The effects of pallidotomy on Parkinson's disease: study design and assessment techniques.
Identifieur interne : 001734 ( PubMed/Checkpoint ); précédent : 001733; suivant : 001735The effects of pallidotomy on Parkinson's disease: study design and assessment techniques.
Auteurs : R E Gross [Canada] ; A M Lozano ; A E Lang ; R R Tasker ; W D Hutchison ; J O DostrovskySource :
- Acta neurochirurgica. Supplement [ 0065-1419 ] ; 1997.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (adverse effects), Brain Mapping, Dyskinesia, Drug-Induced (diagnosis), Dyskinesia, Drug-Induced (physiopathology), Dyskinesia, Drug-Induced (surgery), Female, Globus Pallidus (physiopathology), Globus Pallidus (surgery), Humans, Levodopa (adverse effects), Male, Middle Aged, Neurologic Examination, Outcome Assessment (Health Care), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Postoperative Complications (diagnosis), Postoperative Complications (physiopathology), Single-Blind Method, Stereotaxic Techniques, Video Recording.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- diagnosis : Dyskinesia, Drug-Induced, Parkinson Disease, Postoperative Complications.
- physiopathology : Dyskinesia, Drug-Induced, Globus Pallidus, Parkinson Disease, Postoperative Complications.
- surgery : Dyskinesia, Drug-Induced, Globus Pallidus, Parkinson Disease.
- Adult, Aged, Brain Mapping, Female, Humans, Male, Middle Aged, Neurologic Examination, Outcome Assessment (Health Care), Single-Blind Method, Stereotaxic Techniques, Video Recording.
Abstract
Lesions of the internal segment of the globus pallidus are increasingly being utilized in the surgical treatment of advanced Parkinson's disease, yet studies to demonstrate the safety and efficacy of these procedures are only now being completed. The importance of procedural variations between centres in the outcome of pallidotomy is not yet known. In order to compare accurately results between centres, carefully designed, prospective studies are needed. The authors utilized blinded, randomly evaluated videotaped examinations of pre- and post-operative patients undergoing microelectrode-guided GPi pallidotomy. Their results demonstrate significant effects on contralateral akinesia and tremor in the "off" state, and striking attenuation of levodopa-induced dyskinesias in the "on" state. More modest effects on postural stability and gait disturbance were seen only in non-blinded evaluations. This type of study design should enable many of the outstanding issues related to pallidotomy indications, procedures and outcomes to be addressed.
PubMed: 9233409
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effects of pallidotomy on Parkinson's disease: study design and assessment techniques.</title><author><name sortKey="Gross, R E" sort="Gross, R E" uniqKey="Gross R" first="R E" last="Gross">R E Gross</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Morton and Gloria Shulman Movement Disorders Centre, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, Morton and Gloria Shulman Movement Disorders Centre, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A M" last="Lozano">A M Lozano</name></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name></author><author><name sortKey="Tasker, R R" sort="Tasker, R R" uniqKey="Tasker R" first="R R" last="Tasker">R R Tasker</name></author><author><name sortKey="Hutchison, W D" sort="Hutchison, W D" uniqKey="Hutchison W" first="W D" last="Hutchison">W D Hutchison</name></author><author><name sortKey="Dostrovsky, J O" sort="Dostrovsky, J O" uniqKey="Dostrovsky J" first="J O" last="Dostrovsky">J O Dostrovsky</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9233409</idno><idno type="pmid">9233409</idno><idno type="wicri:Area/PubMed/Corpus">001842</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001842</idno><idno type="wicri:Area/PubMed/Curation">001842</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001842</idno><idno type="wicri:Area/PubMed/Checkpoint">001842</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001842</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effects of pallidotomy on Parkinson's disease: study design and assessment techniques.</title><author><name sortKey="Gross, R E" sort="Gross, R E" uniqKey="Gross R" first="R E" last="Gross">R E Gross</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Morton and Gloria Shulman Movement Disorders Centre, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, Morton and Gloria Shulman Movement Disorders Centre, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A M" last="Lozano">A M Lozano</name></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name></author><author><name sortKey="Tasker, R R" sort="Tasker, R R" uniqKey="Tasker R" first="R R" last="Tasker">R R Tasker</name></author><author><name sortKey="Hutchison, W D" sort="Hutchison, W D" uniqKey="Hutchison W" first="W D" last="Hutchison">W D Hutchison</name></author><author><name sortKey="Dostrovsky, J O" sort="Dostrovsky, J O" uniqKey="Dostrovsky J" first="J O" last="Dostrovsky">J O Dostrovsky</name></author></analytic><series><title level="j">Acta neurochirurgica. Supplement</title><idno type="ISSN">0065-1419</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antiparkinson Agents (adverse effects)</term><term>Brain Mapping</term><term>Dyskinesia, Drug-Induced (diagnosis)</term><term>Dyskinesia, Drug-Induced (physiopathology)</term><term>Dyskinesia, Drug-Induced (surgery)</term><term>Female</term><term>Globus Pallidus (physiopathology)</term><term>Globus Pallidus (surgery)</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Outcome Assessment (Health Care)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (surgery)</term><term>Postoperative Complications (diagnosis)</term><term>Postoperative Complications (physiopathology)</term><term>Single-Blind Method</term><term>Stereotaxic Techniques</term><term>Video Recording</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Parkinson Disease</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Globus Pallidus</term><term>Parkinson Disease</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Globus Pallidus</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Outcome Assessment (Health Care)</term><term>Single-Blind Method</term><term>Stereotaxic Techniques</term><term>Video Recording</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lesions of the internal segment of the globus pallidus are increasingly being utilized in the surgical treatment of advanced Parkinson's disease, yet studies to demonstrate the safety and efficacy of these procedures are only now being completed. The importance of procedural variations between centres in the outcome of pallidotomy is not yet known. In order to compare accurately results between centres, carefully designed, prospective studies are needed. The authors utilized blinded, randomly evaluated videotaped examinations of pre- and post-operative patients undergoing microelectrode-guided GPi pallidotomy. Their results demonstrate significant effects on contralateral akinesia and tremor in the "off" state, and striking attenuation of levodopa-induced dyskinesias in the "on" state. More modest effects on postural stability and gait disturbance were seen only in non-blinded evaluations. This type of study design should enable many of the outstanding issues related to pallidotomy indications, procedures and outcomes to be addressed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9233409</PMID><DateCreated><Year>1997</Year><Month>10</Month><Day>01</Day></DateCreated><DateCompleted><Year>1997</Year><Month>10</Month><Day>01</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0065-1419</ISSN><JournalIssue CitedMedium="Print"><Volume>68</Volume><PubDate><Year>1997</Year></PubDate></JournalIssue><Title>Acta neurochirurgica. Supplement</Title><ISOAbbreviation>Acta Neurochir. Suppl.</ISOAbbreviation></Journal><ArticleTitle>The effects of pallidotomy on Parkinson's disease: study design and assessment techniques.</ArticleTitle><Pagination><MedlinePgn>24-8</MedlinePgn></Pagination><Abstract><AbstractText>Lesions of the internal segment of the globus pallidus are increasingly being utilized in the surgical treatment of advanced Parkinson's disease, yet studies to demonstrate the safety and efficacy of these procedures are only now being completed. The importance of procedural variations between centres in the outcome of pallidotomy is not yet known. In order to compare accurately results between centres, carefully designed, prospective studies are needed. The authors utilized blinded, randomly evaluated videotaped examinations of pre- and post-operative patients undergoing microelectrode-guided GPi pallidotomy. Their results demonstrate significant effects on contralateral akinesia and tremor in the "off" state, and striking attenuation of levodopa-induced dyskinesias in the "on" state. More modest effects on postural stability and gait disturbance were seen only in non-blinded evaluations. This type of study design should enable many of the outstanding issues related to pallidotomy indications, procedures and outcomes to be addressed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gross</LastName><ForeName>R E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>Department of Surgery, Morton and Gloria Shulman Movement Disorders Centre, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lozano</LastName><ForeName>A M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Lang</LastName><ForeName>A E</ForeName><Initials>AE</Initials></Author><Author ValidYN="Y"><LastName>Tasker</LastName><ForeName>R R</ForeName><Initials>RR</Initials></Author><Author ValidYN="Y"><LastName>Hutchison</LastName><ForeName>W D</ForeName><Initials>WD</Initials></Author><Author ValidYN="Y"><LastName>Dostrovsky</LastName><ForeName>J O</ForeName><Initials>JO</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Austria</Country><MedlineTA>Acta Neurochir Suppl</MedlineTA><NlmUniqueID>100962752</NlmUniqueID><ISSNLinking>0065-1419</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" 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MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009460" MajorTopicYN="Y">Neurologic Examination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017063" MajorTopicYN="N">Outcome Assessment (Health Care)</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011183" MajorTopicYN="N">Postoperative Complications</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016037" MajorTopicYN="N">Single-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013238" MajorTopicYN="Y">Stereotaxic Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014741" MajorTopicYN="N">Video Recording</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1997</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1997</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1997</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9233409</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Dostrovsky, J O" sort="Dostrovsky, J O" uniqKey="Dostrovsky J" first="J O" last="Dostrovsky">J O Dostrovsky</name><name sortKey="Hutchison, W D" sort="Hutchison, W D" uniqKey="Hutchison W" first="W D" last="Hutchison">W D Hutchison</name><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A E" last="Lang">A E Lang</name><name sortKey="Lozano, A M" sort="Lozano, A M" uniqKey="Lozano A" first="A M" last="Lozano">A M Lozano</name><name sortKey="Tasker, R R" sort="Tasker, R R" uniqKey="Tasker R" first="R R" last="Tasker">R R Tasker</name></noCountry><country name="Canada"><noRegion><name sortKey="Gross, R E" sort="Gross, R E" uniqKey="Gross R" first="R E" last="Gross">R E Gross</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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