Weight as predictors of clinical progression and treatment failure: results from the TREAT Asia Pediatric HIV Observational Database.
Identifieur interne : 003403 ( PubMed/Curation ); précédent : 003402; suivant : 003404Weight as predictors of clinical progression and treatment failure: results from the TREAT Asia Pediatric HIV Observational Database.
Auteurs : Azar Kariminia [Indonésie] ; Nicolas Durier ; Gonzague Jourdain ; Suneeta Saghayam ; Chau V. Do ; Lam Van Nguyen ; Rawiwan Hansudewechakul ; Pagakrong Lumbiganon ; Kulkanya Chokephaibulkit ; Khanh Huu Truong ; Virat Sirisanthana ; Vibol Ung ; Saphonn Vonthanak ; Jintanat Ananworanich ; Nik Khairulddin Nik Yusoff ; Nia Kurniati ; Kamarul Azahar Razali ; Moy Siew Fong ; Revathy Nallusamy ; Dewi Kumara WatiSource :
- Journal of acquired immune deficiency syndromes (1999) [ 1944-7884 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Agents antiVIH (usage thérapeutique), Asie, Charge virale, Enfant, Enfant d'âge préscolaire, Estimation de Kaplan-Meier, Femelle, Humains, Infections à VIH (physiopathologie), Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Modèles de hasards proportionnels, Mâle, Numération des lymphocytes CD4, Poids du corps (physiologie), Taille (physiologie), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification), Échec thérapeutique, Études de cohortes, Évolution de la maladie.
- MESH :
- isolement et purification : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- physiologie : Poids du corps, Taille.
- physiopathologie : Infections à VIH.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH.
- virologie : Infections à VIH.
- Adolescent, Asie, Charge virale, Enfant, Enfant d'âge préscolaire, Estimation de Kaplan-Meier, Femelle, Humains, Modèles de hasards proportionnels, Mâle, Numération des lymphocytes CD4, Échec thérapeutique, Études de cohortes, Évolution de la maladie.
English descriptors
- KwdEn :
- Adolescent, Anti-HIV Agents (therapeutic use), Asia, Body Height (physiology), Body Weight (physiology), CD4 Lymphocyte Count, Child, Child, Preschool, Cohort Studies, Disease Progression, Female, HIV Infections (drug therapy), HIV Infections (physiopathology), HIV Infections (virology), HIV-1 (isolation & purification), Humans, Kaplan-Meier Estimate, Male, Proportional Hazards Models, Treatment Failure, Viral Load.
- MESH :
- chemical , therapeutic use : Anti-HIV Agents.
- geographic : Asia.
- drug therapy : HIV Infections.
- isolation & purification : HIV-1.
- physiology : Body Height, Body Weight.
- physiopathology : HIV Infections.
- virology : HIV Infections.
- Adolescent, CD4 Lymphocyte Count, Child, Child, Preschool, Cohort Studies, Disease Progression, Female, Humans, Kaplan-Meier Estimate, Male, Proportional Hazards Models, Treatment Failure, Viral Load.
Abstract
To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART).
DOI: 10.1097/QAI.0000000000000227
PubMed: 24872132
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†TREAT Asia/amfAR-The Foundation for AIDS Research, Bangkok, Thailand; ‡Programs for HIV Prevention and Treatment, Institut de Recherche pour le Développement, France, and Chiang Mai University, Chiang Mai, Thailand; §YR Gaitonde Centre for AIDS Research and Education, Chennai, India; ‖Infectious Disease Department, Children's Hospital 2, Ho Chi Minh City, Vietnam; ¶Infectious Disease Department, National Hospital of Pediatrics, Hanoi, Vietnam; #Pediatric Department, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; **Pediatric Department , Khon Kaen University, Khon Kaen, Thailand; ††Pediatric Department , Siriraj Hospital, Mahidol University, Bangkok, Thailand; ‡‡Infectious Disease Department, Children's Hospital 1, Ho Chi Minh City, Vietnam; §§Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; ‖‖TB/HIV Department, National Pediatric Hospital, Phnom Penh, Cambodia; ¶¶Research Unit, National Centre for HIV/AIDS, Dermatology and STDs, Phnom Penh, Cambodia; ##HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; ***Department of Pediatrics, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia; †††Pediatric Allergy-Immunology Division, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; ‡‡‡Pediatric Institute, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia; §§§Department of Pediatrics, Hospital Likas, Kota Kinabalu, Malaysia; ‖‖‖Department of Pediatrics, Penang Hospital, Penang, Malaysia; and ¶¶¶Allergy-Immunology Division, Sanglah Hospital, Udayana University, Bali, Indonesia.</nlm:affiliation><country xml:lang="fr">Indonésie</country><wicri:regionArea>*The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, Australia; †TREAT Asia/amfAR-The Foundation for AIDS Research, Bangkok, Thailand; ‡Programs for HIV Prevention and Treatment, Institut de Recherche pour le Développement, France, and Chiang Mai University, Chiang Mai, Thailand; §YR Gaitonde Centre for AIDS Research and Education, Chennai, India; ‖Infectious Disease Department, Children's Hospital 2, Ho Chi Minh City, Vietnam; ¶Infectious Disease Department, National Hospital of Pediatrics, Hanoi, Vietnam; #Pediatric Department, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; **Pediatric Department , Khon Kaen University, Khon Kaen, Thailand; ††Pediatric Department , Siriraj Hospital, Mahidol University, Bangkok, Thailand; ‡‡Infectious Disease Department, Children's Hospital 1, Ho Chi Minh City, Vietnam; §§Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; ‖‖TB/HIV Department, National Pediatric Hospital, Phnom Penh, Cambodia; ¶¶Research Unit, National Centre for HIV/AIDS, Dermatology and STDs, Phnom Penh, Cambodia; ##HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; ***Department of Pediatrics, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia; †††Pediatric Allergy-Immunology Division, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; ‡‡‡Pediatric Institute, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia; §§§Department of Pediatrics, Hospital Likas, Kota Kinabalu, Malaysia; ‖‖‖Department of Pediatrics, Penang Hospital, Penang, Malaysia; and ¶¶¶Allergy-Immunology Division, Sanglah Hospital, Udayana University, Bali</wicri:regionArea></affiliation></author><author><name sortKey="Durier, Nicolas" sort="Durier, Nicolas" uniqKey="Durier N" first="Nicolas" last="Durier">Nicolas Durier</name></author><author><name sortKey="Jourdain, Gonzague" sort="Jourdain, Gonzague" uniqKey="Jourdain G" first="Gonzague" last="Jourdain">Gonzague Jourdain</name></author><author><name sortKey="Saghayam, Suneeta" sort="Saghayam, Suneeta" uniqKey="Saghayam S" first="Suneeta" last="Saghayam">Suneeta Saghayam</name></author><author><name sortKey="Do, Chau V" sort="Do, Chau V" uniqKey="Do C" first="Chau V" last="Do">Chau V. Do</name></author><author><name sortKey="Nguyen, Lam Van" sort="Nguyen, Lam Van" uniqKey="Nguyen L" first="Lam Van" last="Nguyen">Lam Van Nguyen</name></author><author><name sortKey="Hansudewechakul, Rawiwan" sort="Hansudewechakul, Rawiwan" uniqKey="Hansudewechakul R" first="Rawiwan" last="Hansudewechakul">Rawiwan Hansudewechakul</name></author><author><name sortKey="Lumbiganon, Pagakrong" sort="Lumbiganon, Pagakrong" uniqKey="Lumbiganon P" first="Pagakrong" last="Lumbiganon">Pagakrong Lumbiganon</name></author><author><name sortKey="Chokephaibulkit, Kulkanya" sort="Chokephaibulkit, Kulkanya" uniqKey="Chokephaibulkit K" first="Kulkanya" last="Chokephaibulkit">Kulkanya Chokephaibulkit</name></author><author><name sortKey="Truong, Khanh Huu" sort="Truong, Khanh Huu" uniqKey="Truong K" first="Khanh Huu" last="Truong">Khanh Huu Truong</name></author><author><name sortKey="Sirisanthana, Virat" sort="Sirisanthana, Virat" uniqKey="Sirisanthana V" first="Virat" last="Sirisanthana">Virat Sirisanthana</name></author><author><name sortKey="Ung, Vibol" sort="Ung, Vibol" uniqKey="Ung V" first="Vibol" last="Ung">Vibol Ung</name></author><author><name sortKey="Vonthanak, Saphonn" sort="Vonthanak, Saphonn" uniqKey="Vonthanak S" first="Saphonn" last="Vonthanak">Saphonn Vonthanak</name></author><author><name sortKey="Ananworanich, Jintanat" sort="Ananworanich, Jintanat" uniqKey="Ananworanich J" first="Jintanat" last="Ananworanich">Jintanat Ananworanich</name></author><author><name sortKey="Nik Yusoff, Nik Khairulddin" sort="Nik Yusoff, Nik Khairulddin" uniqKey="Nik Yusoff N" first="Nik Khairulddin" last="Nik Yusoff">Nik Khairulddin Nik Yusoff</name></author><author><name sortKey="Kurniati, Nia" sort="Kurniati, Nia" uniqKey="Kurniati N" first="Nia" last="Kurniati">Nia Kurniati</name></author><author><name sortKey="Azahar Razali, Kamarul" sort="Azahar Razali, Kamarul" uniqKey="Azahar Razali K" first="Kamarul" last="Azahar Razali">Kamarul Azahar Razali</name></author><author><name sortKey="Fong, Moy Siew" sort="Fong, Moy Siew" uniqKey="Fong M" first="Moy Siew" last="Fong">Moy Siew Fong</name></author><author><name sortKey="Nallusamy, Revathy" sort="Nallusamy, Revathy" uniqKey="Nallusamy R" first="Revathy" last="Nallusamy">Revathy Nallusamy</name></author><author><name sortKey="Wati, Dewi Kumara" sort="Wati, Dewi Kumara" uniqKey="Wati D" first="Dewi Kumara" last="Wati">Dewi Kumara Wati</name></author></analytic><series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title><idno type="eISSN">1944-7884</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Anti-HIV Agents (therapeutic use)</term><term>Asia</term><term>Body Height (physiology)</term><term>Body Weight (physiology)</term><term>CD4 Lymphocyte Count</term><term>Child</term><term>Child, Preschool</term><term>Cohort Studies</term><term>Disease Progression</term><term>Female</term><term>HIV Infections (drug therapy)</term><term>HIV Infections (physiopathology)</term><term>HIV Infections (virology)</term><term>HIV-1 (isolation & purification)</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Male</term><term>Proportional Hazards Models</term><term>Treatment Failure</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Agents antiVIH (usage thérapeutique)</term><term>Asie</term><term>Charge virale</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Estimation de Kaplan-Meier</term><term>Femelle</term><term>Humains</term><term>Infections à VIH (physiopathologie)</term><term>Infections à VIH (traitement médicamenteux)</term><term>Infections à VIH (virologie)</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Numération des lymphocytes CD4</term><term>Poids du corps (physiologie)</term><term>Taille (physiologie)</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification)</term><term>Échec thérapeutique</term><term>Études de cohortes</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Asia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Poids du corps</term><term>Taille</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Body Height</term><term>Body Weight</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>CD4 Lymphocyte Count</term><term>Child</term><term>Child, Preschool</term><term>Cohort Studies</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Male</term><term>Proportional Hazards Models</term><term>Treatment Failure</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Asie</term><term>Charge virale</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Estimation de Kaplan-Meier</term><term>Femelle</term><term>Humains</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Numération des lymphocytes CD4</term><term>Échec thérapeutique</term><term>Études de cohortes</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24872132</PMID><DateCreated><Year>2014</Year><Month>08</Month><Day>13</Day></DateCreated><DateCompleted><Year>2015</Year><Month>01</Month><Day>13</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1944-7884</ISSN><JournalIssue CitedMedium="Internet"><Volume>67</Volume><Issue>1</Issue><PubDate><Year>2014</Year><Month>Sep</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of acquired immune deficiency syndromes (1999)</Title><ISOAbbreviation>J. Acquir. Immune Defic. Syndr.</ISOAbbreviation></Journal><ArticleTitle>Weight as predictors of clinical progression and treatment failure: results from the TREAT Asia Pediatric HIV Observational Database.</ArticleTitle><Pagination><MedlinePgn>71-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/QAI.0000000000000227</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We used Cox regression to analyze data of a cohort of Asian children.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score < -3 was associated with mortality (P < 0.001) independent of CD4% and < -2 was associated with immunological failure (P ≤ 0.03) independent of age at cART.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kariminia</LastName><ForeName>Azar</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>*The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, Australia; †TREAT Asia/amfAR-The Foundation for AIDS Research, Bangkok, Thailand; ‡Programs for HIV Prevention and Treatment, Institut de Recherche pour le Développement, France, and Chiang Mai University, Chiang Mai, Thailand; §YR Gaitonde Centre for AIDS Research and Education, Chennai, India; ‖Infectious Disease Department, Children's Hospital 2, Ho Chi Minh City, Vietnam; ¶Infectious Disease Department, National Hospital of Pediatrics, Hanoi, Vietnam; #Pediatric Department, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; **Pediatric Department , Khon Kaen University, Khon Kaen, Thailand; ††Pediatric Department , Siriraj Hospital, Mahidol University, Bangkok, Thailand; ‡‡Infectious Disease Department, Children's Hospital 1, Ho Chi Minh City, Vietnam; §§Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; ‖‖TB/HIV Department, National Pediatric Hospital, Phnom Penh, Cambodia; ¶¶Research Unit, National Centre for HIV/AIDS, Dermatology and STDs, Phnom Penh, Cambodia; ##HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; ***Department of Pediatrics, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia; †††Pediatric Allergy-Immunology Division, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; ‡‡‡Pediatric Institute, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia; §§§Department of Pediatrics, Hospital Likas, Kota Kinabalu, Malaysia; ‖‖‖Department of Pediatrics, Penang Hospital, Penang, Malaysia; and ¶¶¶Allergy-Immunology Division, Sanglah Hospital, Udayana University, Bali, Indonesia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Durier</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Jourdain</LastName><ForeName>Gonzague</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Saghayam</LastName><ForeName>Suneeta</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Do</LastName><ForeName>Chau V</ForeName><Initials>CV</Initials></Author><Author ValidYN="Y"><LastName>Nguyen</LastName><ForeName>Lam Van</ForeName><Initials>LV</Initials></Author><Author ValidYN="Y"><LastName>Hansudewechakul</LastName><ForeName>Rawiwan</ForeName><Initials>R</Initials></Author><Author 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