Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease
Identifieur interne : 001C58 ( Ncbi/Curation ); précédent : 001C57; suivant : 001C59Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease
Auteurs : Joseph J. Locascio [États-Unis] ; Shirley Eberly [États-Unis] ; Zhixiang Liao [États-Unis] ; Ganqiang Liu [États-Unis] ; Ashley N. Hoesing [États-Unis] ; Karen Duong [États-Unis] ; Ana Trisini-Lipsanopoulos [États-Unis] ; Kaltra Dhima [États-Unis] ; Albert Y. Hung [États-Unis] ; Alice W. Flaherty [États-Unis] ; Michael A. Schwarzschild [États-Unis] ; Michael T. Hayes [États-Unis] ; Anne-Marie Wills [États-Unis] ; U. Shivraj Sohur [États-Unis] ; Nicte I. Mejia [États-Unis] ; Dennis J. Selkoe [États-Unis] ; David Oakes [États-Unis] ; Ira Shoulson [États-Unis] ; Xianjun Dong [États-Unis] ; Ken Marek [États-Unis] ; Bin Zheng [États-Unis] ; Adrian Ivinson [États-Unis] ; Bradley T. Hyman [États-Unis] ; John H. Growdon [États-Unis] ; Lewis R. Sudarsky [États-Unis] ; Michael G. Schlossmacher [États-Unis] ; Bernard Ravina [Canada] ; Clemens R. Scherzer [États-Unis]Source :
- Brain [ 0006-8950 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Cognition Disorders (etiology), Cognition Disorders (genetics), Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Gene Expression Regulation, Genetic Testing, Humans, Male, Microarray Analysis, Middle Aged, Neuroimaging, Parkinson Disease (complications), Parkinson Disease (diagnostic imaging), Parkinson Disease (genetics), Parkinson Disease (pathology), RNA, Messenger (metabolism), Radionuclide Imaging, Severity of Illness Index, Tropanes, alpha-Synuclein (blood), alpha-Synuclein (genetics).
- MESH :
- chemical , blood : alpha-Synuclein.
- chemical , genetics : alpha-Synuclein.
- chemical , metabolism : Dopamine Plasma Membrane Transport Proteins, RNA, Messenger.
- complications : Parkinson Disease.
- diagnostic imaging : Parkinson Disease.
- etiology : Cognition Disorders.
- genetics : Cognition Disorders, Parkinson Disease.
- pathology : Parkinson Disease.
- Aged, Female, Gene Expression Regulation, Genetic Testing, Humans, Male, Microarray Analysis, Middle Aged, Neuroimaging, Radionuclide Imaging, Severity of Illness Index, Tropanes.
Abstract
The α-synuclein gene,
Url:
DOI: 10.1093/brain/awv202
PubMed: 26220939
PubMed Central: 4643625
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PMC:4643625Le document en format XML
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<affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff>
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<author><name sortKey="Ivinson, Adrian" sort="Ivinson, Adrian" uniqKey="Ivinson A" first="Adrian" last="Ivinson">Adrian Ivinson</name>
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<affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff>
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<author><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name>
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<author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name>
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<author><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R." last="Sudarsky">Lewis R. Sudarsky</name>
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<author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF9">9 Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA</nlm:aff>
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<author><name sortKey="Ravina, Bernard" sort="Ravina, Bernard" uniqKey="Ravina B" first="Bernard" last="Ravina">Bernard Ravina</name>
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<country xml:lang="fr">Canada</country>
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</author>
<author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name>
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</analytic>
<series><title level="j">Brain</title>
<idno type="ISSN">0006-8950</idno>
<idno type="eISSN">1460-2156</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cognition Disorders (etiology)</term>
<term>Cognition Disorders (genetics)</term>
<term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Genetic Testing</term>
<term>Humans</term>
<term>Male</term>
<term>Microarray Analysis</term>
<term>Middle Aged</term>
<term>Neuroimaging</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (pathology)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Radionuclide Imaging</term>
<term>Severity of Illness Index</term>
<term>Tropanes</term>
<term>alpha-Synuclein (blood)</term>
<term>alpha-Synuclein (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term>
<term>RNA, Messenger</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Genetic Testing</term>
<term>Humans</term>
<term>Male</term>
<term>Microarray Analysis</term>
<term>Middle Aged</term>
<term>Neuroimaging</term>
<term>Radionuclide Imaging</term>
<term>Severity of Illness Index</term>
<term>Tropanes</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The α-synuclein gene, <italic>SNCA</italic>
, is selectively expressed in blood cells and neurons. Locascio <italic>et al.</italic>
reveal a paradoxical reduction in <italic>SNCA</italic>
transcript counts in the blood of individuals with early-stage, neuroimaging-supported Parkinson’s disease in three regional, national, and international populations. Low <italic>SCNA</italic>
transcript abundance predicted subsequent cognitive decline.</p>
</div>
</front>
</TEI>
</record>
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