Cell delivery to the central nervous system.
Identifieur interne : 000115 ( Ncbi/Checkpoint ); précédent : 000114; suivant : 000116Cell delivery to the central nervous system.
Auteurs : M S Shoichet [Canada] ; S R WinnSource :
- Advanced drug delivery reviews [ 0169-409X ] ; 2000.
English descriptors
- KwdEn :
- MESH :
Abstract
A dysfunctional central nervous system (CNS) resulting from neurological disorders and diseases impacts all of humanity. The outcome presents a staggering health care issue with a tremendous potential for developing interventive therapies. The delivery of therapeutic molecules to the CNS has been hampered by the presence of the blood-brain barrier (BBB). To circumvent this barrier, putative therapeutic molecules have been delivered to the CNS by such methods as pumps/osmotic pumps, osmotic opening of the BBB, sustained polymer release systems and cell delivery via site-specific transplantation of cells. This review presents an overview of some of the CNS delivery technologies with special emphasis on transplantation of cells with and without the use of polymer encapsulation technology.
PubMed: 10942816
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001623
- to stream PubMed, to step Curation: 001623
- to stream PubMed, to step Checkpoint: 001623
- to stream Ncbi, to step Merge: 000115
- to stream Ncbi, to step Curation: 000115
Links to Exploration step
pubmed:10942816Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cell delivery to the central nervous system.</title><author><name sortKey="Shoichet, M S" sort="Shoichet, M S" uniqKey="Shoichet M" first="M S" last="Shoichet">M S Shoichet</name><affiliation wicri:level="4"><nlm:affiliation>Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, 200 College Street, Toronto, M55 3E5, Ontario, Canada. molly@ecf.utoronto.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, 200 College Street, Toronto, M55 3E5, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Winn, S R" sort="Winn, S R" uniqKey="Winn S" first="S R" last="Winn">S R Winn</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10942816</idno><idno type="pmid">10942816</idno><idno type="wicri:Area/PubMed/Corpus">001623</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001623</idno><idno type="wicri:Area/PubMed/Curation">001623</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001623</idno><idno type="wicri:Area/PubMed/Checkpoint">001623</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001623</idno><idno type="wicri:Area/Ncbi/Merge">000115</idno><idno type="wicri:Area/Ncbi/Curation">000115</idno><idno type="wicri:Area/Ncbi/Checkpoint">000115</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cell delivery to the central nervous system.</title><author><name sortKey="Shoichet, M S" sort="Shoichet, M S" uniqKey="Shoichet M" first="M S" last="Shoichet">M S Shoichet</name><affiliation wicri:level="4"><nlm:affiliation>Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, 200 College Street, Toronto, M55 3E5, Ontario, Canada. molly@ecf.utoronto.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, 200 College Street, Toronto, M55 3E5, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Winn, S R" sort="Winn, S R" uniqKey="Winn S" first="S R" last="Winn">S R Winn</name></author></analytic><series><title level="j">Advanced drug delivery reviews</title><idno type="ISSN">0169-409X</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Blood-Brain Barrier</term><term>Brain Diseases (therapy)</term><term>Cell Survival</term><term>Cell Transplantation</term><term>Drug Delivery Systems</term><term>Humans</term><term>Infusion Pumps</term><term>Microinjections</term><term>Osmotic Pressure</term><term>Parkinson Disease (therapy)</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Brain Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Blood-Brain Barrier</term><term>Cell Survival</term><term>Cell Transplantation</term><term>Drug Delivery Systems</term><term>Humans</term><term>Infusion Pumps</term><term>Microinjections</term><term>Osmotic Pressure</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A dysfunctional central nervous system (CNS) resulting from neurological disorders and diseases impacts all of humanity. The outcome presents a staggering health care issue with a tremendous potential for developing interventive therapies. The delivery of therapeutic molecules to the CNS has been hampered by the presence of the blood-brain barrier (BBB). To circumvent this barrier, putative therapeutic molecules have been delivered to the CNS by such methods as pumps/osmotic pumps, osmotic opening of the BBB, sustained polymer release systems and cell delivery via site-specific transplantation of cells. This review presents an overview of some of the CNS delivery technologies with special emphasis on transplantation of cells with and without the use of polymer encapsulation technology.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Winn, S R" sort="Winn, S R" uniqKey="Winn S" first="S R" last="Winn">S R Winn</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Shoichet, M S" sort="Shoichet, M S" uniqKey="Shoichet M" first="M S" last="Shoichet">M S Shoichet</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000115 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000115 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:10942816
|texte= Cell delivery to the central nervous system.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:10942816" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |