Assessment of human antihuman antibodies to eculizumab after long-term treatment in patients with paroxysmal nocturnal hemoglobinuria.
Identifieur interne : 002337 ( Main/Curation ); précédent : 002336; suivant : 002338Assessment of human antihuman antibodies to eculizumab after long-term treatment in patients with paroxysmal nocturnal hemoglobinuria.
Auteurs : Peter Hillmen [Royaume-Uni] ; Petra Muus [Pays-Bas] ; Jeffrey Szer [Australie] ; Anita Hill [Royaume-Uni] ; Britta Höchsmann [Allemagne] ; Austin Kulasekararaj [Royaume-Uni] ; Antonio M. Risitano [Italie] ; Eric Van Den Neste [Belgique] ; Maria Liljeholm [Suède] ; Kurt S. Ebrahim [États-Unis] ; Camille L. Bedrosian [États-Unis] ; Xiang Gao [États-Unis] ; Donna Ames [États-Unis] ; Gérard Socié [France]Source :
- American journal of hematology [ 1096-8652 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Anticorps monoclonaux humanisés (administration et posologie), Anticorps monoclonaux humanisés (effets indésirables), Anticorps monoclonaux humanisés (usage thérapeutique), Anticorps neutralisants (sang), Complément C5 (antagonistes et inhibiteurs), Facteurs temps, Femelle, Humains, Hémoglobinurie paroxystique (immunologie), Hémoglobinurie paroxystique (sang), Hémoglobinurie paroxystique (traitement médicamenteux), Hémolyse (), Hémolyse (immunologie), Inhibiteurs du complément (administration et posologie), Inhibiteurs du complément (effets indésirables), Inhibiteurs du complément (usage thérapeutique), Mâle, Relation dose-effet des médicaments.
- MESH :
- administration et posologie : Anticorps monoclonaux humanisés, Inhibiteurs du complément.
- antagonistes et inhibiteurs : Complément C5.
- effets indésirables : Anticorps monoclonaux humanisés, Inhibiteurs du complément.
- immunologie : Hémoglobinurie paroxystique, Hémolyse.
- sang : Anticorps neutralisants, Hémoglobinurie paroxystique.
- traitement médicamenteux : Hémoglobinurie paroxystique.
- usage thérapeutique : Anticorps monoclonaux humanisés, Inhibiteurs du complément.
- Adulte d'âge moyen, Facteurs temps, Femelle, Humains, Hémolyse, Mâle, Relation dose-effet des médicaments.
English descriptors
- KwdEn :
- Antibodies, Monoclonal, Humanized (administration & dosage), Antibodies, Monoclonal, Humanized (adverse effects), Antibodies, Monoclonal, Humanized (therapeutic use), Antibodies, Neutralizing (blood), Complement C5 (antagonists & inhibitors), Complement Inactivating Agents (administration & dosage), Complement Inactivating Agents (adverse effects), Complement Inactivating Agents (therapeutic use), Dose-Response Relationship, Drug, Female, Hemoglobinuria, Paroxysmal (blood), Hemoglobinuria, Paroxysmal (drug therapy), Hemoglobinuria, Paroxysmal (immunology), Hemolysis (drug effects), Hemolysis (immunology), Humans, Male, Middle Aged, Time Factors.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Humanized, Complement Inactivating Agents.
- chemical , adverse effects : Antibodies, Monoclonal, Humanized, Complement Inactivating Agents.
- chemical , antagonists & inhibitors : Complement C5.
- chemical , blood : Antibodies, Neutralizing.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Complement Inactivating Agents.
- blood : Hemoglobinuria, Paroxysmal.
- drug effects : Hemolysis.
- drug therapy : Hemoglobinuria, Paroxysmal.
- immunology : Hemoglobinuria, Paroxysmal, Hemolysis.
- Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Time Factors.
DOI: 10.1002/ajh.24280
PubMed: 26690023
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wicri:level="1"><nlm:affiliation>Section of Experimental Haematology, St James's University Hospital, Leeds, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Experimental Haematology, St James's University Hospital, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Muus, Petra" sort="Muus, Petra" uniqKey="Muus P" first="Petra" last="Muus">Petra Muus</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Radboud University Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hematology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Haematology and BMT Service, The Royal Melbourne Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Clinical Haematology and BMT Service, The Royal Melbourne Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hill, Anita" sort="Hill, Anita" uniqKey="Hill A" first="Anita" last="Hill">Anita Hill</name><affiliation wicri:level="1"><nlm:affiliation>Department of Haematology, St James' Institute of Oncology, Leeds Teaching Hospitals, Leeds, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, St James' Institute of Oncology, Leeds Teaching Hospitals, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Hochsmann, Britta" sort="Hochsmann, Britta" uniqKey="Hochsmann B" first="Britta" last="Höchsmann">Britta Höchsmann</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Transfusion Medicine, University of Ulm, Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen, and University Hospital Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Transfusion Medicine, University of Ulm, Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen, and University Hospital Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Kulasekararaj, Austin" sort="Kulasekararaj, Austin" uniqKey="Kulasekararaj A" first="Austin" last="Kulasekararaj">Austin Kulasekararaj</name><affiliation wicri:level="3"><nlm:affiliation>King's College Hospital, Hill, Denmark, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>King's College Hospital, Hill, Denmark, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Risitano, Antonio M" sort="Risitano, Antonio M" uniqKey="Risitano A" first="Antonio M" last="Risitano">Antonio M. Risitano</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento Di Medicina Clinica E Chirurgia Dell' Università Degli Studi Di Napoli Federico II, Napoli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento Di Medicina Clinica E Chirurgia Dell' Università Degli Studi Di Napoli Federico II, Napoli</wicri:regionArea><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Neste, Eric" sort="Van Den Neste, Eric" uniqKey="Van Den Neste E" first="Eric" last="Van Den Neste">Eric Van Den Neste</name><affiliation wicri:level="3"><nlm:affiliation>Hematology Department, Cliniques Universitaires UCL Saint-Luc, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Hematology Department, Cliniques Universitaires UCL Saint-Luc, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Liljeholm, Maria" sort="Liljeholm, Maria" uniqKey="Liljeholm M" first="Maria" last="Liljeholm">Maria Liljeholm</name><affiliation wicri:level="1"><nlm:affiliation>Hematology Department, University Hospital of Umea, Umea, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Hematology Department, University Hospital of Umea, Umea</wicri:regionArea><wicri:noRegion>Umea</wicri:noRegion></affiliation></author><author><name sortKey="Ebrahim, Kurt S" sort="Ebrahim, Kurt S" uniqKey="Ebrahim K" first="Kurt S" last="Ebrahim">Kurt S. Ebrahim</name><affiliation wicri:level="2"><nlm:affiliation>New England Cancer Specialists, Scarborough, Maine.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maine (État)</region></placeName><wicri:cityArea>New England Cancer Specialists, Scarborough</wicri:cityArea></affiliation></author><author><name sortKey="Bedrosian, Camille L" sort="Bedrosian, Camille L" uniqKey="Bedrosian C" first="Camille L" last="Bedrosian">Camille L. Bedrosian</name><affiliation wicri:level="2"><nlm:affiliation>Alexion Pharmaceuticals, Inc, Cheshire, Connecticut.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Alexion Pharmaceuticals, Inc, Cheshire</wicri:cityArea></affiliation></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><affiliation wicri:level="2"><nlm:affiliation>Alexion Pharmaceuticals, Inc, Cheshire, Connecticut.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Alexion Pharmaceuticals, Inc, Cheshire</wicri:cityArea></affiliation></author><author><name sortKey="Ames, Donna" sort="Ames, Donna" uniqKey="Ames D" first="Donna" last="Ames">Donna Ames</name><affiliation wicri:level="2"><nlm:affiliation>Alexion Pharmaceuticals, Inc, Cheshire, Connecticut.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Alexion Pharmaceuticals, Inc, Cheshire</wicri:cityArea></affiliation></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socié">Gérard Socié</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP Hematology Hospital Saint Louis, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP Hematology Hospital Saint Louis, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">American journal of hematology</title><idno type="eISSN">1096-8652</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords 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Paroxysmal</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hemolysis</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hemoglobinuria, Paroxysmal</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term><term>Inhibiteurs du complément</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Hémoglobinurie paroxystique</term><term>Hémolyse</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Hemoglobinuria, Paroxysmal</term><term>Hemolysis</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps neutralisants</term><term>Hémoglobinurie paroxystique</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hémoglobinurie paroxystique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" 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