AustralieFrV1, Main, Curation, bibRecord, 003365

Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV Observational Database (TApHOD)

Identifieur interne : 003365 ( Main/Curation ); précédent : 003364; suivant : 003366

Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV Observational Database (TApHOD)

Auteurs : Azar Kariminia [Australie] ; Nicolas Durier [Thaïlande] ; Gonzague Jourdain [Thaïlande] ; Suneeta Saghayam [Inde] ; Chau V. Do [Viêt Nam] ; Lam Van Nguyên [Viêt Nam] ; Rawiwan Hansudewechakul [Thaïlande] ; Pagakrong Lumbiganon [Thaïlande] ; Kulkanya Chokephaibulkit [Thaïlande] ; Khanh Huu Truong [Viêt Nam] ; Virat Sirisanthana [Thaïlande] ; Vibol Ung [Cambodge] ; Saphonn Vonthanak [Cambodge] ; Jintanat Ananworanich [Thaïlande] ; Nik Khairulddin N. Yusoff [Malaisie] ; Nia Kurniati [Indonésie] ; Kamarul Azahar Razali [Malaisie] ; Moy Siew Fong [Malaisie] ; Revathy Nallusamy [Malaisie] ; Dewi Kumara Wati [Indonésie]

Source :

Journal of acquired immune deficiency syndromes (1999) [ 1525-4135 ] ; 2014.

RBID : PMC:4134392

Descripteurs français

KwdFr :
- Adolescent, Agents antiVIH (usage thérapeutique), Asie, Charge virale, Enfant, Enfant d'âge préscolaire, Estimation de Kaplan-Meier, Femelle, Humains, Infections à VIH (physiopathologie), Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Modèles de hasards proportionnels, Mâle, Numération des lymphocytes CD4, Poids du corps (physiologie), Taille (physiologie), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification), Échec thérapeutique, Études de cohortes, Évolution de la maladie.
MESH :
- isolement et purification : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- physiologie : Poids du corps, Taille.
- physiopathologie : Infections à VIH.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH.
- virologie : Infections à VIH.
- Adolescent, Asie, Charge virale, Enfant, Enfant d'âge préscolaire, Estimation de Kaplan-Meier, Femelle, Humains, Modèles de hasards proportionnels, Mâle, Numération des lymphocytes CD4, Échec thérapeutique, Études de cohortes, Évolution de la maladie.

English descriptors

KwdEn :
- Adolescent, Anti-HIV Agents (therapeutic use), Asia, Body Height (physiology), Body Weight (physiology), CD4 Lymphocyte Count, Child, Child, Preschool, Cohort Studies, Disease Progression, Female, HIV Infections (drug therapy), HIV Infections (physiopathology), HIV Infections (virology), HIV-1 (isolation & purification), Humans, Kaplan-Meier Estimate, Male, Proportional Hazards Models, Treatment Failure, Viral Load.
MESH :
- chemical , therapeutic use : Anti-HIV Agents.
- geographic : Asia.
- drug therapy : HIV Infections.
- isolation & purification : HIV-1.
- physiology : Body Height, Body Weight.
- physiopathology : HIV Infections.
- virology : HIV Infections.
- Adolescent, CD4 Lymphocyte Count, Child, Child, Preschool, Cohort Studies, Disease Progression, Female, Humans, Kaplan-Meier Estimate, Male, Proportional Hazards Models, Treatment Failure, Viral Load.

Abstract

Objective

To evaluate the value of time-updated weight and height in predicting clinical progression, immunological and virological failure in children receiving combination antiretroviral therapy (cART).

Methods

We used Cox regression to analyse data of a cohort of Asian children.

Results

2608 children were included; median age at cART was 5.7 years. Time-updated weight for age Z score <−3 was associated with mortality (P < 0.001) independent of CD4%; and <−2 was associated with immunological failure (P ≤ 0.03) independent of age at cART.

Conclusion

Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134392

DOI: 10.1097/QAI.0000000000000227
PubMed: 24872132
PubMed Central: 4134392

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Le document en format XML

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<author><name sortKey="Lumbiganon, Pagakrong" sort="Lumbiganon, Pagakrong" uniqKey="Lumbiganon P" first="Pagakrong" last="Lumbiganon">Pagakrong Lumbiganon</name>
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</affiliation>
</author>
<author><name sortKey="Vonthanak, Saphonn" sort="Vonthanak, Saphonn" uniqKey="Vonthanak S" first="Saphonn" last="Vonthanak">Saphonn Vonthanak</name>
<affiliation wicri:level="1"><nlm:aff id="A13">National Centre for HIV/AIDS, Dermatology and STDs, Phnom Penh, Cambodia</nlm:aff>
<country xml:lang="fr">Cambodge</country>
<wicri:regionArea>National Centre for HIV/AIDS, Dermatology and STDs, Phnom Penh</wicri:regionArea>
<wicri:noRegion>Phnom Penh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ananworanich, Jintanat" sort="Ananworanich, Jintanat" uniqKey="Ananworanich J" first="Jintanat" last="Ananworanich">Jintanat Ananworanich</name>
<affiliation wicri:level="1"><nlm:aff id="A14">HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand</nlm:aff>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yusoff, Nik Khairulddin N" sort="Yusoff, Nik Khairulddin N" uniqKey="Yusoff N" first="Nik Khairulddin N." last="Yusoff">Nik Khairulddin N. Yusoff</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Hospital Raja Perempuan Zainab II, Kelantan, Malaysia</nlm:aff>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Hospital Raja Perempuan Zainab II, Kelantan</wicri:regionArea>
<wicri:noRegion>Kelantan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kurniati, Nia" sort="Kurniati, Nia" uniqKey="Kurniati N" first="Nia" last="Kurniati">Nia Kurniati</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Cipto Mangunkusumo General Hospital, Jakarta, Indonesia</nlm:aff>
<country xml:lang="fr">Indonésie</country>
<wicri:regionArea>Cipto Mangunkusumo General Hospital, Jakarta</wicri:regionArea>
<wicri:noRegion>Jakarta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Razali, Kamarul Azahar" sort="Razali, Kamarul Azahar" uniqKey="Razali K" first="Kamarul Azahar" last="Razali">Kamarul Azahar Razali</name>
<affiliation wicri:level="1"><nlm:aff id="A17">Pediatric Institute, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia</nlm:aff>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Pediatric Institute, Hospital Kuala Lumpur, Kuala Lumpur</wicri:regionArea>
<wicri:noRegion>Kuala Lumpur</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fong, Moy Siew" sort="Fong, Moy Siew" uniqKey="Fong M" first="Moy Siew" last="Fong">Moy Siew Fong</name>
<affiliation wicri:level="1"><nlm:aff id="A18">Hospital Likas, Kota Kinabalu, Malaysia</nlm:aff>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Hospital Likas, Kota Kinabalu</wicri:regionArea>
<wicri:noRegion>Kota Kinabalu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nallusamy, Revathy" sort="Nallusamy, Revathy" uniqKey="Nallusamy R" first="Revathy" last="Nallusamy">Revathy Nallusamy</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Penang Hospital, Penang, Malaysia</nlm:aff>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Penang Hospital, Penang</wicri:regionArea>
<wicri:noRegion>Penang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wati, Dewi Kumara" sort="Wati, Dewi Kumara" uniqKey="Wati D" first="Dewi Kumara" last="Wati">Dewi Kumara Wati</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Sanglah Hospital, Udayana University, Bali, Indonesia</nlm:aff>
<country xml:lang="fr">Indonésie</country>
<wicri:regionArea>Sanglah Hospital, Udayana University, Bali</wicri:regionArea>
<wicri:noRegion>Bali</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title>
<idno type="ISSN">1525-4135</idno>
<idno type="eISSN">1944-7884</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Anti-HIV Agents (therapeutic use)</term>
<term>Asia</term>
<term>Body Height (physiology)</term>
<term>Body Weight (physiology)</term>
<term>CD4 Lymphocyte Count</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Cohort Studies</term>
<term>Disease Progression</term>
<term>Female</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (physiopathology)</term>
<term>HIV Infections (virology)</term>
<term>HIV-1 (isolation & purification)</term>
<term>Humans</term>
<term>Kaplan-Meier Estimate</term>
<term>Male</term>
<term>Proportional Hazards Models</term>
<term>Treatment Failure</term>
<term>Viral Load</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Agents antiVIH (usage thérapeutique)</term>
<term>Asie</term>
<term>Charge virale</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Estimation de Kaplan-Meier</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à VIH (physiopathologie)</term>
<term>Infections à VIH (traitement médicamenteux)</term>
<term>Infections à VIH (virologie)</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Numération des lymphocytes CD4</term>
<term>Poids du corps (physiologie)</term>
<term>Taille (physiologie)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification)</term>
<term>Échec thérapeutique</term>
<term>Études de cohortes</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Asia</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Poids du corps</term>
<term>Taille</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Body Height</term>
<term>Body Weight</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>CD4 Lymphocyte Count</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Cohort Studies</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Kaplan-Meier Estimate</term>
<term>Male</term>
<term>Proportional Hazards Models</term>
<term>Treatment Failure</term>
<term>Viral Load</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Asie</term>
<term>Charge virale</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Estimation de Kaplan-Meier</term>
<term>Femelle</term>
<term>Humains</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Numération des lymphocytes CD4</term>
<term>Échec thérapeutique</term>
<term>Études de cohortes</term>
<term>Évolution de la maladie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">To evaluate the value of time-updated weight and height in predicting clinical progression, immunological and virological failure in children receiving combination antiretroviral therapy (cART).</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We used Cox regression to analyse data of a cohort of Asian children.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">2608 children were included; median age at cART was 5.7 years. Time-updated weight for age Z score <−3 was associated with mortality (<italic>P</italic>
 < 0.001) independent of CD4%; and <−2 was associated with immunological failure (<italic>P</italic>
 ≤ 0.03) independent of age at cART.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.</p>
</sec>
</div>
</front>
</TEI>
</record>

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Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV Observational Database (TApHOD)

Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV Observational Database (TApHOD)

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