ParkinsonCanadaV1, PascalFrancis, Checkpoint, bibRecord, 000167

Epigenetic programming of neurodegenerative diseases by an adverse environment

Identifieur interne : 000167 ( PascalFrancis/Checkpoint ); précédent : 000166; suivant : 000168

Epigenetic programming of neurodegenerative diseases by an adverse environment

Auteurs : Olena Babenko [Canada] ; Igor Kovalchuk [Canada] ; Gerlinde A. Metz [Canada]

Source :

Brain research [ 0006-8993 ] ; 2012.

RBID : Pascal:12-0152281

Descripteurs français

Pascal (Inist)
- Epigenèse, Stress, Micro ARN, Méthylation, Maladie de Parkinson, Chorée de Huntington, Sclérose en plaques, Maladie dégénérative, Démence d'Alzheimer, Article synthèse.

English descriptors

KwdEn :
- Alzheimer disease, Degenerative disease, Epigenesis, Huntington disease, Methylation, Micro RNA, Multiple sclerosis, Parkinson disease, Review, Stress.

Abstract

Experience and environment can critically influence the risk and progression of neurodegenerative disorders. Epigenetic mechanisms, such as miRNA expression, DNA methylation, and histone modifications, readily respond to experience and environmental factors. Here we propose that epigenetic regulation of gene expression and environmental modulation thereof may play a key role in the onset and course of common neurological conditions, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis. For example, epigenetic mechanisms may mediate long-term responses to adverse experience, such as stress, to affect disease susceptibility and the course of neurodegenerative events. This review introduces the epigenetic components and their possible role in mediating neuropathological processes in response to stress. We argue that epigenetic modifications will affect neurodegenerative events through altered gene function. The study of epigenetic states in neurodegenerative diseases presents an opportunity to gain new insights into risk factors and pathogenic mechanisms. Moreover, research into epigenetic regulation of disease may revolutionize health care by opening new avenues of personalized, preventive and curative medicine.

Affiliations:

Canada

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Pascal:12-0152281

Le document en format XML

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Epigenetic programming of neurodegenerative diseases by an adverse environment

Epigenetic programming of neurodegenerative diseases by an adverse environment

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