Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease
Identifieur interne : 000354 ( Pmc/Checkpoint ); précédent : 000353; suivant : 000355Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease
Auteurs : Joseph J. Locascio [États-Unis] ; Shirley Eberly [États-Unis] ; Zhixiang Liao [États-Unis] ; Ganqiang Liu [États-Unis] ; Ashley N. Hoesing [États-Unis] ; Karen Duong [États-Unis] ; Ana Trisini-Lipsanopoulos [États-Unis] ; Kaltra Dhima [États-Unis] ; Albert Y. Hung [États-Unis] ; Alice W. Flaherty [États-Unis] ; Michael A. Schwarzschild [États-Unis] ; Michael T. Hayes [États-Unis] ; Anne-Marie Wills [États-Unis] ; U. Shivraj Sohur [États-Unis] ; Nicte I. Mejia [États-Unis] ; Dennis J. Selkoe [États-Unis] ; David Oakes [États-Unis] ; Ira Shoulson [États-Unis] ; Xianjun Dong [États-Unis] ; Ken Marek [États-Unis] ; Bin Zheng [États-Unis] ; Adrian Ivinson [États-Unis] ; Bradley T. Hyman [États-Unis] ; John H. Growdon [États-Unis] ; Lewis R. Sudarsky [États-Unis] ; Michael G. Schlossmacher [États-Unis] ; Bernard Ravina [Canada] ; Clemens R. Scherzer [États-Unis]Source :
- Brain [ 0006-8950 ] ; 2015.
Abstract
The α-synuclein gene,
Url:
DOI: 10.1093/brain/awv202
PubMed: 26220939
PubMed Central: 4643625
Affiliations:
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USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 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Selkoe</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF3">3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea><wicri:noRegion>NY 14642</wicri:noRegion></affiliation></author><author><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF8">8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007</wicri:regionArea><wicri:noRegion>DC 20007</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Xianjun" sort="Dong, Xianjun" uniqKey="Dong X" first="Xianjun" last="Dong">Xianjun Dong</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF8">8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007</wicri:regionArea><wicri:noRegion>DC 20007</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Bin" sort="Zheng, Bin" uniqKey="Zheng B" first="Bin" last="Zheng">Bin Zheng</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Ivinson, Adrian" sort="Ivinson, Adrian" uniqKey="Ivinson A" first="Adrian" last="Ivinson">Adrian Ivinson</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation></author><author><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R." last="Sudarsky">Lewis R. Sudarsky</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF9">9 Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>9 Institute for Neurodegenerative Disorders, New Haven, CT 06510</wicri:regionArea><wicri:noRegion>CT 06510</wicri:noRegion></affiliation></author><author><name sortKey="Ravina, Bernard" sort="Ravina, Bernard" uniqKey="Ravina B" first="Bernard" last="Ravina">Bernard Ravina</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF10">10 Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario K1H8M5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>10 Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario K1H8M5</wicri:regionArea><wicri:noRegion>Ontario K1H8M5</wicri:noRegion></affiliation></author><author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26220939</idno><idno type="pmc">4643625</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643625</idno><idno type="RBID">PMC:4643625</idno><idno type="doi">10.1093/brain/awv202</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000030</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000030</idno><idno type="wicri:Area/Pmc/Curation">000030</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000030</idno><idno type="wicri:Area/Pmc/Checkpoint">000354</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000354</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease</title><author><name sortKey="Locascio, Joseph J" sort="Locascio, Joseph J" uniqKey="Locascio J" first="Joseph J." last="Locascio">Joseph J. Locascio</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation></author><author><name sortKey="Eberly, Shirley" sort="Eberly, Shirley" uniqKey="Eberly S" first="Shirley" last="Eberly">Shirley Eberly</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF3">3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea><wicri:noRegion>NY 14642</wicri:noRegion></affiliation></author><author><name sortKey="Liao, Zhixiang" sort="Liao, Zhixiang" uniqKey="Liao Z" first="Zhixiang" last="Liao">Zhixiang Liao</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Ganqiang" sort="Liu, Ganqiang" uniqKey="Liu G" first="Ganqiang" last="Liu">Ganqiang Liu</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N." last="Hoesing">Ashley N. Hoesing</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, 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USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Hung, Albert Y" sort="Hung, Albert Y" uniqKey="Hung A" first="Albert Y." last="Hung">Albert Y. Hung</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation></author><author><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W." last="Flaherty">Alice W. 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University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea><wicri:noRegion>NY 14642</wicri:noRegion></affiliation></author><author><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF8">8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007</wicri:regionArea><wicri:noRegion>DC 20007</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Xianjun" sort="Dong, Xianjun" uniqKey="Dong X" first="Xianjun" last="Dong">Xianjun Dong</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF8">8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007</wicri:regionArea><wicri:noRegion>DC 20007</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Bin" sort="Zheng, Bin" uniqKey="Zheng B" first="Bin" last="Zheng">Bin Zheng</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Ivinson, Adrian" sort="Ivinson, Adrian" uniqKey="Ivinson A" first="Adrian" last="Ivinson">Adrian Ivinson</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation></author><author><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R." last="Sudarsky">Lewis R. Sudarsky</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author><author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF9">9 Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>9 Institute for Neurodegenerative Disorders, New Haven, CT 06510</wicri:regionArea><wicri:noRegion>CT 06510</wicri:noRegion></affiliation></author><author><name sortKey="Ravina, Bernard" sort="Ravina, Bernard" uniqKey="Ravina B" first="Bernard" last="Ravina">Bernard Ravina</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF10">10 Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario K1H8M5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>10 Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario K1H8M5</wicri:regionArea><wicri:noRegion>Ontario K1H8M5</wicri:noRegion></affiliation></author><author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><affiliation wicri:level="1"><nlm:aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea><wicri:noRegion>MA 02139</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea><wicri:noRegion>MA 02114</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea><wicri:noRegion>MA 02115</wicri:noRegion></affiliation></author></analytic><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The α-synuclein gene, <italic>SNCA</italic>, is selectively expressed in blood cells and neurons. Locascio <italic>et al.</italic> reveal a paradoxical reduction in <italic>SNCA</italic> transcript counts in the blood of individuals with early-stage, neuroimaging-supported Parkinson’s disease in three regional, national, and international populations. Low <italic>SCNA</italic> transcript abundance predicted subsequent cognitive decline.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Brain</journal-id><journal-id journal-id-type="iso-abbrev">Brain</journal-id><journal-id journal-id-type="publisher-id">brainj</journal-id><journal-id journal-id-type="hwp">brain</journal-id><journal-title-group><journal-title>Brain</journal-title></journal-title-group><issn pub-type="ppub">0006-8950</issn><issn pub-type="epub">1460-2156</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26220939</article-id><article-id pub-id-type="pmc">4643625</article-id><article-id pub-id-type="doi">10.1093/brain/awv202</article-id><article-id pub-id-type="publisher-id">awv202</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>1040</subject></subj-group></article-categories><title-group><article-title>Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Locascio</surname><given-names>Joseph J.</given-names></name><xref ref-type="aff" rid="awv202-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awv202-AFF2"><sup>2</sup></xref><xref ref-type="author-notes" rid="awv202-FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Eberly</surname><given-names>Shirley</given-names></name><xref ref-type="aff" rid="awv202-AFF3"><sup>3</sup></xref><xref ref-type="author-notes" rid="awv202-FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Liao</surname><given-names>Zhixiang</given-names></name><xref ref-type="aff" rid="awv202-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awv202-AFF4"><sup>4</sup></xref><xref ref-type="author-notes" rid="awv202-FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Ganqiang</given-names></name><xref ref-type="aff" rid="awv202-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awv202-AFF4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hoesing</surname><given-names>Ashley N.</given-names></name><xref ref-type="aff" rid="awv202-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awv202-AFF4"><sup>4</sup></xref><xref ref-type="aff" rid="awv202-AFF5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Duong</surname><given-names>Karen</given-names></name><xref ref-type="aff" rid="awv202-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awv202-AFF4"><sup>4</sup></xref><xref ref-type="aff" rid="awv202-AFF5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Trisini-Lipsanopoulos</surname><given-names>Ana</given-names></name><xref ref-type="aff" rid="awv202-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awv202-AFF4"><sup>4</sup></xref><xref ref-type="aff" rid="awv202-AFF5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dhima</surname><given-names>Kaltra</given-names></name><xref ref-type="aff" rid="awv202-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awv202-AFF4"><sup>4</sup></xref><xref ref-type="aff" rid="awv202-AFF5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hung</surname><given-names>Albert Y.</given-names></name><xref ref-type="aff" rid="awv202-AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Flaherty</surname><given-names>Alice W.</given-names></name><xref ref-type="aff" rid="awv202-AFF2"><sup>2</sup></xref><xref ref-type="aff" rid="awv202-AFF6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schwarzschild</surname><given-names>Michael A.</given-names></name><xref ref-type="aff" rid="awv202-AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hayes</surname><given-names>Michael T.</given-names></name><xref ref-type="aff" rid="awv202-AFF7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wills</surname><given-names>Anne-Marie</given-names></name><xref ref-type="aff" rid="awv202-AFF2"><sup>2</sup></xref><xref ref-type="aff" rid="awv202-AFF5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shivraj Sohur</surname><given-names>U.</given-names></name><xref ref-type="aff" rid="awv202-AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mejia</surname><given-names>Nicte I.</given-names></name><xref ref-type="aff" rid="awv202-AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Selkoe</surname><given-names>Dennis J.</given-names></name><xref ref-type="aff" rid="awv202-AFF4"><sup>4</sup></xref><xref ref-type="aff" rid="awv202-AFF7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Oakes</surname><given-names>David</given-names></name><xref ref-type="aff" rid="awv202-AFF3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shoulson</surname><given-names>Ira</given-names></name><xref ref-type="aff" rid="awv202-AFF8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dong</surname><given-names>Xianjun</given-names></name><xref ref-type="aff" rid="awv202-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awv202-AFF4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Marek</surname><given-names>Ken</given-names></name><xref ref-type="aff" rid="awv202-AFF8"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Bin</given-names></name><xref ref-type="aff" rid="awv202-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awv202-AFF4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ivinson</surname><given-names>Adrian</given-names></name><xref ref-type="aff" rid="awv202-AFF4"><sup>4</sup></xref><xref ref-type="aff" rid="awv202-AFF5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hyman</surname><given-names>Bradley T.</given-names></name><xref ref-type="aff" rid="awv202-AFF2"><sup>2</sup></xref><xref ref-type="aff" rid="awv202-AFF5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Growdon</surname><given-names>John H.</given-names></name><xref ref-type="aff" rid="awv202-AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sudarsky</surname><given-names>Lewis R.</given-names></name><xref ref-type="aff" rid="awv202-AFF7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schlossmacher</surname><given-names>Michael G.</given-names></name><xref ref-type="aff" rid="awv202-AFF9"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ravina</surname><given-names>Bernard</given-names></name><xref ref-type="aff" rid="awv202-AFF10"><sup>11</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Scherzer</surname><given-names>Clemens R.</given-names></name><xref ref-type="aff" rid="awv202-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awv202-AFF2"><sup>2</sup></xref><xref ref-type="aff" rid="awv202-AFF4"><sup>4</sup></xref><xref ref-type="aff" rid="awv202-AFF5"><sup>5</sup></xref><xref ref-type="aff" rid="awv202-AFF7"><sup>7</sup></xref></contrib><aff id="awv202-AFF1">1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139, USA</aff><aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</aff><aff id="awv202-AFF3">3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA</aff><aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</aff><aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</aff><aff id="awv202-AFF6">6 Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA</aff><aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</aff><aff id="awv202-AFF8">8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007, USA</aff><aff id="awv202-AFF9">9 Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA</aff><aff id="awv202-AFF10">10 Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario K1H8M5, Canada</aff><aff id="awv202-AFF11">11 Voyager Therapeutics, Clinical Development, Cambridge, MA 02142, USA</aff></contrib-group><author-notes><corresp>Correspondence to: Clemens R. Scherzer, MD, Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, 65 Landsdowne Street, Suite 307A, Cambridge, MA 02139, USA E-mail: <email>cscherzer@rics.bwh.harvard.edu</email></corresp><fn id="awv202-FN1"><p>*These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="ppub"><month>9</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>28</day><month>7</month><year>2015</year></pub-date><volume>138</volume><issue>9</issue><fpage>2659</fpage><lpage>2671</lpage><history><date date-type="received"><day>14</day><month>11</month><year>2014</year></date><date date-type="rev-recd"><day>12</day><month>5</month><year>2015</year></date><date date-type="accepted"><day>25</day><month>5</month><year>2015</year></date></history><permissions><copyright-statement>© The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract abstract-type="precis"><p>The α-synuclein gene, <italic>SNCA</italic>, is selectively expressed in blood cells and neurons. Locascio <italic>et al.</italic> reveal a paradoxical reduction in <italic>SNCA</italic> transcript counts in the blood of individuals with early-stage, neuroimaging-supported Parkinson’s disease in three regional, national, and international populations. Low <italic>SCNA</italic> transcript abundance predicted subsequent cognitive decline.</p></abstract><abstract abstract-type="graphical"><p><fig id="fig1g" fig-type="featured" position="float"><caption><p>The α-synuclein gene, <italic>SNCA</italic>, is selectively expressed in blood cells and neurons. Locascio <italic>et al.</italic> reveal a paradoxical reduction in <italic>SNCA</italic> transcript counts in the blood of individuals with early-stage, neuroimaging-supported Parkinson’s disease in three regional, national, and international populations. Low <italic>SCNA</italic> transcript abundance predicted subsequent cognitive decline.</p></caption><graphic xlink:href="awv202fig1g"></graphic></fig></p></abstract><abstract><p>There are no cures for neurodegenerative diseases and this is partially due to the difficulty of monitoring pathogenic molecules in patients during life. The Parkinson’s disease gene α-synuclein (<italic>SNCA</italic>) is selectively expressed in blood cells and neurons. Here we show that <italic>SNCA</italic> transcripts in circulating blood cells are paradoxically reduced in early stage, untreated and dopamine transporter neuroimaging-supported Parkinson’s disease in three independent regional, national, and international populations representing 500 cases and 363 controls and on three analogue and digital platforms with <italic>P</italic> < 0.0001 in meta-analysis. Individuals with <italic>SNCA</italic> transcripts in the lowest quartile of counts had an odds ratio for Parkinson’s disease of 2.45 compared to individuals in the highest quartile. Disease-relevant transcript isoforms were low even near disease onset. Importantly, low <italic>SNCA</italic> transcript abundance predicted cognitive decline in patients with Parkinson’s disease during up to 5 years of longitudinal follow-up. This study reveals a consistent association of reduced <italic>SNCA</italic> transcripts in accessible peripheral blood and early-stage Parkinson’s disease in 863 participants and suggests a clinical role as potential predictor of cognitive decline. Moreover, the three independent biobank cohorts provide a generally useful platform for rapidly validating any biological marker of this common disease.</p></abstract><kwd-group kwd-group-type="keywords"><kwd>α-synuclein</kwd><kwd>biomarker</kwd><kwd>gene expression</kwd><kwd>biobank</kwd><kwd>mitochondria</kwd><kwd>cognitive decline</kwd></kwd-group><counts><page-count count="13"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Canada</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Locascio, Joseph J" sort="Locascio, Joseph J" uniqKey="Locascio J" first="Joseph J." last="Locascio">Joseph J. Locascio</name></noRegion><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name><name sortKey="Dong, Xianjun" sort="Dong, Xianjun" uniqKey="Dong X" first="Xianjun" last="Dong">Xianjun Dong</name><name sortKey="Dong, Xianjun" sort="Dong, Xianjun" uniqKey="Dong X" first="Xianjun" last="Dong">Xianjun Dong</name><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name><name sortKey="Eberly, Shirley" sort="Eberly, Shirley" uniqKey="Eberly S" first="Shirley" last="Eberly">Shirley Eberly</name><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W." last="Flaherty">Alice W. Flaherty</name><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W." last="Flaherty">Alice W. Flaherty</name><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name><name sortKey="Hayes, Michael T" sort="Hayes, Michael T" uniqKey="Hayes M" first="Michael T." last="Hayes">Michael T. Hayes</name><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N." last="Hoesing">Ashley N. Hoesing</name><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N." last="Hoesing">Ashley N. Hoesing</name><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N." last="Hoesing">Ashley N. Hoesing</name><name sortKey="Hung, Albert Y" sort="Hung, Albert Y" uniqKey="Hung A" first="Albert Y." last="Hung">Albert Y. Hung</name><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name><name sortKey="Ivinson, Adrian" sort="Ivinson, Adrian" uniqKey="Ivinson A" first="Adrian" last="Ivinson">Adrian Ivinson</name><name sortKey="Ivinson, Adrian" sort="Ivinson, Adrian" uniqKey="Ivinson A" first="Adrian" last="Ivinson">Adrian Ivinson</name><name sortKey="Liao, Zhixiang" sort="Liao, Zhixiang" uniqKey="Liao Z" first="Zhixiang" last="Liao">Zhixiang Liao</name><name sortKey="Liao, Zhixiang" sort="Liao, Zhixiang" uniqKey="Liao Z" first="Zhixiang" last="Liao">Zhixiang Liao</name><name sortKey="Liu, Ganqiang" sort="Liu, Ganqiang" uniqKey="Liu G" first="Ganqiang" last="Liu">Ganqiang Liu</name><name sortKey="Liu, Ganqiang" sort="Liu, Ganqiang" uniqKey="Liu G" first="Ganqiang" last="Liu">Ganqiang Liu</name><name sortKey="Locascio, Joseph J" sort="Locascio, Joseph J" uniqKey="Locascio J" first="Joseph J." last="Locascio">Joseph J. Locascio</name><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name><name sortKey="Mejia, Nicte I" sort="Mejia, Nicte I" uniqKey="Mejia N" first="Nicte I." last="Mejia">Nicte I. Mejia</name><name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name><name sortKey="Selkoe, Dennis J" sort="Selkoe, Dennis J" uniqKey="Selkoe D" first="Dennis J." last="Selkoe">Dennis J. Selkoe</name><name sortKey="Selkoe, Dennis J" sort="Selkoe, Dennis J" uniqKey="Selkoe D" first="Dennis J." last="Selkoe">Dennis J. Selkoe</name><name sortKey="Shivraj Sohur, U" sort="Shivraj Sohur, U" uniqKey="Shivraj Sohur U" first="U." last="Shivraj Sohur">U. Shivraj Sohur</name><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R." last="Sudarsky">Lewis R. Sudarsky</name><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name><name sortKey="Zheng, Bin" sort="Zheng, Bin" uniqKey="Zheng B" first="Bin" last="Zheng">Bin Zheng</name><name sortKey="Zheng, Bin" sort="Zheng, Bin" uniqKey="Zheng B" first="Bin" last="Zheng">Bin Zheng</name></country><country name="Canada"><noRegion><name sortKey="Ravina, Bernard" sort="Ravina, Bernard" uniqKey="Ravina B" first="Bernard" last="Ravina">Bernard Ravina</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Pmc/Checkpoint
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Ou
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{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:4643625
|texte= Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease
}}
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| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
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