Cell delivery to the central nervous system.
Identifieur interne : 001623 ( PubMed/Corpus ); précédent : 001622; suivant : 001624Cell delivery to the central nervous system.
Auteurs : M S Shoichet ; S R WinnSource :
- Advanced drug delivery reviews [ 0169-409X ] ; 2000.
English descriptors
- KwdEn :
- MESH :
Abstract
A dysfunctional central nervous system (CNS) resulting from neurological disorders and diseases impacts all of humanity. The outcome presents a staggering health care issue with a tremendous potential for developing interventive therapies. The delivery of therapeutic molecules to the CNS has been hampered by the presence of the blood-brain barrier (BBB). To circumvent this barrier, putative therapeutic molecules have been delivered to the CNS by such methods as pumps/osmotic pumps, osmotic opening of the BBB, sustained polymer release systems and cell delivery via site-specific transplantation of cells. This review presents an overview of some of the CNS delivery technologies with special emphasis on transplantation of cells with and without the use of polymer encapsulation technology.
PubMed: 10942816
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pubmed:10942816Le document en format XML
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The outcome presents a staggering health care issue with a tremendous potential for developing interventive therapies. The delivery of therapeutic molecules to the CNS has been hampered by the presence of the blood-brain barrier (BBB). To circumvent this barrier, putative therapeutic molecules have been delivered to the CNS by such methods as pumps/osmotic pumps, osmotic opening of the BBB, sustained polymer release systems and cell delivery via site-specific transplantation of cells. This review presents an overview of some of the CNS delivery technologies with special emphasis on transplantation of cells with and without the use of polymer encapsulation technology.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10942816</PMID><DateCreated><Year>2000</Year><Month>09</Month><Day>25</Day></DateCreated><DateCompleted><Year>2000</Year><Month>09</Month><Day>25</Day></DateCompleted><DateRevised><Year>2005</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0169-409X</ISSN><JournalIssue CitedMedium="Print"><Volume>42</Volume><Issue>1-2</Issue><PubDate><Year>2000</Year><Month>Aug</Month><Day>20</Day></PubDate></JournalIssue><Title>Advanced drug delivery reviews</Title><ISOAbbreviation>Adv. Drug Deliv. 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