La maladie de Parkinson au Canada (serveur d'exploration)

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Head injuries and Parkinson's disease in a case-control study

Identifieur interne : 000B73 ( PascalFrancis/Curation ); précédent : 000B72; suivant : 000B74

Head injuries and Parkinson's disease in a case-control study

Auteurs : M. Anne Harris [Canada] ; HUI SHEN [Canada] ; Stephen A. Marion [Canada] ; Joseph K. C. Tsui [Canada] ; Kay Teschke [Canada]

Source :

RBID : Pascal:14-0023164

Descripteurs français

English descriptors

Abstract

Background Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms. Methods We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history. Results Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant. Conclusions This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.
pA  
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A03   1    @0 Occup. environ. med. : (Lond.)
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A08 01  1  ENG  @1 Head injuries and Parkinson's disease in a case-control study
A11 01  1    @1 HARRIS (M. Anne)
A11 02  1    @1 HUI SHEN
A11 03  1    @1 MARION (Stephen A.)
A11 04  1    @1 TSUI (Joseph K. C.)
A11 05  1    @1 TESCHKE (Kay)
A14 01      @1 School of Occupational and Public Health, Ryerson University @2 Toronto, Ontario @3 CAN @Z 1 aut.
A14 02      @1 School of Population and Public Health, University of British Columbia @2 Vancouver, British Columbia @3 CAN @Z 2 aut. @Z 3 aut. @Z 5 aut.
A14 03      @1 Pacific Parkinson's Research Centre, University of British Columbia @2 Vancouver, British Columbia @3 CAN @Z 4 aut.
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A21       @1 2013
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A44       @0 0000 @1 © 2014 INIST-CNRS. All rights reserved.
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C01 01    ENG  @0 Background Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms. Methods We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history. Results Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant. Conclusions This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.
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C03 01  X  SPA  @0 Craneoencefálico @5 02
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C03 04  X  SPA  @0 Salud pública @5 06
C03 05  X  FRE  @0 Homme @5 08
C03 05  X  ENG  @0 Human @5 08
C03 05  X  SPA  @0 Hombre @5 08
C03 06  X  FRE  @0 Traumatisme crânien @2 NM @5 10
C03 06  X  ENG  @0 Head trauma @2 NM @5 10
C03 06  X  SPA  @0 Traumatismo craneoencefálico @2 NM @5 10
C03 07  X  FRE  @0 Maladie de Parkinson @2 NM @5 13
C03 07  X  ENG  @0 Parkinson disease @2 NM @5 13
C03 07  X  SPA  @0 Parkinson enfermedad @2 NM @5 13
C07 01  X  FRE  @0 Pathologie du système nerveux @5 61
C07 01  X  ENG  @0 Nervous system diseases @5 61
C07 01  X  SPA  @0 Sistema nervioso patología @5 61
C07 02  X  FRE  @0 Pathologie de l'encéphale @5 62
C07 02  X  ENG  @0 Cerebral disorder @5 62
C07 02  X  SPA  @0 Encéfalo patología @5 62
C07 03  X  FRE  @0 Syndrome extrapyramidal @5 63
C07 03  X  ENG  @0 Extrapyramidal syndrome @5 63
C07 03  X  SPA  @0 Extrapiramidal síndrome @5 63
C07 04  X  FRE  @0 Maladie dégénérative @5 64
C07 04  X  ENG  @0 Degenerative disease @5 64
C07 04  X  SPA  @0 Enfermedad degenerativa @5 64
C07 05  X  FRE  @0 Pathologie du système nerveux central @5 65
C07 05  X  ENG  @0 Central nervous system disease @5 65
C07 05  X  SPA  @0 Sistema nervosio central patología @5 65
N21       @1 020

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<div type="abstract" xml:lang="en">Background Head injury is a hypothesised risk factor for Parkinson's disease, but there is a knowledge gap concerning the potential effect of injury circumstances (eg, work-related injuries) on risk. The objective of this study is to address this gap while addressing issues of recall bias and potential for reverse causation by prediagnosis symptoms. Methods We conducted a population based case-control study of Parkinson's disease in British Columbia, Canada (403 cases, 405 controls). Interviews queried injury history; whether injuries occurred at work, in a motor vehicle accident or during sports. Participants were also asked to report their suspicions about the causes of Parkinson's disease to provide an indicator of potential recall bias. Associations were estimated with logistic regression, adjusted for age, sex and smoking history. Results Associations were strongest for injuries involving concussion (OR: 2.08, 95% CI 1.30 to 3.33) and unconsciousness (OR: 2.64, 95% CI 1.39 to 5.03). Effects remained for injuries that occurred long before diagnosis and after adjustment for suspicion of head injury as a cause of Parkinson's disease. Injuries that occurred at work were consistently associated with stronger ORs, although small numbers meant that estimates were not statistically significant. Conclusions This study adds to the body of literature suggesting a link between head injury and Parkinson's disease and indicates further scrutiny of workplace incurred head injuries is warranted.</div>
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<s5>62</s5>
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<fC07 i1="02" i2="X" l="SPA">
<s0>Encéfalo patología</s0>
<s5>62</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Syndrome extrapyramidal</s0>
<s5>63</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>63</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>63</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Maladie dégénérative</s0>
<s5>64</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>64</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>64</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Pathologie du système nerveux central</s0>
<s5>65</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>65</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>65</s5>
</fC07>
<fN21>
<s1>020</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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