Sex Differences in Response to Reduced Nicotine Content Cigarettes
Identifieur interne : 001396 ( Main/Merge ); précédent : 001395; suivant : 001397Sex Differences in Response to Reduced Nicotine Content Cigarettes
Auteurs : Rachel Isaksson Vogel [États-Unis] ; Louise A. Hertsgaard [États-Unis] ; Sarah S. Dermody [États-Unis] ; Xianghua Luo [États-Unis] ; Lor Moua [États-Unis] ; Sharon Allen [États-Unis] ; Mustafa Al Bsi [États-Unis] ; Dorothy K. Hatsukami [États-Unis]Source :
- Addictive behaviors [ 0306-4603 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Nicotine.
- analyse : Nicotine.
- Adulte, Adulte d'âge moyen, Facteurs sexuels, Femelle, Humains, Mâle, Produits de sevrage tabagique, Produits du tabac, Résultat thérapeutique, Sevrage tabagique.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Nicotine.
- chemical , analysis : Nicotine.
- methods : Smoking Cessation.
- Adult, Female, Humans, Male, Middle Aged, Sex Factors, Tobacco Products, Tobacco Use Cessation Products, Treatment Outcome.
Abstract
When switching from usual brand cigarettes, very low nicotine content (VLNC) cigarettes lead to a reduction in the number of cigarettes smoked, toxicant exposure, withdrawal symptoms and dependence. One area that has been relatively unexplored is what factors might moderate the effects of VLNC cigarettes. This exploratory analysis focuses on sex differences in responses to VLNC cigarettes and nicotine replacement therapy (NRT).
An exploratory secondary analysis of a randomized trial of 235 participants (58% female, mean age 47 years) comparing a) 0.05–0.09 mg nicotine yield cigarettes; b) 21 mg nicotine patch and 3) 0.05–0.09 nicotine yield cigarettes with 21 mg nicotine patch was conducted. We focused on sex differences in product use, and impact of products on withdrawal response from usual brand cigarettes and abstinence by randomized group.
The combination of VLNC cigarettes and nicotine patch was more effective in reducing use of VLNC cigarettes and withdrawal symptoms among males than females, whereas females were equally responsive to VLNC cigarettes with and without the nicotine patch. Females were more likely to quit smoking than males when assigned to either of the conditions that incorporated the VLNC cigarettes; however, males were more likely to quit smoking in the nicotine patch alone condition than females.
Sex of the smoker may be an important determinant for effects of VLNC cigarettes and nicotine patch. Future large randomized trials to confirm these results are needed.
Url:
DOI: 10.1016/j.addbeh.2014.03.021
PubMed: 24746485
PubMed Central: 4084708
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PMC:4084708Le document en format XML
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Hatsukami</name><affiliation wicri:level="2"><nlm:aff id="A1">University of Minnesota, Masonic Comprehensive Cancer Center, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>University of Minnesota, Masonic Comprehensive Cancer Center, Minneapolis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">University of Minnesota, Tobacco Research Programs, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>University of Minnesota, Tobacco Research Programs, Minneapolis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A7">University of Minnesota, Department of Psychiatry, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>University of Minnesota, Department of Psychiatry, Minneapolis</wicri:cityArea></affiliation></author></analytic><series><title level="j">Addictive behaviors</title><idno type="ISSN">0306-4603</idno><idno type="eISSN">1873-6327</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nicotine (administration & dosage)</term><term>Nicotine (analysis)</term><term>Sex Factors</term><term>Smoking Cessation (methods)</term><term>Tobacco Products</term><term>Tobacco Use Cessation Products</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs sexuels</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Nicotine (administration et posologie)</term><term>Nicotine (analyse)</term><term>Produits de sevrage tabagique</term><term>Produits du tabac</term><term>Résultat thérapeutique</term><term>Sevrage tabagique ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Nicotine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Nicotine</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Nicotine</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Nicotine</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Smoking Cessation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Sex Factors</term><term>Tobacco Products</term><term>Tobacco Use Cessation Products</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs sexuels</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Produits de sevrage tabagique</term><term>Produits du tabac</term><term>Résultat thérapeutique</term><term>Sevrage tabagique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P2">When switching from usual brand cigarettes, very low nicotine content (VLNC) cigarettes lead to a reduction in the number of cigarettes smoked, toxicant exposure, withdrawal symptoms and dependence. One area that has been relatively unexplored is what factors might moderate the effects of VLNC cigarettes. This exploratory analysis focuses on sex differences in responses to VLNC cigarettes and nicotine replacement therapy (NRT).</p></sec><sec id="S2"><title>Methods</title><p id="P3">An exploratory secondary analysis of a randomized trial of 235 participants (58% female, mean age 47 years) comparing a) 0.05–0.09 mg nicotine yield cigarettes; b) 21 mg nicotine patch and 3) 0.05–0.09 nicotine yield cigarettes with 21 mg nicotine patch was conducted. We focused on sex differences in product use, and impact of products on withdrawal response from usual brand cigarettes and abstinence by randomized group.</p></sec><sec id="S3"><title>Results</title><p id="P4">The combination of VLNC cigarettes and nicotine patch was more effective in reducing use of VLNC cigarettes and withdrawal symptoms among males than females, whereas females were equally responsive to VLNC cigarettes with and without the nicotine patch. Females were more likely to quit smoking than males when assigned to either of the conditions that incorporated the VLNC cigarettes; however, males were more likely to quit smoking in the nicotine patch alone condition than females.</p></sec><sec id="S4"><title>Conclusion</title><p id="P5">Sex of the smoker may be an important determinant for effects of VLNC cigarettes and nicotine patch. Future large randomized trials to confirm these results are needed.</p></sec></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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