An early inflammatory gene profile in visceral adipose tissue in children
Identifieur interne : 006497 ( Main/Curation ); précédent : 006496; suivant : 006498An early inflammatory gene profile in visceral adipose tissue in children
Auteurs : Charmaine S. Tam [Australie, France, États-Unis] ; Leonie K. Heilbronn [Australie] ; Corneliu Henegar [France] ; Melanie Wong [Australie] ; Christopher T. Cowell [Australie] ; Mark J. Cowley [Australie] ; Warren Kaplan [Australie] ; Karine Clément [France] ; Louise A. Baur [Australie]Source :
- International Journal of Pediatric Obesity [ 1747-7166 ] ; 2011-06.
Descripteurs français
- Wicri :
- topic : Médiateur, Recherche médicale.
English descriptors
- KwdEn :
- Adiponectin, Adipose, Adipose tissue, Cardiovascular risk, Ccl5, Cell growth, Chemokine, Chronic obesity, Clin endocrinol metab, Cohort, Developmental genes, Differentially, Garvan institute, Gene, Gene expression, Genes ccl2, Growth factor, Haptoglobin, Haptoglobin mrna levels, Human adipose tissue, Insulin resistance, Leptin, Macrophage, Mediator, Medical research, Microarray, Microarray analyses, Mrna, Ndings, Neuronatin, Obes, Obes surg, Obese, Obese adults, Omental adipose tissue, Overweight children, Prepubertal, Prepubertal children, Receptor, Silver spring, Subcutaneous, Subcutaneous adipose tissue, Vegf, Visceral, Visceral adipose tissue, Westmead, Whole cohort, Young children.
- Teeft :
- Adiponectin, Adipose, Adipose tissue, Cardiovascular risk, Ccl5, Cell growth, Chemokine, Chronic obesity, Clin endocrinol metab, Cohort, Developmental genes, Differentially, Garvan institute, Gene, Gene expression, Genes ccl2, Growth factor, Haptoglobin, Haptoglobin mrna levels, Human adipose tissue, Insulin resistance, Leptin, Macrophage, Mediator, Medical research, Microarray, Microarray analyses, Mrna, Ndings, Neuronatin, Obes, Obes surg, Obese, Obese adults, Omental adipose tissue, Overweight children, Prepubertal, Prepubertal children, Receptor, Silver spring, Subcutaneous, Subcutaneous adipose tissue, Vegf, Visceral, Visceral adipose tissue, Westmead, Whole cohort, Young children.
Abstract
The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n = 71, [54 boys], 6.0 ± 4.3 years). Affymetrix microarrays (n = 20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. Likewise, qPCR performed in the whole cohort showed a 30‐fold increase in haptoglobin (P = 0.005), 7‐fold increase in IL‐10 (P < 0.001), 8‐fold decrease in VEGF (P = 0.01) and a 28‐fold decrease in TBOX15 (P < 0.001) in visceral compared to subcutaneous adipose tissue. The inflammatory pattern in visceral adipose tissue may represent an early stage of the adverse effects of this depot, and combined with chronic obesity, may contribute to increased metabolic and cardiovascular risk.
Url:
- https://api.istex.fr/document/4EAE5BC230129E85C244676EC19380E84E46E409/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829917
DOI: 10.3109/17477166.2011.575152
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<term>Adipose</term>
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<term>Cardiovascular risk</term>
<term>Ccl5</term>
<term>Cell growth</term>
<term>Chemokine</term>
<term>Chronic obesity</term>
<term>Clin endocrinol metab</term>
<term>Cohort</term>
<term>Developmental genes</term>
<term>Differentially</term>
<term>Garvan institute</term>
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<term>Gene expression</term>
<term>Genes ccl2</term>
<term>Growth factor</term>
<term>Haptoglobin</term>
<term>Haptoglobin mrna levels</term>
<term>Human adipose tissue</term>
<term>Insulin resistance</term>
<term>Leptin</term>
<term>Macrophage</term>
<term>Mediator</term>
<term>Medical research</term>
<term>Microarray</term>
<term>Microarray analyses</term>
<term>Mrna</term>
<term>Ndings</term>
<term>Neuronatin</term>
<term>Obes</term>
<term>Obes surg</term>
<term>Obese</term>
<term>Obese adults</term>
<term>Omental adipose tissue</term>
<term>Overweight children</term>
<term>Prepubertal</term>
<term>Prepubertal children</term>
<term>Receptor</term>
<term>Silver spring</term>
<term>Subcutaneous</term>
<term>Subcutaneous adipose tissue</term>
<term>Vegf</term>
<term>Visceral</term>
<term>Visceral adipose tissue</term>
<term>Westmead</term>
<term>Whole cohort</term>
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<term>Adipose tissue</term>
<term>Cardiovascular risk</term>
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<term>Cell growth</term>
<term>Chemokine</term>
<term>Chronic obesity</term>
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<term>Cohort</term>
<term>Developmental genes</term>
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<term>Garvan institute</term>
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<term>Gene expression</term>
<term>Genes ccl2</term>
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<term>Insulin resistance</term>
<term>Leptin</term>
<term>Macrophage</term>
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<term>Medical research</term>
<term>Microarray</term>
<term>Microarray analyses</term>
<term>Mrna</term>
<term>Ndings</term>
<term>Neuronatin</term>
<term>Obes</term>
<term>Obes surg</term>
<term>Obese</term>
<term>Obese adults</term>
<term>Omental adipose tissue</term>
<term>Overweight children</term>
<term>Prepubertal</term>
<term>Prepubertal children</term>
<term>Receptor</term>
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<term>Visceral</term>
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<term>Whole cohort</term>
<term>Young children</term>
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<front><div type="abstract" xml:lang="en">The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n = 71, [54 boys], 6.0 ± 4.3 years). Affymetrix microarrays (n = 20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. Likewise, qPCR performed in the whole cohort showed a 30‐fold increase in haptoglobin (P = 0.005), 7‐fold increase in IL‐10 (P < 0.001), 8‐fold decrease in VEGF (P = 0.01) and a 28‐fold decrease in TBOX15 (P < 0.001) in visceral compared to subcutaneous adipose tissue. The inflammatory pattern in visceral adipose tissue may represent an early stage of the adverse effects of this depot, and combined with chronic obesity, may contribute to increased metabolic and cardiovascular risk.</div>
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