ParkinsonCanadaV1, Ncbi, Merge, bibRecord, 001C58

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease

Identifieur interne : 001C58 ( Ncbi/Merge ); précédent : 001C57; suivant : 001C59

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease

Auteurs : Joseph J. Locascio [États-Unis] ; Shirley Eberly [États-Unis] ; Zhixiang Liao [États-Unis] ; Ganqiang Liu [États-Unis] ; Ashley N. Hoesing [États-Unis] ; Karen Duong [États-Unis] ; Ana Trisini-Lipsanopoulos [États-Unis] ; Kaltra Dhima [États-Unis] ; Albert Y. Hung [États-Unis] ; Alice W. Flaherty [États-Unis] ; Michael A. Schwarzschild [États-Unis] ; Michael T. Hayes [États-Unis] ; Anne-Marie Wills [États-Unis] ; U. Shivraj Sohur [États-Unis] ; Nicte I. Mejia [États-Unis] ; Dennis J. Selkoe [États-Unis] ; David Oakes [États-Unis] ; Ira Shoulson [États-Unis] ; Xianjun Dong [États-Unis] ; Ken Marek [États-Unis] ; Bin Zheng [États-Unis] ; Adrian Ivinson [États-Unis] ; Bradley T. Hyman [États-Unis] ; John H. Growdon [États-Unis] ; Lewis R. Sudarsky [États-Unis] ; Michael G. Schlossmacher [États-Unis] ; Bernard Ravina [Canada] ; Clemens R. Scherzer [États-Unis]

Source :

Brain [ 0006-8950 ] ; 2015.

RBID : PMC:4643625

English descriptors

KwdEn :
- Aged, Cognition Disorders (etiology), Cognition Disorders (genetics), Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Gene Expression Regulation, Genetic Testing, Humans, Male, Microarray Analysis, Middle Aged, Neuroimaging, Parkinson Disease (complications), Parkinson Disease (diagnostic imaging), Parkinson Disease (genetics), Parkinson Disease (pathology), RNA, Messenger (metabolism), Radionuclide Imaging, Severity of Illness Index, Tropanes, alpha-Synuclein (blood), alpha-Synuclein (genetics).
MESH :
- chemical , blood : alpha-Synuclein.
- chemical , genetics : alpha-Synuclein.
- chemical , metabolism : Dopamine Plasma Membrane Transport Proteins, RNA, Messenger.
- complications : Parkinson Disease.
- diagnostic imaging : Parkinson Disease.
- etiology : Cognition Disorders.
- genetics : Cognition Disorders, Parkinson Disease.
- pathology : Parkinson Disease.
- Aged, Female, Gene Expression Regulation, Genetic Testing, Humans, Male, Microarray Analysis, Middle Aged, Neuroimaging, Radionuclide Imaging, Severity of Illness Index, Tropanes.

Abstract

The α-synuclein gene, SNCA, is selectively expressed in blood cells and neurons. Locascio et al. reveal a paradoxical reduction in SNCA transcript counts in the blood of individuals with early-stage, neuroimaging-supported Parkinson’s disease in three regional, national, and international populations. Low SCNA transcript abundance predicted subsequent cognitive decline.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643625

DOI: 10.1093/brain/awv202
PubMed: 26220939
PubMed Central: 4643625

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Le document en format XML

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<author><name sortKey="Ivinson, Adrian" sort="Ivinson, Adrian" uniqKey="Ivinson A" first="Adrian" last="Ivinson">Adrian Ivinson</name>
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<affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name>
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<author><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R." last="Sudarsky">Lewis R. Sudarsky</name>
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<author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name>
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<author><name sortKey="Ravina, Bernard" sort="Ravina, Bernard" uniqKey="Ravina B" first="Bernard" last="Ravina">Bernard Ravina</name>
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<country xml:lang="fr">Canada</country>
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</author>
<author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name>
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<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="1"><nlm:aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff>
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</analytic>
<series><title level="j">Brain</title>
<idno type="ISSN">0006-8950</idno>
<idno type="eISSN">1460-2156</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cognition Disorders (etiology)</term>
<term>Cognition Disorders (genetics)</term>
<term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Genetic Testing</term>
<term>Humans</term>
<term>Male</term>
<term>Microarray Analysis</term>
<term>Middle Aged</term>
<term>Neuroimaging</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (pathology)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Radionuclide Imaging</term>
<term>Severity of Illness Index</term>
<term>Tropanes</term>
<term>alpha-Synuclein (blood)</term>
<term>alpha-Synuclein (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term>
<term>RNA, Messenger</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Genetic Testing</term>
<term>Humans</term>
<term>Male</term>
<term>Microarray Analysis</term>
<term>Middle Aged</term>
<term>Neuroimaging</term>
<term>Radionuclide Imaging</term>
<term>Severity of Illness Index</term>
<term>Tropanes</term>
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<front><div type="abstract" xml:lang="en"><p>The α-synuclein gene, <italic>SNCA</italic>
, is selectively expressed in blood cells and neurons. Locascio <italic>et al.</italic>
 reveal a paradoxical reduction in <italic>SNCA</italic>
 transcript counts in the blood of individuals with early-stage, neuroimaging-supported Parkinson’s disease in three regional, national, and international populations. Low <italic>SCNA</italic>
 transcript abundance predicted subsequent cognitive decline.</p>
</div>
</front>
</TEI>
<double pmid="26220939"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease</title>
<author><name sortKey="Locascio, Joseph J" sort="Locascio, Joseph J" uniqKey="Locascio J" first="Joseph J." last="Locascio">Joseph J. Locascio</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Eberly, Shirley" sort="Eberly, Shirley" uniqKey="Eberly S" first="Shirley" last="Eberly">Shirley Eberly</name>
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<country xml:lang="fr">États-Unis</country>
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</author>
<author><name sortKey="Liao, Zhixiang" sort="Liao, Zhixiang" uniqKey="Liao Z" first="Zhixiang" last="Liao">Zhixiang Liao</name>
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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Liu, Ganqiang" sort="Liu, Ganqiang" uniqKey="Liu G" first="Ganqiang" last="Liu">Ganqiang Liu</name>
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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N." last="Hoesing">Ashley N. Hoesing</name>
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<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff>
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<author><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea>
<wicri:noRegion>MA 02139</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea>
<wicri:noRegion>MA 02115</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea>
<wicri:noRegion>MA 02139</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea>
<wicri:noRegion>MA 02139</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea>
<wicri:noRegion>MA 02115</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea>
<wicri:noRegion>MA 02115</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hung, Albert Y" sort="Hung, Albert Y" uniqKey="Hung A" first="Albert Y." last="Hung">Albert Y. Hung</name>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea>
<wicri:noRegion>MA 02114</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W." last="Flaherty">Alice W. Flaherty</name>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea>
<wicri:noRegion>MA 02114</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF6">6 Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>6 Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea>
<wicri:noRegion>MA 02114</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea>
<wicri:noRegion>MA 02114</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hayes, Michael T" sort="Hayes, Michael T" uniqKey="Hayes M" first="Michael T." last="Hayes">Michael T. Hayes</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea>
<wicri:noRegion>MA 02115</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea>
<wicri:noRegion>MA 02114</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Shivraj Sohur, U" sort="Shivraj Sohur, U" uniqKey="Shivraj Sohur U" first="U." last="Shivraj Sohur">U. Shivraj Sohur</name>
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<country xml:lang="fr">États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Mejia, Nicte I" sort="Mejia, Nicte I" uniqKey="Mejia N" first="Nicte I." last="Mejia">Nicte I. Mejia</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name>
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</affiliation>
</author>
<author><name sortKey="Shivraj Sohur, U" sort="Shivraj Sohur, U" uniqKey="Shivraj Sohur U" first="U." last="Shivraj Sohur">U. Shivraj Sohur</name>
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<country xml:lang="fr">États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Mejia, Nicte I" sort="Mejia, Nicte I" uniqKey="Mejia N" first="Nicte I." last="Mejia">Nicte I. Mejia</name>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Selkoe, Dennis J" sort="Selkoe, Dennis J" uniqKey="Selkoe D" first="Dennis J." last="Selkoe">Dennis J. Selkoe</name>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF3">3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>8 Program for Regulatory Science and Medicine, Department of Neurology, Georgetown University, Washington, DC 20007</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Dong, Xianjun" sort="Dong, Xianjun" uniqKey="Dong X" first="Xianjun" last="Dong">Xianjun Dong</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea>
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</affiliation>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name>
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<country xml:lang="fr">États-Unis</country>
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</affiliation>
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<author><name sortKey="Zheng, Bin" sort="Zheng, Bin" uniqKey="Zheng B" first="Bin" last="Zheng">Bin Zheng</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women’s Hospital, Cambridge, MA 02139</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Ivinson, Adrian" sort="Ivinson, Adrian" uniqKey="Ivinson A" first="Adrian" last="Ivinson">Adrian Ivinson</name>
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<country xml:lang="fr">États-Unis</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T." last="Hyman">Bradley T. Hyman</name>
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<country xml:lang="fr">États-Unis</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H." last="Growdon">John H. Growdon</name>
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<country xml:lang="fr">États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R." last="Sudarsky">Lewis R. Sudarsky</name>
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<country xml:lang="fr">États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF9">9 Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>9 Institute for Neurodegenerative Disorders, New Haven, CT 06510</wicri:regionArea>
<wicri:noRegion>CT 06510</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ravina, Bernard" sort="Ravina, Bernard" uniqKey="Ravina B" first="Bernard" last="Ravina">Bernard Ravina</name>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF10">10 Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario K1H8M5, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>10 Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario K1H8M5</wicri:regionArea>
<wicri:noRegion>Ontario K1H8M5</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R." last="Scherzer">Clemens R. Scherzer</name>
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<country xml:lang="fr">États-Unis</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF2">2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF4">4 Ann Romney Centre for Neurologic Diseases, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF5">5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="awv202-AFF7">7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>7 Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115</wicri:regionArea>
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</affiliation>
</author>
</analytic>
<series><title level="j">Brain</title>
<idno type="ISSN">0006-8950</idno>
<idno type="eISSN">1460-2156</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The α-synuclein gene, <italic>SNCA</italic>
, is selectively expressed in blood cells and neurons. Locascio <italic>et al.</italic>
 reveal a paradoxical reduction in <italic>SNCA</italic>
 transcript counts in the blood of individuals with early-stage, neuroimaging-supported Parkinson’s disease in three regional, national, and international populations. Low <italic>SCNA</italic>
 transcript abundance predicted subsequent cognitive decline.</p>
</div>
</front>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.</title>
<author><name sortKey="Locascio, Joseph J" sort="Locascio, Joseph J" uniqKey="Locascio J" first="Joseph J" last="Locascio">Joseph J. Locascio</name>
<affiliation wicri:level="2"><nlm:affiliation>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA 2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eberly, Shirley" sort="Eberly, Shirley" uniqKey="Eberly S" first="Shirley" last="Eberly">Shirley Eberly</name>
<affiliation wicri:level="2"><nlm:affiliation>3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>3 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY 14642</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liao, Zhixiang" sort="Liao, Zhixiang" uniqKey="Liao Z" first="Zhixiang" last="Liao">Zhixiang Liao</name>
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<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Ganqiang" sort="Liu, Ganqiang" uniqKey="Liu G" first="Ganqiang" last="Liu">Ganqiang Liu</name>
<affiliation wicri:level="2"><nlm:affiliation>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA 4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoesing, Ashley N" sort="Hoesing, Ashley N" uniqKey="Hoesing A" first="Ashley N" last="Hoesing">Ashley N. Hoesing</name>
<affiliation wicri:level="2"><nlm:affiliation>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA 4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duong, Karen" sort="Duong, Karen" uniqKey="Duong K" first="Karen" last="Duong">Karen Duong</name>
<affiliation wicri:level="2"><nlm:affiliation>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA 4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA 4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trisini Lipsanopoulos, Ana" sort="Trisini Lipsanopoulos, Ana" uniqKey="Trisini Lipsanopoulos A" first="Ana" last="Trisini-Lipsanopoulos">Ana Trisini-Lipsanopoulos</name>
<affiliation wicri:level="2"><nlm:affiliation>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA 4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dhima, Kaltra" sort="Dhima, Kaltra" uniqKey="Dhima K" first="Kaltra" last="Dhima">Kaltra Dhima</name>
<affiliation wicri:level="2"><nlm:affiliation>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA 4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hung, Albert Y" sort="Hung, Albert Y" uniqKey="Hung A" first="Albert Y" last="Hung">Albert Y. Hung</name>
<affiliation wicri:level="2"><nlm:affiliation>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Flaherty, Alice W" sort="Flaherty, Alice W" uniqKey="Flaherty A" first="Alice W" last="Flaherty">Alice W. Flaherty</name>
<affiliation wicri:level="2"><nlm:affiliation>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA 6 Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA 6 Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A" last="Schwarzschild">Michael A. Schwarzschild</name>
<affiliation wicri:level="2"><nlm:affiliation>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hayes, Michael T" sort="Hayes, Michael T" uniqKey="Hayes M" first="Michael T" last="Hayes">Michael T. Hayes</name>
<affiliation wicri:level="2"><nlm:affiliation>7 Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>7 Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name>
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<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shivraj Sohur, U" sort="Shivraj Sohur, U" uniqKey="Shivraj Sohur U" first="U" last="Shivraj Sohur">U. Shivraj Sohur</name>
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<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mejia, Nicte I" sort="Mejia, Nicte I" uniqKey="Mejia N" first="Nicte I" last="Mejia">Nicte I. Mejia</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.</title>
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<author><name sortKey="Ivinson, Adrian" sort="Ivinson, Adrian" uniqKey="Ivinson A" first="Adrian" last="Ivinson">Adrian Ivinson</name>
<affiliation wicri:level="2"><nlm:affiliation>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hyman, Bradley T" sort="Hyman, Bradley T" uniqKey="Hyman B" first="Bradley T" last="Hyman">Bradley T. Hyman</name>
<affiliation wicri:level="2"><nlm:affiliation>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Growdon, John H" sort="Growdon, John H" uniqKey="Growdon J" first="John H" last="Growdon">John H. Growdon</name>
<affiliation wicri:level="2"><nlm:affiliation>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sudarsky, Lewis R" sort="Sudarsky, Lewis R" uniqKey="Sudarsky L" first="Lewis R" last="Sudarsky">Lewis R. Sudarsky</name>
<affiliation wicri:level="2"><nlm:affiliation>7 Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>7 Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G" last="Schlossmacher">Michael G. Schlossmacher</name>
<affiliation wicri:level="2"><nlm:affiliation>9 Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>9 Institute for Neurodegenerative Disorders, New Haven, CT 06510</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ravina, Bernard" sort="Ravina, Bernard" uniqKey="Ravina B" first="Bernard" last="Ravina">Bernard Ravina</name>
<affiliation wicri:level="1"><nlm:affiliation>10 Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario K1H8M5, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>10 Program in Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario K1H8M5</wicri:regionArea>
<wicri:noRegion>Ontario K1H8M5</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scherzer, Clemens R" sort="Scherzer, Clemens R" uniqKey="Scherzer C" first="Clemens R" last="Scherzer">Clemens R. Scherzer</name>
<affiliation wicri:level="2"><nlm:affiliation>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA 2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA 4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA 7 Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA cscherzer@rics.bwh.harvard.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
<wicri:regionArea>1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA 2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA 4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA 7 Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Brain : a journal of neurology</title>
<idno type="eISSN">1460-2156</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cognition Disorders (etiology)</term>
<term>Cognition Disorders (genetics)</term>
<term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Genetic Testing</term>
<term>Humans</term>
<term>Male</term>
<term>Microarray Analysis</term>
<term>Middle Aged</term>
<term>Neuroimaging</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (pathology)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Radionuclide Imaging</term>
<term>Severity of Illness Index</term>
<term>Tropanes</term>
<term>alpha-Synuclein (blood)</term>
<term>alpha-Synuclein (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term>
<term>RNA, Messenger</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Gene Expression Regulation</term>
<term>Genetic Testing</term>
<term>Humans</term>
<term>Male</term>
<term>Microarray Analysis</term>
<term>Middle Aged</term>
<term>Neuroimaging</term>
<term>Radionuclide Imaging</term>
<term>Severity of Illness Index</term>
<term>Tropanes</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">There are no cures for neurodegenerative diseases and this is partially due to the difficulty of monitoring pathogenic molecules in patients during life. The Parkinson's disease gene α-synuclein (SNCA) is selectively expressed in blood cells and neurons. Here we show that SNCA transcripts in circulating blood cells are paradoxically reduced in early stage, untreated and dopamine transporter neuroimaging-supported Parkinson's disease in three independent regional, national, and international populations representing 500 cases and 363 controls and on three analogue and digital platforms with P < 0.0001 in meta-analysis. Individuals with SNCA transcripts in the lowest quartile of counts had an odds ratio for Parkinson's disease of 2.45 compared to individuals in the highest quartile. Disease-relevant transcript isoforms were low even near disease onset. Importantly, low SNCA transcript abundance predicted cognitive decline in patients with Parkinson's disease during up to 5 years of longitudinal follow-up. This study reveals a consistent association of reduced SNCA transcripts in accessible peripheral blood and early-stage Parkinson's disease in 863 participants and suggests a clinical role as potential predictor of cognitive decline. Moreover, the three independent biobank cohorts provide a generally useful platform for rapidly validating any biological marker of this common disease.</div>
</front>
</TEI>
</pubmed>
</double>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease

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