A common variant near TGFBR3 is associated with primary open angle glaucoma.
Identifieur interne : 002B73 ( PubMed/Corpus ); précédent : 002B72; suivant : 002B74A common variant near TGFBR3 is associated with primary open angle glaucoma.
Auteurs : Zheng Li ; R Rand Allingham ; Masakazu Nakano ; Liyun Jia ; Yuhong Chen ; Yoko Ikeda ; Baskaran Mani ; Li-Jia Chen ; Changwon Kee ; David F. Garway-Heath ; Sarangapani Sripriya ; Nobuo Fuse ; Khaled K. Abu-Amero ; Chukai Huang ; Prasanthi Namburi ; Kathryn Burdon ; Shamira A. Perera ; Puya Gharahkhani ; Ying Lin ; Morio Ueno ; Mineo Ozaki ; Takanori Mizoguchi ; Subbiah Ramasamy Krishnadas ; Essam A. Osman ; Mei Chin Lee ; Anita S Y. Chan ; Liza-Sharmini A. Tajudin ; Tan Do ; Aurelien Goncalves ; Pascal Reynier ; Hong Zhang ; Rupert Bourne ; David Goh ; David Broadway ; Rahat Husain ; Anil K. Negi ; Daniel H. Su ; Ching-Lin Ho ; Augusto Azuara Blanco ; Christopher K S. Leung ; Tina T. Wong ; Azhany Yakub ; Yutao Liu ; Monisha E. Nongpiur ; Jong Chul Han ; Do Nhu Hon ; Balekudaru Shantha ; Bowen Zhao ; Jinghong Sang ; Nihong Zhang ; Ryuichi Sato ; Kengo Yoshii ; Songhomita Panda-Jonas ; Allison E. Ashley Koch ; Leon W. Herndon ; Sayoko E. Moroi ; Pratap Challa ; Jia Nee Foo ; Jin-Xin Bei ; Yi-Xin Zeng ; Cameron P. Simmons ; Tran Nguyen Bich Chau ; Philomenadin Ferdinamarie Sharmila ; Merwyn Chew ; Blanche Lim ; Pansy O S. Tam ; Elaine Chua ; Xiao Yu Ng ; Victor H K. Yong ; Yaan Fun Chong ; Wee Yang Meah ; Saravanan Vijayan ; Sohn Seongsoo ; Wang Xu ; Yik Ying Teo ; Jessica N. Cooke Bailey ; Jae H. Kang ; Jonathan L. Haines ; Ching Yu Cheng ; Seang-Mei Saw ; E-Shyong Tai ; Julia E. Richards ; Robert Ritch ; Douglas E. Gaasterland ; Louis R. Pasquale ; Jianjun Liu ; Jost B. Jonas ; Dan Milea ; Ronnie George ; Saleh A. Al-Obeidan ; Kazuhiko Mori ; Stuart Macgregor ; Alex W. Hewitt ; Christopher A. Girkin ; Mingzhi Zhang ; Periasamy Sundaresan ; Lingam Vijaya ; David A. Mackey ; Tien Yin Wong ; Jamie E. Craig ; Xinghuai Sun ; Shigeru Kinoshita ; Janey L. Wiggs ; Chiea-Chuen Khor ; Zhenglin Yang ; Chi Pui Pang ; Ningli Wang ; Michael A. Hauser ; Kei Tashiro ; Tin Aung ; Eranga N. VithanaSource :
- Human molecular genetics [ 1460-2083 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Proteoglycans, Receptors, Transforming Growth Factor beta.
- genetics : Glaucoma, Open-Angle.
- Aged, Aged, 80 and over, Alleles, Female, Genetic Variation, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide.
Abstract
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis.
DOI: 10.1093/hmg/ddv128
PubMed: 25861811
Links to Exploration step
pubmed:25861811Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A common variant near TGFBR3 is associated with primary open angle glaucoma.</title><author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name><affiliation><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name><affiliation><nlm:affiliation>Department of Genomic Medical Sciences.</nlm:affiliation></affiliation></author><author><name sortKey="Jia, Liyun" sort="Jia, Liyun" uniqKey="Jia L" first="Liyun" last="Jia">Liyun Jia</name><affiliation><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Yuhong" sort="Chen, Yuhong" uniqKey="Chen Y" first="Yuhong" last="Chen">Yuhong Chen</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School.</nlm:affiliation></affiliation></author><author><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation></affiliation></author><author><name sortKey="Mani, Baskaran" sort="Mani, Baskaran" uniqKey="Mani B" first="Baskaran" last="Mani">Baskaran Mani</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Li Jia" sort="Chen, Li Jia" uniqKey="Chen L" first="Li-Jia" last="Chen">Li-Jia Chen</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Kee, Changwon" sort="Kee, Changwon" uniqKey="Kee C" first="Changwon" last="Kee">Changwon Kee</name><affiliation><nlm:affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Garway Heath, David F" sort="Garway Heath, David F" uniqKey="Garway Heath D" first="David F" last="Garway-Heath">David F. Garway-Heath</name><affiliation><nlm:affiliation>National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sripriya, Sarangapani" sort="Sripriya, Sarangapani" uniqKey="Sripriya S" first="Sarangapani" last="Sripriya">Sarangapani Sripriya</name><affiliation><nlm:affiliation>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation></affiliation></author><author><name sortKey="Fuse, Nobuo" sort="Fuse, Nobuo" uniqKey="Fuse N" first="Nobuo" last="Fuse">Nobuo Fuse</name><affiliation><nlm:affiliation>Department of Integrative Genomics, Tohoku Medical Megabank Organization, Sendai, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K" last="Abu-Amero">Khaled K. Abu-Amero</name><affiliation><nlm:affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Chukai" sort="Huang, Chukai" uniqKey="Huang C" first="Chukai" last="Huang">Chukai Huang</name><affiliation><nlm:affiliation>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Namburi, Prasanthi" sort="Namburi, Prasanthi" uniqKey="Namburi P" first="Prasanthi" last="Namburi">Prasanthi Namburi</name><affiliation><nlm:affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</nlm:affiliation></affiliation></author><author><name sortKey="Burdon, Kathryn" sort="Burdon, Kathryn" uniqKey="Burdon K" first="Kathryn" last="Burdon">Kathryn Burdon</name><affiliation><nlm:affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A" last="Perera">Shamira A. Perera</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Gharahkhani, Puya" sort="Gharahkhani, Puya" uniqKey="Gharahkhani P" first="Puya" last="Gharahkhani">Puya Gharahkhani</name><affiliation><nlm:affiliation>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><affiliation><nlm:affiliation>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation></affiliation></author><author><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name><affiliation><nlm:affiliation>Ozaki Eye Hospital, 1-15, Kamezaki, Hyuga, Miyazaki 883-0066, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name><affiliation><nlm:affiliation>Mizoguchi Eye Hospital, 6-13 Tawara-machi, Sasebo, Nagasaki 857-0016, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Krishnadas, Subbiah Ramasamy" sort="Krishnadas, Subbiah Ramasamy" uniqKey="Krishnadas S" first="Subbiah Ramasamy" last="Krishnadas">Subbiah Ramasamy Krishnadas</name><affiliation><nlm:affiliation>Glaucoma Services, Aravind Eye Hospital, Madurai, Tamilnadu, India.</nlm:affiliation></affiliation></author><author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A" last="Osman">Essam A. Osman</name><affiliation><nlm:affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S Y" last="Chan">Anita S Y. Chan</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Tajudin, Liza Sharmini A" sort="Tajudin, Liza Sharmini A" uniqKey="Tajudin L" first="Liza-Sharmini A" last="Tajudin">Liza-Sharmini A. Tajudin</name><affiliation><nlm:affiliation>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.</nlm:affiliation></affiliation></author><author><name sortKey="Do, Tan" sort="Do, Tan" uniqKey="Do T" first="Tan" last="Do">Tan Do</name><affiliation><nlm:affiliation>Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Goncalves, Aurelien" sort="Goncalves, Aurelien" uniqKey="Goncalves A" first="Aurelien" last="Goncalves">Aurelien Goncalves</name><affiliation><nlm:affiliation>Ophthalmology Department.</nlm:affiliation></affiliation></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name><affiliation><nlm:affiliation>Biochemistry Department, Angers University Hospital, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation><nlm:affiliation>Department of Ophthalmology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Bourne, Rupert" sort="Bourne, Rupert" uniqKey="Bourne R" first="Rupert" last="Bourne">Rupert Bourne</name><affiliation><nlm:affiliation>Huntingdon Glaucoma Diagnostic & Research Centre, Hinchingbrooke Hospital, Huntingdon, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Goh, David" sort="Goh, David" uniqKey="Goh D" first="David" last="Goh">David Goh</name><affiliation><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Broadway, David" sort="Broadway, David" uniqKey="Broadway D" first="David" last="Broadway">David Broadway</name><affiliation><nlm:affiliation>Norfolk & Norwich University Hospital NHS Trust, Norwich, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name><affiliation><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Negi, Anil K" sort="Negi, Anil K" uniqKey="Negi A" first="Anil K" last="Negi">Anil K. Negi</name><affiliation><nlm:affiliation>Heart of UK NHS Foundation Trust, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Su, Daniel H" sort="Su, Daniel H" uniqKey="Su D" first="Daniel H" last="Su">Daniel H. Su</name><affiliation><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Ho, Ching Lin" sort="Ho, Ching Lin" uniqKey="Ho C" first="Ching-Lin" last="Ho">Ching-Lin Ho</name><affiliation><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Blanco, Augusto Azuara" sort="Blanco, Augusto Azuara" uniqKey="Blanco A" first="Augusto Azuara" last="Blanco">Augusto Azuara Blanco</name><affiliation><nlm:affiliation>School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, Queen's University Belfast, Northern Ireland, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Leung, Christopher K S" sort="Leung, Christopher K S" uniqKey="Leung C" first="Christopher K S" last="Leung">Christopher K S. Leung</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, Tina T" sort="Wong, Tina T" uniqKey="Wong T" first="Tina T" last="Wong">Tina T. Wong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Yakub, Azhany" sort="Yakub, Azhany" uniqKey="Yakub A" first="Azhany" last="Yakub">Azhany Yakub</name><affiliation><nlm:affiliation>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name><affiliation><nlm:affiliation>Department of Medicine, Duke University Medical Center, Durham, NC, USA, Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Nongpiur, Monisha E" sort="Nongpiur, Monisha E" uniqKey="Nongpiur M" first="Monisha E" last="Nongpiur">Monisha E. Nongpiur</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Han, Jong Chul" sort="Han, Jong Chul" uniqKey="Han J" first="Jong Chul" last="Han">Jong Chul Han</name><affiliation><nlm:affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Hon, Do Nhu" sort="Hon, Do Nhu" uniqKey="Hon D" first="Do Nhu" last="Hon">Do Nhu Hon</name><affiliation><nlm:affiliation>Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Shantha, Balekudaru" sort="Shantha, Balekudaru" uniqKey="Shantha B" first="Balekudaru" last="Shantha">Balekudaru Shantha</name><affiliation><nlm:affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name><affiliation><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name><affiliation><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name><affiliation><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sato, Ryuichi" sort="Sato, Ryuichi" uniqKey="Sato R" first="Ryuichi" last="Sato">Ryuichi Sato</name><affiliation><nlm:affiliation>Department of Genomic Medical Sciences.</nlm:affiliation></affiliation></author><author><name sortKey="Yoshii, Kengo" sort="Yoshii, Kengo" uniqKey="Yoshii K" first="Kengo" last="Yoshii">Kengo Yoshii</name><affiliation><nlm:affiliation>Department of Medical Statistics, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Panda Jonas, Songhomita" sort="Panda Jonas, Songhomita" uniqKey="Panda Jonas S" first="Songhomita" last="Panda-Jonas">Songhomita Panda-Jonas</name><affiliation><nlm:affiliation>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E" last="Ashley Koch">Allison E. Ashley Koch</name><affiliation><nlm:affiliation>Department of Medicine, Duke University Medical Center, Durham, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Herndon, Leon W" sort="Herndon, Leon W" uniqKey="Herndon L" first="Leon W" last="Herndon">Leon W. Herndon</name><affiliation><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E" last="Moroi">Sayoko E. Moroi</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences.</nlm:affiliation></affiliation></author><author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name><affiliation><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name><affiliation><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Bei, Jin Xin" sort="Bei, Jin Xin" uniqKey="Bei J" first="Jin-Xin" last="Bei">Jin-Xin Bei</name><affiliation><nlm:affiliation>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zeng, Yi Xin" sort="Zeng, Yi Xin" uniqKey="Zeng Y" first="Yi-Xin" last="Zeng">Yi-Xin Zeng</name><affiliation><nlm:affiliation>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P" last="Simmons">Cameron P. Simmons</name><affiliation><nlm:affiliation>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7LJ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bich Chau, Tran Nguyen" sort="Bich Chau, Tran Nguyen" uniqKey="Bich Chau T" first="Tran Nguyen" last="Bich Chau">Tran Nguyen Bich Chau</name><affiliation><nlm:affiliation>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Sharmila, Philomenadin Ferdinamarie" sort="Sharmila, Philomenadin Ferdinamarie" uniqKey="Sharmila P" first="Philomenadin Ferdinamarie" last="Sharmila">Philomenadin Ferdinamarie Sharmila</name><affiliation><nlm:affiliation>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation></affiliation></author><author><name sortKey="Chew, Merwyn" sort="Chew, Merwyn" uniqKey="Chew M" first="Merwyn" last="Chew">Merwyn Chew</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Lim, Blanche" sort="Lim, Blanche" uniqKey="Lim B" first="Blanche" last="Lim">Blanche Lim</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Tam, Pansy O S" sort="Tam, Pansy O S" uniqKey="Tam P" first="Pansy O S" last="Tam">Pansy O S. Tam</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chua, Elaine" sort="Chua, Elaine" uniqKey="Chua E" first="Elaine" last="Chua">Elaine Chua</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Ng, Xiao Yu" sort="Ng, Xiao Yu" uniqKey="Ng X" first="Xiao Yu" last="Ng">Xiao Yu Ng</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Yong, Victor H K" sort="Yong, Victor H K" uniqKey="Yong V" first="Victor H K" last="Yong">Victor H K. Yong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Chong, Yaan Fun" sort="Chong, Yaan Fun" uniqKey="Chong Y" first="Yaan Fun" last="Chong">Yaan Fun Chong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name><affiliation><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name><affiliation><nlm:affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</nlm:affiliation></affiliation></author><author><name sortKey="Seongsoo, Sohn" sort="Seongsoo, Sohn" uniqKey="Seongsoo S" first="Sohn" last="Seongsoo">Sohn Seongsoo</name><affiliation><nlm:affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Wang" sort="Xu, Wang" uniqKey="Xu W" first="Wang" last="Xu">Wang Xu</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><affiliation><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Cooke Bailey, Jessica N" sort="Cooke Bailey, Jessica N" uniqKey="Cooke Bailey J" first="Jessica N" last="Cooke Bailey">Jessica N. Cooke Bailey</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H" last="Kang">Jae H. Kang</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation><nlm:affiliation>Department of Medicine, National University Health System & National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E" last="Richards">Julia E. Richards</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name><affiliation><nlm:affiliation>Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gaasterland, Douglas E" sort="Gaasterland, Douglas E" uniqKey="Gaasterland D" first="Douglas E" last="Gaasterland">Douglas E. Gaasterland</name><affiliation><nlm:affiliation>Eye Doctors of Washington DC, Washington, DC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R" last="Pasquale">Louis R. Pasquale</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B" last="Jonas">Jost B. Jonas</name><affiliation><nlm:affiliation>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Milea">Dan Milea</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="George, Ronnie" sort="George, Ronnie" uniqKey="George R" first="Ronnie" last="George">Ronnie George</name><affiliation><nlm:affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation></affiliation></author><author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A" last="Al-Obeidan">Saleh A. Al-Obeidan</name><affiliation><nlm:affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation><nlm:affiliation>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name><affiliation><nlm:affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Girkin, Christopher A" sort="Girkin, Christopher A" uniqKey="Girkin C" first="Christopher A" last="Girkin">Christopher A. Girkin</name><affiliation><nlm:affiliation>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Mingzhi" sort="Zhang, Mingzhi" uniqKey="Zhang M" first="Mingzhi" last="Zhang">Mingzhi Zhang</name><affiliation><nlm:affiliation>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><affiliation><nlm:affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</nlm:affiliation></affiliation></author><author><name sortKey="Vijaya, Lingam" sort="Vijaya, Lingam" uniqKey="Vijaya L" first="Lingam" last="Vijaya">Lingam Vijaya</name><affiliation><nlm:affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name><affiliation><nlm:affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, WA, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name><affiliation><nlm:affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Xinghuai" sort="Sun, Xinghuai" uniqKey="Sun X" first="Xinghuai" last="Sun">Xinghuai Sun</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China, Myopia Key Laboratory of the Ministry of Health of China, Shanghai, China and.</nlm:affiliation></affiliation></author><author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L" last="Wiggs">Janey L. Wiggs</name><affiliation><nlm:affiliation>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, eranga.n.v@sericom.sg khorcc@gis.a-star.edu.sg.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation><nlm:affiliation>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Chinese Academy of Sciences, Sichuan Translational Medicine Hospital, Chengdu, China.</nlm:affiliation></affiliation></author><author><name sortKey="Pang, Chi Pui" sort="Pang, Chi Pui" uniqKey="Pang C" first="Chi Pui" last="Pang">Chi Pui Pang</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name><affiliation><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name><affiliation><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA, Department of Medicine, Duke University Medical Center, Durham, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name><affiliation><nlm:affiliation>Department of Genomic Medical Sciences.</nlm:affiliation></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N" last="Vithana">Eranga N. Vithana</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, eranga.n.v@sericom.sg khorcc@gis.a-star.edu.sg.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25861811</idno><idno type="pmid">25861811</idno><idno type="doi">10.1093/hmg/ddv128</idno><idno type="wicri:Area/PubMed/Corpus">002B73</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B73</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A common variant near TGFBR3 is associated with primary open angle glaucoma.</title><author><name sortKey="Li, Zheng" sort="Li, Zheng" uniqKey="Li Z" first="Zheng" last="Li">Zheng Li</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name><affiliation><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nakano, Masakazu" sort="Nakano, Masakazu" uniqKey="Nakano M" first="Masakazu" last="Nakano">Masakazu Nakano</name><affiliation><nlm:affiliation>Department of Genomic Medical Sciences.</nlm:affiliation></affiliation></author><author><name sortKey="Jia, Liyun" sort="Jia, Liyun" uniqKey="Jia L" first="Liyun" last="Jia">Liyun Jia</name><affiliation><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Yuhong" sort="Chen, Yuhong" uniqKey="Chen Y" first="Yuhong" last="Chen">Yuhong Chen</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School.</nlm:affiliation></affiliation></author><author><name sortKey="Ikeda, Yoko" sort="Ikeda, Yoko" uniqKey="Ikeda Y" first="Yoko" last="Ikeda">Yoko Ikeda</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation></affiliation></author><author><name sortKey="Mani, Baskaran" sort="Mani, Baskaran" uniqKey="Mani B" first="Baskaran" last="Mani">Baskaran Mani</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Li Jia" sort="Chen, Li Jia" uniqKey="Chen L" first="Li-Jia" last="Chen">Li-Jia Chen</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Kee, Changwon" sort="Kee, Changwon" uniqKey="Kee C" first="Changwon" last="Kee">Changwon Kee</name><affiliation><nlm:affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Garway Heath, David F" sort="Garway Heath, David F" uniqKey="Garway Heath D" first="David F" last="Garway-Heath">David F. Garway-Heath</name><affiliation><nlm:affiliation>National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sripriya, Sarangapani" sort="Sripriya, Sarangapani" uniqKey="Sripriya S" first="Sarangapani" last="Sripriya">Sarangapani Sripriya</name><affiliation><nlm:affiliation>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation></affiliation></author><author><name sortKey="Fuse, Nobuo" sort="Fuse, Nobuo" uniqKey="Fuse N" first="Nobuo" last="Fuse">Nobuo Fuse</name><affiliation><nlm:affiliation>Department of Integrative Genomics, Tohoku Medical Megabank Organization, Sendai, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Abu Amero, Khaled K" sort="Abu Amero, Khaled K" uniqKey="Abu Amero K" first="Khaled K" last="Abu-Amero">Khaled K. Abu-Amero</name><affiliation><nlm:affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Chukai" sort="Huang, Chukai" uniqKey="Huang C" first="Chukai" last="Huang">Chukai Huang</name><affiliation><nlm:affiliation>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Namburi, Prasanthi" sort="Namburi, Prasanthi" uniqKey="Namburi P" first="Prasanthi" last="Namburi">Prasanthi Namburi</name><affiliation><nlm:affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</nlm:affiliation></affiliation></author><author><name sortKey="Burdon, Kathryn" sort="Burdon, Kathryn" uniqKey="Burdon K" first="Kathryn" last="Burdon">Kathryn Burdon</name><affiliation><nlm:affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Perera, Shamira A" sort="Perera, Shamira A" uniqKey="Perera S" first="Shamira A" last="Perera">Shamira A. Perera</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Gharahkhani, Puya" sort="Gharahkhani, Puya" uniqKey="Gharahkhani P" first="Puya" last="Gharahkhani">Puya Gharahkhani</name><affiliation><nlm:affiliation>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><affiliation><nlm:affiliation>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ueno, Morio" sort="Ueno, Morio" uniqKey="Ueno M" first="Morio" last="Ueno">Morio Ueno</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation></affiliation></author><author><name sortKey="Ozaki, Mineo" sort="Ozaki, Mineo" uniqKey="Ozaki M" first="Mineo" last="Ozaki">Mineo Ozaki</name><affiliation><nlm:affiliation>Ozaki Eye Hospital, 1-15, Kamezaki, Hyuga, Miyazaki 883-0066, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Mizoguchi, Takanori" sort="Mizoguchi, Takanori" uniqKey="Mizoguchi T" first="Takanori" last="Mizoguchi">Takanori Mizoguchi</name><affiliation><nlm:affiliation>Mizoguchi Eye Hospital, 6-13 Tawara-machi, Sasebo, Nagasaki 857-0016, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Krishnadas, Subbiah Ramasamy" sort="Krishnadas, Subbiah Ramasamy" uniqKey="Krishnadas S" first="Subbiah Ramasamy" last="Krishnadas">Subbiah Ramasamy Krishnadas</name><affiliation><nlm:affiliation>Glaucoma Services, Aravind Eye Hospital, Madurai, Tamilnadu, India.</nlm:affiliation></affiliation></author><author><name sortKey="Osman, Essam A" sort="Osman, Essam A" uniqKey="Osman E" first="Essam A" last="Osman">Essam A. Osman</name><affiliation><nlm:affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Mei Chin" sort="Lee, Mei Chin" uniqKey="Lee M" first="Mei Chin" last="Lee">Mei Chin Lee</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, Anita S Y" sort="Chan, Anita S Y" uniqKey="Chan A" first="Anita S Y" last="Chan">Anita S Y. Chan</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Tajudin, Liza Sharmini A" sort="Tajudin, Liza Sharmini A" uniqKey="Tajudin L" first="Liza-Sharmini A" last="Tajudin">Liza-Sharmini A. Tajudin</name><affiliation><nlm:affiliation>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.</nlm:affiliation></affiliation></author><author><name sortKey="Do, Tan" sort="Do, Tan" uniqKey="Do T" first="Tan" last="Do">Tan Do</name><affiliation><nlm:affiliation>Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Goncalves, Aurelien" sort="Goncalves, Aurelien" uniqKey="Goncalves A" first="Aurelien" last="Goncalves">Aurelien Goncalves</name><affiliation><nlm:affiliation>Ophthalmology Department.</nlm:affiliation></affiliation></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name><affiliation><nlm:affiliation>Biochemistry Department, Angers University Hospital, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation><nlm:affiliation>Department of Ophthalmology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Bourne, Rupert" sort="Bourne, Rupert" uniqKey="Bourne R" first="Rupert" last="Bourne">Rupert Bourne</name><affiliation><nlm:affiliation>Huntingdon Glaucoma Diagnostic & Research Centre, Hinchingbrooke Hospital, Huntingdon, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Goh, David" sort="Goh, David" uniqKey="Goh D" first="David" last="Goh">David Goh</name><affiliation><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Broadway, David" sort="Broadway, David" uniqKey="Broadway D" first="David" last="Broadway">David Broadway</name><affiliation><nlm:affiliation>Norfolk & Norwich University Hospital NHS Trust, Norwich, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Husain, Rahat" sort="Husain, Rahat" uniqKey="Husain R" first="Rahat" last="Husain">Rahat Husain</name><affiliation><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Negi, Anil K" sort="Negi, Anil K" uniqKey="Negi A" first="Anil K" last="Negi">Anil K. Negi</name><affiliation><nlm:affiliation>Heart of UK NHS Foundation Trust, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Su, Daniel H" sort="Su, Daniel H" uniqKey="Su D" first="Daniel H" last="Su">Daniel H. Su</name><affiliation><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Ho, Ching Lin" sort="Ho, Ching Lin" uniqKey="Ho C" first="Ching-Lin" last="Ho">Ching-Lin Ho</name><affiliation><nlm:affiliation>Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Blanco, Augusto Azuara" sort="Blanco, Augusto Azuara" uniqKey="Blanco A" first="Augusto Azuara" last="Blanco">Augusto Azuara Blanco</name><affiliation><nlm:affiliation>School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, Queen's University Belfast, Northern Ireland, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Leung, Christopher K S" sort="Leung, Christopher K S" uniqKey="Leung C" first="Christopher K S" last="Leung">Christopher K S. Leung</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, Tina T" sort="Wong, Tina T" uniqKey="Wong T" first="Tina T" last="Wong">Tina T. Wong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Yakub, Azhany" sort="Yakub, Azhany" uniqKey="Yakub A" first="Azhany" last="Yakub">Azhany Yakub</name><affiliation><nlm:affiliation>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Yutao" sort="Liu, Yutao" uniqKey="Liu Y" first="Yutao" last="Liu">Yutao Liu</name><affiliation><nlm:affiliation>Department of Medicine, Duke University Medical Center, Durham, NC, USA, Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Nongpiur, Monisha E" sort="Nongpiur, Monisha E" uniqKey="Nongpiur M" first="Monisha E" last="Nongpiur">Monisha E. Nongpiur</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Han, Jong Chul" sort="Han, Jong Chul" uniqKey="Han J" first="Jong Chul" last="Han">Jong Chul Han</name><affiliation><nlm:affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Hon, Do Nhu" sort="Hon, Do Nhu" uniqKey="Hon D" first="Do Nhu" last="Hon">Do Nhu Hon</name><affiliation><nlm:affiliation>Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Shantha, Balekudaru" sort="Shantha, Balekudaru" uniqKey="Shantha B" first="Balekudaru" last="Shantha">Balekudaru Shantha</name><affiliation><nlm:affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Bowen" sort="Zhao, Bowen" uniqKey="Zhao B" first="Bowen" last="Zhao">Bowen Zhao</name><affiliation><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sang, Jinghong" sort="Sang, Jinghong" uniqKey="Sang J" first="Jinghong" last="Sang">Jinghong Sang</name><affiliation><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Nihong" sort="Zhang, Nihong" uniqKey="Zhang N" first="Nihong" last="Zhang">Nihong Zhang</name><affiliation><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sato, Ryuichi" sort="Sato, Ryuichi" uniqKey="Sato R" first="Ryuichi" last="Sato">Ryuichi Sato</name><affiliation><nlm:affiliation>Department of Genomic Medical Sciences.</nlm:affiliation></affiliation></author><author><name sortKey="Yoshii, Kengo" sort="Yoshii, Kengo" uniqKey="Yoshii K" first="Kengo" last="Yoshii">Kengo Yoshii</name><affiliation><nlm:affiliation>Department of Medical Statistics, Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Panda Jonas, Songhomita" sort="Panda Jonas, Songhomita" uniqKey="Panda Jonas S" first="Songhomita" last="Panda-Jonas">Songhomita Panda-Jonas</name><affiliation><nlm:affiliation>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ashley Koch, Allison E" sort="Ashley Koch, Allison E" uniqKey="Ashley Koch A" first="Allison E" last="Ashley Koch">Allison E. Ashley Koch</name><affiliation><nlm:affiliation>Department of Medicine, Duke University Medical Center, Durham, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Herndon, Leon W" sort="Herndon, Leon W" uniqKey="Herndon L" first="Leon W" last="Herndon">Leon W. Herndon</name><affiliation><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E" last="Moroi">Sayoko E. Moroi</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences.</nlm:affiliation></affiliation></author><author><name sortKey="Challa, Pratap" sort="Challa, Pratap" uniqKey="Challa P" first="Pratap" last="Challa">Pratap Challa</name><affiliation><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia Nee" last="Foo">Jia Nee Foo</name><affiliation><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Bei, Jin Xin" sort="Bei, Jin Xin" uniqKey="Bei J" first="Jin-Xin" last="Bei">Jin-Xin Bei</name><affiliation><nlm:affiliation>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zeng, Yi Xin" sort="Zeng, Yi Xin" uniqKey="Zeng Y" first="Yi-Xin" last="Zeng">Yi-Xin Zeng</name><affiliation><nlm:affiliation>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P" last="Simmons">Cameron P. Simmons</name><affiliation><nlm:affiliation>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7LJ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bich Chau, Tran Nguyen" sort="Bich Chau, Tran Nguyen" uniqKey="Bich Chau T" first="Tran Nguyen" last="Bich Chau">Tran Nguyen Bich Chau</name><affiliation><nlm:affiliation>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam.</nlm:affiliation></affiliation></author><author><name sortKey="Sharmila, Philomenadin Ferdinamarie" sort="Sharmila, Philomenadin Ferdinamarie" uniqKey="Sharmila P" first="Philomenadin Ferdinamarie" last="Sharmila">Philomenadin Ferdinamarie Sharmila</name><affiliation><nlm:affiliation>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation></affiliation></author><author><name sortKey="Chew, Merwyn" sort="Chew, Merwyn" uniqKey="Chew M" first="Merwyn" last="Chew">Merwyn Chew</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Lim, Blanche" sort="Lim, Blanche" uniqKey="Lim B" first="Blanche" last="Lim">Blanche Lim</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Tam, Pansy O S" sort="Tam, Pansy O S" uniqKey="Tam P" first="Pansy O S" last="Tam">Pansy O S. Tam</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chua, Elaine" sort="Chua, Elaine" uniqKey="Chua E" first="Elaine" last="Chua">Elaine Chua</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Ng, Xiao Yu" sort="Ng, Xiao Yu" uniqKey="Ng X" first="Xiao Yu" last="Ng">Xiao Yu Ng</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Yong, Victor H K" sort="Yong, Victor H K" uniqKey="Yong V" first="Victor H K" last="Yong">Victor H K. Yong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Chong, Yaan Fun" sort="Chong, Yaan Fun" uniqKey="Chong Y" first="Yaan Fun" last="Chong">Yaan Fun Chong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute.</nlm:affiliation></affiliation></author><author><name sortKey="Meah, Wee Yang" sort="Meah, Wee Yang" uniqKey="Meah W" first="Wee Yang" last="Meah">Wee Yang Meah</name><affiliation><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Vijayan, Saravanan" sort="Vijayan, Saravanan" uniqKey="Vijayan S" first="Saravanan" last="Vijayan">Saravanan Vijayan</name><affiliation><nlm:affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</nlm:affiliation></affiliation></author><author><name sortKey="Seongsoo, Sohn" sort="Seongsoo, Sohn" uniqKey="Seongsoo S" first="Sohn" last="Seongsoo">Sohn Seongsoo</name><affiliation><nlm:affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Wang" sort="Xu, Wang" uniqKey="Xu W" first="Wang" last="Xu">Wang Xu</name><affiliation><nlm:affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Teo, Yik Ying" sort="Teo, Yik Ying" uniqKey="Teo Y" first="Yik Ying" last="Teo">Yik Ying Teo</name><affiliation><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Cooke Bailey, Jessica N" sort="Cooke Bailey, Jessica N" uniqKey="Cooke Bailey J" first="Jessica N" last="Cooke Bailey">Jessica N. Cooke Bailey</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H" last="Kang">Jae H. Kang</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching Yu" last="Cheng">Ching Yu Cheng</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang-Mei" last="Saw">Seang-Mei Saw</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E-Shyong" last="Tai">E-Shyong Tai</name><affiliation><nlm:affiliation>Department of Medicine, National University Health System & National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E" last="Richards">Julia E. Richards</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ritch, Robert" sort="Ritch, Robert" uniqKey="Ritch R" first="Robert" last="Ritch">Robert Ritch</name><affiliation><nlm:affiliation>Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gaasterland, Douglas E" sort="Gaasterland, Douglas E" uniqKey="Gaasterland D" first="Douglas E" last="Gaasterland">Douglas E. Gaasterland</name><affiliation><nlm:affiliation>Eye Doctors of Washington DC, Washington, DC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R" last="Pasquale">Louis R. Pasquale</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Jonas, Jost B" sort="Jonas, Jost B" uniqKey="Jonas J" first="Jost B" last="Jonas">Jost B. Jonas</name><affiliation><nlm:affiliation>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Milea">Dan Milea</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="George, Ronnie" sort="George, Ronnie" uniqKey="George R" first="Ronnie" last="George">Ronnie George</name><affiliation><nlm:affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation></affiliation></author><author><name sortKey="Al Obeidan, Saleh A" sort="Al Obeidan, Saleh A" uniqKey="Al Obeidan S" first="Saleh A" last="Al-Obeidan">Saleh A. Al-Obeidan</name><affiliation><nlm:affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Mori, Kazuhiko" sort="Mori, Kazuhiko" uniqKey="Mori K" first="Kazuhiko" last="Mori">Kazuhiko Mori</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation><nlm:affiliation>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name><affiliation><nlm:affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Girkin, Christopher A" sort="Girkin, Christopher A" uniqKey="Girkin C" first="Christopher A" last="Girkin">Christopher A. Girkin</name><affiliation><nlm:affiliation>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Mingzhi" sort="Zhang, Mingzhi" uniqKey="Zhang M" first="Mingzhi" last="Zhang">Mingzhi Zhang</name><affiliation><nlm:affiliation>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sundaresan, Periasamy" sort="Sundaresan, Periasamy" uniqKey="Sundaresan P" first="Periasamy" last="Sundaresan">Periasamy Sundaresan</name><affiliation><nlm:affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</nlm:affiliation></affiliation></author><author><name sortKey="Vijaya, Lingam" sort="Vijaya, Lingam" uniqKey="Vijaya L" first="Lingam" last="Vijaya">Lingam Vijaya</name><affiliation><nlm:affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</nlm:affiliation></affiliation></author><author><name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name><affiliation><nlm:affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, WA, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, Tien Yin" sort="Wong, Tien Yin" uniqKey="Wong T" first="Tien Yin" last="Wong">Tien Yin Wong</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name><affiliation><nlm:affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Xinghuai" sort="Sun, Xinghuai" uniqKey="Sun X" first="Xinghuai" last="Sun">Xinghuai Sun</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China, Myopia Key Laboratory of the Ministry of Health of China, Shanghai, China and.</nlm:affiliation></affiliation></author><author><name sortKey="Kinoshita, Shigeru" sort="Kinoshita, Shigeru" uniqKey="Kinoshita S" first="Shigeru" last="Kinoshita">Shigeru Kinoshita</name><affiliation><nlm:affiliation>Department of Ophthalmology.</nlm:affiliation></affiliation></author><author><name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L" last="Wiggs">Janey L. Wiggs</name><affiliation><nlm:affiliation>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea-Chuen" last="Khor">Chiea-Chuen Khor</name><affiliation><nlm:affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, eranga.n.v@sericom.sg khorcc@gis.a-star.edu.sg.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Zhenglin" sort="Yang, Zhenglin" uniqKey="Yang Z" first="Zhenglin" last="Yang">Zhenglin Yang</name><affiliation><nlm:affiliation>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Chinese Academy of Sciences, Sichuan Translational Medicine Hospital, Chengdu, China.</nlm:affiliation></affiliation></author><author><name sortKey="Pang, Chi Pui" sort="Pang, Chi Pui" uniqKey="Pang C" first="Chi Pui" last="Pang">Chi Pui Pang</name><affiliation><nlm:affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Ningli" sort="Wang, Ningli" uniqKey="Wang N" first="Ningli" last="Wang">Ningli Wang</name><affiliation><nlm:affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name><affiliation><nlm:affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA, Department of Medicine, Duke University Medical Center, Durham, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tashiro, Kei" sort="Tashiro, Kei" uniqKey="Tashiro K" first="Kei" last="Tashiro">Kei Tashiro</name><affiliation><nlm:affiliation>Department of Genomic Medical Sciences.</nlm:affiliation></affiliation></author><author><name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N" last="Vithana">Eranga N. Vithana</name><affiliation><nlm:affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, eranga.n.v@sericom.sg khorcc@gis.a-star.edu.sg.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Human molecular genetics</title><idno type="eISSN">1460-2083</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Glaucoma, Open-Angle (genetics)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Proteoglycans (genetics)</term><term>Receptors, Transforming Growth Factor beta (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proteoglycans</term><term>Receptors, Transforming Growth Factor beta</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Glaucoma, Open-Angle</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alleles</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25861811</PMID><DateCreated><Year>2015</Year><Month>06</Month><Day>09</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>28</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1460-2083</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>13</Issue><PubDate><Year>2015</Year><Month>Jul</Month><Day>01</Day></PubDate></JournalIssue><Title>Human molecular genetics</Title><ISOAbbreviation>Hum. Mol. Genet.</ISOAbbreviation></Journal><ArticleTitle>A common variant near TGFBR3 is associated with primary open angle glaucoma.</ArticleTitle><Pagination><MedlinePgn>3880-92</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/hmg/ddv128</ELocationID><Abstract><AbstractText>Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis.</AbstractText><CopyrightInformation>© The Author 2015. Published by Oxford University Press.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Zheng</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allingham</LastName><ForeName>R Rand</ForeName><Initials>RR</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nakano</LastName><ForeName>Masakazu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Genomic Medical Sciences.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jia</LastName><ForeName>Liyun</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yuhong</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ikeda</LastName><ForeName>Yoko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mani</LastName><ForeName>Baskaran</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Li-Jia</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kee</LastName><ForeName>Changwon</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garway-Heath</LastName><ForeName>David F</ForeName><Initials>DF</Initials><AffiliationInfo><Affiliation>National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sripriya</LastName><ForeName>Sarangapani</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fuse</LastName><ForeName>Nobuo</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Integrative Genomics, Tohoku Medical Megabank Organization, Sendai, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abu-Amero</LastName><ForeName>Khaled K</ForeName><Initials>KK</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Chukai</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Namburi</LastName><ForeName>Prasanthi</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burdon</LastName><ForeName>Kathryn</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Department of Ophthalmology, Flinders University, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perera</LastName><ForeName>Shamira A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gharahkhani</LastName><ForeName>Puya</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Ying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ueno</LastName><ForeName>Morio</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ozaki</LastName><ForeName>Mineo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Ozaki Eye Hospital, 1-15, Kamezaki, Hyuga, Miyazaki 883-0066, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mizoguchi</LastName><ForeName>Takanori</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Mizoguchi Eye Hospital, 6-13 Tawara-machi, Sasebo, Nagasaki 857-0016, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krishnadas</LastName><ForeName>Subbiah Ramasamy</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Glaucoma Services, Aravind Eye Hospital, Madurai, Tamilnadu, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Osman</LastName><ForeName>Essam A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Mei Chin</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Anita S Y</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tajudin</LastName><ForeName>Liza-Sharmini A</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Do</LastName><ForeName>Tan</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goncalves</LastName><ForeName>Aurelien</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Ophthalmology Department.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reynier</LastName><ForeName>Pascal</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Biochemistry Department, Angers University Hospital, Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Hong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bourne</LastName><ForeName>Rupert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Huntingdon Glaucoma Diagnostic & Research Centre, Hinchingbrooke Hospital, Huntingdon, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goh</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Singapore National Eye Center, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Broadway</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Norfolk & Norwich University Hospital NHS Trust, Norwich, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Husain</LastName><ForeName>Rahat</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Singapore National Eye Center, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Negi</LastName><ForeName>Anil K</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Heart of UK NHS Foundation Trust, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Daniel H</ForeName><Initials>DH</Initials><AffiliationInfo><Affiliation>Singapore National Eye Center, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ho</LastName><ForeName>Ching-Lin</ForeName><Initials>CL</Initials><AffiliationInfo><Affiliation>Singapore National Eye Center, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blanco</LastName><ForeName>Augusto Azuara</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, Queen's University Belfast, Northern Ireland, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leung</LastName><ForeName>Christopher K S</ForeName><Initials>CK</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Tina T</ForeName><Initials>TT</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yakub</LastName><ForeName>Azhany</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yutao</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Medicine, Duke University Medical Center, Durham, NC, USA, Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nongpiur</LastName><ForeName>Monisha E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Jong Chul</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hon</LastName><ForeName>Do Nhu</ForeName><Initials>DN</Initials><AffiliationInfo><Affiliation>Vietnam National Institute of Ophthalmology, Hanoi, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shantha</LastName><ForeName>Balekudaru</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Bowen</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sang</LastName><ForeName>Jinghong</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>NiHong</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sato</LastName><ForeName>Ryuichi</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Genomic Medical Sciences.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yoshii</LastName><ForeName>Kengo</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medical Statistics, Kyoto Prefectural University of Medicine, Kyoto, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Panda-Jonas</LastName><ForeName>Songhomita</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ashley Koch</LastName><ForeName>Allison E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>Department of Medicine, Duke University Medical Center, Durham, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herndon</LastName><ForeName>Leon W</ForeName><Initials>LW</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moroi</LastName><ForeName>Sayoko E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Sciences.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Challa</LastName><ForeName>Pratap</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foo</LastName><ForeName>Jia Nee</ForeName><Initials>JN</Initials><AffiliationInfo><Affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bei</LastName><ForeName>Jin-Xin</ForeName><Initials>JX</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeng</LastName><ForeName>Yi-Xin</ForeName><Initials>YX</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Oncology in Southern China, Guangzhou, China, Department of Experimental Research, Sun Yat-Sen University Cancer Centre, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simmons</LastName><ForeName>Cameron P</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford OX3 7LJ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bich Chau</LastName><ForeName>Tran Nguyen</ForeName><Initials>TN</Initials><AffiliationInfo><Affiliation>Clinical Research Unit, Oxford University, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharmila</LastName><ForeName>Philomenadin Ferdinamarie</ForeName><Initials>PF</Initials><AffiliationInfo><Affiliation>SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chew</LastName><ForeName>Merwyn</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Blanche</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tam</LastName><ForeName>Pansy O S</ForeName><Initials>PO</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chua</LastName><ForeName>Elaine</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Xiao Yu</ForeName><Initials>XY</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yong</LastName><ForeName>Victor H K</ForeName><Initials>VH</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chong</LastName><ForeName>Yaan Fun</ForeName><Initials>YF</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meah</LastName><ForeName>Wee Yang</ForeName><Initials>WY</Initials><AffiliationInfo><Affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vijayan</LastName><ForeName>Saravanan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seongsoo</LastName><ForeName>Sohn</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Seoul Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Wang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teo</LastName><ForeName>Yik Ying</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooke Bailey</LastName><ForeName>Jessica N</ForeName><Initials>JN</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Jae H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haines</LastName><ForeName>Jonathan L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Ching Yu</ForeName><Initials>CY</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saw</LastName><ForeName>Seang-Mei</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tai</LastName><ForeName>E-Shyong</ForeName><Initials>ES</Initials><AffiliationInfo><Affiliation>Department of Medicine, National University Health System & National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>ICAARE-Glaucoma Consortium</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>NEIGHBORHOOD Consortium</CollectiveName></Author><Author ValidYN="Y"><LastName>Richards</LastName><ForeName>Julia E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Sciences, Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ritch</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaasterland</LastName><ForeName>Douglas E</ForeName><Initials>DE</Initials><AffiliationInfo><Affiliation>Eye Doctors of Washington DC, Washington, DC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pasquale</LastName><ForeName>Louis R</ForeName><Initials>LR</Initials><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jianjun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jonas</LastName><ForeName>Jost B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Milea</LastName><ForeName>Dan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore National Eye Center, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>George</LastName><ForeName>Ronnie</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Obeidan</LastName><ForeName>Saleh A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mori</LastName><ForeName>Kazuhiko</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Macgregor</LastName><ForeName>Stuart</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hewitt</LastName><ForeName>Alex W</ForeName><Initials>AW</Initials><AffiliationInfo><Affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Girkin</LastName><ForeName>Christopher A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Mingzhi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Chinese University of Hong Kong Joint Shantou International Eye Center, Shantou University, Shantou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sundaresan</LastName><ForeName>Periasamy</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vijaya</LastName><ForeName>Lingam</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Medical Research Foundation, Sankara Nethralaya, Chennai, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mackey</LastName><ForeName>David A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, WA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Tien Yin</ForeName><Initials>TY</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Craig</LastName><ForeName>Jamie E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Flinders University, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Xinghuai</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical School, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China, Myopia Key Laboratory of the Ministry of Health of China, Shanghai, China and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kinoshita</LastName><ForeName>Shigeru</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wiggs</LastName><ForeName>Janey L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khor</LastName><ForeName>Chiea-Chuen</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, eranga.n.v@sericom.sg khorcc@gis.a-star.edu.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Zhenglin</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, China, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, Chinese Academy of Sciences, Sichuan Translational Medicine Hospital, Chengdu, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pang</LastName><ForeName>Chi Pui</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology and Visual Sciences, The Chinese Uuniversity of Hong Kong Eye Hospital, Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Ningli</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hauser</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Duke University Eye Center, Durham, NC, USA, Department of Medicine, Duke University Medical Center, Durham, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tashiro</LastName><ForeName>Kei</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Genomic Medical Sciences.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aung</LastName><ForeName>Tin</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vithana</LastName><ForeName>Eranga N</ForeName><Initials>EN</Initials><AffiliationInfo><Affiliation>Singapore Eye Research Institute, Department of Ophthalmology, Yong Loo Lin School of Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore, eranga.n.v@sericom.sg khorcc@gis.a-star.edu.sg.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 EY011671</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY023646</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HG004728</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HG004446</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 EY005722</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY011008</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 CA087969</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United 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EY022305</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P20 RR015574</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY015473</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA167552</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY009580</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 EY012118</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA049449</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 EY014104</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY015872</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY009847</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY010886</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA049449</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HG004608</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY013315</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY023512</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY018660</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>04</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Hum Mol Genet</MedlineTA><NlmUniqueID>9208958</NlmUniqueID><ISSNLinking>0964-6906</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011509">Proteoglycans</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018125">Receptors, Transforming Growth Factor beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>145170-29-2</RegistryNumber><NameOfSubstance UI="C071736">betaglycan</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C562750">Glaucoma, Primary Open 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MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="Y">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011509" MajorTopicYN="N">Proteoglycans</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018125" MajorTopicYN="N">Receptors, Transforming Growth Factor beta</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4459396</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate 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