Assessment of human antihuman antibodies to eculizumab after long-term treatment in patients with paroxysmal nocturnal hemoglobinuria.
Identifieur interne : 002E97 ( Ncbi/Merge ); précédent : 002E96; suivant : 002E98Assessment of human antihuman antibodies to eculizumab after long-term treatment in patients with paroxysmal nocturnal hemoglobinuria.
Auteurs : Peter Hillmen [Royaume-Uni] ; Petra Muus [Pays-Bas] ; Jeffrey Szer [Australie] ; Anita Hill [Royaume-Uni] ; Britta Höchsmann [Allemagne] ; Austin Kulasekararaj [Royaume-Uni] ; Antonio M. Risitano [Italie] ; Eric Van Den Neste [Belgique] ; Maria Liljeholm [Suède] ; Kurt S. Ebrahim [États-Unis] ; Camille L. Bedrosian [États-Unis] ; Xiang Gao [États-Unis] ; Donna Ames [États-Unis] ; Gérard Socié [France]Source :
- American journal of hematology [ 1096-8652 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Anticorps monoclonaux humanisés (administration et posologie), Anticorps monoclonaux humanisés (effets indésirables), Anticorps monoclonaux humanisés (usage thérapeutique), Anticorps neutralisants (sang), Complément C5 (antagonistes et inhibiteurs), Facteurs temps, Femelle, Humains, Hémoglobinurie paroxystique (immunologie), Hémoglobinurie paroxystique (sang), Hémoglobinurie paroxystique (traitement médicamenteux), Hémolyse (), Hémolyse (immunologie), Inhibiteurs du complément (administration et posologie), Inhibiteurs du complément (effets indésirables), Inhibiteurs du complément (usage thérapeutique), Mâle, Relation dose-effet des médicaments.
- MESH :
- administration et posologie : Anticorps monoclonaux humanisés, Inhibiteurs du complément.
- antagonistes et inhibiteurs : Complément C5.
- effets indésirables : Anticorps monoclonaux humanisés, Inhibiteurs du complément.
- immunologie : Hémoglobinurie paroxystique, Hémolyse.
- sang : Anticorps neutralisants, Hémoglobinurie paroxystique.
- traitement médicamenteux : Hémoglobinurie paroxystique.
- usage thérapeutique : Anticorps monoclonaux humanisés, Inhibiteurs du complément.
- Adulte d'âge moyen, Facteurs temps, Femelle, Humains, Hémolyse, Mâle, Relation dose-effet des médicaments.
English descriptors
- KwdEn :
- Antibodies, Monoclonal, Humanized (administration & dosage), Antibodies, Monoclonal, Humanized (adverse effects), Antibodies, Monoclonal, Humanized (therapeutic use), Antibodies, Neutralizing (blood), Complement C5 (antagonists & inhibitors), Complement Inactivating Agents (administration & dosage), Complement Inactivating Agents (adverse effects), Complement Inactivating Agents (therapeutic use), Dose-Response Relationship, Drug, Female, Hemoglobinuria, Paroxysmal (blood), Hemoglobinuria, Paroxysmal (drug therapy), Hemoglobinuria, Paroxysmal (immunology), Hemolysis (drug effects), Hemolysis (immunology), Humans, Male, Middle Aged, Time Factors.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Humanized, Complement Inactivating Agents.
- chemical , adverse effects : Antibodies, Monoclonal, Humanized, Complement Inactivating Agents.
- chemical , antagonists & inhibitors : Complement C5.
- chemical , blood : Antibodies, Neutralizing.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Complement Inactivating Agents.
- blood : Hemoglobinuria, Paroxysmal.
- drug effects : Hemolysis.
- drug therapy : Hemoglobinuria, Paroxysmal.
- immunology : Hemoglobinuria, Paroxysmal, Hemolysis.
- Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Time Factors.
DOI: 10.1002/ajh.24280
PubMed: 26690023
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002150
- to stream PubMed, to step Curation: 002124
- to stream PubMed, to step Checkpoint: 002124
Links to Exploration step
pubmed:26690023Le document en format XML
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<author><name sortKey="Van Den Neste, Eric" sort="Van Den Neste, Eric" uniqKey="Van Den Neste E" first="Eric" last="Van Den Neste">Eric Van Den Neste</name>
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<author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socié">Gérard Socié</name>
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<term>Antibodies, Monoclonal, Humanized (therapeutic use)</term>
<term>Antibodies, Neutralizing (blood)</term>
<term>Complement C5 (antagonists & inhibitors)</term>
<term>Complement Inactivating Agents (administration & dosage)</term>
<term>Complement Inactivating Agents (adverse effects)</term>
<term>Complement Inactivating Agents (therapeutic use)</term>
<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Hemoglobinuria, Paroxysmal (blood)</term>
<term>Hemoglobinuria, Paroxysmal (drug therapy)</term>
<term>Hemoglobinuria, Paroxysmal (immunology)</term>
<term>Hemolysis (drug effects)</term>
<term>Hemolysis (immunology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Anticorps monoclonaux humanisés (administration et posologie)</term>
<term>Anticorps monoclonaux humanisés (effets indésirables)</term>
<term>Anticorps monoclonaux humanisés (usage thérapeutique)</term>
<term>Anticorps neutralisants (sang)</term>
<term>Complément C5 (antagonistes et inhibiteurs)</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémoglobinurie paroxystique (immunologie)</term>
<term>Hémoglobinurie paroxystique (sang)</term>
<term>Hémoglobinurie paroxystique (traitement médicamenteux)</term>
<term>Hémolyse ()</term>
<term>Hémolyse (immunologie)</term>
<term>Inhibiteurs du complément (administration et posologie)</term>
<term>Inhibiteurs du complément (effets indésirables)</term>
<term>Inhibiteurs du complément (usage thérapeutique)</term>
<term>Mâle</term>
<term>Relation dose-effet des médicaments</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term>
<term>Complement Inactivating Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term>
<term>Complement Inactivating Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Complement C5</term>
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<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term>
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<term>Complement Inactivating Agents</term>
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<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term>
<term>Inhibiteurs du complément</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Complément C5</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Hemoglobinuria, Paroxysmal</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hemolysis</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hemoglobinuria, Paroxysmal</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term>
<term>Inhibiteurs du complément</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Hémoglobinurie paroxystique</term>
<term>Hémolyse</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Hemoglobinuria, Paroxysmal</term>
<term>Hemolysis</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps neutralisants</term>
<term>Hémoglobinurie paroxystique</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hémoglobinurie paroxystique</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term>
<term>Inhibiteurs du complément</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémolyse</term>
<term>Mâle</term>
<term>Relation dose-effet des médicaments</term>
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<DateCompleted><Year>2016</Year>
<Month>07</Month>
<Day>06</Day>
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<Month>02</Month>
<Day>22</Day>
</DateRevised>
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<JournalIssue CitedMedium="Internet"><Volume>91</Volume>
<Issue>3</Issue>
<PubDate><Year>2016</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>American journal of hematology</Title>
<ISOAbbreviation>Am. J. Hematol.</ISOAbbreviation>
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<ArticleTitle>Assessment of human antihuman antibodies to eculizumab after long-term treatment in patients with paroxysmal nocturnal hemoglobinuria.</ArticleTitle>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hillmen</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Section of Experimental Haematology, St James's University Hospital, Leeds, United Kingdom.</Affiliation>
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<ForeName>Jeffrey</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Haematology and BMT Service, The Royal Melbourne Hospital, Melbourne, Australia.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Hill</LastName>
<ForeName>Anita</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Haematology, St James' Institute of Oncology, Leeds Teaching Hospitals, Leeds, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Höchsmann</LastName>
<ForeName>Britta</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Institute of Transfusion Medicine, University of Ulm, Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen, and University Hospital Ulm, Ulm, Germany.</Affiliation>
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<Initials>A</Initials>
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</AffiliationInfo>
</Author>
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<ForeName>Antonio M</ForeName>
<Initials>AM</Initials>
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<Initials>E</Initials>
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</AffiliationInfo>
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<ForeName>Maria</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Hematology Department, University Hospital of Umea, Umea, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ebrahim</LastName>
<ForeName>Kurt S</ForeName>
<Initials>KS</Initials>
<AffiliationInfo><Affiliation>New England Cancer Specialists, Scarborough, Maine.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bedrosian</LastName>
<ForeName>Camille L</ForeName>
<Initials>CL</Initials>
<AffiliationInfo><Affiliation>Alexion Pharmaceuticals, Inc, Cheshire, Connecticut.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Xiang</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Alexion Pharmaceuticals, Inc, Cheshire, Connecticut.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ames</LastName>
<ForeName>Donna</ForeName>
<Initials>D</Initials>
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</Author>
<Author ValidYN="Y"><LastName>Socié</LastName>
<ForeName>Gérard</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>AP-HP Hematology Hospital Saint Louis, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
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<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Am J Hematol</MedlineTA>
<NlmUniqueID>7610369</NlmUniqueID>
<ISSNLinking>0361-8609</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D061067">Antibodies, Monoclonal, Humanized</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D057134">Antibodies, Neutralizing</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D003182">Complement C5</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051056">Complement Inactivating Agents</NameOfSubstance>
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<NameOfSubstance UI="C481642">eculizumab</NameOfSubstance>
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<MeshHeading><DescriptorName UI="D006461" MajorTopicYN="N">Hemolysis</DescriptorName>
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