La maladie de Parkinson au Canada (serveur d'exploration)

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Epigenetic programming of neurodegenerative diseases by an adverse environment

Identifieur interne : 000A36 ( PascalFrancis/Curation ); précédent : 000A35; suivant : 000A37

Epigenetic programming of neurodegenerative diseases by an adverse environment

Auteurs : Olena Babenko [Canada] ; Igor Kovalchuk [Canada] ; Gerlinde A. Metz [Canada]

Source :

RBID : Pascal:12-0152281

Descripteurs français

English descriptors

Abstract

Experience and environment can critically influence the risk and progression of neurodegenerative disorders. Epigenetic mechanisms, such as miRNA expression, DNA methylation, and histone modifications, readily respond to experience and environmental factors. Here we propose that epigenetic regulation of gene expression and environmental modulation thereof may play a key role in the onset and course of common neurological conditions, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis. For example, epigenetic mechanisms may mediate long-term responses to adverse experience, such as stress, to affect disease susceptibility and the course of neurodegenerative events. This review introduces the epigenetic components and their possible role in mediating neuropathological processes in response to stress. We argue that epigenetic modifications will affect neurodegenerative events through altered gene function. The study of epigenetic states in neurodegenerative diseases presents an opportunity to gain new insights into risk factors and pathogenic mechanisms. Moreover, research into epigenetic regulation of disease may revolutionize health care by opening new avenues of personalized, preventive and curative medicine.
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A11 03  1    @1 METZ (Gerlinde A.)
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C01 01    ENG  @0 Experience and environment can critically influence the risk and progression of neurodegenerative disorders. Epigenetic mechanisms, such as miRNA expression, DNA methylation, and histone modifications, readily respond to experience and environmental factors. Here we propose that epigenetic regulation of gene expression and environmental modulation thereof may play a key role in the onset and course of common neurological conditions, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and multiple sclerosis. For example, epigenetic mechanisms may mediate long-term responses to adverse experience, such as stress, to affect disease susceptibility and the course of neurodegenerative events. This review introduces the epigenetic components and their possible role in mediating neuropathological processes in response to stress. We argue that epigenetic modifications will affect neurodegenerative events through altered gene function. The study of epigenetic states in neurodegenerative diseases presents an opportunity to gain new insights into risk factors and pathogenic mechanisms. Moreover, research into epigenetic regulation of disease may revolutionize health care by opening new avenues of personalized, preventive and curative medicine.
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C03 04  X  SPA  @0 Metilación @5 04
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C03 05  X  ENG  @0 Parkinson disease @2 NM @5 05
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C03 06  X  FRE  @0 Chorée de Huntington @5 06
C03 06  X  ENG  @0 Huntington disease @5 06
C03 06  X  SPA  @0 Corea Huntington @5 06
C03 07  X  FRE  @0 Sclérose en plaques @2 NM @5 07
C03 07  X  ENG  @0 Multiple sclerosis @2 NM @5 07
C03 07  X  SPA  @0 Esclerosis en placa @2 NM @5 07
C03 08  X  FRE  @0 Maladie dégénérative @5 09
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C07 01  X  SPA  @0 Silencio expresión genética
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C07 03  X  SPA  @0 Encéfalo patología @5 21
C07 04  X  FRE  @0 Pathologie du système nerveux central @5 22
C07 04  X  ENG  @0 Central nervous system disease @5 22
C07 04  X  SPA  @0 Sistema nervosio central patología @5 22
C07 05  X  FRE  @0 Syndrome extrapyramidal @5 23
C07 05  X  ENG  @0 Extrapyramidal syndrome @5 23
C07 05  X  SPA  @0 Extrapiramidal síndrome @5 23
C07 06  X  FRE  @0 Maladie héréditaire @5 24
C07 06  X  ENG  @0 Genetic disease @5 24
C07 06  X  SPA  @0 Enfermedad hereditaria @5 24
C07 07  X  FRE  @0 Maladie inflammatoire @5 25
C07 07  X  ENG  @0 Inflammatory disease @5 25
C07 07  X  SPA  @0 Enfermedad inflamatoria @5 25
N21       @1 114

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Pascal:12-0152281

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<s0>Syndrome extrapyramidal</s0>
<s5>23</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>23</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>23</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE">
<s0>Maladie héréditaire</s0>
<s5>24</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG">
<s0>Genetic disease</s0>
<s5>24</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Enfermedad hereditaria</s0>
<s5>24</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE">
<s0>Maladie inflammatoire</s0>
<s5>25</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG">
<s0>Inflammatory disease</s0>
<s5>25</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA">
<s0>Enfermedad inflamatoria</s0>
<s5>25</s5>
</fC07>
<fN21>
<s1>114</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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