An early inflammatory gene profile in visceral adipose tissue in children
Identifieur interne : 000E86 ( Istex/Curation ); précédent : 000E85; suivant : 000E87An early inflammatory gene profile in visceral adipose tissue in children
Auteurs : Charmaine S. Tam [Australie, France, États-Unis] ; Leonie K. Heilbronn [Australie] ; Corneliu Henegar [France] ; Melanie Wong [Australie] ; Christopher T. Cowell [Australie] ; Mark J. Cowley [Australie] ; Warren Kaplan [Australie] ; Karine Clément [France] ; Louise A. Baur [Australie]Source :
- International Journal of Pediatric Obesity [ 1747-7166 ] ; 2011-06.
Descripteurs français
- Wicri :
- topic : Médiateur, Recherche médicale.
English descriptors
- KwdEn :
- Adiponectin, Adipose, Adipose tissue, Cardiovascular risk, Ccl5, Cell growth, Chemokine, Chronic obesity, Clin endocrinol metab, Cohort, Developmental genes, Differentially, Garvan institute, Gene, Gene expression, Genes ccl2, Growth factor, Haptoglobin, Haptoglobin mrna levels, Human adipose tissue, Insulin resistance, Leptin, Macrophage, Mediator, Medical research, Microarray, Microarray analyses, Mrna, Ndings, Neuronatin, Obes, Obes surg, Obese, Obese adults, Omental adipose tissue, Overweight children, Prepubertal, Prepubertal children, Receptor, Silver spring, Subcutaneous, Subcutaneous adipose tissue, Vegf, Visceral, Visceral adipose tissue, Westmead, Whole cohort, Young children.
- Teeft :
- Adiponectin, Adipose, Adipose tissue, Cardiovascular risk, Ccl5, Cell growth, Chemokine, Chronic obesity, Clin endocrinol metab, Cohort, Developmental genes, Differentially, Garvan institute, Gene, Gene expression, Genes ccl2, Growth factor, Haptoglobin, Haptoglobin mrna levels, Human adipose tissue, Insulin resistance, Leptin, Macrophage, Mediator, Medical research, Microarray, Microarray analyses, Mrna, Ndings, Neuronatin, Obes, Obes surg, Obese, Obese adults, Omental adipose tissue, Overweight children, Prepubertal, Prepubertal children, Receptor, Silver spring, Subcutaneous, Subcutaneous adipose tissue, Vegf, Visceral, Visceral adipose tissue, Westmead, Whole cohort, Young children.
Abstract
The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n = 71, [54 boys], 6.0 ± 4.3 years). Affymetrix microarrays (n = 20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. Likewise, qPCR performed in the whole cohort showed a 30‐fold increase in haptoglobin (P = 0.005), 7‐fold increase in IL‐10 (P < 0.001), 8‐fold decrease in VEGF (P = 0.01) and a 28‐fold decrease in TBOX15 (P < 0.001) in visceral compared to subcutaneous adipose tissue. The inflammatory pattern in visceral adipose tissue may represent an early stage of the adverse effects of this depot, and combined with chronic obesity, may contribute to increased metabolic and cardiovascular risk.
Url:
DOI: 10.3109/17477166.2011.575152
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Cowell</name><affiliation><mods:affiliation>Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead</wicri:regionArea></affiliation></author><author><name sortKey="Cowley, Mark J" sort="Cowley, Mark J" uniqKey="Cowley M" first="Mark J." last="Cowley">Mark J. Cowley</name><affiliation wicri:level="1"><mods:affiliation>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Sydney, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Kaplan, Warren" sort="Kaplan, Warren" uniqKey="Kaplan W" first="Warren" last="Kaplan">Warren Kaplan</name><affiliation wicri:level="1"><mods:affiliation>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Sydney, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Clement, Karine" sort="Clement, Karine" uniqKey="Clement K" first="Karine" last="Clément">Karine Clément</name><affiliation wicri:level="3"><mods:affiliation>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</mods:affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872</wicri:orgArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Assistance Publique‐Hôpitaux de Paris, Pitie‐Salpêtrière Hospital, Nutrition and Endocrinology Department, Paris, France, Centre de Recherche des Cordeliers, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique‐Hôpitaux de Paris, Pitie‐Salpêtrière Hospital, Nutrition and Endocrinology Department, Paris, France, Centre de Recherche des Cordeliers, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Baur, Louise A" sort="Baur, Louise A" uniqKey="Baur L" first="Louise A." last="Baur">Louise A. Baur</name><affiliation wicri:level="1"><mods:affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">International Journal of Pediatric Obesity</title><title level="j" type="alt">INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY</title><idno type="ISSN">1747-7166</idno><idno type="eISSN">1747-7174</idno><imprint><biblScope unit="vol">6</biblScope><biblScope unit="issue">2Part2</biblScope><biblScope unit="page" from="e360">e360</biblScope><biblScope unit="page" to="e363">e363</biblScope><biblScope unit="page-count">4</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-06">2011-06</date></imprint><idno type="ISSN">1747-7166</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1747-7166</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adiponectin</term><term>Adipose</term><term>Adipose tissue</term><term>Cardiovascular risk</term><term>Ccl5</term><term>Cell growth</term><term>Chemokine</term><term>Chronic obesity</term><term>Clin endocrinol metab</term><term>Cohort</term><term>Developmental genes</term><term>Differentially</term><term>Garvan institute</term><term>Gene</term><term>Gene expression</term><term>Genes ccl2</term><term>Growth factor</term><term>Haptoglobin</term><term>Haptoglobin mrna levels</term><term>Human adipose tissue</term><term>Insulin resistance</term><term>Leptin</term><term>Macrophage</term><term>Mediator</term><term>Medical research</term><term>Microarray</term><term>Microarray analyses</term><term>Mrna</term><term>Ndings</term><term>Neuronatin</term><term>Obes</term><term>Obes surg</term><term>Obese</term><term>Obese adults</term><term>Omental adipose tissue</term><term>Overweight children</term><term>Prepubertal</term><term>Prepubertal children</term><term>Receptor</term><term>Silver spring</term><term>Subcutaneous</term><term>Subcutaneous adipose tissue</term><term>Vegf</term><term>Visceral</term><term>Visceral adipose tissue</term><term>Westmead</term><term>Whole cohort</term><term>Young children</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adiponectin</term><term>Adipose</term><term>Adipose tissue</term><term>Cardiovascular risk</term><term>Ccl5</term><term>Cell growth</term><term>Chemokine</term><term>Chronic obesity</term><term>Clin endocrinol metab</term><term>Cohort</term><term>Developmental genes</term><term>Differentially</term><term>Garvan institute</term><term>Gene</term><term>Gene expression</term><term>Genes ccl2</term><term>Growth factor</term><term>Haptoglobin</term><term>Haptoglobin mrna levels</term><term>Human adipose tissue</term><term>Insulin resistance</term><term>Leptin</term><term>Macrophage</term><term>Mediator</term><term>Medical research</term><term>Microarray</term><term>Microarray analyses</term><term>Mrna</term><term>Ndings</term><term>Neuronatin</term><term>Obes</term><term>Obes surg</term><term>Obese</term><term>Obese adults</term><term>Omental adipose tissue</term><term>Overweight children</term><term>Prepubertal</term><term>Prepubertal children</term><term>Receptor</term><term>Silver spring</term><term>Subcutaneous</term><term>Subcutaneous adipose tissue</term><term>Vegf</term><term>Visceral</term><term>Visceral adipose tissue</term><term>Westmead</term><term>Whole cohort</term><term>Young children</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Médiateur</term><term>Recherche médicale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n = 71, [54 boys], 6.0 ± 4.3 years). Affymetrix microarrays (n = 20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. Likewise, qPCR performed in the whole cohort showed a 30‐fold increase in haptoglobin (P = 0.005), 7‐fold increase in IL‐10 (P < 0.001), 8‐fold decrease in VEGF (P = 0.01) and a 28‐fold decrease in TBOX15 (P < 0.001) in visceral compared to subcutaneous adipose tissue. The inflammatory pattern in visceral adipose tissue may represent an early stage of the adverse effects of this depot, and combined with chronic obesity, may contribute to increased metabolic and cardiovascular risk.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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