Sex Differences in Response to Reduced Nicotine Content Cigarettes
Identifieur interne : 001328 ( Pmc/Curation ); précédent : 001327; suivant : 001329Sex Differences in Response to Reduced Nicotine Content Cigarettes
Auteurs : Rachel Isaksson Vogel [États-Unis] ; Louise A. Hertsgaard [États-Unis] ; Sarah S. Dermody [États-Unis] ; Xianghua Luo [États-Unis] ; Lor Moua [États-Unis] ; Sharon Allen [États-Unis] ; Mustafa Al Bsi [États-Unis] ; Dorothy K. Hatsukami [États-Unis]Source :
- Addictive behaviors [ 0306-4603 ] ; 2014.
Abstract
When switching from usual brand cigarettes, very low nicotine content (VLNC) cigarettes lead to a reduction in the number of cigarettes smoked, toxicant exposure, withdrawal symptoms and dependence. One area that has been relatively unexplored is what factors might moderate the effects of VLNC cigarettes. This exploratory analysis focuses on sex differences in responses to VLNC cigarettes and nicotine replacement therapy (NRT).
An exploratory secondary analysis of a randomized trial of 235 participants (58% female, mean age 47 years) comparing a) 0.05–0.09 mg nicotine yield cigarettes; b) 21 mg nicotine patch and 3) 0.05–0.09 nicotine yield cigarettes with 21 mg nicotine patch was conducted. We focused on sex differences in product use, and impact of products on withdrawal response from usual brand cigarettes and abstinence by randomized group.
The combination of VLNC cigarettes and nicotine patch was more effective in reducing use of VLNC cigarettes and withdrawal symptoms among males than females, whereas females were equally responsive to VLNC cigarettes with and without the nicotine patch. Females were more likely to quit smoking than males when assigned to either of the conditions that incorporated the VLNC cigarettes; however, males were more likely to quit smoking in the nicotine patch alone condition than females.
Sex of the smoker may be an important determinant for effects of VLNC cigarettes and nicotine patch. Future large randomized trials to confirm these results are needed.
Url:
DOI: 10.1016/j.addbeh.2014.03.021
PubMed: 24746485
PubMed Central: 4084708
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Hertsgaard</name><affiliation wicri:level="2"><nlm:aff id="A2">University of Minnesota, Tobacco Research Programs, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>University of Minnesota, Tobacco Research Programs, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Dermody, Sarah S" sort="Dermody, Sarah S" uniqKey="Dermody S" first="Sarah S." last="Dermody">Sarah S. Dermody</name><affiliation wicri:level="2"><nlm:aff id="A3">University of Pittsburgh, Department of Psychology, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh, Department of Psychology, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Luo, Xianghua" sort="Luo, Xianghua" uniqKey="Luo X" first="Xianghua" last="Luo">Xianghua Luo</name><affiliation wicri:level="2"><nlm:aff id="A1">University of Minnesota, Masonic Comprehensive Cancer Center, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>University of Minnesota, Masonic Comprehensive Cancer Center, Minneapolis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Moua, Lor" sort="Moua, Lor" uniqKey="Moua L" first="Lor" last="Moua">Lor Moua</name><affiliation wicri:level="2"><nlm:aff id="A2">University of Minnesota, Tobacco Research Programs, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>University of Minnesota, Tobacco Research Programs, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Allen, Sharon" sort="Allen, Sharon" uniqKey="Allen S" first="Sharon" last="Allen">Sharon Allen</name><affiliation wicri:level="2"><nlm:aff id="A2">University of Minnesota, Tobacco Research Programs, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>University of Minnesota, Tobacco Research Programs, Minneapolis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">University of Minnesota, Family Medicine and Community Health, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>University of Minnesota, Family Medicine and Community Health, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Al Bsi, Mustafa" sort="Al Bsi, Mustafa" uniqKey="Al Bsi M" first="Mustafa" last="Al Bsi">Mustafa Al Bsi</name><affiliation wicri:level="2"><nlm:aff id="A6">University of Minnesota, Departments of Family Medicine and Community Health and Behavioral Sciences, Duluth, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>University of Minnesota, Departments of Family Medicine and Community Health and Behavioral Sciences, Duluth</wicri:cityArea></affiliation></author><author><name sortKey="Hatsukami, Dorothy K" sort="Hatsukami, Dorothy K" uniqKey="Hatsukami D" first="Dorothy K." last="Hatsukami">Dorothy K. Hatsukami</name><affiliation wicri:level="2"><nlm:aff id="A1">University of Minnesota, Masonic Comprehensive Cancer Center, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>University of Minnesota, Masonic Comprehensive Cancer Center, Minneapolis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">University of Minnesota, Tobacco Research Programs, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>University of Minnesota, Tobacco Research Programs, Minneapolis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A7">University of Minnesota, Department of Psychiatry, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>University of Minnesota, Department of Psychiatry, Minneapolis</wicri:cityArea></affiliation></author></analytic><series><title level="j">Addictive behaviors</title><idno type="ISSN">0306-4603</idno><idno type="eISSN">1873-6327</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P2">When switching from usual brand cigarettes, very low nicotine content (VLNC) cigarettes lead to a reduction in the number of cigarettes smoked, toxicant exposure, withdrawal symptoms and dependence. One area that has been relatively unexplored is what factors might moderate the effects of VLNC cigarettes. This exploratory analysis focuses on sex differences in responses to VLNC cigarettes and nicotine replacement therapy (NRT).</p></sec><sec id="S2"><title>Methods</title><p id="P3">An exploratory secondary analysis of a randomized trial of 235 participants (58% female, mean age 47 years) comparing a) 0.05–0.09 mg nicotine yield cigarettes; b) 21 mg nicotine patch and 3) 0.05–0.09 nicotine yield cigarettes with 21 mg nicotine patch was conducted. We focused on sex differences in product use, and impact of products on withdrawal response from usual brand cigarettes and abstinence by randomized group.</p></sec><sec id="S3"><title>Results</title><p id="P4">The combination of VLNC cigarettes and nicotine patch was more effective in reducing use of VLNC cigarettes and withdrawal symptoms among males than females, whereas females were equally responsive to VLNC cigarettes with and without the nicotine patch. Females were more likely to quit smoking than males when assigned to either of the conditions that incorporated the VLNC cigarettes; however, males were more likely to quit smoking in the nicotine patch alone condition than females.</p></sec><sec id="S4"><title>Conclusion</title><p id="P5">Sex of the smoker may be an important determinant for effects of VLNC cigarettes and nicotine patch. Future large randomized trials to confirm these results are needed.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7603486</journal-id><journal-id journal-id-type="pubmed-jr-id">244</journal-id><journal-id journal-id-type="nlm-ta">Addict Behav</journal-id><journal-id journal-id-type="iso-abbrev">Addict Behav</journal-id><journal-title-group><journal-title>Addictive behaviors</journal-title></journal-title-group><issn pub-type="ppub">0306-4603</issn><issn pub-type="epub">1873-6327</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24746485</article-id><article-id pub-id-type="pmc">4084708</article-id><article-id pub-id-type="doi">10.1016/j.addbeh.2014.03.021</article-id><article-id pub-id-type="manuscript">NIHMS588804</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Sex Differences in Response to Reduced Nicotine Content Cigarettes</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Vogel</surname><given-names>Rachel Isaksson</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hertsgaard</surname><given-names>Louise A.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Dermody</surname><given-names>Sarah S.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Luo</surname><given-names>Xianghua</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Moua</surname><given-names>Lor</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Allen</surname><given-names>Sharon</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>al’Absi</surname><given-names>Mustafa</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Hatsukami</surname><given-names>Dorothy K.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A7">7</xref></contrib></contrib-group><aff id="A1"><label>1</label>University of Minnesota, Masonic Comprehensive Cancer Center, Minneapolis, MN</aff><aff id="A2"><label>2</label>University of Minnesota, Tobacco Research Programs, Minneapolis, MN</aff><aff id="A3"><label>3</label>University of Pittsburgh, Department of Psychology, Pittsburgh, PA</aff><aff id="A4"><label>4</label>Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN</aff><aff id="A5"><label>5</label>University of Minnesota, Family Medicine and Community Health, Minneapolis, MN</aff><aff id="A6"><label>6</label>University of Minnesota, Departments of Family Medicine and Community Health and Behavioral Sciences, Duluth, MN</aff><aff id="A7"><label>7</label>University of Minnesota, Department of Psychiatry, Minneapolis, MN</aff><author-notes><corresp id="FN1">Correspondence Dorothy K. Hatsukami, 717 Delaware St. SE, Minneapolis, MN 55414, Fax: 612 624-4610, Phone: 612 626-2121, <email>hatsu001@umn.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>6</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>30</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2015</year></pub-date><volume>39</volume><issue>7</issue><fpage>1197</fpage><lpage>1204</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.addbeh.2014.03.021</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><sec id="S1"><title>Background</title><p id="P2">When switching from usual brand cigarettes, very low nicotine content (VLNC) cigarettes lead to a reduction in the number of cigarettes smoked, toxicant exposure, withdrawal symptoms and dependence. One area that has been relatively unexplored is what factors might moderate the effects of VLNC cigarettes. This exploratory analysis focuses on sex differences in responses to VLNC cigarettes and nicotine replacement therapy (NRT).</p></sec><sec id="S2"><title>Methods</title><p id="P3">An exploratory secondary analysis of a randomized trial of 235 participants (58% female, mean age 47 years) comparing a) 0.05–0.09 mg nicotine yield cigarettes; b) 21 mg nicotine patch and 3) 0.05–0.09 nicotine yield cigarettes with 21 mg nicotine patch was conducted. We focused on sex differences in product use, and impact of products on withdrawal response from usual brand cigarettes and abstinence by randomized group.</p></sec><sec id="S3"><title>Results</title><p id="P4">The combination of VLNC cigarettes and nicotine patch was more effective in reducing use of VLNC cigarettes and withdrawal symptoms among males than females, whereas females were equally responsive to VLNC cigarettes with and without the nicotine patch. Females were more likely to quit smoking than males when assigned to either of the conditions that incorporated the VLNC cigarettes; however, males were more likely to quit smoking in the nicotine patch alone condition than females.</p></sec><sec id="S4"><title>Conclusion</title><p id="P5">Sex of the smoker may be an important determinant for effects of VLNC cigarettes and nicotine patch. Future large randomized trials to confirm these results are needed.</p></sec></abstract><kwd-group><kwd>reduced nicotine cigarettes</kwd><kwd>tobacco addiction</kwd><kwd>cigarette consumption</kwd><kwd>sex differences</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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