Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease
Identifieur interne : 000075 ( PascalFrancis/Checkpoint ); précédent : 000074; suivant : 000076Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease
Auteurs : William Reginold [Canada] ; Sarah Duff-Canning [Canada] ; Christopher Meaney [Canada] ; Melissa J. Armstrong [Canada] ; Susan Fox [Canada] ; Brandon Rothberg [Canada] ; Cindy Zadikoff [États-Unis] ; Nancy Kennedy [États-Unis] ; David Gill [États-Unis] ; Paul Eslinger [États-Unis] ; Fred Marshall [États-Unis] ; Mark Mapstone [États-Unis] ; Kelvin L. Chou [États-Unis] ; Carol Persad [États-Unis] ; Irene Litvan [États-Unis] ; Benjamin Mast [États-Unis] ; David Tang-Wai [Canada] ; Anthony E. Lang [Canada] ; Connie Marras [Canada]Source :
- Dementia and geriatric cognitive disorders [ 1420-8008 ] ; 2013.
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Abstract
Background/Aims: To assess the impact of mild cognitive impairment (MCI) or cognitive decline on health-related quality of life (HR-QOL) in Parkinson's disease (PD). Methods: HR-QOL measured by the Parkinson Disease Quality of Life Questionnaire (PDQ-39), MCI according to Movement Disorder Society Task Force criteria and cognitive decline from premorbid baseline were assessed in non-demented PD patients at 6 movement disorder clinics. Results: Among 137 patients, after adjusting for education, gender, disease duration, and Movement Disorder Society Unified Parkinson's Disease Rating Scale total score, MCI was associated with worse scores within the PDQ-39 dimension of communication (p = 0.008). Subjects were divided into tertiles of cognitive decline from premorbid level. Scores in the dimension of stigma were worst in the second tertile of cognitive decline (p = 0.03). MCI was associated with worse social support scores in the second tertile of cognitive decline (p = 0.008). Conclusion: MCI and cognitive decline from premorbid baseline are associated with reduced HR-QOL in communication, stigma, and social support domains. The cognitive decline from premorbid baseline modifies the association between MCI and HR-QOL in PD and knowing both will allow a better appreciation of difficulties patients face in daily life.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease</title><author><name sortKey="Reginold, William" sort="Reginold, William" uniqKey="Reginold W" first="William" last="Reginold">William Reginold</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. 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Armstrong</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. 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Safra Program in Parkinson's Disease</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Susan" sort="Fox, Susan" uniqKey="Fox S" first="Susan" last="Fox">Susan Fox</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ont.</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmond J. Safra Program in Parkinson's Disease</wicri:noRegion></affiliation></author><author><name sortKey="Rothberg, Brandon" sort="Rothberg, Brandon" uniqKey="Rothberg B" first="Brandon" last="Rothberg">Brandon Rothberg</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ont.</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmond J. Safra Program in Parkinson's Disease</wicri:noRegion></affiliation></author><author><name sortKey="Zadikoff, Cindy" sort="Zadikoff, Cindy" uniqKey="Zadikoff C" first="Cindy" last="Zadikoff">Cindy Zadikoff</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Northwestern University</s1><s2>Evanston, Ill.</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, Ill.</wicri:noRegion></affiliation></author><author><name sortKey="Kennedy, Nancy" sort="Kennedy, Nancy" uniqKey="Kennedy N" first="Nancy" last="Kennedy">Nancy Kennedy</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychiatry and Behavioral Science, Northwestern University</s1><s2>Evanston, Ill.</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, Ill.</wicri:noRegion></affiliation></author><author><name sortKey="Gill, David" sort="Gill, David" uniqKey="Gill D" first="David" last="Gill">David Gill</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Penn State University</s1><s2>Hershey, Pa.</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Hershey, Pa.</wicri:noRegion></affiliation></author><author><name sortKey="Eslinger, Paul" sort="Eslinger, Paul" uniqKey="Eslinger P" first="Paul" last="Eslinger">Paul Eslinger</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Penn State University</s1><s2>Hershey, Pa.</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Hershey, Pa.</wicri:noRegion></affiliation></author><author><name sortKey="Marshall, Fred" sort="Marshall, Fred" uniqKey="Marshall F" first="Fred" last="Marshall">Fred Marshall</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, University of Rochester</s1><s2>Rochester, N.Y.</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Rochester, N.Y.</wicri:noRegion></affiliation></author><author><name sortKey="Mapstone, Mark" sort="Mapstone, Mark" uniqKey="Mapstone M" first="Mark" last="Mapstone">Mark Mapstone</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, University of Rochester</s1><s2>Rochester, N.Y.</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Rochester, N.Y.</wicri:noRegion></affiliation></author><author><name sortKey="Chou, Kelvin L" sort="Chou, Kelvin L" uniqKey="Chou K" first="Kelvin L." last="Chou">Kelvin L. Chou</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Neurology, University of Michigan</s1><s2>Ann Arbor, Mich.</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Ann Arbor, Mich.</wicri:noRegion></affiliation></author><author><name sortKey="Persad, Carol" sort="Persad, Carol" uniqKey="Persad C" first="Carol" last="Persad">Carol Persad</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Psychiatry, University of Michigan</s1><s2>Ann Arbor, Mich.</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Ann Arbor, Mich.</wicri:noRegion></affiliation></author><author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Neurology, University of California, San Diego</s1><s2>La Jolla, Calif.</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mast, Benjamin" sort="Mast, Benjamin" uniqKey="Mast B" first="Benjamin" last="Mast">Benjamin Mast</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Psychological and Brain Sciences, University of Louisville</s1><s2>Louisville, Ky.</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Louisville, Ky.</wicri:noRegion></affiliation></author><author><name sortKey="Tang Wai, David" sort="Tang Wai, David" uniqKey="Tang Wai D" first="David" last="Tang-Wai">David Tang-Wai</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ont.</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmond J. Safra Program in Parkinson's Disease</wicri:noRegion></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ont.</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmond J. Safra Program in Parkinson's Disease</wicri:noRegion></affiliation></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ont.</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmond J. Safra Program in Parkinson's Disease</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0276732</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0276732 INIST</idno><idno type="RBID">Pascal:13-0276732</idno><idno type="wicri:Area/PascalFrancis/Corpus">000076</idno><idno type="wicri:Area/PascalFrancis/Curation">000B57</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000075</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000075</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease</title><author><name sortKey="Reginold, William" sort="Reginold, William" uniqKey="Reginold W" first="William" last="Reginold">William Reginold</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ont.</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmond J. Safra Program in Parkinson's Disease</wicri:noRegion></affiliation></author><author><name sortKey="Duff Canning, Sarah" sort="Duff Canning, Sarah" uniqKey="Duff Canning S" first="Sarah" last="Duff-Canning">Sarah Duff-Canning</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuropsychology Toronto, University Health Network</s1><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Neuropsychology Toronto, University Health Network</wicri:noRegion></affiliation></author><author><name sortKey="Meaney, Christopher" sort="Meaney, Christopher" uniqKey="Meaney C" first="Christopher" last="Meaney">Christopher Meaney</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Family and Community Medicine, Research Division, University of Toronto</s1><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Armstrong, Melissa J" sort="Armstrong, Melissa J" uniqKey="Armstrong M" first="Melissa J." last="Armstrong">Melissa J. Armstrong</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ont.</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmond J. Safra Program in Parkinson's Disease</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Susan" sort="Fox, Susan" uniqKey="Fox S" first="Susan" last="Fox">Susan Fox</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ont.</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmond J. Safra Program in Parkinson's Disease</wicri:noRegion></affiliation></author><author><name sortKey="Rothberg, Brandon" sort="Rothberg, Brandon" uniqKey="Rothberg B" first="Brandon" last="Rothberg">Brandon Rothberg</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ont.</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmond J. Safra Program in Parkinson's Disease</wicri:noRegion></affiliation></author><author><name sortKey="Zadikoff, Cindy" sort="Zadikoff, Cindy" uniqKey="Zadikoff C" first="Cindy" last="Zadikoff">Cindy Zadikoff</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Northwestern University</s1><s2>Evanston, Ill.</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, Ill.</wicri:noRegion></affiliation></author><author><name sortKey="Kennedy, Nancy" sort="Kennedy, Nancy" uniqKey="Kennedy N" first="Nancy" last="Kennedy">Nancy Kennedy</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychiatry and Behavioral Science, Northwestern University</s1><s2>Evanston, Ill.</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, Ill.</wicri:noRegion></affiliation></author><author><name sortKey="Gill, David" sort="Gill, David" uniqKey="Gill D" first="David" last="Gill">David Gill</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Penn State University</s1><s2>Hershey, Pa.</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Hershey, Pa.</wicri:noRegion></affiliation></author><author><name sortKey="Eslinger, Paul" sort="Eslinger, Paul" uniqKey="Eslinger P" first="Paul" last="Eslinger">Paul Eslinger</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Penn State University</s1><s2>Hershey, Pa.</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Hershey, Pa.</wicri:noRegion></affiliation></author><author><name sortKey="Marshall, Fred" sort="Marshall, Fred" uniqKey="Marshall F" first="Fred" last="Marshall">Fred Marshall</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, University of Rochester</s1><s2>Rochester, N.Y.</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Rochester, N.Y.</wicri:noRegion></affiliation></author><author><name sortKey="Mapstone, Mark" sort="Mapstone, Mark" uniqKey="Mapstone M" first="Mark" last="Mapstone">Mark Mapstone</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, University of Rochester</s1><s2>Rochester, N.Y.</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Rochester, N.Y.</wicri:noRegion></affiliation></author><author><name sortKey="Chou, Kelvin L" sort="Chou, Kelvin L" uniqKey="Chou K" first="Kelvin L." last="Chou">Kelvin L. Chou</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Neurology, University of Michigan</s1><s2>Ann Arbor, Mich.</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Ann Arbor, Mich.</wicri:noRegion></affiliation></author><author><name sortKey="Persad, Carol" sort="Persad, Carol" uniqKey="Persad C" first="Carol" last="Persad">Carol Persad</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Psychiatry, University of Michigan</s1><s2>Ann Arbor, Mich.</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Ann Arbor, Mich.</wicri:noRegion></affiliation></author><author><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Neurology, University of California, San Diego</s1><s2>La Jolla, Calif.</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mast, Benjamin" sort="Mast, Benjamin" uniqKey="Mast B" first="Benjamin" last="Mast">Benjamin Mast</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Psychological and Brain Sciences, University of Louisville</s1><s2>Louisville, Ky.</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Louisville, Ky.</wicri:noRegion></affiliation></author><author><name sortKey="Tang Wai, David" sort="Tang Wai, David" uniqKey="Tang Wai D" first="David" last="Tang-Wai">David Tang-Wai</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ont.</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmond J. Safra Program in Parkinson's Disease</wicri:noRegion></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ont.</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmond J. Safra Program in Parkinson's Disease</wicri:noRegion></affiliation></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ont.</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmond J. Safra Program in Parkinson's Disease</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Dementia and geriatric cognitive disorders</title><title level="j" type="abbreviated">Dement. geriatr. cogn. disord.</title><idno type="ISSN">1420-8008</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Dementia and geriatric cognitive disorders</title><title level="j" type="abbreviated">Dement. geriatr. cogn. disord.</title><idno type="ISSN">1420-8008</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognitive disorder</term><term>Degenerative disease</term><term>Dementia</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Quality of life</term><term>mild cognitive impairment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Déficit cognitif léger</term><term>Trouble cognitif</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Démence</term><term>Maladie dégénérative</term><term>Qualité de vie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background/Aims: To assess the impact of mild cognitive impairment (MCI) or cognitive decline on health-related quality of life (HR-QOL) in Parkinson's disease (PD). Methods: HR-QOL measured by the Parkinson Disease Quality of Life Questionnaire (PDQ-39), MCI according to Movement Disorder Society Task Force criteria and cognitive decline from premorbid baseline were assessed in non-demented PD patients at 6 movement disorder clinics. Results: Among 137 patients, after adjusting for education, gender, disease duration, and Movement Disorder Society Unified Parkinson's Disease Rating Scale total score, MCI was associated with worse scores within the PDQ-39 dimension of communication (p = 0.008). Subjects were divided into tertiles of cognitive decline from premorbid level. Scores in the dimension of stigma were worst in the second tertile of cognitive decline (p = 0.03). MCI was associated with worse social support scores in the second tertile of cognitive decline (p = 0.008). Conclusion: MCI and cognitive decline from premorbid baseline are associated with reduced HR-QOL in communication, stigma, and social support domains. The cognitive decline from premorbid baseline modifies the association between MCI and HR-QOL in PD and knowing both will allow a better appreciation of difficulties patients face in daily life.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1420-8008</s0></fA01><fA03 i2="1"><s0>Dement. geriatr. cogn. disord.</s0></fA03><fA05><s2>36</s2></fA05><fA06><s2>1-2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease</s1></fA08><fA11 i1="01" i2="1"><s1>REGINOLD (William)</s1></fA11><fA11 i1="02" i2="1"><s1>DUFF-CANNING (Sarah)</s1></fA11><fA11 i1="03" i2="1"><s1>MEANEY (Christopher)</s1></fA11><fA11 i1="04" i2="1"><s1>ARMSTRONG (Melissa J.)</s1></fA11><fA11 i1="05" i2="1"><s1>FOX (Susan)</s1></fA11><fA11 i1="06" i2="1"><s1>ROTHBERG (Brandon)</s1></fA11><fA11 i1="07" i2="1"><s1>ZADIKOFF (Cindy)</s1></fA11><fA11 i1="08" i2="1"><s1>KENNEDY (Nancy)</s1></fA11><fA11 i1="09" i2="1"><s1>GILL (David)</s1></fA11><fA11 i1="10" i2="1"><s1>ESLINGER (Paul)</s1></fA11><fA11 i1="11" i2="1"><s1>MARSHALL (Fred)</s1></fA11><fA11 i1="12" i2="1"><s1>MAPSTONE (Mark)</s1></fA11><fA11 i1="13" i2="1"><s1>CHOU (Kelvin L.)</s1></fA11><fA11 i1="14" i2="1"><s1>PERSAD (Carol)</s1></fA11><fA11 i1="15" i2="1"><s1>LITVAN (Irene)</s1></fA11><fA11 i1="16" i2="1"><s1>MAST (Benjamin)</s1></fA11><fA11 i1="17" i2="1"><s1>TANG-WAI (David)</s1></fA11><fA11 i1="18" i2="1"><s1>LANG (Anthony E.)</s1></fA11><fA11 i1="19" i2="1"><s1>MARRAS (Connie)</s1></fA11><fA14 i1="01"><s1>Toronto Western Hospital</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="02"><s1>Neuropsychology Toronto, University Health Network</s1><s3>CAN</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Movement Disorders Centre, Division of Neurology, University of Toronto</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="04"><s1>Family and Community Medicine, Research Division, University of Toronto</s1><s3>CAN</s3><sZ>3 aut.</sZ></fA14><fA14 i1="05"><s1>Edmond J. Safra Program in Parkinson's Disease</s1><s2>Toronto, Ont.</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Neurology, Northwestern University</s1><s2>Evanston, Ill.</s2><s3>USA</s3><sZ>7 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Psychiatry and Behavioral Science, Northwestern University</s1><s2>Evanston, Ill.</s2><s3>USA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Neurology, Penn State University</s1><s2>Hershey, Pa.</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="09"><s1>Department of Neurology, University of Rochester</s1><s2>Rochester, N.Y.</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></fA14><fA14 i1="10"><s1>Department of Neurology, University of Michigan</s1><s2>Ann Arbor, Mich.</s2><s3>USA</s3><sZ>13 aut.</sZ></fA14><fA14 i1="11"><s1>Department of Psychiatry, University of Michigan</s1><s2>Ann Arbor, Mich.</s2><s3>USA</s3><sZ>14 aut.</sZ></fA14><fA14 i1="12"><s1>Neurology, University of California, San Diego</s1><s2>La Jolla, Calif.</s2><s3>USA</s3><sZ>15 aut.</sZ></fA14><fA14 i1="13"><s1>Psychological and Brain Sciences, University of Louisville</s1><s2>Louisville, Ky.</s2><s3>USA</s3><sZ>16 aut.</sZ></fA14><fA20><s1>67-75</s1></fA20><fA21><s1>2013</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>22106</s2><s5>354000501924680060</s5></fA43><fA44><s0>0000</s0><s1>© 2013 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>32 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>13-0276732</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Dementia and geriatric cognitive disorders</s0></fA64><fA66 i1="01"><s0>CHE</s0></fA66><fC01 i1="01" l="ENG"><s0>Background/Aims: To assess the impact of mild cognitive impairment (MCI) or cognitive decline on health-related quality of life (HR-QOL) in Parkinson's disease (PD). Methods: HR-QOL measured by the Parkinson Disease Quality of Life Questionnaire (PDQ-39), MCI according to Movement Disorder Society Task Force criteria and cognitive decline from premorbid baseline were assessed in non-demented PD patients at 6 movement disorder clinics. Results: Among 137 patients, after adjusting for education, gender, disease duration, and Movement Disorder Society Unified Parkinson's Disease Rating Scale total score, MCI was associated with worse scores within the PDQ-39 dimension of communication (p = 0.008). Subjects were divided into tertiles of cognitive decline from premorbid level. Scores in the dimension of stigma were worst in the second tertile of cognitive decline (p = 0.03). MCI was associated with worse social support scores in the second tertile of cognitive decline (p = 0.008). Conclusion: MCI and cognitive decline from premorbid baseline are associated with reduced HR-QOL in communication, stigma, and social support domains. The cognitive decline from premorbid baseline modifies the association between MCI and HR-QOL in PD and knowing both will allow a better appreciation of difficulties patients face in daily life.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC02 i1="02" i2="X"><s0>002B17C</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Déficit cognitif léger</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>mild cognitive impairment</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Disturbio cognitivo ligero</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Trouble cognitif</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Cognitive disorder</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Trastorno cognitivo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Démence</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Dementia</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Demencia</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Qualité de vie</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Quality of life</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Calidad vida</s0><s5>09</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>39</s5></fC07><fN21><s1>259</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Californie</li><li>Ontario</li></region><settlement><li>San Diego</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Reginold, William" sort="Reginold, William" uniqKey="Reginold W" first="William" last="Reginold">William Reginold</name></noRegion><name sortKey="Armstrong, Melissa J" sort="Armstrong, Melissa J" uniqKey="Armstrong M" first="Melissa J." last="Armstrong">Melissa J. Armstrong</name><name sortKey="Armstrong, Melissa J" sort="Armstrong, Melissa J" uniqKey="Armstrong M" first="Melissa J." last="Armstrong">Melissa J. Armstrong</name><name sortKey="Armstrong, Melissa J" sort="Armstrong, Melissa J" uniqKey="Armstrong M" first="Melissa J." last="Armstrong">Melissa J. Armstrong</name><name sortKey="Duff Canning, Sarah" sort="Duff Canning, Sarah" uniqKey="Duff Canning S" first="Sarah" last="Duff-Canning">Sarah Duff-Canning</name><name sortKey="Fox, Susan" sort="Fox, Susan" uniqKey="Fox S" first="Susan" last="Fox">Susan Fox</name><name sortKey="Fox, Susan" sort="Fox, Susan" uniqKey="Fox S" first="Susan" last="Fox">Susan Fox</name><name sortKey="Fox, Susan" sort="Fox, Susan" uniqKey="Fox S" first="Susan" last="Fox">Susan Fox</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name><name sortKey="Meaney, Christopher" sort="Meaney, Christopher" uniqKey="Meaney C" first="Christopher" last="Meaney">Christopher Meaney</name><name sortKey="Reginold, William" sort="Reginold, William" uniqKey="Reginold W" first="William" last="Reginold">William Reginold</name><name sortKey="Reginold, William" sort="Reginold, William" uniqKey="Reginold W" first="William" last="Reginold">William Reginold</name><name sortKey="Rothberg, Brandon" sort="Rothberg, Brandon" uniqKey="Rothberg B" first="Brandon" last="Rothberg">Brandon Rothberg</name><name sortKey="Rothberg, Brandon" sort="Rothberg, Brandon" uniqKey="Rothberg B" first="Brandon" last="Rothberg">Brandon Rothberg</name><name sortKey="Rothberg, Brandon" sort="Rothberg, Brandon" uniqKey="Rothberg B" first="Brandon" last="Rothberg">Brandon Rothberg</name><name sortKey="Tang Wai, David" sort="Tang Wai, David" uniqKey="Tang Wai D" first="David" last="Tang-Wai">David Tang-Wai</name><name sortKey="Tang Wai, David" sort="Tang Wai, David" uniqKey="Tang Wai D" first="David" last="Tang-Wai">David Tang-Wai</name><name sortKey="Tang Wai, David" sort="Tang Wai, David" uniqKey="Tang Wai D" first="David" last="Tang-Wai">David Tang-Wai</name></country><country name="États-Unis"><noRegion><name sortKey="Zadikoff, Cindy" sort="Zadikoff, Cindy" uniqKey="Zadikoff C" first="Cindy" last="Zadikoff">Cindy Zadikoff</name></noRegion><name sortKey="Chou, Kelvin L" sort="Chou, Kelvin L" uniqKey="Chou K" first="Kelvin L." last="Chou">Kelvin L. Chou</name><name sortKey="Eslinger, Paul" sort="Eslinger, Paul" uniqKey="Eslinger P" first="Paul" last="Eslinger">Paul Eslinger</name><name sortKey="Gill, David" sort="Gill, David" uniqKey="Gill D" first="David" last="Gill">David Gill</name><name sortKey="Kennedy, Nancy" sort="Kennedy, Nancy" uniqKey="Kennedy N" first="Nancy" last="Kennedy">Nancy Kennedy</name><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><name sortKey="Mapstone, Mark" sort="Mapstone, Mark" uniqKey="Mapstone M" first="Mark" last="Mapstone">Mark Mapstone</name><name sortKey="Marshall, Fred" sort="Marshall, Fred" uniqKey="Marshall F" first="Fred" last="Marshall">Fred Marshall</name><name sortKey="Mast, Benjamin" sort="Mast, Benjamin" uniqKey="Mast B" first="Benjamin" last="Mast">Benjamin Mast</name><name sortKey="Persad, Carol" sort="Persad, Carol" uniqKey="Persad C" first="Carol" last="Persad">Carol Persad</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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