato, Ryuichi" sort="Sato, Ryuichi" uniqKey="Sato R" first="Ryuichi" last="Sato">Ryuichi Sato</name><affiliation><nlm:affiliation>Department of Genomic Medical Sciences.</nlm:affiliation><wicri:noCountry code="no comma">Department of Genomic Medical Sciences.</wicri:noCountry></affiliation></author><author><name sortKey="Yoshii, Kengo" sort="Yoshii, Kengo" uniqKey="Yoshii K" first="Kengo" last="Yoshii">Kengo Yoshii</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Statistics, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medical Statistics, Kyoto Prefectural University of Medicine, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Panda Jonas, Songhomita" sort="Panda Jonas, Songhomita" uniqKey="Panda Jonas S" first="Songhomita" last="Panda-Jonas">Songhomita Panda-Jonas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E" last="Ashley Koch">Allison E. Ashley Koch</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Duke University Medical Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Herndon, Leon W" sort="Herndon, Leon W" uniqKey="Herndon L" first="Leon W" last="Herndon">Leon W. Herndon</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Eye Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E" last="Moroi">Sayoko E. Moroi</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences.</nlm:affiliation><wicri:noCountry code="no comma">Department of Ophthalmology and Visual Sciences.</wicri:noCountry></affiliation></author><author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Eye Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Human Genetics, Genome Institute of Singapore, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Bei, Jin Xin" sort="Bei, Jin Xin" uniqKey="Bei J" first="Jin-Xin" last="Bei">Jin-Xin Bei</name><affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zeng, Yi Xin" sort="Zeng, Yi Xin" uniqKey="Zeng Y" first="Yi-Xin" last="Zeng">Yi-Xin Zeng</name><affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P" last="Simmons">Cameron P. Simmons</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7LJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7LJ</wicri:regionArea><wicri:noRegion>Oxford OX3 7LJ</wicri:noRegion></affiliation></author><author><name sortKey="Bich Chau, Tran Nguyen" sort="Bich Chau, Tran Nguyen" uniqKey="Bich Chau T" first="Tran Nguyen" last="Bich Chau">Tran Nguyen Bich Chau</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Sharmila, Philomenadin Ferdinamarie" sort="Sharmila, Philomenadin Ferdinamarie" uniqKey="Sharmila P" first="Philomenadin Ferdinamarie" last="Sharmila">Philomenadin Ferdinamarie Sharmila</name><affiliation wicri:level="1"><nlm:affiliation>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai</wicri:regionArea><wicri:noRegion>Chennai</wicri:noRegion></affiliation></author><author><name sortKey="Chew, Merwyn" sort="Chew, Merwyn" uniqKey="Chew M" first="Merwyn" last="Chew">Merwyn Chew</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Lim, Blanche" sort="Lim, Blanche" uniqKey="Lim B" first="Blanche" last="Lim">Blanche Lim</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Tam, Pansy O S" sort="Tam, Pansy O S" uniqKey="Tam P" first="Pansy O S" last="Tam">Pansy O S. Tam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Chua, Elaine" sort="Chua, Elaine" uniqKey="Chua E" first="Elaine" last="Chua">Elaine Chua</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Ng, Xiao Yu" sort="Ng, Xiao Yu" uniqKey="Ng X" first="Xiao Yu" last="Ng">Xiao Yu Ng</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Yong, Victor H K" sort="Yong, Victor H K" uniqKey="Yong V" first="Victor H K" last="Yong">Victor H K. Yong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Chong, Yaan Fun" sort="Chong, Yaan Fun" uniqKey="Chong Y" first="Yaan Fun" last="Chong">Yaan Fun Chong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation><wicri:noCountry code="no comma">Singapore Eye Research Institute.</wicri:noCountry></affiliation></author><author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Human Genetics, Genome Institute of Singapore, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu</wicri:regionArea><wicri:noRegion>Tamilnadu</wicri:noRegion></affiliation></author><author><name sortKey="Seongsoo, Sohn" sort="Seongsoo, Sohn" uniqKey="Seongsoo S" first="Sohn" last="Seongsoo">Sohn Seongsoo</name><affiliation><nlm:affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</nlm:affiliation><wicri:noCountry code="subField">Seoul Korea</wicri:noCountry></affiliation></author><author><name sortKey="Xu, Wang" sort="Xu, Wang" uniqKey="Xu W" first="Wang" last="Xu">Wang Xu</name><affiliation wicri:level="4"><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore, Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><affiliation wicri:level="4"><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Cooke Bailey, Jessica N" sort="Cooke Bailey, Jessica N" uniqKey="Cooke Bailey J" first="Jessica N" last="Cooke Bailey">Jessica N. Cooke Bailey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H" last="Kang">Jae H. Kang</name><affiliation wicri:level="2"><nlm:affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation wicri:level="4"><nlm:affiliation>Singapore Eye Research Institute, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Saw Swee Hock School of Public Health, National University of Singapore, Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, National University Health System & National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Medicine, National University Health System & National University of Singapore</wicri:regionArea><wicri:noRegion>National University Health System & National University of Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E" last="Richards">Julia E. Richards</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, Department of Epidemiology, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name><affiliation wicri:level="2"><nlm:affiliation>Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Gaasterland, Douglas E" sort="Gaasterland, Douglas E" uniqKey="Gaasterland D" first="Douglas E" last="Gaasterland">Douglas E. Gaasterland</name><affiliation wicri:level="2"><nlm:affiliation>Eye Doctors of Washington DC, Washington, DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eye Doctors of Washington DC, Washington, DC</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R" last="Pasquale">Louis R. Pasquale</name><affiliation wicri:level="2"><nlm:affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of Human Genetics, Genome Institute of Singapore, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B" last="Jonas">Jost B. Jonas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Milea">Dan Milea</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="George, Ronnie" sort="George, Ronnie" uniqKey="George R" first="Ronnie" last="George">Ronnie George</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Medical Research Foundation, Sankara Nethralaya, Chennai</wicri:regionArea><wicri:noRegion>Chennai</wicri:noRegion></affiliation></author><author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A" last="Al-Obeidan">Saleh A. Al-Obeidan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Ophthalmology.</wicri:noCountry></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name><affiliation wicri:level="1"><nlm:affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Girkin, Christopher A" sort="Girkin, Christopher A" uniqKey="Girkin C" first="Christopher A" last="Girkin">Christopher A. Girkin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Zhang, Mingzhi" sort="Zhang, Mingzhi" uniqKey="Zhang M" first="Mingzhi" last="Zhang">Mingzhi Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou</wicri:regionArea><wicri:noRegion>Shantou</wicri:noRegion></affiliation></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu</wicri:regionArea><wicri:noRegion>Tamilnadu</wicri:noRegion></affiliation></author><author><name sortKey="Vijaya, Lingam" sort="Vijaya, Lingam" uniqKey="Vijaya L" first="Lingam" last="Vijaya">Lingam Vijaya</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Medical Research Foundation, Sankara Nethralaya, Chennai</wicri:regionArea><wicri:noRegion>Chennai</wicri:noRegion></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name><affiliation wicri:level="1"><nlm:affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine.</nlm:affiliation><wicri:noCountry code="subField">Yong Loo Lin School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Ophthalmology, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Xinghuai" sort="Sun, Xinghuai" uniqKey="Sun X" first="Xinghuai" last="Sun">Xinghuai Sun</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China, Myopia Key Laboratory of the Ministry of Health of China, Shanghai, China and.</nlm:affiliation><wicri:noCountry code="subField">China and</wicri:noCountry></affiliation></author><author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Ophthalmology.</wicri:noCountry></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L" last="Wiggs">Janey L. Wiggs</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation wicri:level="1"><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, eranga.n.v@sericom.sg khorcc@gis.a-star.edu.sg.</nlm:affiliation><country wicri:rule="url">Singapour</country><wicri:regionArea>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine</wicri:regionArea><wicri:noRegion>Yong Loo Lin School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation wicri:level="1"><nlm:affiliation>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Chinese Academy of Sciences, Sichuan Translational Medicine Hospital, Chengdu, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Chinese Academy of Sciences, Sichuan Translational Medicine Hospital, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Pang, Chi Pui" sort="Pang, Chi Pui" uniqKey="Pang C" first="Chi Pui" last="Pang">Chi Pui Pang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name><affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA, Department of Medicine, Duke University Medical Center, Durham, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA, Department of Medicine, Duke University Medical Center, Durham, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name><affiliation><nlm:affiliation>Department of Genomic Medical Sciences.</nlm:affiliation><wicri:noCountry code="no comma">Department of Genomic Medical Sciences.</wicri:noCountry></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N" last="Vithana">Eranga N. Vithana</name><affiliation wicri:level="1"><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, eranga.n.v@sericom.sg khorcc@gis.a-star.edu.sg.</nlm:affiliation><country wicri:rule="url">Singapour</country><wicri:regionArea>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author></analytic><series><title level="j">Human molecular genetics</title><idno type="eISSN">1460-2083</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Glaucoma, Open-Angle (genetics)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Proteoglycans (genetics)</term><term>Receptors, Transforming Growth Factor beta (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Allèles</term><term>Femelle</term><term>Glaucome à angle ouvert (génétique)</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Protéoglycanes (génétique)</term><term>Récepteurs TGF-bêta (génétique)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Variation génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proteoglycans</term><term>Receptors, Transforming Growth Factor beta</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Glaucoma, Open-Angle</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glaucome à angle ouvert</term><term>Protéoglycanes</term><term>Récepteurs TGF-bêta</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Allèles</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Variation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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