Environmental and Occupational Risk Factors for Progressive Supranuclear Palsy: Case-Control Study
Identifieur interne : 000847 ( Pmc/Curation ); précédent : 000846; suivant : 000848Environmental and Occupational Risk Factors for Progressive Supranuclear Palsy: Case-Control Study
Auteurs : Irene Litvan [États-Unis] ; Peter S. J. Lees [États-Unis] ; Christopher R. Cunningham [États-Unis] ; Shesh N. Rai [États-Unis] ; Alexander C. Cambon [États-Unis] ; David G. Standaert [Canada] ; Connie Marras [États-Unis] ; Jorge Juncos [États-Unis] ; David Riley [États-Unis] ; Stephen Reich [États-Unis] ; Deborah Hall [États-Unis] ; Benzi Kluger [États-Unis] ; Yvette Bordelon [États-Unis] ; David R. Shprecher [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2016.
Abstract
The cause of progressive supranuclear palsy (PSP) is largely unknown. Based on evidence for impaired mitochondrial activity in PSP, we hypothesized that the disease may be related to exposure to environmental toxins, some of which are mitochondrial inhibitors.
This multicenter case-control study included 284 incident PSP cases out of 350 cases and 284 age-, sex- and race-matched controls primarily from the same geographical areas. All subjects were administered standardized interviews to obtain data on demographics, residential history and lifetime occupational history. An industrial hygienist and a toxicologist unaware of case status assessed occupational histories to estimate past exposure to metals, pesticides, organic solvents and other chemicals.
Cases and controls were similar on demographic factors. In unadjusted analyses, PSP was associated with lower education, lower income, more smoking pack-years, more years of drinking well water, more years living on a farm, more years living one mile from an agricultural region, more transportation jobs, and more jobs with exposure to metals in general. However, in adjusted models, only more years of drinking well water was significantly associated with PSP. There was an inverse association with having a college degree.
We did not find evidence for a specific causative chemical exposure; higher number of years of drinking well water is a risk factor for PSP. This result remained significant after adjusting for income, smoking, education and occupational exposures. This is the first case-control study to demonstrate PSP is associated with environmental factors.
US National Institutes of Health 5R01AG024040.
Url:
DOI: 10.1002/mds.26512
PubMed: 26854325
PubMed Central: 4861658
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Shprecher</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Neurology, University of Utah, Salt City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Utah, Salt City, Utah</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26854325</idno><idno type="pmc">4861658</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861658</idno><idno type="RBID">PMC:4861658</idno><idno type="doi">10.1002/mds.26512</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000847</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000847</idno><idno type="wicri:Area/Pmc/Curation">000847</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000847</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Environmental and Occupational Risk Factors for Progressive Supranuclear Palsy: Case-Control Study</title><author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Movement Disorders, Department of Neurology, University of Louisville School of Medicine, Louisville, KY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Movement Disorders, Department of Neurology, University of Louisville School of Medicine, Louisville, KY</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Movement Disorder Center, Department of Neurosciences, University of California San Diego, San Diego, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Movement Disorder Center, Department of Neurosciences, University of California San Diego, San Diego, CA</wicri:regionArea></affiliation></author><author><name sortKey="Lees, Peter S J" sort="Lees, Peter S J" uniqKey="Lees P" first="Peter S. J." last="Lees">Peter S. J. Lees</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Cunningham, Christopher R" sort="Cunningham, Christopher R" uniqKey="Cunningham C" first="Christopher R." last="Cunningham">Christopher R. Cunningham</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Movement Disorders, Department of Neurology, University of Louisville School of Medicine, Louisville, KY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Movement Disorders, Department of Neurology, University of Louisville School of Medicine, Louisville, KY</wicri:regionArea></affiliation></author><author><name sortKey="Rai, Shesh N" sort="Rai, Shesh N" uniqKey="Rai S" first="Shesh N." last="Rai">Shesh N. Rai</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY</wicri:regionArea></affiliation></author><author><name sortKey="Cambon, Alexander C" sort="Cambon, Alexander C" uniqKey="Cambon A" first="Alexander C." last="Cambon">Alexander C. Cambon</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY</wicri:regionArea></affiliation></author><author><name sortKey="Standaert, David G" sort="Standaert, David G" uniqKey="Standaert D" first="David G." last="Standaert">David G. Standaert</name><affiliation wicri:level="1"><nlm:aff id="A6">Morto and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Morto and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research, Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama</wicri:regionArea></affiliation></author><author><name sortKey="Juncos, Jorge" sort="Juncos, Jorge" uniqKey="Juncos J" first="Jorge" last="Juncos">Jorge Juncos</name><affiliation wicri:level="1"><nlm:aff id="A8">InMotion, Warrensville Heights, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>InMotion, Warrensville Heights, OH</wicri:regionArea></affiliation></author><author><name sortKey="Riley, David" sort="Riley, David" uniqKey="Riley D" first="David" last="Riley">David Riley</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Neurology, Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Emory University, Atlanta, GA</wicri:regionArea></affiliation></author><author><name sortKey="Reich, Stephen" sort="Reich, Stephen" uniqKey="Reich S" first="Stephen" last="Reich">Stephen Reich</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Neurology, University of Colorado, Denver, Colorado, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Colorado, Denver, Colorado</wicri:regionArea></affiliation></author><author><name sortKey="Hall, Deborah" sort="Hall, Deborah" uniqKey="Hall D" first="Deborah" last="Hall">Deborah Hall</name><affiliation wicri:level="1"><nlm:aff id="A9">Department of Neurology, University of Maryland, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Maryland, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Kluger, Benzi" sort="Kluger, Benzi" uniqKey="Kluger B" first="Benzi" last="Kluger">Benzi Kluger</name><affiliation wicri:level="1"><nlm:aff id="A10">Department of Neurological Sciences, Rush University, Chicago, ILL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University, Chicago, ILL</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Department of Neurology, University of Colorado, Denver, Colorado, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Colorado, Denver, Colorado</wicri:regionArea></affiliation></author><author><name sortKey="Bordelon, Yvette" sort="Bordelon, Yvette" uniqKey="Bordelon Y" first="Yvette" last="Bordelon">Yvette Bordelon</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Neurology, University of California Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of California Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Shprecher, David R" sort="Shprecher, David R" uniqKey="Shprecher D" first="David R." last="Shprecher">David R. Shprecher</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Neurology, University of Utah, Salt City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Utah, Salt City, Utah</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">The cause of progressive supranuclear palsy (PSP) is largely unknown. Based on evidence for impaired mitochondrial activity in PSP, we hypothesized that the disease may be related to exposure to environmental toxins, some of which are mitochondrial inhibitors.</p></sec><sec id="S2"><title>Methods</title><p id="P2">This multicenter case-control study included 284 incident PSP cases out of 350 cases and 284 age-, sex- and race-matched controls primarily from the same geographical areas. All subjects were administered standardized interviews to obtain data on demographics, residential history and lifetime occupational history. An industrial hygienist and a toxicologist unaware of case status assessed occupational histories to estimate past exposure to metals, pesticides, organic solvents and other chemicals.</p></sec><sec id="S3"><title>Findings</title><p id="P3">Cases and controls were similar on demographic factors. In unadjusted analyses, PSP was associated with lower education, lower income, more smoking pack-years, more years of drinking well water, more years living on a farm, more years living one mile from an agricultural region, more transportation jobs, and more jobs with exposure to metals in general. However, in adjusted models, only more years of drinking well water was significantly associated with PSP. There was an inverse association with having a college degree.</p></sec><sec id="S4"><title>Interpretation</title><p id="P4">We did not find evidence for a specific causative chemical exposure; higher number of years of drinking well water is a risk factor for PSP. This result remained significant after adjusting for income, smoking, education and occupational exposures. This is the first case-control study to demonstrate PSP is associated with environmental factors.</p></sec><sec id="S5"><title>Funding</title><p id="P5">US National Institutes of Health 5R01AG024040.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26854325</article-id><article-id pub-id-type="pmc">4861658</article-id><article-id pub-id-type="doi">10.1002/mds.26512</article-id><article-id pub-id-type="manuscript">NIHMS741214</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Environmental and Occupational Risk Factors for Progressive Supranuclear Palsy: Case-Control Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Litvan</surname><given-names>Irene</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lees</surname><given-names>Peter S.J.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Cunningham</surname><given-names>Christopher R.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rai</surname><given-names>Shesh N.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Cambon</surname><given-names>Alexander C.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Standaert</surname><given-names>David G.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Marras</surname><given-names>Connie</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Juncos</surname><given-names>Jorge</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Riley</surname><given-names>David</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Reich</surname><given-names>Stephen</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Deborah</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Kluger</surname><given-names>Benzi</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Bordelon</surname><given-names>Yvette</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Shprecher</surname><given-names>David R.</given-names></name><degrees>DO, MSci</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><collab>ENGENE-PSP</collab><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Movement Disorders, Department of Neurology, University of Louisville School of Medicine, Louisville, KY, USA</aff><aff id="A2"><label>2</label> Movement Disorder Center, Department of Neurosciences, University of California San Diego, San Diego, CA, USA</aff><aff id="A3"><label>3</label>Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</aff><aff id="A4"><label>4</label>Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA</aff><aff id="A5"><label>5</label>Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA</aff><aff id="A6"><label>6</label>Morto and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A7"><label>7</label>Department of Neurology, Emory University, Atlanta, GA, USA</aff><aff id="A8"><label>8</label>InMotion, Warrensville Heights, OH, USA</aff><aff id="A9"><label>9</label>Department of Neurology, University of Maryland, Baltimore, MD, USA</aff><aff id="A10"><label>10</label>Department of Neurological Sciences, Rush University, Chicago, ILL, USA</aff><aff id="A11"><label>11</label>Department of Neurology, University of Colorado, Denver, Colorado, USA</aff><aff id="A12"><label>12</label>Department of Neurology, University of California Los Angeles, CA, USA</aff><aff id="A13"><label>13</label>Department of Neurology, University of Utah, Salt City, Utah, USA</aff><author-notes><corresp id="FN1">Correspondence: Irene Litvan, M.D., UC San Diego Department of Neurosciences, 8950 Villa La Jolla Dr, Ste C112, La Jolla, CA 92037, Phone: 858-822-5872, Fax: 858-822-5743, <email>ilitvan@ucsd.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>1</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>08</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2017</year></pub-date><volume>31</volume><issue>5</issue><fpage>644</fpage><lpage>652</lpage><pmc-comment>elocation-id from pubmed: 10.1002/mds.26512</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">The cause of progressive supranuclear palsy (PSP) is largely unknown. Based on evidence for impaired mitochondrial activity in PSP, we hypothesized that the disease may be related to exposure to environmental toxins, some of which are mitochondrial inhibitors.</p></sec><sec id="S2"><title>Methods</title><p id="P2">This multicenter case-control study included 284 incident PSP cases out of 350 cases and 284 age-, sex- and race-matched controls primarily from the same geographical areas. All subjects were administered standardized interviews to obtain data on demographics, residential history and lifetime occupational history. An industrial hygienist and a toxicologist unaware of case status assessed occupational histories to estimate past exposure to metals, pesticides, organic solvents and other chemicals.</p></sec><sec id="S3"><title>Findings</title><p id="P3">Cases and controls were similar on demographic factors. In unadjusted analyses, PSP was associated with lower education, lower income, more smoking pack-years, more years of drinking well water, more years living on a farm, more years living one mile from an agricultural region, more transportation jobs, and more jobs with exposure to metals in general. However, in adjusted models, only more years of drinking well water was significantly associated with PSP. There was an inverse association with having a college degree.</p></sec><sec id="S4"><title>Interpretation</title><p id="P4">We did not find evidence for a specific causative chemical exposure; higher number of years of drinking well water is a risk factor for PSP. This result remained significant after adjusting for income, smoking, education and occupational exposures. This is the first case-control study to demonstrate PSP is associated with environmental factors.</p></sec><sec id="S5"><title>Funding</title><p id="P5">US National Institutes of Health 5R01AG024040.</p></sec></abstract><kwd-group><kwd><bold>Keywords:</bold> Progressive supranuclear palsy</kwd><kwd>case-control study</kwd><kwd>epidemiology</kwd><kwd>risk factors</kwd><kwd>Parkinsonism</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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