Head injuries and Parkinson's disease in a case-control study
Identifieur interne : 000076 ( PascalFrancis/Checkpoint ); précédent : 000075; suivant : 000077Head injuries and Parkinson's disease in a case-control study
Auteurs : M. Anne Harris [Canada] ; HUI SHEN [Canada] ; Stephen A. Marion [Canada] ; Joseph K. C. Tsui [Canada] ; Kay Teschke [Canada]Source :
- Occupational and environmental medicine : (London) [ 1351-0711 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Santé publique, Homme.
English descriptors
- KwdEn :
Abstract
Background Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms. Methods We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history. Results Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant. Conclusions This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.
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Anne Harris</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Occupational and Public Health, Ryerson University</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hui Shen" sort="Hui Shen" uniqKey="Hui Shen" last="Hui Shen">HUI SHEN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A." last="Marion">Stephen A. Marion</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K. C." last="Tsui">Joseph K. C. Tsui</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0023164</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 14-0023164 INIST</idno><idno type="RBID">Pascal:14-0023164</idno><idno type="wicri:Area/PascalFrancis/Corpus">000045</idno><idno type="stanalyst">FRANCIS 14-0023164 INIST</idno><idno type="wicri:Area/PascalFrancis/Corpus">000060</idno><idno type="wicri:Area/PascalFrancis/Curation">000B73</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000076</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000076</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Head injuries and Parkinson's disease in a case-control study</title><author><name sortKey="Harris, M Anne" sort="Harris, M Anne" uniqKey="Harris M" first="M. Anne" last="Harris">M. Anne Harris</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Occupational and Public Health, Ryerson University</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hui Shen" sort="Hui Shen" uniqKey="Hui Shen" last="Hui Shen">HUI SHEN</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A." last="Marion">Stephen A. Marion</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K. C." last="Tsui">Joseph K. C. Tsui</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Occupational and environmental medicine : (London)</title><title level="j" type="abbreviated">Occup. environ. med. : (Lond.)</title><idno type="ISSN">1351-0711</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Occupational and environmental medicine : (London)</title><title level="j" type="abbreviated">Occup. environ. med. : (Lond.)</title><idno type="ISSN">1351-0711</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case control study</term><term>Craniocerebral</term><term>Epidemiology</term><term>Head trauma</term><term>Human</term><term>Parkinson disease</term><term>Public health</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Crânioencéphalique</term><term>Etude cas témoin</term><term>Epidémiologie</term><term>Santé publique</term><term>Homme</term><term>Traumatisme crânien</term><term>Maladie de Parkinson</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Santé publique</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms. Methods We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history. Results Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant. Conclusions This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1351-0711</s0></fA01><fA03 i2="1"><s0>Occup. environ. med. : (Lond.)</s0></fA03><fA05><s2>70</s2></fA05><fA06><s2>12</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Head injuries and Parkinson's disease in a case-control study</s1></fA08><fA11 i1="01" i2="1"><s1>HARRIS (M. Anne)</s1></fA11><fA11 i1="02" i2="1"><s1>HUI SHEN</s1></fA11><fA11 i1="03" i2="1"><s1>MARION (Stephen A.)</s1></fA11><fA11 i1="04" i2="1"><s1>TSUI (Joseph K. C.)</s1></fA11><fA11 i1="05" i2="1"><s1>TESCHKE (Kay)</s1></fA11><fA14 i1="01"><s1>School of Occupational and Public Health, Ryerson University</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="03"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>4 aut.</sZ></fA14><fA20><s1>839-844</s1></fA20><fA21><s1>2013</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>5586</s2><s5>354000504260150050</s5></fA43><fA44><s0>0000</s0><s1>© 2014 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>24 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>14-0023164</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Occupational and environmental medicine : (London)</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Background Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms. Methods We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history. Results Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant. Conclusions This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.</s0></fC01><fC02 i1="01" i2="X"><s0>002B16B</s0></fC02><fC02 i1="02" i2="X"><s0>002B18C13</s0></fC02><fC02 i1="03" i2="X"><s0>002B17G</s0></fC02><fC02 i1="04" i2="X"><s0>002B17A01</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Crânioencéphalique</s0><s5>02</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Craniocerebral</s0><s5>02</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Craneoencefálico</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Etude cas témoin</s0><s5>03</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Case control study</s0><s5>03</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Estudio caso control</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Epidémiologie</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Epidemiology</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Epidemiología</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Santé publique</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Public health</s0><s5>06</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Salud pública</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Human</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Traumatisme crânien</s0><s2>NM</s2><s5>10</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Head trauma</s0><s2>NM</s2><s5>10</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Traumatismo craneoencefálico</s0><s2>NM</s2><s5>10</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>13</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>13</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>13</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>61</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>61</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>61</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>62</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>62</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>62</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>63</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>63</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>63</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>64</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>64</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>64</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>65</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>65</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>65</s5></fC07><fN21><s1>020</s1></fN21></pA></standard></inist><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Harris, M Anne" sort="Harris, M Anne" uniqKey="Harris M" first="M. Anne" last="Harris">M. Anne Harris</name></noRegion><name sortKey="Hui Shen" sort="Hui Shen" uniqKey="Hui Shen" last="Hui Shen">HUI SHEN</name><name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A." last="Marion">Stephen A. Marion</name><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name><name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K. C." last="Tsui">Joseph K. C. Tsui</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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