Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.
Identifieur interne : 001915 ( PubMed/Curation ); précédent : 001914; suivant : 001916Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.
Auteurs : Wei Deng [États-Unis] ; Yan Xu [États-Unis] ; Wenchun Chen [États-Unis] ; David S. Paul [États-Unis] ; Anum K. Syed [États-Unis] ; Matthew A. Dragovich [États-Unis] ; Xin Liang [États-Unis] ; Philip Zakas [États-Unis] ; Michael C. Berndt [Australie] ; Jorge Di Paola [États-Unis] ; Jerry Ware [États-Unis] ; Francois Lanza [France] ; Christopher B. Doering [États-Unis] ; Wolfgang Bergmeier [États-Unis] ; X Frank Zhang [États-Unis] ; Renhao Li [États-Unis]Source :
- Nature communications [ 2041-1723 ] ; 2016.
Abstract
Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib-IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable and mechanosensitive domain in the GPIbα subunit of GPIb-IX was identified. Here we show that binding of its ligand, von Willebrand factor, under physiological shear stress induces unfolding of this mechanosensory domain (MSD) on the platelet surface. The unfolded MSD, particularly the juxtamembrane 'Trigger' sequence therein, leads to intracellular signalling and rapid platelet clearance. These results illustrate the initial molecular event underlying platelet shear sensing and provide a mechanism linking GPIb-IX to platelet clearance. Our results have implications on the mechanism of platelet activation, and on the pathophysiology of von Willebrand disease and related thrombocytopenic disorders. The mechanosensation via receptor unfolding may be applicable for many other cell adhesion receptors.
DOI: 10.1038/ncomms12863
PubMed: 27670775
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001938
Links to Exploration step
pubmed:27670775Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.</title><author><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Yan" sort="Xu, Yan" uniqKey="Xu Y" first="Yan" last="Xu">Yan Xu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Wenchun" sort="Chen, Wenchun" uniqKey="Chen W" first="Wenchun" last="Chen">Wenchun Chen</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author><author><name sortKey="Paul, David S" sort="Paul, David S" uniqKey="Paul D" first="David S" last="Paul">David S. Paul</name><affiliation wicri:level="1"><nlm:affiliation>McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27516, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27516</wicri:regionArea></affiliation></author><author><name sortKey="Syed, Anum K" sort="Syed, Anum K" uniqKey="Syed A" first="Anum K" last="Syed">Anum K. Syed</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author><author><name sortKey="Dragovich, Matthew A" sort="Dragovich, Matthew A" uniqKey="Dragovich M" first="Matthew A" last="Dragovich">Matthew A. Dragovich</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015</wicri:regionArea></affiliation></author><author><name sortKey="Liang, Xin" sort="Liang, Xin" uniqKey="Liang X" first="Xin" last="Liang">Xin Liang</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author><author><name sortKey="Zakas, Philip" sort="Zakas, Philip" uniqKey="Zakas P" first="Philip" last="Zakas">Philip Zakas</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author><author><name sortKey="Berndt, Michael C" sort="Berndt, Michael C" uniqKey="Berndt M" first="Michael C" last="Berndt">Michael C. Berndt</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health Sciences, Curtin University, Perth, Western Australia 6845, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Health Sciences, Curtin University, Perth, Western Australia 6845</wicri:regionArea></affiliation></author><author><name sortKey="Di Paola, Jorge" sort="Di Paola, Jorge" uniqKey="Di Paola J" first="Jorge" last="Di Paola">Jorge Di Paola</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics and Human Genetics, Genomics Program, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics and Human Genetics, Genomics Program, University of Colorado School of Medicine, Aurora, Colorado 80045</wicri:regionArea></affiliation></author><author><name sortKey="Ware, Jerry" sort="Ware, Jerry" uniqKey="Ware J" first="Jerry" last="Ware">Jerry Ware</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205</wicri:regionArea></affiliation></author><author><name sortKey="Lanza, Francois" sort="Lanza, Francois" uniqKey="Lanza F" first="Francois" last="Lanza">Francois Lanza</name><affiliation wicri:level="1"><nlm:affiliation>UMR_S949 INSERM, Université de Strasbourg, EFS-Alsace, Strasbourg 67065, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR_S949 INSERM, Université de Strasbourg, EFS-Alsace, Strasbourg 67065</wicri:regionArea></affiliation></author><author><name sortKey="Doering, Christopher B" sort="Doering, Christopher B" uniqKey="Doering C" first="Christopher B" last="Doering">Christopher B. Doering</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author><author><name sortKey="Bergmeier, Wolfgang" sort="Bergmeier, Wolfgang" uniqKey="Bergmeier W" first="Wolfgang" last="Bergmeier">Wolfgang Bergmeier</name><affiliation wicri:level="1"><nlm:affiliation>McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27516, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27516</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, X Frank" sort="Zhang, X Frank" uniqKey="Zhang X" first="X Frank" last="Zhang">X Frank Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015</wicri:regionArea></affiliation></author><author><name sortKey="Li, Renhao" sort="Li, Renhao" uniqKey="Li R" first="Renhao" last="Li">Renhao Li</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27670775</idno><idno type="pmid">27670775</idno><idno type="doi">10.1038/ncomms12863</idno><idno type="wicri:Area/PubMed/Corpus">001938</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001938</idno><idno type="wicri:Area/PubMed/Curation">001915</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001915</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.</title><author><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Yan" sort="Xu, Yan" uniqKey="Xu Y" first="Yan" last="Xu">Yan Xu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Wenchun" sort="Chen, Wenchun" uniqKey="Chen W" first="Wenchun" last="Chen">Wenchun Chen</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author><author><name sortKey="Paul, David S" sort="Paul, David S" uniqKey="Paul D" first="David S" last="Paul">David S. Paul</name><affiliation wicri:level="1"><nlm:affiliation>McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27516, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27516</wicri:regionArea></affiliation></author><author><name sortKey="Syed, Anum K" sort="Syed, Anum K" uniqKey="Syed A" first="Anum K" last="Syed">Anum K. Syed</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author><author><name sortKey="Dragovich, Matthew A" sort="Dragovich, Matthew A" uniqKey="Dragovich M" first="Matthew A" last="Dragovich">Matthew A. Dragovich</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015</wicri:regionArea></affiliation></author><author><name sortKey="Liang, Xin" sort="Liang, Xin" uniqKey="Liang X" first="Xin" last="Liang">Xin Liang</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author><author><name sortKey="Zakas, Philip" sort="Zakas, Philip" uniqKey="Zakas P" first="Philip" last="Zakas">Philip Zakas</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author><author><name sortKey="Berndt, Michael C" sort="Berndt, Michael C" uniqKey="Berndt M" first="Michael C" last="Berndt">Michael C. Berndt</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health Sciences, Curtin University, Perth, Western Australia 6845, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Health Sciences, Curtin University, Perth, Western Australia 6845</wicri:regionArea></affiliation></author><author><name sortKey="Di Paola, Jorge" sort="Di Paola, Jorge" uniqKey="Di Paola J" first="Jorge" last="Di Paola">Jorge Di Paola</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics and Human Genetics, Genomics Program, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics and Human Genetics, Genomics Program, University of Colorado School of Medicine, Aurora, Colorado 80045</wicri:regionArea></affiliation></author><author><name sortKey="Ware, Jerry" sort="Ware, Jerry" uniqKey="Ware J" first="Jerry" last="Ware">Jerry Ware</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205</wicri:regionArea></affiliation></author><author><name sortKey="Lanza, Francois" sort="Lanza, Francois" uniqKey="Lanza F" first="Francois" last="Lanza">Francois Lanza</name><affiliation wicri:level="1"><nlm:affiliation>UMR_S949 INSERM, Université de Strasbourg, EFS-Alsace, Strasbourg 67065, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR_S949 INSERM, Université de Strasbourg, EFS-Alsace, Strasbourg 67065</wicri:regionArea></affiliation></author><author><name sortKey="Doering, Christopher B" sort="Doering, Christopher B" uniqKey="Doering C" first="Christopher B" last="Doering">Christopher B. Doering</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author><author><name sortKey="Bergmeier, Wolfgang" sort="Bergmeier, Wolfgang" uniqKey="Bergmeier W" first="Wolfgang" last="Bergmeier">Wolfgang Bergmeier</name><affiliation wicri:level="1"><nlm:affiliation>McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27516, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27516</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, X Frank" sort="Zhang, X Frank" uniqKey="Zhang X" first="X Frank" last="Zhang">X Frank Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015</wicri:regionArea></affiliation></author><author><name sortKey="Li, Renhao" sort="Li, Renhao" uniqKey="Li R" first="Renhao" last="Li">Renhao Li</name><affiliation wicri:level="1"><nlm:affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib-IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable and mechanosensitive domain in the GPIbα subunit of GPIb-IX was identified. Here we show that binding of its ligand, von Willebrand factor, under physiological shear stress induces unfolding of this mechanosensory domain (MSD) on the platelet surface. The unfolded MSD, particularly the juxtamembrane 'Trigger' sequence therein, leads to intracellular signalling and rapid platelet clearance. These results illustrate the initial molecular event underlying platelet shear sensing and provide a mechanism linking GPIb-IX to platelet clearance. Our results have implications on the mechanism of platelet activation, and on the pathophysiology of von Willebrand disease and related thrombocytopenic disorders. The mechanosensation via receptor unfolding may be applicable for many other cell adhesion receptors.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">27670775</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>27</Day></DateCreated><DateRevised><Year>2017</Year><Month>04</Month><Day>21</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><PubDate><Year>2016</Year><Month>Sep</Month><Day>27</Day></PubDate></JournalIssue><Title>Nature communications</Title><ISOAbbreviation>Nat Commun</ISOAbbreviation></Journal><ArticleTitle>Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.</ArticleTitle><Pagination><MedlinePgn>12863</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ncomms12863</ELocationID><Abstract><AbstractText>Mechanisms by which blood cells sense shear stress are poorly characterized. In platelets, glycoprotein (GP)Ib-IX receptor complex has been long suggested to be a shear sensor and receptor. Recently, a relatively unstable and mechanosensitive domain in the GPIbα subunit of GPIb-IX was identified. Here we show that binding of its ligand, von Willebrand factor, under physiological shear stress induces unfolding of this mechanosensory domain (MSD) on the platelet surface. The unfolded MSD, particularly the juxtamembrane 'Trigger' sequence therein, leads to intracellular signalling and rapid platelet clearance. These results illustrate the initial molecular event underlying platelet shear sensing and provide a mechanism linking GPIb-IX to platelet clearance. Our results have implications on the mechanism of platelet activation, and on the pathophysiology of von Willebrand disease and related thrombocytopenic disorders. The mechanosensation via receptor unfolding may be applicable for many other cell adhesion receptors.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Wenchun</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paul</LastName><ForeName>David S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27516, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Syed</LastName><ForeName>Anum K</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dragovich</LastName><ForeName>Matthew A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Xin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zakas</LastName><ForeName>Philip</ForeName><Initials>P</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4919-5182</Identifier><AffiliationInfo><Affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berndt</LastName><ForeName>Michael C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Faculty of Health Sciences, Curtin University, Perth, Western Australia 6845, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Di Paola</LastName><ForeName>Jorge</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pediatrics and Human Genetics, Genomics Program, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ware</LastName><ForeName>Jerry</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lanza</LastName><ForeName>Francois</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>UMR_S949 INSERM, Université de Strasbourg, EFS-Alsace, Strasbourg 67065, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Doering</LastName><ForeName>Christopher B</ForeName><Initials>CB</Initials><AffiliationInfo><Affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bergmeier</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27516, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biochemistry/Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>X Frank</ForeName><Initials>XF</Initials><AffiliationInfo><Affiliation>Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Renhao</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 HL082808</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL123984</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 GM008602</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>09</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Commun</MedlineTA><NlmUniqueID>101528555</NlmUniqueID><ISSNLinking>2041-1723</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Biochem. 1998;67:395-424</RefSource><PMID Version="1">9759493</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1981 May;78(5):2712-6</RefSource><PMID Version="1">6265903</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2002 Jan 25;277(4):2965-72</RefSource><PMID Version="1">11713259</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2015 Jan 15;125(3):562-9</RefSource><PMID Version="1">25359992</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 1999 Dec 15;94(12):4112-21</RefSource><PMID Version="1">10590056</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2008 Sep;118(9):3195-207</RefSource><PMID Version="1">18725999</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2011 Nov 10;118(19):5292-301</RefSource><PMID Version="1">21908432</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2003 Dec 1;102(12):4229-35</RefSource><PMID Version="1">12907434</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Thromb Haemost. 2012 Sep;10(9):1875-86</RefSource><PMID Version="1">22759073</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arterioscler Thromb Vasc Biol. 2000 May;20(5):1347-53</RefSource><PMID Version="1">10807753</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Vox Sang. 2000;79(1):21-6</RefSource><PMID Version="1">10971210</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biophys J. 2014 Sep 2;107(5):1185-95</RefSource><PMID Version="1">25185554</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2000 Oct 1;96(7):2520-7</RefSource><PMID Version="1">11001906</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Lab Med. 2010 Jun;30(2):475-87</RefSource><PMID Version="1">20513565</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2004 Nov 15;104(10):3161-8</RefSource><PMID Version="1">15271795</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochemistry. 1988 Jan 26;27(2):633-40</RefSource><PMID Version="1">2450575</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 1997 Feb 15;99(4):559-64</RefSource><PMID Version="1">9045854</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Neurosci. 2003;26:565-97</RefSource><PMID Version="1">12730322</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2006 Aug 11;281(32):23050-9</RefSource><PMID Version="1">16757483</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2010 Aug 19;466(7309):992-5</RefSource><PMID Version="1">20725043</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 1986 Dec;78(6):1456-61</RefSource><PMID Version="1">3491092</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Thromb Haemost. 2001 Jul;86(1):178-88</RefSource><PMID Version="1">11487006</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2014 Feb 28;289(9):5565-79</RefSource><PMID Version="1">24391089</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 1990 Jan 5;265(1):274-80</RefSource><PMID Version="1">2104618</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2001 Jan 1;97(1):162-8</RefSource><PMID Version="1">11133756</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 1988 Jun;81(6):1734-40</RefSource><PMID Version="1">3384948</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arterioscler Thromb Vasc Biol. 1995 Jun;15(6):793-800</RefSource><PMID Version="1">7773736</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Thromb Haemost. 2007 Jul;5(7):1530-7</RefSource><PMID Version="1">17445093</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2008 Jun;14(6):648-55</RefSource><PMID Version="1">18488037</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Sci Rep. 2016 Apr 22;6:24789</RefSource><PMID Version="1">27102061</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2009 Jan 15;113(3):526-34</RefSource><PMID Version="1">18805962</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Thromb Haemost. 2015 Jan;113(1):107-17</RefSource><PMID Version="1">25231551</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Thromb Haemost. 2014 Jan;12(1):82-9</RefSource><PMID Version="1">24406065</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2002 Aug 16;297(5584):1176-9</RefSource><PMID Version="1">12183630</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Thromb Haemost. 2006 Jan;95(1):100-6</RefSource><PMID Version="1">16543968</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Struct Mol Biol. 2005 Feb;12(2):152-9</RefSource><PMID Version="1">15665869</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2005 May 6;280(18):18025-32</RefSource><PMID Version="1">15741160</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 1996 Sep 1;88(5):1525-41</RefSource><PMID Version="1">8781407</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2005 Apr 15;280(15):14462-8</RefSource><PMID Version="1">15691827</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1221-9</RefSource><PMID Version="1">23559635</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 1980 May 8;302(19):1047-51</RefSource><PMID Version="1">6767976</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2010 Mar 4;115(9):1835-42</RefSource><PMID Version="1">19965619</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Thromb Haemost. 2006 Jun;4(6):1367-78</RefSource><PMID Version="1">16706984</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Thromb Haemost. 2004 Dec;2(12 ):2213-22</RefSource><PMID Version="1">15613029</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2012 Oct 9;109 (41):E2757-65</RefSource><PMID Version="1">23011796</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 1994 Jun 1;83(11):3218-24</RefSource><PMID Version="1">8193356</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 1999 Dec 17;274(51):36241-51</RefSource><PMID Version="1">10593912</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1997 Feb 20;385(6618):729-33</RefSource><PMID Version="1">9034190</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2005 Oct 15;106(8):2750-6</RefSource><PMID Version="1">15985541</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Commun. 2015 Jul 17;6:7737</RefSource><PMID Version="1">26185093</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Thromb Haemost. 2013 Dec;11(12):2155-62</RefSource><PMID Version="1">24119228</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2013 Oct 17;122(16):2893-902</RefSource><PMID Version="1">23945153</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1981 May;78(5):3230-4</RefSource><PMID Version="1">6789334</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Thromb Haemost. 2013 Apr;11(4):605-14</RefSource><PMID Version="1">23336709</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochemistry. 2011 Dec 13;50(49):10598-606</RefSource><PMID Version="1">22080766</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2007 Jan 15;109(2):603-9</RefSource><PMID Version="1">17008541</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2002 Sep 15;100(6):2102-7</RefSource><PMID Version="1">12200373</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2012 Feb 2;119(5):1263-73</RefSource><PMID Version="1">22101895</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2000 Dec 29;275(52):41377-88</RefSource><PMID Version="1">10967111</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2011 Mar 3;117(9):2718-27</RefSource><PMID Version="1">21156842</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochemistry. 1989 Oct 17;28(21):8317-26</RefSource><PMID Version="1">2557900</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 1992 Jul 1;80(1):113-20</RefSource><PMID Version="1">1611079</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biophys J. 2016 Aug 9;111(3):601-8</RefSource><PMID Version="1">27508443</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circ Res. 2004 Oct 1;95(7):677-83</RefSource><PMID Version="1">15345652</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2009 Nov;15(11):1273-80</RefSource><PMID Version="1">19783995</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1821-8</RefSource><PMID Version="1">27417583</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2014 Aug 28;124(9):1412-25</RefSource><PMID Version="1">24928861</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Thromb Haemost. 2001 Nov;86(5):1238-48</RefSource><PMID Version="1">11816713</PMID></CommentsCorrections></CommentsCorrectionsList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>01</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>08</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>9</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>9</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27670775</ArticleId><ArticleId IdType="pii">ncomms12863</ArticleId><ArticleId IdType="doi">10.1038/ncomms12863</ArticleId><ArticleId IdType="pmc">PMC5052631</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001915 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001915 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:27670775
|texte= Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:27670775" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |