ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000D75

Analysis of rapid alternating movements in Cree subjects exposed to methylmercury and in subjects with neurological deficits

Identifieur interne : 000D75 ( PascalFrancis/Corpus ); précédent : 000D74; suivant : 000D76

Analysis of rapid alternating movements in Cree subjects exposed to methylmercury and in subjects with neurological deficits

Auteurs : A. Beuter ; A. De Geoffroy ; R. Edwards

Source :

Environmental research : (New York, NY) [ 0013-9351 ] ; 1999.

RBID : Pascal:99-0196404

Descripteurs français

Pascal (Inist)
- Mercure, Métal lourd, Toxicité, Trouble neurologique, Trouble motricité, Amérindien, Homme, Mouvement alternatif, Québec, Test neuropsychologique, Méthode mesure, Mouvement corporel, Membre supérieur, Activité manuelle, Mercure(méthyl).

English descriptors

KwdEn :
- Alternate motion, Amerindian, Body movement, Heavy metal, Human, Manual activity, Measurement method, Mercury, Motility disorder, Neurological disorder, Neuropsychological test, Quebec, Toxicity, Upper limb.

Abstract

To quantify rapid alternating movements (RAMs) we used a simple prototype developed in our laboratory that requires the subject to rotate two handheld foam spheres connected to optical encoders via flexible rods. Ninety-six participants, including 30 control subjects, 36 Cree subjects exposed to methylmercury, 21 subjects with Parkinson's disease, 6 subjects with cerebellar deficits, and 3 subjects with essential tremor, were involved in the study (though data for 5 were later removed). Twelve characteristics were developed and calculated from the raw data. Conditions examined included two hands at natural cadence (NC2), right and left hands separately at fast cadence (FCl), and both hands at fast cadence (FC2). Two ratios (FC2/NC2) and (FC2/FC1) combining these conditions were also examined. Test-retest reliability was >0.80 for most characteristics but was <0.70 for some characteristics, especially in the conditions executed at normal cadence. Correlations between characteristics and numbers of outliers with respect to the control group distribution were used to reduce the set of characteristics from 12 to 7 (i.e., duration, range, maximum slope, similarity in shape, smoothness, sharpness, and coherence). ANOVAs on the three largest groups generated significant results for most characteristics in the three conditions and the two ratios for Cree subjects and subjects with Parkinson's disease. ANOVAs on 3 age-matched groups (n = 6) suggest that methylmercury affects the performance of the Cree subjects with the higher exposure, especially in terms of smoothness, sharpness, and coherence. These preliminary results suggest that this test is sufficiently specific and sensitive to characterize the performance of different groups of subjects. Ratios tend to improve discrimination for Cree subjects in a few characteristics but not for patients with Parkinson's disease.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 99-0196404 INIST
ET :	Analysis of rapid alternating movements in Cree subjects exposed to methylmercury and in subjects with neurological deficits
AU :	BEUTER (A.); DE GEOFFROY (A.); EDWARDS (R.)
AF :	Laboratoire de Neurocinétique, Département de Kinanthropologie, Université du Québec à Montréal, CP 8888, Succursale Centre-ville/Montréal, Quebec H3C 3P8/Canada (1 aut., 2 aut., 3 aut.); Centre for Nonlinear Dynamics in Physiology and Medicine, McGill University/Montréal, Québec/Canada (1 aut., 3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Environmental research : (New York, NY); ISSN 0013-9351; Coden ENVRAL; Etats-Unis; Da. 1999; Vol. 80; No. 1; Pp. 64-79; Bibl. 8 ref.
LA :	Anglais
EA :	To quantify rapid alternating movements (RAMs) we used a simple prototype developed in our laboratory that requires the subject to rotate two handheld foam spheres connected to optical encoders via flexible rods. Ninety-six participants, including 30 control subjects, 36 Cree subjects exposed to methylmercury, 21 subjects with Parkinson's disease, 6 subjects with cerebellar deficits, and 3 subjects with essential tremor, were involved in the study (though data for 5 were later removed). Twelve characteristics were developed and calculated from the raw data. Conditions examined included two hands at natural cadence (NC2), right and left hands separately at fast cadence (FCl), and both hands at fast cadence (FC2). Two ratios (FC2/NC2) and (FC2/FC1) combining these conditions were also examined. Test-retest reliability was >0.80 for most characteristics but was <0.70 for some characteristics, especially in the conditions executed at normal cadence. Correlations between characteristics and numbers of outliers with respect to the control group distribution were used to reduce the set of characteristics from 12 to 7 (i.e., duration, range, maximum slope, similarity in shape, smoothness, sharpness, and coherence). ANOVAs on the three largest groups generated significant results for most characteristics in the three conditions and the two ratios for Cree subjects and subjects with Parkinson's disease. ANOVAs on 3 age-matched groups (n = 6) suggest that methylmercury affects the performance of the Cree subjects with the higher exposure, especially in terms of smoothness, sharpness, and coherence. These preliminary results suggest that this test is sufficiently specific and sensitive to characterize the performance of different groups of subjects. Ratios tend to improve discrimination for Cree subjects in a few characteristics but not for patients with Parkinson's disease.
CC :	002B03L05
FD :	Mercure; Métal lourd; Toxicité; Trouble neurologique; Trouble motricité; Amérindien; Homme; Mouvement alternatif; Québec; Test neuropsychologique; Méthode mesure; Mouvement corporel; Membre supérieur; Activité manuelle; Mercure(méthyl)
FG :	Système nerveux pathologie; Canada; Amérique du Nord; Amérique
ED :	Mercury; Heavy metal; Toxicity; Neurological disorder; Motility disorder; Amerindian; Human; Alternate motion; Quebec; Neuropsychological test; Measurement method; Body movement; Upper limb; Manual activity
EG :	Nervous system diseases; Canada; North America; America
SD :	Mercurio; Metal pesado; Toxicidad; Trastorno neurológico; Trastorno motilidad; Amerindio; Hombre; Movimiento alternativo; Quebec; Prueba neuropsichologica; Método medida; Movimiento corporal; Miembro superior; Actividad manual
LO :	INIST-13896.354000073560830080
ID :	99-0196404

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Pascal:99-0196404

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<front><div type="abstract" xml:lang="en">To quantify rapid alternating movements (RAMs) we used a simple prototype developed in our laboratory that requires the subject to rotate two handheld foam spheres connected to optical encoders via flexible rods. Ninety-six participants, including 30 control subjects, 36 Cree subjects exposed to methylmercury, 21 subjects with Parkinson's disease, 6 subjects with cerebellar deficits, and 3 subjects with essential tremor, were involved in the study (though data for 5 were later removed). Twelve characteristics were developed and calculated from the raw data. Conditions examined included two hands at natural cadence (NC2), right and left hands separately at fast cadence (FCl), and both hands at fast cadence (FC2). Two ratios (FC2/NC2) and (FC2/FC1) combining these conditions were also examined. Test-retest reliability was >0.80 for most characteristics but was <0.70 for some characteristics, especially in the conditions executed at normal cadence. Correlations between characteristics and numbers of outliers with respect to the control group distribution were used to reduce the set of characteristics from 12 to 7 (i.e., duration, range, maximum slope, similarity in shape, smoothness, sharpness, and coherence). ANOVAs on the three largest groups generated significant results for most characteristics in the three conditions and the two ratios for Cree subjects and subjects with Parkinson's disease. ANOVAs on 3 age-matched groups (n = 6) suggest that methylmercury affects the performance of the Cree subjects with the higher exposure, especially in terms of smoothness, sharpness, and coherence. These preliminary results suggest that this test is sufficiently specific and sensitive to characterize the performance of different groups of subjects. Ratios tend to improve discrimination for Cree subjects in a few characteristics but not for patients with Parkinson's disease.</div>
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<server><NO>PASCAL 99-0196404 INIST</NO>
<ET>Analysis of rapid alternating movements in Cree subjects exposed to methylmercury and in subjects with neurological deficits</ET>
<AU>BEUTER (A.); DE GEOFFROY (A.); EDWARDS (R.)</AU>
<AF>Laboratoire de Neurocinétique, Département de Kinanthropologie, Université du Québec à Montréal, CP 8888, Succursale Centre-ville/Montréal, Quebec H3C 3P8/Canada (1 aut., 2 aut., 3 aut.); Centre for Nonlinear Dynamics in Physiology and Medicine, McGill University/Montréal, Québec/Canada (1 aut., 3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Environmental research : (New York, NY); ISSN 0013-9351; Coden ENVRAL; Etats-Unis; Da. 1999; Vol. 80; No. 1; Pp. 64-79; Bibl. 8 ref.</SO>
<LA>Anglais</LA>
<EA>To quantify rapid alternating movements (RAMs) we used a simple prototype developed in our laboratory that requires the subject to rotate two handheld foam spheres connected to optical encoders via flexible rods. Ninety-six participants, including 30 control subjects, 36 Cree subjects exposed to methylmercury, 21 subjects with Parkinson's disease, 6 subjects with cerebellar deficits, and 3 subjects with essential tremor, were involved in the study (though data for 5 were later removed). Twelve characteristics were developed and calculated from the raw data. Conditions examined included two hands at natural cadence (NC2), right and left hands separately at fast cadence (FCl), and both hands at fast cadence (FC2). Two ratios (FC2/NC2) and (FC2/FC1) combining these conditions were also examined. Test-retest reliability was >0.80 for most characteristics but was <0.70 for some characteristics, especially in the conditions executed at normal cadence. Correlations between characteristics and numbers of outliers with respect to the control group distribution were used to reduce the set of characteristics from 12 to 7 (i.e., duration, range, maximum slope, similarity in shape, smoothness, sharpness, and coherence). ANOVAs on the three largest groups generated significant results for most characteristics in the three conditions and the two ratios for Cree subjects and subjects with Parkinson's disease. ANOVAs on 3 age-matched groups (n = 6) suggest that methylmercury affects the performance of the Cree subjects with the higher exposure, especially in terms of smoothness, sharpness, and coherence. These preliminary results suggest that this test is sufficiently specific and sensitive to characterize the performance of different groups of subjects. Ratios tend to improve discrimination for Cree subjects in a few characteristics but not for patients with Parkinson's disease.</EA>
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<FG>Système nerveux pathologie; Canada; Amérique du Nord; Amérique</FG>
<ED>Mercury; Heavy metal; Toxicity; Neurological disorder; Motility disorder; Amerindian; Human; Alternate motion; Quebec; Neuropsychological test; Measurement method; Body movement; Upper limb; Manual activity</ED>
<EG>Nervous system diseases; Canada; North America; America</EG>
<SD>Mercurio; Metal pesado; Toxicidad; Trastorno neurológico; Trastorno motilidad; Amerindio; Hombre; Movimiento alternativo; Quebec; Prueba neuropsichologica; Método medida; Movimiento corporal; Miembro superior; Actividad manual</SD>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Analysis of rapid alternating movements in Cree subjects exposed to methylmercury and in subjects with neurological deficits

Analysis of rapid alternating movements in Cree subjects exposed to methylmercury and in subjects with neurological deficits

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