Assessment of human antihuman antibodies to eculizumab after long-term treatment in patients with paroxysmal nocturnal hemoglobinuria.
Identifieur interne : 002E97 ( Ncbi/Curation ); précédent : 002E96; suivant : 002E98Assessment of human antihuman antibodies to eculizumab after long-term treatment in patients with paroxysmal nocturnal hemoglobinuria.
Auteurs : Peter Hillmen [Royaume-Uni] ; Petra Muus [Pays-Bas] ; Jeffrey Szer [Australie] ; Anita Hill [Royaume-Uni] ; Britta Höchsmann [Allemagne] ; Austin Kulasekararaj [Royaume-Uni] ; Antonio M. Risitano [Italie] ; Eric Van Den Neste [Belgique] ; Maria Liljeholm [Suède] ; Kurt S. Ebrahim [États-Unis] ; Camille L. Bedrosian [États-Unis] ; Xiang Gao [États-Unis] ; Donna Ames [États-Unis] ; Gérard Socié [France]Source :
- American journal of hematology [ 1096-8652 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Anticorps monoclonaux humanisés (administration et posologie), Anticorps monoclonaux humanisés (effets indésirables), Anticorps monoclonaux humanisés (usage thérapeutique), Anticorps neutralisants (sang), Complément C5 (antagonistes et inhibiteurs), Facteurs temps, Femelle, Humains, Hémoglobinurie paroxystique (immunologie), Hémoglobinurie paroxystique (sang), Hémoglobinurie paroxystique (traitement médicamenteux), Hémolyse (), Hémolyse (immunologie), Inhibiteurs du complément (administration et posologie), Inhibiteurs du complément (effets indésirables), Inhibiteurs du complément (usage thérapeutique), Mâle, Relation dose-effet des médicaments.
- MESH :
- administration et posologie : Anticorps monoclonaux humanisés, Inhibiteurs du complément.
- antagonistes et inhibiteurs : Complément C5.
- effets indésirables : Anticorps monoclonaux humanisés, Inhibiteurs du complément.
- immunologie : Hémoglobinurie paroxystique, Hémolyse.
- sang : Anticorps neutralisants, Hémoglobinurie paroxystique.
- traitement médicamenteux : Hémoglobinurie paroxystique.
- usage thérapeutique : Anticorps monoclonaux humanisés, Inhibiteurs du complément.
- Adulte d'âge moyen, Facteurs temps, Femelle, Humains, Hémolyse, Mâle, Relation dose-effet des médicaments.
English descriptors
- KwdEn :
- Antibodies, Monoclonal, Humanized (administration & dosage), Antibodies, Monoclonal, Humanized (adverse effects), Antibodies, Monoclonal, Humanized (therapeutic use), Antibodies, Neutralizing (blood), Complement C5 (antagonists & inhibitors), Complement Inactivating Agents (administration & dosage), Complement Inactivating Agents (adverse effects), Complement Inactivating Agents (therapeutic use), Dose-Response Relationship, Drug, Female, Hemoglobinuria, Paroxysmal (blood), Hemoglobinuria, Paroxysmal (drug therapy), Hemoglobinuria, Paroxysmal (immunology), Hemolysis (drug effects), Hemolysis (immunology), Humans, Male, Middle Aged, Time Factors.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Humanized, Complement Inactivating Agents.
- chemical , adverse effects : Antibodies, Monoclonal, Humanized, Complement Inactivating Agents.
- chemical , antagonists & inhibitors : Complement C5.
- chemical , blood : Antibodies, Neutralizing.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Complement Inactivating Agents.
- blood : Hemoglobinuria, Paroxysmal.
- drug effects : Hemolysis.
- drug therapy : Hemoglobinuria, Paroxysmal.
- immunology : Hemoglobinuria, Paroxysmal, Hemolysis.
- Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Time Factors.
DOI: 10.1002/ajh.24280
PubMed: 26690023
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pubmed:26690023Le document en format XML
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<author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socié">Gérard Socié</name>
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<term>Antibodies, Monoclonal, Humanized (adverse effects)</term>
<term>Antibodies, Monoclonal, Humanized (therapeutic use)</term>
<term>Antibodies, Neutralizing (blood)</term>
<term>Complement C5 (antagonists & inhibitors)</term>
<term>Complement Inactivating Agents (administration & dosage)</term>
<term>Complement Inactivating Agents (adverse effects)</term>
<term>Complement Inactivating Agents (therapeutic use)</term>
<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Hemoglobinuria, Paroxysmal (blood)</term>
<term>Hemoglobinuria, Paroxysmal (drug therapy)</term>
<term>Hemoglobinuria, Paroxysmal (immunology)</term>
<term>Hemolysis (drug effects)</term>
<term>Hemolysis (immunology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Anticorps monoclonaux humanisés (administration et posologie)</term>
<term>Anticorps monoclonaux humanisés (effets indésirables)</term>
<term>Anticorps monoclonaux humanisés (usage thérapeutique)</term>
<term>Anticorps neutralisants (sang)</term>
<term>Complément C5 (antagonistes et inhibiteurs)</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémoglobinurie paroxystique (immunologie)</term>
<term>Hémoglobinurie paroxystique (sang)</term>
<term>Hémoglobinurie paroxystique (traitement médicamenteux)</term>
<term>Hémolyse ()</term>
<term>Hémolyse (immunologie)</term>
<term>Inhibiteurs du complément (administration et posologie)</term>
<term>Inhibiteurs du complément (effets indésirables)</term>
<term>Inhibiteurs du complément (usage thérapeutique)</term>
<term>Mâle</term>
<term>Relation dose-effet des médicaments</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term>
<term>Complement Inactivating Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term>
<term>Complement Inactivating Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Complement C5</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term>
</keywords>
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<term>Complement Inactivating Agents</term>
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<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps neutralisants</term>
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<term>Inhibiteurs du complément</term>
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<keywords scheme="MESH" xml:lang="en"><term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time Factors</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémolyse</term>
<term>Mâle</term>
<term>Relation dose-effet des médicaments</term>
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