AustralieFrV1, Istex, Curation, bibRecord, 001C72

Linear order of new and established DNA markers around the fragile site at Xq27.3

Identifieur interne : 001C72 ( Istex/Curation ); précédent : 001C71; suivant : 001C73

Linear order of new and established DNA markers around the fragile site at Xq27.3

Auteurs : M. C. Hirst [Royaume-Uni] ; A. Roche [Royaume-Uni] ; T. J. Flint [Royaume-Uni] ; R. N. Mackinnon [Royaume-Uni] ; J. H. D. Bassett [Royaume-Uni] ; Y. Nakahori [Royaume-Uni] ; J. E. V. Watson [Royaume-Uni] ; M. V. Bell [Royaume-Uni] ; M. N. Patterson [Royaume-Uni] ; Y. Boyd [Royaume-Uni] ; N. S. T. Thomas [Royaume-Uni] ; S. J. L. Knight [Royaume-Uni] ; S. T. Warren [États-Unis] ; M. Hors-Cayla [France] ; M. Schmidt [Australie] ; G. R. Sutherland [Australie] ; K. E. Davies [Royaume-Uni]

Source :

Genomics [ 0888-7543 ] ; 1991.

RBID : ISTEX:972B102FB12AA5CF605C8E69FDA938F694848B88

English descriptors

KwdEn :
- Amer, Breakpoint, Breakpoints, Cell lines, Chromosome, Clone, Cosmid, Fragile, Fragile site, Genet, Hirst, Hybrid, Hybrid breakpoints, Hybridization, Ledbetter, Localization, Locus, Mackinnon, Marker, Mental retardation, Microclone, Microclones, Microdissection, Microdissection library, Mutation, Nucleic acids, Physical mapping, Polymerase, Polymerase chain reaction, Rapid isolation, Somatic, Somatic cell, Somatic cell hybrids, Suthers, Xqter, Xqter content.
Teeft :
- Amer, Breakpoint, Breakpoints, Cell lines, Chromosome, Clone, Cosmid, Fragile, Fragile site, Genet, Hirst, Hybrid, Hybrid breakpoints, Hybridization, Ledbetter, Localization, Locus, Mackinnon, Marker, Mental retardation, Microclone, Microclones, Microdissection, Microdissection library, Mutation, Nucleic acids, Physical mapping, Polymerase, Polymerase chain reaction, Rapid isolation, Somatic, Somatic cell, Somatic cell hybrids, Suthers, Xqter, Xqter content.

Abstract

Abstract: We have used recombinant clones derived from microdissection of the fragile X region to characterize breakpoints around the fragile site at Xq27.3. So far, no microdissection markers derived from Xq28 material have been found, thus allowing a rapid screening for clones surrounding the fragile site by their presence in a somatic cell hybrid containing Xq27.2-Xqter. A total of 43 new DNA markers from Xq27 have been sublocalized within this chromosome band. Of these new DNA markers, 5 lie in an interval defined as containing the fragile X region. The saturation of Xq27 with DNA markers by microdissection demonstrates the power of this technique and provides the resources for generating a complete physical map of the region.

Url:

https://api.istex.fr/document/972B102FB12AA5CF605C8E69FDA938F694848B88/fulltext/pdf

DOI: 10.1016/0888-7543(91)90506-A

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ISTEX:972B102FB12AA5CF605C8E69FDA938F694848B88

Le document en format XML

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<author><name sortKey="Bell, M V" sort="Bell, M V" uniqKey="Bell M" first="M. V." last="Bell">M. V. Bell</name>
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<author><name sortKey="Patterson, M N" sort="Patterson, M N" uniqKey="Patterson M" first="M. N." last="Patterson">M. N. Patterson</name>
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<author><name sortKey="Thomas, N S T" sort="Thomas, N S T" uniqKey="Thomas N" first="N. S. T." last="Thomas">N. S. T. Thomas</name>
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<author><name sortKey="Knight, S J L" sort="Knight, S J L" uniqKey="Knight S" first="S. J. L." last="Knight">S. J. L. Knight</name>
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<author><name sortKey="Warren, S T" sort="Warren, S T" uniqKey="Warren S" first="S. T." last="Warren">S. T. Warren</name>
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<placeName><region type="state">Géorgie (États-Unis)</region>
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<wicri:cityArea>Department of Biochemistry and Pediatrics, Emory University School of Medicine, Rollins Research Center, Atlanta</wicri:cityArea>
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<author><name sortKey="Hors Cayla, M" sort="Hors Cayla, M" uniqKey="Hors Cayla M" first="M." last="Hors-Cayla">M. Hors-Cayla</name>
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<author><name sortKey="Schmidt, M" sort="Schmidt, M" uniqKey="Schmidt M" first="M." last="Schmidt">M. Schmidt</name>
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<country xml:lang="fr">Australie</country>
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<author><name sortKey="Davies, K E" sort="Davies, K E" uniqKey="Davies K" first="K. E." last="Davies">K. E. Davies</name>
<affiliation wicri:level="1"><mods:affiliation>Molecular Genetics Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom</mods:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
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<title level="j" type="abbrev">YGENO</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amer</term>
<term>Breakpoint</term>
<term>Breakpoints</term>
<term>Cell lines</term>
<term>Chromosome</term>
<term>Clone</term>
<term>Cosmid</term>
<term>Fragile</term>
<term>Fragile site</term>
<term>Genet</term>
<term>Hirst</term>
<term>Hybrid</term>
<term>Hybrid breakpoints</term>
<term>Hybridization</term>
<term>Ledbetter</term>
<term>Localization</term>
<term>Locus</term>
<term>Mackinnon</term>
<term>Marker</term>
<term>Mental retardation</term>
<term>Microclone</term>
<term>Microclones</term>
<term>Microdissection</term>
<term>Microdissection library</term>
<term>Mutation</term>
<term>Nucleic acids</term>
<term>Physical mapping</term>
<term>Polymerase</term>
<term>Polymerase chain reaction</term>
<term>Rapid isolation</term>
<term>Somatic</term>
<term>Somatic cell</term>
<term>Somatic cell hybrids</term>
<term>Suthers</term>
<term>Xqter</term>
<term>Xqter content</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Amer</term>
<term>Breakpoint</term>
<term>Breakpoints</term>
<term>Cell lines</term>
<term>Chromosome</term>
<term>Clone</term>
<term>Cosmid</term>
<term>Fragile</term>
<term>Fragile site</term>
<term>Genet</term>
<term>Hirst</term>
<term>Hybrid</term>
<term>Hybrid breakpoints</term>
<term>Hybridization</term>
<term>Ledbetter</term>
<term>Localization</term>
<term>Locus</term>
<term>Mackinnon</term>
<term>Marker</term>
<term>Mental retardation</term>
<term>Microclone</term>
<term>Microclones</term>
<term>Microdissection</term>
<term>Microdissection library</term>
<term>Mutation</term>
<term>Nucleic acids</term>
<term>Physical mapping</term>
<term>Polymerase</term>
<term>Polymerase chain reaction</term>
<term>Rapid isolation</term>
<term>Somatic</term>
<term>Somatic cell</term>
<term>Somatic cell hybrids</term>
<term>Suthers</term>
<term>Xqter</term>
<term>Xqter content</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: We have used recombinant clones derived from microdissection of the fragile X region to characterize breakpoints around the fragile site at Xq27.3. So far, no microdissection markers derived from Xq28 material have been found, thus allowing a rapid screening for clones surrounding the fragile site by their presence in a somatic cell hybrid containing Xq27.2-Xqter. A total of 43 new DNA markers from Xq27 have been sublocalized within this chromosome band. Of these new DNA markers, 5 lie in an interval defined as containing the fragile X region. The saturation of Xq27 with DNA markers by microdissection demonstrates the power of this technique and provides the resources for generating a complete physical map of the region.</div>
</front>
</TEI>
</record>

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Linear order of new and established DNA markers around the fragile site at Xq27.3

Linear order of new and established DNA markers around the fragile site at Xq27.3

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