La maladie de Parkinson au Canada (serveur d'exploration)

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Analysis of rapid alternating movements in Cree subjects exposed to methylmercury and in subjects with neurological deficits

Identifieur interne : 000D75 ( PascalFrancis/Corpus ); précédent : 000D74; suivant : 000D76

Analysis of rapid alternating movements in Cree subjects exposed to methylmercury and in subjects with neurological deficits

Auteurs : A. Beuter ; A. De Geoffroy ; R. Edwards

Source :

RBID : Pascal:99-0196404

Descripteurs français

English descriptors

Abstract

To quantify rapid alternating movements (RAMs) we used a simple prototype developed in our laboratory that requires the subject to rotate two handheld foam spheres connected to optical encoders via flexible rods. Ninety-six participants, including 30 control subjects, 36 Cree subjects exposed to methylmercury, 21 subjects with Parkinson's disease, 6 subjects with cerebellar deficits, and 3 subjects with essential tremor, were involved in the study (though data for 5 were later removed). Twelve characteristics were developed and calculated from the raw data. Conditions examined included two hands at natural cadence (NC2), right and left hands separately at fast cadence (FCl), and both hands at fast cadence (FC2). Two ratios (FC2/NC2) and (FC2/FC1) combining these conditions were also examined. Test-retest reliability was >0.80 for most characteristics but was <0.70 for some characteristics, especially in the conditions executed at normal cadence. Correlations between characteristics and numbers of outliers with respect to the control group distribution were used to reduce the set of characteristics from 12 to 7 (i.e., duration, range, maximum slope, similarity in shape, smoothness, sharpness, and coherence). ANOVAs on the three largest groups generated significant results for most characteristics in the three conditions and the two ratios for Cree subjects and subjects with Parkinson's disease. ANOVAs on 3 age-matched groups (n = 6) suggest that methylmercury affects the performance of the Cree subjects with the higher exposure, especially in terms of smoothness, sharpness, and coherence. These preliminary results suggest that this test is sufficiently specific and sensitive to characterize the performance of different groups of subjects. Ratios tend to improve discrimination for Cree subjects in a few characteristics but not for patients with Parkinson's disease.

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Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO : PASCAL 99-0196404 INIST
ET : Analysis of rapid alternating movements in Cree subjects exposed to methylmercury and in subjects with neurological deficits
AU : BEUTER (A.); DE GEOFFROY (A.); EDWARDS (R.)
AF : Laboratoire de Neurocinétique, Département de Kinanthropologie, Université du Québec à Montréal, CP 8888, Succursale Centre-ville/Montréal, Quebec H3C 3P8/Canada (1 aut., 2 aut., 3 aut.); Centre for Nonlinear Dynamics in Physiology and Medicine, McGill University/Montréal, Québec/Canada (1 aut., 3 aut.)
DT : Publication en série; Niveau analytique
SO : Environmental research : (New York, NY); ISSN 0013-9351; Coden ENVRAL; Etats-Unis; Da. 1999; Vol. 80; No. 1; Pp. 64-79; Bibl. 8 ref.
LA : Anglais
EA : To quantify rapid alternating movements (RAMs) we used a simple prototype developed in our laboratory that requires the subject to rotate two handheld foam spheres connected to optical encoders via flexible rods. Ninety-six participants, including 30 control subjects, 36 Cree subjects exposed to methylmercury, 21 subjects with Parkinson's disease, 6 subjects with cerebellar deficits, and 3 subjects with essential tremor, were involved in the study (though data for 5 were later removed). Twelve characteristics were developed and calculated from the raw data. Conditions examined included two hands at natural cadence (NC2), right and left hands separately at fast cadence (FCl), and both hands at fast cadence (FC2). Two ratios (FC2/NC2) and (FC2/FC1) combining these conditions were also examined. Test-retest reliability was >0.80 for most characteristics but was <0.70 for some characteristics, especially in the conditions executed at normal cadence. Correlations between characteristics and numbers of outliers with respect to the control group distribution were used to reduce the set of characteristics from 12 to 7 (i.e., duration, range, maximum slope, similarity in shape, smoothness, sharpness, and coherence). ANOVAs on the three largest groups generated significant results for most characteristics in the three conditions and the two ratios for Cree subjects and subjects with Parkinson's disease. ANOVAs on 3 age-matched groups (n = 6) suggest that methylmercury affects the performance of the Cree subjects with the higher exposure, especially in terms of smoothness, sharpness, and coherence. These preliminary results suggest that this test is sufficiently specific and sensitive to characterize the performance of different groups of subjects. Ratios tend to improve discrimination for Cree subjects in a few characteristics but not for patients with Parkinson's disease.
CC : 002B03L05
FD : Mercure; Métal lourd; Toxicité; Trouble neurologique; Trouble motricité; Amérindien; Homme; Mouvement alternatif; Québec; Test neuropsychologique; Méthode mesure; Mouvement corporel; Membre supérieur; Activité manuelle; Mercure(méthyl)
FG : Système nerveux pathologie; Canada; Amérique du Nord; Amérique
ED : Mercury; Heavy metal; Toxicity; Neurological disorder; Motility disorder; Amerindian; Human; Alternate motion; Quebec; Neuropsychological test; Measurement method; Body movement; Upper limb; Manual activity
EG : Nervous system diseases; Canada; North America; America
SD : Mercurio; Metal pesado; Toxicidad; Trastorno neurológico; Trastorno motilidad; Amerindio; Hombre; Movimiento alternativo; Quebec; Prueba neuropsichologica; Método medida; Movimiento corporal; Miembro superior; Actividad manual
LO : INIST-13896.354000073560830080
ID : 99-0196404

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Pascal:99-0196404

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<div type="abstract" xml:lang="en">To quantify rapid alternating movements (RAMs) we used a simple prototype developed in our laboratory that requires the subject to rotate two handheld foam spheres connected to optical encoders via flexible rods. Ninety-six participants, including 30 control subjects, 36 Cree subjects exposed to methylmercury, 21 subjects with Parkinson's disease, 6 subjects with cerebellar deficits, and 3 subjects with essential tremor, were involved in the study (though data for 5 were later removed). Twelve characteristics were developed and calculated from the raw data. Conditions examined included two hands at natural cadence (NC2), right and left hands separately at fast cadence (FCl), and both hands at fast cadence (FC2). Two ratios (FC2/NC2) and (FC2/FC1) combining these conditions were also examined. Test-retest reliability was >0.80 for most characteristics but was <0.70 for some characteristics, especially in the conditions executed at normal cadence. Correlations between characteristics and numbers of outliers with respect to the control group distribution were used to reduce the set of characteristics from 12 to 7 (i.e., duration, range, maximum slope, similarity in shape, smoothness, sharpness, and coherence). ANOVAs on the three largest groups generated significant results for most characteristics in the three conditions and the two ratios for Cree subjects and subjects with Parkinson's disease. ANOVAs on 3 age-matched groups (n = 6) suggest that methylmercury affects the performance of the Cree subjects with the higher exposure, especially in terms of smoothness, sharpness, and coherence. These preliminary results suggest that this test is sufficiently specific and sensitive to characterize the performance of different groups of subjects. Ratios tend to improve discrimination for Cree subjects in a few characteristics but not for patients with Parkinson's disease.</div>
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<fC03 i1="01" i2="X" l="ENG">
<s0>Mercury</s0>
<s2>NC</s2>
<s2>FX</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Mercurio</s0>
<s2>NC</s2>
<s2>FX</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Métal lourd</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Heavy metal</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Metal pesado</s0>
<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Toxicité</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Toxicity</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Toxicidad</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Trouble neurologique</s0>
<s5>11</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Neurological disorder</s0>
<s5>11</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Trastorno neurológico</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Trouble motricité</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Motility disorder</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Trastorno motilidad</s0>
<s5>13</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Amérindien</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Amerindian</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Amerindio</s0>
<s5>14</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Homme</s0>
<s5>16</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Human</s0>
<s5>16</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Hombre</s0>
<s5>16</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Mouvement alternatif</s0>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Alternate motion</s0>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Movimiento alternativo</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE">
<s0>Québec</s0>
<s2>NG</s2>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG">
<s0>Quebec</s0>
<s2>NG</s2>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA">
<s0>Quebec</s0>
<s2>NG</s2>
<s5>18</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE">
<s0>Test neuropsychologique</s0>
<s5>20</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG">
<s0>Neuropsychological test</s0>
<s5>20</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA">
<s0>Prueba neuropsichologica</s0>
<s5>20</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE">
<s0>Méthode mesure</s0>
<s5>21</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG">
<s0>Measurement method</s0>
<s5>21</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA">
<s0>Método medida</s0>
<s5>21</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE">
<s0>Mouvement corporel</s0>
<s5>22</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG">
<s0>Body movement</s0>
<s5>22</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA">
<s0>Movimiento corporal</s0>
<s5>22</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE">
<s0>Membre supérieur</s0>
<s5>23</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG">
<s0>Upper limb</s0>
<s5>23</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA">
<s0>Miembro superior</s0>
<s5>23</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE">
<s0>Activité manuelle</s0>
<s5>24</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG">
<s0>Manual activity</s0>
<s5>24</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA">
<s0>Actividad manual</s0>
<s5>24</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE">
<s0>Mercure(méthyl)</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Système nerveux pathologie</s0>
<s5>10</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Nervous system diseases</s0>
<s5>10</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Sistema nervioso patología</s0>
<s5>10</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Canada</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Canada</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Canada</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Amérique du Nord</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>North America</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>America del norte</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Amérique</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>America</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>America</s0>
<s2>NG</s2>
</fC07>
<fN21>
<s1>123</s1>
</fN21>
</pA>
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<server>
<NO>PASCAL 99-0196404 INIST</NO>
<ET>Analysis of rapid alternating movements in Cree subjects exposed to methylmercury and in subjects with neurological deficits</ET>
<AU>BEUTER (A.); DE GEOFFROY (A.); EDWARDS (R.)</AU>
<AF>Laboratoire de Neurocinétique, Département de Kinanthropologie, Université du Québec à Montréal, CP 8888, Succursale Centre-ville/Montréal, Quebec H3C 3P8/Canada (1 aut., 2 aut., 3 aut.); Centre for Nonlinear Dynamics in Physiology and Medicine, McGill University/Montréal, Québec/Canada (1 aut., 3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Environmental research : (New York, NY); ISSN 0013-9351; Coden ENVRAL; Etats-Unis; Da. 1999; Vol. 80; No. 1; Pp. 64-79; Bibl. 8 ref.</SO>
<LA>Anglais</LA>
<EA>To quantify rapid alternating movements (RAMs) we used a simple prototype developed in our laboratory that requires the subject to rotate two handheld foam spheres connected to optical encoders via flexible rods. Ninety-six participants, including 30 control subjects, 36 Cree subjects exposed to methylmercury, 21 subjects with Parkinson's disease, 6 subjects with cerebellar deficits, and 3 subjects with essential tremor, were involved in the study (though data for 5 were later removed). Twelve characteristics were developed and calculated from the raw data. Conditions examined included two hands at natural cadence (NC2), right and left hands separately at fast cadence (FCl), and both hands at fast cadence (FC2). Two ratios (FC2/NC2) and (FC2/FC1) combining these conditions were also examined. Test-retest reliability was >0.80 for most characteristics but was <0.70 for some characteristics, especially in the conditions executed at normal cadence. Correlations between characteristics and numbers of outliers with respect to the control group distribution were used to reduce the set of characteristics from 12 to 7 (i.e., duration, range, maximum slope, similarity in shape, smoothness, sharpness, and coherence). ANOVAs on the three largest groups generated significant results for most characteristics in the three conditions and the two ratios for Cree subjects and subjects with Parkinson's disease. ANOVAs on 3 age-matched groups (n = 6) suggest that methylmercury affects the performance of the Cree subjects with the higher exposure, especially in terms of smoothness, sharpness, and coherence. These preliminary results suggest that this test is sufficiently specific and sensitive to characterize the performance of different groups of subjects. Ratios tend to improve discrimination for Cree subjects in a few characteristics but not for patients with Parkinson's disease.</EA>
<CC>002B03L05</CC>
<FD>Mercure; Métal lourd; Toxicité; Trouble neurologique; Trouble motricité; Amérindien; Homme; Mouvement alternatif; Québec; Test neuropsychologique; Méthode mesure; Mouvement corporel; Membre supérieur; Activité manuelle; Mercure(méthyl)</FD>
<FG>Système nerveux pathologie; Canada; Amérique du Nord; Amérique</FG>
<ED>Mercury; Heavy metal; Toxicity; Neurological disorder; Motility disorder; Amerindian; Human; Alternate motion; Quebec; Neuropsychological test; Measurement method; Body movement; Upper limb; Manual activity</ED>
<EG>Nervous system diseases; Canada; North America; America</EG>
<SD>Mercurio; Metal pesado; Toxicidad; Trastorno neurológico; Trastorno motilidad; Amerindio; Hombre; Movimiento alternativo; Quebec; Prueba neuropsichologica; Método medida; Movimiento corporal; Miembro superior; Actividad manual</SD>
<LO>INIST-13896.354000073560830080</LO>
<ID>99-0196404</ID>
</server>
</inist>
</record>

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