An early inflammatory gene profile in visceral adipose tissue in children
Identifieur interne : 000E86 ( Istex/Corpus ); précédent : 000E85; suivant : 000E87An early inflammatory gene profile in visceral adipose tissue in children
Auteurs : Charmaine S. Tam ; Leonie K. Heilbronn ; Corneliu Henegar ; Melanie Wong ; Christopher T. Cowell ; Mark J. Cowley ; Warren Kaplan ; Karine Clément ; Louise A. BaurSource :
- International Journal of Pediatric Obesity [ 1747-7166 ] ; 2011-06.
English descriptors
- KwdEn :
- Adiponectin, Adipose, Adipose tissue, Cardiovascular risk, Ccl5, Cell growth, Chemokine, Chronic obesity, Clin endocrinol metab, Cohort, Developmental genes, Differentially, Garvan institute, Gene, Gene expression, Genes ccl2, Growth factor, Haptoglobin, Haptoglobin mrna levels, Human adipose tissue, Insulin resistance, Leptin, Macrophage, Mediator, Medical research, Microarray, Microarray analyses, Mrna, Ndings, Neuronatin, Obes, Obes surg, Obese, Obese adults, Omental adipose tissue, Overweight children, Prepubertal, Prepubertal children, Receptor, Silver spring, Subcutaneous, Subcutaneous adipose tissue, Vegf, Visceral, Visceral adipose tissue, Westmead, Whole cohort, Young children.
- Teeft :
- Adiponectin, Adipose, Adipose tissue, Cardiovascular risk, Ccl5, Cell growth, Chemokine, Chronic obesity, Clin endocrinol metab, Cohort, Developmental genes, Differentially, Garvan institute, Gene, Gene expression, Genes ccl2, Growth factor, Haptoglobin, Haptoglobin mrna levels, Human adipose tissue, Insulin resistance, Leptin, Macrophage, Mediator, Medical research, Microarray, Microarray analyses, Mrna, Ndings, Neuronatin, Obes, Obes surg, Obese, Obese adults, Omental adipose tissue, Overweight children, Prepubertal, Prepubertal children, Receptor, Silver spring, Subcutaneous, Subcutaneous adipose tissue, Vegf, Visceral, Visceral adipose tissue, Westmead, Whole cohort, Young children.
Abstract
The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n = 71, [54 boys], 6.0 ± 4.3 years). Affymetrix microarrays (n = 20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. Likewise, qPCR performed in the whole cohort showed a 30‐fold increase in haptoglobin (P = 0.005), 7‐fold increase in IL‐10 (P < 0.001), 8‐fold decrease in VEGF (P = 0.01) and a 28‐fold decrease in TBOX15 (P < 0.001) in visceral compared to subcutaneous adipose tissue. The inflammatory pattern in visceral adipose tissue may represent an early stage of the adverse effects of this depot, and combined with chronic obesity, may contribute to increased metabolic and cardiovascular risk.
Url:
DOI: 10.3109/17477166.2011.575152
Links to Exploration step
ISTEX:4EAE5BC230129E85C244676EC19380E84E46E409Le document en format XML
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Tam</name><affiliation><mods:affiliation>Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead</mods:affiliation></affiliation><affiliation><mods:affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: charmaine.tam@pbrc.edu</mods:affiliation></affiliation></author><author><name sortKey="Heilbronn, Leonie K" sort="Heilbronn, Leonie K" uniqKey="Heilbronn L" first="Leonie K." last="Heilbronn">Leonie K. Heilbronn</name><affiliation><mods:affiliation>Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia</mods:affiliation></affiliation></author><author><name sortKey="Henegar, Corneliu" sort="Henegar, Corneliu" uniqKey="Henegar C" first="Corneliu" last="Henegar">Corneliu Henegar</name><affiliation><mods:affiliation>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</mods:affiliation></affiliation><affiliation><mods:affiliation>Assistance Publique‐Hôpitaux de Paris, Pitie‐Salpêtrière Hospital, Nutrition and Endocrinology Department, Paris, France, Centre de Recherche des Cordeliers, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Wong, Melanie" sort="Wong, Melanie" uniqKey="Wong M" first="Melanie" last="Wong">Melanie Wong</name><affiliation><mods:affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</mods:affiliation></affiliation></author><author><name sortKey="Cowell, Christopher T" sort="Cowell, Christopher T" uniqKey="Cowell C" first="Christopher T." last="Cowell">Christopher T. Cowell</name><affiliation><mods:affiliation>Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead</mods:affiliation></affiliation><affiliation><mods:affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</mods:affiliation></affiliation></author><author><name sortKey="Cowley, Mark J" sort="Cowley, Mark J" uniqKey="Cowley M" first="Mark J." last="Cowley">Mark J. Cowley</name><affiliation><mods:affiliation>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Sydney, Australia</mods:affiliation></affiliation></author><author><name sortKey="Kaplan, Warren" sort="Kaplan, Warren" uniqKey="Kaplan W" first="Warren" last="Kaplan">Warren Kaplan</name><affiliation><mods:affiliation>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Sydney, Australia</mods:affiliation></affiliation></author><author><name sortKey="Clement, Karine" sort="Clement, Karine" uniqKey="Clement K" first="Karine" last="Clément">Karine Clément</name><affiliation><mods:affiliation>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</mods:affiliation></affiliation><affiliation><mods:affiliation>Assistance Publique‐Hôpitaux de Paris, Pitie‐Salpêtrière Hospital, Nutrition and Endocrinology Department, Paris, France, Centre de Recherche des Cordeliers, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Baur, Louise A" sort="Baur, Louise A" uniqKey="Baur L" first="Louise A." last="Baur">Louise A. Baur</name><affiliation><mods:affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">International Journal of Pediatric Obesity</title><title level="j" type="alt">INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY</title><idno type="ISSN">1747-7166</idno><idno type="eISSN">1747-7174</idno><imprint><biblScope unit="vol">6</biblScope><biblScope unit="issue">2Part2</biblScope><biblScope unit="page" from="e360">e360</biblScope><biblScope unit="page" to="e363">e363</biblScope><biblScope unit="page-count">4</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-06">2011-06</date></imprint><idno type="ISSN">1747-7166</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1747-7166</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adiponectin</term><term>Adipose</term><term>Adipose tissue</term><term>Cardiovascular risk</term><term>Ccl5</term><term>Cell growth</term><term>Chemokine</term><term>Chronic obesity</term><term>Clin endocrinol metab</term><term>Cohort</term><term>Developmental genes</term><term>Differentially</term><term>Garvan institute</term><term>Gene</term><term>Gene expression</term><term>Genes ccl2</term><term>Growth factor</term><term>Haptoglobin</term><term>Haptoglobin mrna levels</term><term>Human adipose tissue</term><term>Insulin resistance</term><term>Leptin</term><term>Macrophage</term><term>Mediator</term><term>Medical research</term><term>Microarray</term><term>Microarray analyses</term><term>Mrna</term><term>Ndings</term><term>Neuronatin</term><term>Obes</term><term>Obes surg</term><term>Obese</term><term>Obese adults</term><term>Omental adipose tissue</term><term>Overweight children</term><term>Prepubertal</term><term>Prepubertal children</term><term>Receptor</term><term>Silver spring</term><term>Subcutaneous</term><term>Subcutaneous adipose tissue</term><term>Vegf</term><term>Visceral</term><term>Visceral adipose tissue</term><term>Westmead</term><term>Whole cohort</term><term>Young children</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adiponectin</term><term>Adipose</term><term>Adipose tissue</term><term>Cardiovascular risk</term><term>Ccl5</term><term>Cell growth</term><term>Chemokine</term><term>Chronic obesity</term><term>Clin endocrinol metab</term><term>Cohort</term><term>Developmental genes</term><term>Differentially</term><term>Garvan institute</term><term>Gene</term><term>Gene expression</term><term>Genes ccl2</term><term>Growth factor</term><term>Haptoglobin</term><term>Haptoglobin mrna levels</term><term>Human adipose tissue</term><term>Insulin resistance</term><term>Leptin</term><term>Macrophage</term><term>Mediator</term><term>Medical research</term><term>Microarray</term><term>Microarray analyses</term><term>Mrna</term><term>Ndings</term><term>Neuronatin</term><term>Obes</term><term>Obes surg</term><term>Obese</term><term>Obese adults</term><term>Omental adipose tissue</term><term>Overweight children</term><term>Prepubertal</term><term>Prepubertal children</term><term>Receptor</term><term>Silver spring</term><term>Subcutaneous</term><term>Subcutaneous adipose tissue</term><term>Vegf</term><term>Visceral</term><term>Visceral adipose tissue</term><term>Westmead</term><term>Whole cohort</term><term>Young children</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n = 71, [54 boys], 6.0 ± 4.3 years). Affymetrix microarrays (n = 20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. Likewise, qPCR performed in the whole cohort showed a 30‐fold increase in haptoglobin (P = 0.005), 7‐fold increase in IL‐10 (P < 0.001), 8‐fold decrease in VEGF (P = 0.01) and a 28‐fold decrease in TBOX15 (P < 0.001) in visceral compared to subcutaneous adipose tissue. The inflammatory pattern in visceral adipose tissue may represent an early stage of the adverse effects of this depot, and combined with chronic obesity, may contribute to increased metabolic and cardiovascular risk.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>adipose</json:string><json:string>subcutaneous</json:string><json:string>visceral adipose tissue</json:string><json:string>subcutaneous adipose tissue</json:string><json:string>haptoglobin</json:string><json:string>adipose tissue</json:string><json:string>obese</json:string><json:string>ccl5</json:string><json:string>adiponectin</json:string><json:string>mrna</json:string><json:string>ndings</json:string><json:string>mediator</json:string><json:string>obes</json:string><json:string>differentially</json:string><json:string>cohort</json:string><json:string>microarray</json:string><json:string>visceral</json:string><json:string>prepubertal</json:string><json:string>vegf</json:string><json:string>leptin</json:string><json:string>receptor</json:string><json:string>chemokine</json:string><json:string>westmead</json:string><json:string>whole cohort</json:string><json:string>macrophage</json:string><json:string>neuronatin</json:string><json:string>gene expression</json:string><json:string>obese adults</json:string><json:string>gene</json:string><json:string>medical research</json:string><json:string>overweight children</json:string><json:string>growth factor</json:string><json:string>cardiovascular risk</json:string><json:string>developmental genes</json:string><json:string>chronic obesity</json:string><json:string>microarray analyses</json:string><json:string>genes ccl2</json:string><json:string>cell growth</json:string><json:string>insulin resistance</json:string><json:string>haptoglobin mrna levels</json:string><json:string>prepubertal children</json:string><json:string>omental adipose tissue</json:string><json:string>young children</json:string><json:string>human adipose tissue</json:string><json:string>garvan institute</json:string><json:string>obes surg</json:string><json:string>silver spring</json:string><json:string>clin endocrinol metab</json:string></teeft></keywords><author><json:item><name>Dr CHARMAINE S. TAM</name><affiliations><json:string>Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead</json:string><json:string>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</json:string><json:string>Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia</json:string><json:string>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</json:string><json:string>E-mail: charmaine.tam@pbrc.edu</json:string></affiliations></json:item><json:item><name>LEONIE K. HEILBRONN</name><affiliations><json:string>Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia</json:string></affiliations></json:item><json:item><name>CORNELIU HENEGAR</name><affiliations><json:string>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</json:string><json:string>Assistance Publique‐Hôpitaux de Paris, Pitie‐Salpêtrière Hospital, Nutrition and Endocrinology Department, Paris, France, Centre de Recherche des Cordeliers, Paris, France</json:string></affiliations></json:item><json:item><name>MELANIE WONG</name><affiliations><json:string>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</json:string></affiliations></json:item><json:item><name>CHRISTOPHER T. COWELL</name><affiliations><json:string>Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead</json:string><json:string>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</json:string></affiliations></json:item><json:item><name>MARK J. COWLEY</name><affiliations><json:string>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Sydney, Australia</json:string></affiliations></json:item><json:item><name>WARREN KAPLAN</name><affiliations><json:string>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Sydney, Australia</json:string></affiliations></json:item><json:item><name>KARINE CLÉMENT</name><affiliations><json:string>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</json:string><json:string>Assistance Publique‐Hôpitaux de Paris, Pitie‐Salpêtrière Hospital, Nutrition and Endocrinology Department, Paris, France, Centre de Recherche des Cordeliers, Paris, France</json:string></affiliations></json:item><json:item><name>LOUISE A. BAUR</name><affiliations><json:string>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Inflammation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>visceral</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>adipose tissue</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>children</value></json:item></subject><articleId><json:string>IJPO333</json:string></articleId><arkIstex>ark:/67375/WNG-ZMF4X3PW-C</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>shortCommunication</json:string></originalGenre><abstract>The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n = 71, [54 boys], 6.0 ± 4.3 years). Affymetrix microarrays (n = 20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. Likewise, qPCR performed in the whole cohort showed a 30‐fold increase in haptoglobin (P = 0.005), 7‐fold increase in IL‐10 (P > 0.001), 8‐fold decrease in VEGF (P = 0.01) and a 28‐fold decrease in TBOX15 (P > 0.001) in visceral compared to subcutaneous adipose tissue. The inflammatory pattern in visceral adipose tissue may represent an early stage of the adverse effects of this depot, and combined with chronic obesity, may contribute to increased metabolic and cardiovascular risk.</abstract><qualityIndicators><score>6.15</score><pdfWordCount>2158</pdfWordCount><pdfCharCount>14020</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>4</pdfPageCount><pdfPageSize>609.449 x 793.701 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>166</abstractWordCount><abstractCharCount>1087</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>An early inflammatory gene profile in visceral adipose tissue in children</title><pmid><json:string>21609243</json:string></pmid><genre><json:string>brief-communication</json:string></genre><host><title>International Journal of Pediatric Obesity</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1747-7174</json:string></doi><issn><json:string>1747-7166</json:string></issn><eissn><json:string>1747-7174</json:string></eissn><publisherId><json:string>IJPO</json:string></publisherId><volume>6</volume><issue>2Part2</issue><pages><first>e360</first><last>e363</last><total>4</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2011</json:string></date><geogName></geogName><orgName><json:string>Pennington Biomedical Research Center Baton Rouge, LA</json:string><json:string>Department of Surgery and Anaesthesia</json:string><json:string>Research Training</json:string><json:string>Department of Histopathology</json:string><json:string>Garvan Institute of Medical Research, Sydney, Australia Abstract The</json:string><json:string>University of Sydney</json:string><json:string>National Heart Foundation of Australia Postgraduate Biomedical Scholarship</json:string><json:string>University of New South Wales</json:string><json:string>Australian National Health and Medical Research</json:string><json:string>Obesity Research Program, The Garvan Institute of Medical Research, Australia</json:string><json:string>US Centers for Disease</json:string><json:string>Institute of Weight Control</json:string><json:string>Diabetes Australia Research Trust Grant</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Peter Wills</json:string><json:string>Brancatisano</json:string><json:string>Hospital</json:string><json:string>To</json:string><json:string>Eric Ravussin</json:string><json:string>Tony</json:string><json:string>Charmaine Tam</json:string><json:string>Roy</json:string></persName><placeName><json:string>Paris</json:string><json:string>Germany</json:string><json:string>Australia</json:string><json:string>Darmstadt</json:string><json:string>France</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Sbarbati et al.</json:string><json:string>Sabin et al.</json:string><json:string>C. S. Tam et al.</json:string><json:string>Control and Prevention 2000</json:string><json:string>Vohl et al</json:string><json:string>Li et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-ZMF4X3PW-C</json:string></ark><categories><wos></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - endocrinology & metabolism</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Public Health, Environmental and Occupational Health</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Nursing</json:string><json:string>3 - Nutrition and Dietetics</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Health Policy</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Pediatrics, Perinatology, and Child Health</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.3109/17477166.2011.575152</json:string></doi><id>4EAE5BC230129E85C244676EC19380E84E46E409</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/4EAE5BC230129E85C244676EC19380E84E46E409/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/4EAE5BC230129E85C244676EC19380E84E46E409/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/4EAE5BC230129E85C244676EC19380E84E46E409/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">An early inflammatory gene profile in visceral adipose tissue in children</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>2011 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted</licence></availability><date type="published" when="2011-06"></date></publicationStmt><notesStmt><note type="content-type" subtype="brief-communication" source="shortCommunication" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="brief-communication"><analytic><title level="a" type="main">An early inflammatory gene profile in visceral adipose tissue in children</title><author xml:id="author-0000" role="corresp"><persName><addName>Dr</addName><forename type="first">CHARMAINE S.</forename><surname>TAM</surname></persName><affiliation>Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead</affiliation><affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia<address><country key="AU"></country></address></affiliation><affiliation>Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia<address><country key="AU"></country></address></affiliation><affiliation>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</affiliation><affiliation>currently at Pennington Biomedical Research Center Baton Rouge, LA, 70808, USA. Tel: +1 225 763 2778. Fax: +1 225 763 3030. Email: charmaine.tam@pbrc.edu</affiliation></author><author xml:id="author-0001"><persName><forename type="first">LEONIE K.</forename><surname>HEILBRONN</surname></persName><affiliation>Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">CORNELIU</forename><surname>HENEGAR</surname></persName><affiliation>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</affiliation><affiliation>Assistance Publique‐Hôpitaux de Paris, Pitie‐Salpêtrière Hospital, Nutrition and Endocrinology Department, Paris, France, Centre de Recherche des Cordeliers, Paris, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">MELANIE</forename><surname>WONG</surname></persName><affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">CHRISTOPHER T.</forename><surname>COWELL</surname></persName><affiliation>Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead</affiliation><affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">MARK J.</forename><surname>COWLEY</surname></persName><affiliation>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Sydney, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">WARREN</forename><surname>KAPLAN</surname></persName><affiliation>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Sydney, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">KARINE</forename><surname>CLÉMENT</surname></persName><affiliation>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</affiliation><affiliation>Assistance Publique‐Hôpitaux de Paris, Pitie‐Salpêtrière Hospital, Nutrition and Endocrinology Department, Paris, France, Centre de Recherche des Cordeliers, Paris, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">LOUISE A.</forename><surname>BAUR</surname></persName><affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia<address><country key="AU"></country></address></affiliation></author><idno type="istex">4EAE5BC230129E85C244676EC19380E84E46E409</idno><idno type="ark">ark:/67375/WNG-ZMF4X3PW-C</idno><idno type="DOI">10.3109/17477166.2011.575152</idno><idno type="unit">IJPO333</idno><idno type="toTypesetVersion">file:IJPO.IJPO333.pdf</idno></analytic><monogr><title level="j" type="main">International Journal of Pediatric Obesity</title><title level="j" type="alt">INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY</title><idno type="pISSN">1747-7166</idno><idno type="eISSN">1747-7174</idno><idno type="book-DOI">10.1111/(ISSN)1747-7174</idno><idno type="book-part-DOI">10.1111/ijpo.2011.6.issue-2-2</idno><idno type="product">IJPO</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">6</biblScope><biblScope unit="issue">2Part2</biblScope><biblScope unit="page" from="e360">e360</biblScope><biblScope unit="page" to="e363">e363</biblScope><biblScope unit="page-count">4</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-06"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (<hi rend="italic">n</hi> = 71, [54 boys], 6.0 ± 4.3 years). Affymetrix microarrays (<hi rend="italic">n</hi> = 20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. Likewise, qPCR performed in the whole cohort showed a 30‐fold increase in haptoglobin (<hi rend="italic">P</hi> = 0.005), 7‐fold increase in IL‐10 (<hi rend="italic">P</hi> < 0.001), 8‐fold decrease in VEGF (<hi rend="italic">P</hi> = 0.01) and a 28‐fold decrease in TBOX15 (<hi rend="italic">P</hi> < 0.001) in visceral compared to subcutaneous adipose tissue. The inflammatory pattern in visceral adipose tissue may represent an early stage of the adverse effects of this depot, and combined with chronic obesity, may contribute to increased metabolic and cardiovascular risk.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">Inflammation</term><term xml:id="k2">visceral</term><term xml:id="k3">adipose tissue</term><term xml:id="k4">children</term></keywords><keywords rend="tocHeading1"><term>Short Communication</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/4EAE5BC230129E85C244676EC19380E84E46E409/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1747-7174</doi><issn type="print">1747-7166</issn><issn type="electronic">1747-7174</issn><idGroup><id type="product" value="IJPO"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY">International Journal of Pediatric Obesity</title></titleGroup></publicationMeta><publicationMeta level="part" position="06100"><doi origin="wiley">10.1111/ijpo.2011.6.issue-2-2</doi><numberingGroup><numbering type="journalVolume" number="6">6</numbering><numbering type="journalIssue">2Part2</numbering></numberingGroup><coverDate startDate="2011-06">June 2011</coverDate></publicationMeta><publicationMeta level="unit" type="shortCommunication" position="44" status="forIssue"><doi origin="wiley">10.3109/17477166.2011.575152</doi><idGroup><id type="unit" value="IJPO333"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="tocHeading1">Short Communication</title></titleGroup><copyright>2011 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.1.6 mode:FullText" date="2012-08-24"></event><event type="firstOnline" date="2012-08-24"></event><event type="publishedOnlineFinalForm" date="2012-08-24"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-28"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-23"></event></eventGroup><numberingGroup><numbering type="pageFirst">e360</numbering><numbering type="pageLast">e363</numbering></numberingGroup><correspondenceTo> currently at Pennington Biomedical Research Center Baton Rouge, LA, 70808, USA. Tel: +1 225 763 2778. Fax: +1 225 763 3030. Email: <email>charmaine.tam@pbrc.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:IJPO.IJPO333.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 19 October 2010; final version received 25 February 2011</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="0"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="18"></count><count type="linksCrossRef" number="41"></count></countGroup><titleGroup><title type="main">An early inflammatory gene profile in visceral adipose tissue in children</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2 #a3 #a4" corresponding="yes"><personName><honorifics>Dr</honorifics><givenNames>CHARMAINE S.</givenNames><familyName>TAM</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a3"><personName><givenNames>LEONIE K.</givenNames><familyName>HEILBRONN</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a4 #a5"><personName><givenNames>CORNELIU</givenNames><familyName>HENEGAR</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2"><personName><givenNames>MELANIE</givenNames><familyName>WONG</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1 #a2"><personName><givenNames>CHRISTOPHER T.</givenNames><familyName>COWELL</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a6"><personName><givenNames>MARK J.</givenNames><familyName>COWLEY</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a6"><personName><givenNames>WARREN</givenNames><familyName>KAPLAN</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a4 #a5"><personName><givenNames>KARINE</givenNames><familyName>CLÉMENT</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a2"><personName><givenNames>LOUISE A.</givenNames><familyName>BAUR</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="AU"><unparsedAffiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="AU"><unparsedAffiliation>Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia</unparsedAffiliation></affiliation><affiliation xml:id="a4"><unparsedAffiliation>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="FR"><unparsedAffiliation>Assistance Publique‐Hôpitaux de Paris, Pitie‐Salpêtrière Hospital, Nutrition and Endocrinology Department, Paris, France, Centre de Recherche des Cordeliers, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="AU"><unparsedAffiliation>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Sydney, Australia</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Inflammation</keyword><keyword xml:id="k2">visceral</keyword><keyword xml:id="k3">adipose tissue</keyword><keyword xml:id="k4">children</keyword></keywordGroup><supportingInformation><p>Supporting Information</p><supportingInfoItem><mediaResource alt="supporting info item" href="urn-x:wiley:17477166:media:ijpo333:ijpo_333_sm_suppl"></mediaResource><caption>Supporting info item</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (<i>n</i> = 71, [54 boys], 6.0 ± 4.3 years). Affymetrix microarrays (<i>n</i> = 20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. Likewise, qPCR performed in the whole cohort showed a 30‐fold increase in haptoglobin (<i>P</i> = 0.005), 7‐fold increase in IL‐10 (<i>P</i> < 0.001), 8‐fold decrease in VEGF (<i>P</i> = 0.01) and a 28‐fold decrease in TBOX15 (<i>P</i> < 0.001) in visceral compared to subcutaneous adipose tissue. The inflammatory pattern in visceral adipose tissue may represent an early stage of the adverse effects of this depot, and combined with chronic obesity, may contribute to increased metabolic and cardiovascular risk.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>An early inflammatory gene profile in visceral adipose tissue in children</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>An early inflammatory gene profile in visceral adipose tissue in children</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Dr</namePart><namePart type="given">CHARMAINE S.</namePart><namePart type="family">TAM</namePart><affiliation>Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead</affiliation><affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</affiliation><affiliation>Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia</affiliation><affiliation>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</affiliation><affiliation>E-mail: charmaine.tam@pbrc.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LEONIE K.</namePart><namePart type="family">HEILBRONN</namePart><affiliation>Diabetes and Obesity Research Program, The Garvan Institute of Medical Research, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CORNELIU</namePart><namePart type="family">HENEGAR</namePart><affiliation>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</affiliation><affiliation>Assistance Publique‐Hôpitaux de Paris, Pitie‐Salpêtrière Hospital, Nutrition and Endocrinology Department, Paris, France, Centre de Recherche des Cordeliers, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MELANIE</namePart><namePart type="family">WONG</namePart><affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CHRISTOPHER T.</namePart><namePart type="family">COWELL</namePart><affiliation>Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead</affiliation><affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MARK J.</namePart><namePart type="family">COWLEY</namePart><affiliation>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Sydney, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WARREN</namePart><namePart type="family">KAPLAN</namePart><affiliation>Peter Wills Bioinfomatics Centre, The Garvan Institute of Medical Research, Sydney, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KARINE</namePart><namePart type="family">CLÉMENT</namePart><affiliation>INSERM, U872 (Eq.7), Nutriomique, Paris, UniversitÉ Pierre et Marie Curie, Paris 6, Centre de Recherche des Cordeliers, UMRS 872, Paris</affiliation><affiliation>Assistance Publique‐Hôpitaux de Paris, Pitie‐Salpêtrière Hospital, Nutrition and Endocrinology Department, Paris, France, Centre de Recherche des Cordeliers, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LOUISE A.</namePart><namePart type="family">BAUR</namePart><affiliation>Discipline of Paediatrics and Child Health, The Children's Hospital at Westmead Clinical School, University of Sydney, Westmead, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="shortCommunication" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-06</dateIssued><edition>Received 19 October 2010; final version received 25 February 2011</edition><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">0</extent><extent unit="formulas">0</extent><extent unit="references">18</extent><extent unit="linksCrossRef">41</extent></physicalDescription><abstract lang="en">The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n = 71, [54 boys], 6.0 ± 4.3 years). Affymetrix microarrays (n = 20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. Likewise, qPCR performed in the whole cohort showed a 30‐fold increase in haptoglobin (P = 0.005), 7‐fold increase in IL‐10 (P < 0.001), 8‐fold decrease in VEGF (P = 0.01) and a 28‐fold decrease in TBOX15 (P < 0.001) in visceral compared to subcutaneous adipose tissue. The inflammatory pattern in visceral adipose tissue may represent an early stage of the adverse effects of this depot, and combined with chronic obesity, may contribute to increased metabolic and cardiovascular risk.</abstract><subject lang="en"><genre>keywords</genre><topic>Inflammation</topic><topic>visceral</topic><topic>adipose tissue</topic><topic>children</topic></subject><relatedItem type="host"><titleInfo><title>International Journal of Pediatric Obesity</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><note type="content"> Supporting InformationSupporting Info Item: Supporting info item - </note><identifier type="ISSN">1747-7166</identifier><identifier type="eISSN">1747-7174</identifier><identifier type="DOI">10.1111/(ISSN)1747-7174</identifier><identifier type="PublisherID">IJPO</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><detail type="issue"><caption>no.</caption><number>2Part2</number></detail><extent unit="pages"><start>e360</start><end>e363</end><total>4</total></extent></part></relatedItem><identifier type="istex">4EAE5BC230129E85C244676EC19380E84E46E409</identifier><identifier type="ark">ark:/67375/WNG-ZMF4X3PW-C</identifier><identifier type="DOI">10.3109/17477166.2011.575152</identifier><identifier type="ArticleID">IJPO333</identifier><accessCondition type="use and reproduction" contentType="copyright">2011 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/4EAE5BC230129E85C244676EC19380E84E46E409/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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