Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
Identifieur interne : 001945 ( Main/Exploration ); précédent : 001944; suivant : 001946Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
Auteurs : Wei Deng [États-Unis] ; Yan Xu [États-Unis] ; Wenchun Chen [États-Unis] ; David S. Paul [États-Unis] ; Anum K. Syed [États-Unis] ; Matthew A. Dragovich [États-Unis] ; Xin Liang [États-Unis] ; Philip Zakas [États-Unis] ; Michael C. Berndt [Australie] ; Jorge Di Paola [États-Unis] ; Jerry Ware [États-Unis] ; Francois Lanza [France] ; Christopher B. Doering [États-Unis] ; Wolfgang Bergmeier [États-Unis] ; X. Frank Zhang [États-Unis] ; Renhao Li [États-Unis]Source :
- Nature Communications [ 2041-1723 ] ; 2016.
Abstract
Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib–IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable and mechanosensitive domain in the GPIbα subunit of GPIb–IX was identified. Here we show that binding of its ligand, von Willebrand factor, under physiological shear stress induces unfolding of this mechanosensory domain (MSD) on the platelet surface. The unfolded MSD, particularly the juxtamembrane ‘Trigger' sequence therein, leads to intracellular signalling and rapid platelet clearance. These results illustrate the initial molecular event underlying platelet shear sensing and provide a mechanism linking GPIb–IX to platelet clearance. Our results have implications on the mechanism of platelet activation, and on the pathophysiology of von Willebrand disease and related thrombocytopenic disorders. The mechanosensation via receptor unfolding may be applicable for many other cell adhesion receptors.
Url:
DOI: 10.1038/ncomms12863
PubMed: 27670775
PubMed Central: 5052631
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000778
- to stream Pmc, to step Curation: 000777
- to stream Pmc, to step Checkpoint: 000700
- to stream PubMed, to step Corpus: 001938
- to stream PubMed, to step Curation: 001915
- to stream PubMed, to step Checkpoint: 001915
- to stream Ncbi, to step Merge: 003C06
- to stream Ncbi, to step Curation: 003C06
- to stream Ncbi, to step Checkpoint: 003C06
- to stream Main, to step Merge: 001940
- to stream Main, to step Curation: 001945
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor</title><author><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Yan" sort="Xu, Yan" uniqKey="Xu Y" first="Yan" last="Xu">Yan Xu</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University</institution>, Bethlehem, Pennsylvania 18015,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Wenchun" sort="Chen, Wenchun" uniqKey="Chen W" first="Wenchun" last="Chen">Wenchun Chen</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Paul, David S" sort="Paul, David S" uniqKey="Paul D" first="David S." last="Paul">David S. Paul</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>McAllister Heart Institute, University of North Carolina</institution>, Chapel Hill, North Carolina 27516,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Syed, Anum K" sort="Syed, Anum K" uniqKey="Syed A" first="Anum K." last="Syed">Anum K. Syed</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dragovich, Matthew A" sort="Dragovich, Matthew A" uniqKey="Dragovich M" first="Matthew A." last="Dragovich">Matthew A. Dragovich</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University</institution>, Bethlehem, Pennsylvania 18015,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liang, Xin" sort="Liang, Xin" uniqKey="Liang X" first="Xin" last="Liang">Xin Liang</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zakas, Philip" sort="Zakas, Philip" uniqKey="Zakas P" first="Philip" last="Zakas">Philip Zakas</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Berndt, Michael C" sort="Berndt, Michael C" uniqKey="Berndt M" first="Michael C." last="Berndt">Michael C. Berndt</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Faculty of Health Sciences, Curtin University</institution>, Perth, Western Australia 6845,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Di Paola, Jorge" sort="Di Paola, Jorge" uniqKey="Di Paola J" first="Jorge" last="Di Paola">Jorge Di Paola</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Pediatrics and Human Genetics, Genomics Program, University of Colorado School of Medicine</institution>, Aurora, Colorado 80045,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ware, Jerry" sort="Ware, Jerry" uniqKey="Ware J" first="Jerry" last="Ware">Jerry Ware</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Physiology and Biophysics, University of Arkansas for Medical Sciences</institution>, Little Rock, Arkansas 72205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lanza, Francois" sort="Lanza, Francois" uniqKey="Lanza F" first="Francois" last="Lanza">Francois Lanza</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>UMR_S949 INSERM, Université de Strasbourg, EFS-Alsace</institution>, Strasbourg 67065,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Doering, Christopher B" sort="Doering, Christopher B" uniqKey="Doering C" first="Christopher B." last="Doering">Christopher B. Doering</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bergmeier, Wolfgang" sort="Bergmeier, Wolfgang" uniqKey="Bergmeier W" first="Wolfgang" last="Bergmeier">Wolfgang Bergmeier</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>McAllister Heart Institute, University of North Carolina</institution>, Chapel Hill, North Carolina 27516,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Biochemistry/Biophysics, University of North Carolina</institution>, Chapel Hill, North Carolina 27599,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, X Frank" sort="Zhang, X Frank" uniqKey="Zhang X" first="X. Frank" last="Zhang">X. Frank Zhang</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University</institution>, Bethlehem, Pennsylvania 18015,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Renhao" sort="Li, Renhao" uniqKey="Li R" first="Renhao" last="Li">Renhao Li</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27670775</idno><idno type="pmc">5052631</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052631</idno><idno type="RBID">PMC:5052631</idno><idno type="doi">10.1038/ncomms12863</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000778</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000778</idno><idno type="wicri:Area/Pmc/Curation">000777</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000777</idno><idno type="wicri:Area/Pmc/Checkpoint">000700</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000700</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001938</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001938</idno><idno type="wicri:Area/PubMed/Curation">001915</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001915</idno><idno type="wicri:Area/PubMed/Checkpoint">001915</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001915</idno><idno type="wicri:Area/Ncbi/Merge">003C06</idno><idno type="wicri:Area/Ncbi/Curation">003C06</idno><idno type="wicri:Area/Ncbi/Checkpoint">003C06</idno><idno type="wicri:Area/Main/Merge">001940</idno><idno type="wicri:Area/Main/Curation">001945</idno><idno type="wicri:Area/Main/Exploration">001945</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor</title><author><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Yan" sort="Xu, Yan" uniqKey="Xu Y" first="Yan" last="Xu">Yan Xu</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University</institution>, Bethlehem, Pennsylvania 18015,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Wenchun" sort="Chen, Wenchun" uniqKey="Chen W" first="Wenchun" last="Chen">Wenchun Chen</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Paul, David S" sort="Paul, David S" uniqKey="Paul D" first="David S." last="Paul">David S. Paul</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>McAllister Heart Institute, University of North Carolina</institution>, Chapel Hill, North Carolina 27516,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Syed, Anum K" sort="Syed, Anum K" uniqKey="Syed A" first="Anum K." last="Syed">Anum K. Syed</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dragovich, Matthew A" sort="Dragovich, Matthew A" uniqKey="Dragovich M" first="Matthew A." last="Dragovich">Matthew A. Dragovich</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University</institution>, Bethlehem, Pennsylvania 18015,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liang, Xin" sort="Liang, Xin" uniqKey="Liang X" first="Xin" last="Liang">Xin Liang</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zakas, Philip" sort="Zakas, Philip" uniqKey="Zakas P" first="Philip" last="Zakas">Philip Zakas</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Berndt, Michael C" sort="Berndt, Michael C" uniqKey="Berndt M" first="Michael C." last="Berndt">Michael C. Berndt</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Faculty of Health Sciences, Curtin University</institution>, Perth, Western Australia 6845,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Di Paola, Jorge" sort="Di Paola, Jorge" uniqKey="Di Paola J" first="Jorge" last="Di Paola">Jorge Di Paola</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Pediatrics and Human Genetics, Genomics Program, University of Colorado School of Medicine</institution>, Aurora, Colorado 80045,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ware, Jerry" sort="Ware, Jerry" uniqKey="Ware J" first="Jerry" last="Ware">Jerry Ware</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Physiology and Biophysics, University of Arkansas for Medical Sciences</institution>, Little Rock, Arkansas 72205,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lanza, Francois" sort="Lanza, Francois" uniqKey="Lanza F" first="Francois" last="Lanza">Francois Lanza</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>UMR_S949 INSERM, Université de Strasbourg, EFS-Alsace</institution>, Strasbourg 67065,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Doering, Christopher B" sort="Doering, Christopher B" uniqKey="Doering C" first="Christopher B." last="Doering">Christopher B. Doering</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bergmeier, Wolfgang" sort="Bergmeier, Wolfgang" uniqKey="Bergmeier W" first="Wolfgang" last="Bergmeier">Wolfgang Bergmeier</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>McAllister Heart Institute, University of North Carolina</institution>, Chapel Hill, North Carolina 27516,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Biochemistry/Biophysics, University of North Carolina</institution>, Chapel Hill, North Carolina 27599,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, X Frank" sort="Zhang, X Frank" uniqKey="Zhang X" first="X. Frank" last="Zhang">X. Frank Zhang</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University</institution>, Bethlehem, Pennsylvania 18015,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Renhao" sort="Li, Renhao" uniqKey="Li R" first="Renhao" last="Li">Renhao Li</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine</institution>, Atlanta, Georgia 30322,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib–IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable and mechanosensitive domain in the GPIbα subunit of GPIb–IX was identified. Here we show that binding of its ligand, von Willebrand factor, under physiological shear stress induces unfolding of this mechanosensory domain (MSD) on the platelet surface. The unfolded MSD, particularly the juxtamembrane ‘Trigger' sequence therein, leads to intracellular signalling and rapid platelet clearance. These results illustrate the initial molecular event underlying platelet shear sensing and provide a mechanism linking GPIb–IX to platelet clearance. Our results have implications on the mechanism of platelet activation, and on the pathophysiology of von Willebrand disease and related thrombocytopenic disorders. The mechanosensation via receptor unfolding may be applicable for many other cell adhesion receptors.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kroll, M H" uniqKey="Kroll M">M. H. Kroll</name></author><author><name sortKey="Hellums, J D" uniqKey="Hellums J">J. D. Hellums</name></author><author><name sortKey="Mcintire, L V" uniqKey="Mcintire L">L. V. McIntire</name></author><author><name sortKey="Schafer, A I" uniqKey="Schafer A">A. I. Schafer</name></author><author><name sortKey="Moake, J L" uniqKey="Moake J">J. L. Moake</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vicente, V" uniqKey="Vicente V">V. Vicente</name></author><author><name sortKey="Houghten, R A" uniqKey="Houghten R">R. A. Houghten</name></author><author><name sortKey="Ruggeri, Z M" uniqKey="Ruggeri Z">Z. M. Ruggeri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huizinga, E G" uniqKey="Huizinga E">E. G. Huizinga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruggeri, Z M" uniqKey="Ruggeri Z">Z. M. Ruggeri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moake, J L" uniqKey="Moake J">J. L. Moake</name></author><author><name sortKey="Turner, N A" uniqKey="Turner N">N. A. Turner</name></author><author><name sortKey="Stathopoulos, N A" uniqKey="Stathopoulos N">N. A. Stathopoulos</name></author><author><name sortKey="Nolasco, L H" uniqKey="Nolasco L">L. H. Nolasco</name></author><author><name sortKey="Hellums, J D" uniqKey="Hellums J">J. D. Hellums</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Springer, T A" uniqKey="Springer T">T. A. Springer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luo, S Z" uniqKey="Luo S">S. Z. Luo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcewan, P A" uniqKey="Mcewan P">P. A. McEwan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kahn, M L" uniqKey="Kahn M">M. L. Kahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mo, X" uniqKey="Mo X">X. Mo</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L. Liu</name></author><author><name sortKey="Lopez, J A" uniqKey="Lopez J">J. A. Lopez</name></author><author><name sortKey="Li, R" uniqKey="Li R">R. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berndt, M C" uniqKey="Berndt M">M. C. Berndt</name></author><author><name sortKey="Shen, Y" uniqKey="Shen Y">Y. Shen</name></author><author><name sortKey="Dopheide, S M" uniqKey="Dopheide S">S. M. Dopheide</name></author><author><name sortKey="Gardiner, E E" uniqKey="Gardiner E">E. E. Gardiner</name></author><author><name sortKey="Andrews, R K" uniqKey="Andrews R">R. K. Andrews</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanaji, T" uniqKey="Kanaji T">T. Kanaji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rumjantseva, V" uniqKey="Rumjantseva V">V. Rumjantseva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldman, A J" uniqKey="Goldman A">A. J. Goldman</name></author><author><name sortKey="Cox, R G" uniqKey="Cox R">R. G. Cox</name></author><author><name sortKey="Brenner, H" uniqKey="Brenner H">H. Brenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fukuda, K" uniqKey="Fukuda K">K. Fukuda</name></author><author><name sortKey="Doggett, T" uniqKey="Doggett T">T. Doggett</name></author><author><name sortKey="Laurenzi, I J" uniqKey="Laurenzi I">I. J. Laurenzi</name></author><author><name sortKey="Liddington, R C" uniqKey="Liddington R">R. C. Liddington</name></author><author><name sortKey="Diacovo, T G" uniqKey="Diacovo T">T. G. Diacovo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chow, T W" uniqKey="Chow T">T. W. Chow</name></author><author><name sortKey="Hellums, J D" uniqKey="Hellums J">J. D. Hellums</name></author><author><name sortKey="Moake, J L" uniqKey="Moake J">J. L. Moake</name></author><author><name sortKey="Kroll, M H" uniqKey="Kroll M">M. H. Kroll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name></author><author><name sortKey="Pestina, T I" uniqKey="Pestina T">T. I. Pestina</name></author><author><name sortKey="Berndt, M C" uniqKey="Berndt M">M. C. Berndt</name></author><author><name sortKey="Jackson, C W" uniqKey="Jackson C">C. W. Jackson</name></author><author><name sortKey="Gartner, T K" uniqKey="Gartner T">T. K. Gartner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yap, C L" uniqKey="Yap C">C. L. Yap</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nesbitt, W S" uniqKey="Nesbitt W">W. S. Nesbitt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruggeri, Z M" uniqKey="Ruggeri Z">Z. M. Ruggeri</name></author><author><name sortKey="Pareti, F I" uniqKey="Pareti F">F. I. Pareti</name></author><author><name sortKey="Mannucci, P M" uniqKey="Mannucci P">P. M. Mannucci</name></author><author><name sortKey="Ciavarella, N" uniqKey="Ciavarella N">N. Ciavarella</name></author><author><name sortKey="Zimmerman, T S" uniqKey="Zimmerman T">T. S. Zimmerman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrews, R K" uniqKey="Andrews R">R. K. Andrews</name></author><author><name sortKey="Booth, W J" uniqKey="Booth W">W. J. Booth</name></author><author><name sortKey="Gorman, J J" uniqKey="Gorman J">J. J. Gorman</name></author><author><name sortKey="Castaldi, P A" uniqKey="Castaldi P">P. A. Castaldi</name></author><author><name sortKey="Berndt, M C" uniqKey="Berndt M">M. C. Berndt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gardiner, E E" uniqKey="Gardiner E">E. E. Gardiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bergmeier, W" uniqKey="Bergmeier W">W. Bergmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Black, R A" uniqKey="Black R">R. A. Black</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rabie, T" uniqKey="Rabie T">T. Rabie</name></author><author><name sortKey="Strehl, A" uniqKey="Strehl A">A. Strehl</name></author><author><name sortKey="Ludwig, A" uniqKey="Ludwig A">A. Ludwig</name></author><author><name sortKey="Nieswandt, B" uniqKey="Nieswandt B">B. Nieswandt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, X" uniqKey="Liang X">X. Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berndt, M C" uniqKey="Berndt M">M. C. Berndt</name></author><author><name sortKey="Du, X P" uniqKey="Du X">X. P. Du</name></author><author><name sortKey="Booth, W J" uniqKey="Booth W">W. J. Booth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tao, Y" uniqKey="Tao Y">Y. Tao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perrault, C" uniqKey="Perrault C">C. Perrault</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y. Yuan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccarty, O J" uniqKey="Mccarty O">O. J. McCarty</name></author><author><name sortKey="Calaminus, S D" uniqKey="Calaminus S">S. D. Calaminus</name></author><author><name sortKey="Berndt, M C" uniqKey="Berndt M">M. C. Berndt</name></author><author><name sortKey="Machesky, L M" uniqKey="Machesky L">L. M. Machesky</name></author><author><name sortKey="Watson, S P" uniqKey="Watson S">S. P. Watson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maurer, E" uniqKey="Maurer E">E. Maurer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yan, R" uniqKey="Yan R">R. Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brinkhous, K M" uniqKey="Brinkhous K">K. M. Brinkhous</name></author><author><name sortKey="Barnes, D S" uniqKey="Barnes D">D. S. Barnes</name></author><author><name sortKey="Potter, J Y" uniqKey="Potter J">J. Y. Potter</name></author><author><name sortKey="Read, M S" uniqKey="Read M">M. S. Read</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanders, W E" uniqKey="Sanders W">W. E. Sanders</name></author><author><name sortKey="Reddick, R L" uniqKey="Reddick R">R. L. Reddick</name></author><author><name sortKey="Nichols, T C" uniqKey="Nichols T">T. C. Nichols</name></author><author><name sortKey="Brinkhous, K M" uniqKey="Brinkhous K">K. M. Brinkhous</name></author><author><name sortKey="Read, M S" uniqKey="Read M">M. S. Read</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, R" uniqKey="Li R">R. Li</name></author><author><name sortKey="Emsley, J" uniqKey="Emsley J">J. Emsley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanaji, T" uniqKey="Kanaji T">T. Kanaji</name></author><author><name sortKey="Russell, S" uniqKey="Russell S">S. Russell</name></author><author><name sortKey="Ware, J" uniqKey="Ware J">J. Ware</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Federici, A B" uniqKey="Federici A">A. B. Federici</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casari, C" uniqKey="Casari C">C. Casari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grewal, P K" uniqKey="Grewal P">P. K. Grewal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jansen, A J" uniqKey="Jansen A">A. J. Jansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yan, R" uniqKey="Yan R">R. Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Josefsson, E C" uniqKey="Josefsson E">E. C. Josefsson</name></author><author><name sortKey="Gebhard, H H" uniqKey="Gebhard H">H. H. Gebhard</name></author><author><name sortKey="Stossel, T P" uniqKey="Stossel T">T. P. Stossel</name></author><author><name sortKey="Hartwig, J H" uniqKey="Hartwig J">J. H. Hartwig</name></author><author><name sortKey="Hoffmeister, K M" uniqKey="Hoffmeister K">K. M. Hoffmeister</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yago, T" uniqKey="Yago T">T. Yago</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blenner, M A" uniqKey="Blenner M">M. A. Blenner</name></author><author><name sortKey="Dong, X" uniqKey="Dong X">X. Dong</name></author><author><name sortKey="Springer, T A" uniqKey="Springer T">T. A. Springer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tischer, A" uniqKey="Tischer A">A. Tischer</name></author><author><name sortKey="Madde, P" uniqKey="Madde P">P. Madde</name></author><author><name sortKey="Moon Tasson, L" uniqKey="Moon Tasson L">L. Moon-Tasson</name></author><author><name sortKey="Auton, M" uniqKey="Auton M">M. Auton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cadroy, Y" uniqKey="Cadroy Y">Y. Cadroy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nieswandt, B" uniqKey="Nieswandt B">B. Nieswandt</name></author><author><name sortKey="Bergmeier, W" uniqKey="Bergmeier W">W. Bergmeier</name></author><author><name sortKey="Rackebrandt, K" uniqKey="Rackebrandt K">K. Rackebrandt</name></author><author><name sortKey="Gessner, J E" uniqKey="Gessner J">J. E. Gessner</name></author><author><name sortKey="Zirngibl, H" uniqKey="Zirngibl H">H. Zirngibl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cauwenberghs, N" uniqKey="Cauwenberghs N">N. Cauwenberghs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, L" uniqKey="Zhou L">L. Zhou</name></author><author><name sortKey="Yang, W" uniqKey="Yang W">W. Yang</name></author><author><name sortKey="Li, R" uniqKey="Li R">R. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clemetson, K J" uniqKey="Clemetson K">K. J. Clemetson</name></author><author><name sortKey="Naim, H Y" uniqKey="Naim H">H. Y. Naim</name></author><author><name sortKey="Luscher, E F" uniqKey="Luscher E">E. F. Luscher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michelson, A D" uniqKey="Michelson A">A. D. Michelson</name></author><author><name sortKey="Adelman, B" uniqKey="Adelman B">B. Adelman</name></author><author><name sortKey="Barnard, M R" uniqKey="Barnard M">M. R. Barnard</name></author><author><name sortKey="Carroll, E" uniqKey="Carroll E">E. Carroll</name></author><author><name sortKey="Handin, R I" uniqKey="Handin R">R. I. Handin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bergmeier, W" uniqKey="Bergmeier W">W. Bergmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartley, P S" uniqKey="Hartley P">P. S. Hartley</name></author><author><name sortKey="Savill, J" uniqKey="Savill J">J. Savill</name></author><author><name sortKey="Brown, S B" uniqKey="Brown S">S. B. Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devine, D V" uniqKey="Devine D">D. V. Devine</name></author><author><name sortKey="Serrano, K" uniqKey="Serrano K">K. Serrano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kostelijk, E H" uniqKey="Kostelijk E">E. H. Kostelijk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Canault, M" uniqKey="Canault M">M. Canault</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, W" uniqKey="Chen W">W. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sadler, J E" uniqKey="Sadler J">J. E. Sadler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cranmer, S L" uniqKey="Cranmer S">S. L. Cranmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, J F" uniqKey="Dong J">J. F. Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feghhi, S" uniqKey="Feghhi S">S. Feghhi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stephenson, N L" uniqKey="Stephenson N">N. L. Stephenson</name></author><author><name sortKey="Avis, J M" uniqKey="Avis J">J. M. Avis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Selkoe, D" uniqKey="Selkoe D">D. Selkoe</name></author><author><name sortKey="Kopan, R" uniqKey="Kopan R">R. Kopan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, J" uniqKey="Kim J">J. Kim</name></author><author><name sortKey="Zhang, C Z" uniqKey="Zhang C">C. Z. Zhang</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Springer, T A" uniqKey="Springer T">T. A. Springer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mo, X" uniqKey="Mo X">X. Mo</name></author><author><name sortKey="Lu, N" uniqKey="Lu N">N. Lu</name></author><author><name sortKey="Padilla, A" uniqKey="Padilla A">A. Padilla</name></author><author><name sortKey="L Pez, J A" uniqKey="L Pez J">J. A. López</name></author><author><name sortKey="Li, R" uniqKey="Li R">R. Li</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name></noRegion><name sortKey="Bergmeier, Wolfgang" sort="Bergmeier, Wolfgang" uniqKey="Bergmeier W" first="Wolfgang" last="Bergmeier">Wolfgang Bergmeier</name><name sortKey="Bergmeier, Wolfgang" sort="Bergmeier, Wolfgang" uniqKey="Bergmeier W" first="Wolfgang" last="Bergmeier">Wolfgang Bergmeier</name><name sortKey="Chen, Wenchun" sort="Chen, Wenchun" uniqKey="Chen W" first="Wenchun" last="Chen">Wenchun Chen</name><name sortKey="Di Paola, Jorge" sort="Di Paola, Jorge" uniqKey="Di Paola J" first="Jorge" last="Di Paola">Jorge Di Paola</name><name sortKey="Doering, Christopher B" sort="Doering, Christopher B" uniqKey="Doering C" first="Christopher B." last="Doering">Christopher B. Doering</name><name sortKey="Dragovich, Matthew A" sort="Dragovich, Matthew A" uniqKey="Dragovich M" first="Matthew A." last="Dragovich">Matthew A. Dragovich</name><name sortKey="Li, Renhao" sort="Li, Renhao" uniqKey="Li R" first="Renhao" last="Li">Renhao Li</name><name sortKey="Liang, Xin" sort="Liang, Xin" uniqKey="Liang X" first="Xin" last="Liang">Xin Liang</name><name sortKey="Paul, David S" sort="Paul, David S" uniqKey="Paul D" first="David S." last="Paul">David S. Paul</name><name sortKey="Syed, Anum K" sort="Syed, Anum K" uniqKey="Syed A" first="Anum K." last="Syed">Anum K. Syed</name><name sortKey="Ware, Jerry" sort="Ware, Jerry" uniqKey="Ware J" first="Jerry" last="Ware">Jerry Ware</name><name sortKey="Xu, Yan" sort="Xu, Yan" uniqKey="Xu Y" first="Yan" last="Xu">Yan Xu</name><name sortKey="Zakas, Philip" sort="Zakas, Philip" uniqKey="Zakas P" first="Philip" last="Zakas">Philip Zakas</name><name sortKey="Zhang, X Frank" sort="Zhang, X Frank" uniqKey="Zhang X" first="X. Frank" last="Zhang">X. Frank Zhang</name></country><country name="Australie"><noRegion><name sortKey="Berndt, Michael C" sort="Berndt, Michael C" uniqKey="Berndt M" first="Michael C." last="Berndt">Michael C. Berndt</name></noRegion></country><country name="France"><noRegion><name sortKey="Lanza, Francois" sort="Lanza, Francois" uniqKey="Lanza F" first="Francois" last="Lanza">Francois Lanza</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001945 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001945 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5052631
|texte= Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27670775" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |