Analysis of rapid alternating movements in Cree subjects exposed to methylmercury and in subjects with neurological deficits
Identifieur interne : 003840 ( Main/Exploration ); précédent : 003839; suivant : 003841Analysis of rapid alternating movements in Cree subjects exposed to methylmercury and in subjects with neurological deficits
Auteurs : A. Beuter [Canada] ; A. De Geoffroy [Canada] ; R. Edwards [Canada]Source :
- Environmental research : (New York, NY) [ 0013-9351 ] ; 1999.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Mercure, Métal lourd, Homme.
English descriptors
- KwdEn :
- Alternate motion, Amerindian, Body movement, Case-Control Studies, Environmental Exposure (adverse effects), Environmental Exposure (analysis), Hair (chemistry), Heavy metal, Human, Humans, Indians, North American, Manual activity, Measurement method, Mercury, Methylmercury Compounds (adverse effects), Methylmercury Compounds (analysis), Middle Aged, Motility disorder, Movement (drug effects), Movement Disorders (etiology), Movement Disorders (physiopathology), Neurological disorder, Neuropsychological test, Parkinson Disease (physiopathology), Psychomotor Performance (drug effects), Quebec, Sensitivity and Specificity, Toxicity, Upper limb.
- MESH :
- chemical , adverse effects : Methylmercury Compounds.
- geographic : Quebec.
- adverse effects : Environmental Exposure.
- analysis : Environmental Exposure, Methylmercury Compounds.
- chemistry : Hair.
- drug effects : Movement, Psychomotor Performance.
- etiology : Movement Disorders.
- physiopathology : Movement Disorders, Parkinson Disease.
- Case-Control Studies, Humans, Indians, North American, Middle Aged, Sensitivity and Specificity.
Abstract
To quantify rapid alternating movements (RAMs) we used a simple prototype developed in our laboratory that requires the subject to rotate two handheld foam spheres connected to optical encoders via flexible rods. Ninety-six participants, including 30 control subjects, 36 Cree subjects exposed to methylmercury, 21 subjects with Parkinson's disease, 6 subjects with cerebellar deficits, and 3 subjects with essential tremor, were involved in the study (though data for 5 were later removed). Twelve characteristics were developed and calculated from the raw data. Conditions examined included two hands at natural cadence (NC2), right and left hands separately at fast cadence (FCl), and both hands at fast cadence (FC2). Two ratios (FC2/NC2) and (FC2/FC1) combining these conditions were also examined. Test-retest reliability was >0.80 for most characteristics but was <0.70 for some characteristics, especially in the conditions executed at normal cadence. Correlations between characteristics and numbers of outliers with respect to the control group distribution were used to reduce the set of characteristics from 12 to 7 (i.e., duration, range, maximum slope, similarity in shape, smoothness, sharpness, and coherence). ANOVAs on the three largest groups generated significant results for most characteristics in the three conditions and the two ratios for Cree subjects and subjects with Parkinson's disease. ANOVAs on 3 age-matched groups (n = 6) suggest that methylmercury affects the performance of the Cree subjects with the higher exposure, especially in terms of smoothness, sharpness, and coherence. These preliminary results suggest that this test is sufficiently specific and sensitive to characterize the performance of different groups of subjects. Ratios tend to improve discrimination for Cree subjects in a few characteristics but not for patients with Parkinson's disease.
Affiliations:
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Beuter</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratoire de Neurocinétique, Département de Kinanthropologie, Université du Québec à Montréal, CP 8888, Succursale Centre-ville</s1><s2>Montréal, Quebec H3C 3P8</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montréal, Quebec H3C 3P8</wicri:noRegion><orgName type="university">Université du Québec à Montréal</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Centre for Nonlinear Dynamics in Physiology and Medicine, McGill University</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="De Geoffroy, A" sort="De Geoffroy, A" uniqKey="De Geoffroy A" first="A." last="De Geoffroy">A. 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Beuter</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratoire de Neurocinétique, Département de Kinanthropologie, Université du Québec à Montréal, CP 8888, Succursale Centre-ville</s1><s2>Montréal, Quebec H3C 3P8</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montréal, Quebec H3C 3P8</wicri:noRegion><orgName type="university">Université du Québec à Montréal</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Centre for Nonlinear Dynamics in Physiology and Medicine, McGill University</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="De Geoffroy, A" sort="De Geoffroy, A" uniqKey="De Geoffroy A" first="A." last="De Geoffroy">A. De Geoffroy</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratoire de Neurocinétique, Département de Kinanthropologie, Université du Québec à Montréal, CP 8888, Succursale Centre-ville</s1><s2>Montréal, Quebec H3C 3P8</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montréal, Quebec H3C 3P8</wicri:noRegion><orgName type="university">Université du Québec à Montréal</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Edwards, R" sort="Edwards, R" uniqKey="Edwards R" first="R." last="Edwards">R. Edwards</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratoire de Neurocinétique, Département de Kinanthropologie, Université du Québec à Montréal, CP 8888, Succursale Centre-ville</s1><s2>Montréal, Quebec H3C 3P8</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montréal, Quebec H3C 3P8</wicri:noRegion><orgName type="university">Université du Québec à Montréal</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Centre for Nonlinear Dynamics in Physiology and Medicine, McGill University</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université McGill</orgName></affiliation></author></analytic><series><title level="j" type="main">Environmental research : (New York, NY)</title><title level="j" type="abbreviated">Environ. res. : (NY NY)</title><idno type="ISSN">0013-9351</idno><imprint><date when="1999">1999</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Environmental research : (New York, NY)</title><title level="j" type="abbreviated">Environ. res. : (NY NY)</title><idno type="ISSN">0013-9351</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alternate motion</term><term>Amerindian</term><term>Body movement</term><term>Case-Control Studies</term><term>Environmental Exposure (adverse effects)</term><term>Environmental Exposure (analysis)</term><term>Hair (chemistry)</term><term>Heavy metal</term><term>Human</term><term>Humans</term><term>Indians, North American</term><term>Manual activity</term><term>Measurement method</term><term>Mercury</term><term>Methylmercury Compounds (adverse effects)</term><term>Methylmercury Compounds (analysis)</term><term>Middle Aged</term><term>Motility disorder</term><term>Movement (drug effects)</term><term>Movement Disorders (etiology)</term><term>Movement Disorders (physiopathology)</term><term>Neurological disorder</term><term>Neuropsychological test</term><term>Parkinson Disease (physiopathology)</term><term>Psychomotor Performance (drug effects)</term><term>Quebec</term><term>Sensitivity and Specificity</term><term>Toxicity</term><term>Upper limb</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Methylmercury Compounds</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Quebec</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Environmental Exposure</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Environmental Exposure</term><term>Methylmercury Compounds</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Hair</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Movement</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Movement Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Humans</term><term>Indians, North American</term><term>Middle Aged</term><term>Sensitivity and Specificity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Mercure</term><term>Métal lourd</term><term>Toxicité</term><term>Trouble neurologique</term><term>Trouble motricité</term><term>Amérindien</term><term>Homme</term><term>Mouvement alternatif</term><term>Québec</term><term>Test neuropsychologique</term><term>Méthode mesure</term><term>Mouvement corporel</term><term>Membre supérieur</term><term>Activité manuelle</term><term>Mercure(méthyl)</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Mercure</term><term>Métal lourd</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To quantify rapid alternating movements (RAMs) we used a simple prototype developed in our laboratory that requires the subject to rotate two handheld foam spheres connected to optical encoders via flexible rods. Ninety-six participants, including 30 control subjects, 36 Cree subjects exposed to methylmercury, 21 subjects with Parkinson's disease, 6 subjects with cerebellar deficits, and 3 subjects with essential tremor, were involved in the study (though data for 5 were later removed). Twelve characteristics were developed and calculated from the raw data. Conditions examined included two hands at natural cadence (NC2), right and left hands separately at fast cadence (FCl), and both hands at fast cadence (FC2). Two ratios (FC2/NC2) and (FC2/FC1) combining these conditions were also examined. Test-retest reliability was >0.80 for most characteristics but was <0.70 for some characteristics, especially in the conditions executed at normal cadence. Correlations between characteristics and numbers of outliers with respect to the control group distribution were used to reduce the set of characteristics from 12 to 7 (i.e., duration, range, maximum slope, similarity in shape, smoothness, sharpness, and coherence). ANOVAs on the three largest groups generated significant results for most characteristics in the three conditions and the two ratios for Cree subjects and subjects with Parkinson's disease. ANOVAs on 3 age-matched groups (n = 6) suggest that methylmercury affects the performance of the Cree subjects with the higher exposure, especially in terms of smoothness, sharpness, and coherence. These preliminary results suggest that this test is sufficiently specific and sensitive to characterize the performance of different groups of subjects. Ratios tend to improve discrimination for Cree subjects in a few characteristics but not for patients with Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li><li>Université du Québec à Montréal</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Beuter, A" sort="Beuter, A" uniqKey="Beuter A" first="A." last="Beuter">A. Beuter</name></region><name sortKey="Beuter, A" sort="Beuter, A" uniqKey="Beuter A" first="A." last="Beuter">A. Beuter</name><name sortKey="De Geoffroy, A" sort="De Geoffroy, A" uniqKey="De Geoffroy A" first="A." last="De Geoffroy">A. De Geoffroy</name><name sortKey="Edwards, R" sort="Edwards, R" uniqKey="Edwards R" first="R." last="Edwards">R. Edwards</name><name sortKey="Edwards, R" sort="Edwards, R" uniqKey="Edwards R" first="R." last="Edwards">R. 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