ParkinsonCanadaV1, Main, Exploration, bibRecordById, pubmed:10942816

Cell delivery to the central nervous system

Identifieur interne : 003413 ( Main/Exploration ); précédent : 003412; suivant : 003414

Cell delivery to the central nervous system

Auteurs : Molly S. Shoichet [Canada] ; Shelley R. Winn [États-Unis]

Source :

Advanced Drug Delivery Reviews [ 0169-409X ] ; 2000.

RBID : ISTEX:610765AE42BCC4E92DAE61C4BE1547FC49B9D312

English descriptors

KwdEn :
- Animals, Blood-Brain Barrier, Brain Diseases (therapy), Cell Survival, Cell Transplantation, Drug Delivery Systems, Humans, Infusion Pumps, Microinjections, Osmotic Pressure, Parkinson Disease (therapy).
MESH :
- therapy : Brain Diseases, Parkinson Disease.
- Animals, Blood-Brain Barrier, Cell Survival, Cell Transplantation, Drug Delivery Systems, Humans, Infusion Pumps, Microinjections, Osmotic Pressure.

Abstract

A dysfunctional central nervous system (CNS) resulting from neurological disorders and diseases impacts all of humanity. The outcome presents a staggering health care issue with a tremendous potential for developing interventive therapies. The delivery of therapeutic molecules to the CNS has been hampered by the presence of the blood–brain barrier (BBB). To circumvent this barrier, putative therapeutic molecules have been delivered to the CNS by such methods as pumps/osmotic pumps, osmotic opening of the BBB, sustained polymer release systems and cell delivery via site-specific transplantation of cells. This review presents an overview of some of the CNS delivery technologies with special emphasis on transplantation of cells with and without the use of polymer encapsulation technology.

Url:

https://api-v5.istex.fr/document/610765AE42BCC4E92DAE61C4BE1547FC49B9D312/fulltext/pdf

DOI: 10.1016/S0169-409X(00)00055-7

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">A dysfunctional central nervous system (CNS) resulting from neurological disorders and diseases impacts all of humanity. The outcome presents a staggering health care issue with a tremendous potential for developing interventive therapies. The delivery of therapeutic molecules to the CNS has been hampered by the presence of the blood–brain barrier (BBB). To circumvent this barrier, putative therapeutic molecules have been delivered to the CNS by such methods as pumps/osmotic pumps, osmotic opening of the BBB, sustained polymer release systems and cell delivery via site-specific transplantation of cells. This review presents an overview of some of the CNS delivery technologies with special emphasis on transplantation of cells with and without the use of polymer encapsulation technology.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Cell delivery to the central nervous system

Cell delivery to the central nervous system

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.