Cell delivery to the central nervous system.
Identifieur interne : 001623 ( PubMed/Corpus ); précédent : 001622; suivant : 001624Cell delivery to the central nervous system.
Auteurs : M S Shoichet ; S R WinnSource :
- Advanced drug delivery reviews [ 0169-409X ] ; 2000.
English descriptors
- KwdEn :
- MESH :
Abstract
A dysfunctional central nervous system (CNS) resulting from neurological disorders and diseases impacts all of humanity. The outcome presents a staggering health care issue with a tremendous potential for developing interventive therapies. The delivery of therapeutic molecules to the CNS has been hampered by the presence of the blood-brain barrier (BBB). To circumvent this barrier, putative therapeutic molecules have been delivered to the CNS by such methods as pumps/osmotic pumps, osmotic opening of the BBB, sustained polymer release systems and cell delivery via site-specific transplantation of cells. This review presents an overview of some of the CNS delivery technologies with special emphasis on transplantation of cells with and without the use of polymer encapsulation technology.
PubMed: 10942816
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pubmed:10942816Le document en format XML
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<author><name sortKey="Shoichet, M S" sort="Shoichet, M S" uniqKey="Shoichet M" first="M S" last="Shoichet">M S Shoichet</name>
<affiliation><nlm:affiliation>Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, 200 College Street, Toronto, M55 3E5, Ontario, Canada. molly@ecf.utoronto.ca</nlm:affiliation>
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<author><name sortKey="Winn, S R" sort="Winn, S R" uniqKey="Winn S" first="S R" last="Winn">S R Winn</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Cell delivery to the central nervous system.</title>
<author><name sortKey="Shoichet, M S" sort="Shoichet, M S" uniqKey="Shoichet M" first="M S" last="Shoichet">M S Shoichet</name>
<affiliation><nlm:affiliation>Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, 200 College Street, Toronto, M55 3E5, Ontario, Canada. molly@ecf.utoronto.ca</nlm:affiliation>
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<author><name sortKey="Winn, S R" sort="Winn, S R" uniqKey="Winn S" first="S R" last="Winn">S R Winn</name>
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<series><title level="j">Advanced drug delivery reviews</title>
<idno type="ISSN">0169-409X</idno>
<imprint><date when="2000" type="published">2000</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Blood-Brain Barrier</term>
<term>Brain Diseases (therapy)</term>
<term>Cell Survival</term>
<term>Cell Transplantation</term>
<term>Drug Delivery Systems</term>
<term>Humans</term>
<term>Infusion Pumps</term>
<term>Microinjections</term>
<term>Osmotic Pressure</term>
<term>Parkinson Disease (therapy)</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Brain Diseases</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Blood-Brain Barrier</term>
<term>Cell Survival</term>
<term>Cell Transplantation</term>
<term>Drug Delivery Systems</term>
<term>Humans</term>
<term>Infusion Pumps</term>
<term>Microinjections</term>
<term>Osmotic Pressure</term>
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<front><div type="abstract" xml:lang="en">A dysfunctional central nervous system (CNS) resulting from neurological disorders and diseases impacts all of humanity. The outcome presents a staggering health care issue with a tremendous potential for developing interventive therapies. The delivery of therapeutic molecules to the CNS has been hampered by the presence of the blood-brain barrier (BBB). To circumvent this barrier, putative therapeutic molecules have been delivered to the CNS by such methods as pumps/osmotic pumps, osmotic opening of the BBB, sustained polymer release systems and cell delivery via site-specific transplantation of cells. This review presents an overview of some of the CNS delivery technologies with special emphasis on transplantation of cells with and without the use of polymer encapsulation technology.</div>
</front>
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<DateCreated><Year>2000</Year>
<Month>09</Month>
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<DateCompleted><Year>2000</Year>
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<DateRevised><Year>2005</Year>
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<JournalIssue CitedMedium="Print"><Volume>42</Volume>
<Issue>1-2</Issue>
<PubDate><Year>2000</Year>
<Month>Aug</Month>
<Day>20</Day>
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<Title>Advanced drug delivery reviews</Title>
<ISOAbbreviation>Adv. Drug Deliv. Rev.</ISOAbbreviation>
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<ArticleTitle>Cell delivery to the central nervous system.</ArticleTitle>
<Pagination><MedlinePgn>81-102</MedlinePgn>
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<Abstract><AbstractText>A dysfunctional central nervous system (CNS) resulting from neurological disorders and diseases impacts all of humanity. The outcome presents a staggering health care issue with a tremendous potential for developing interventive therapies. The delivery of therapeutic molecules to the CNS has been hampered by the presence of the blood-brain barrier (BBB). To circumvent this barrier, putative therapeutic molecules have been delivered to the CNS by such methods as pumps/osmotic pumps, osmotic opening of the BBB, sustained polymer release systems and cell delivery via site-specific transplantation of cells. This review presents an overview of some of the CNS delivery technologies with special emphasis on transplantation of cells with and without the use of polymer encapsulation technology.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shoichet</LastName>
<ForeName>M S</ForeName>
<Initials>MS</Initials>
<AffiliationInfo><Affiliation>Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, 200 College Street, Toronto, M55 3E5, Ontario, Canada. molly@ecf.utoronto.ca</Affiliation>
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<Author ValidYN="Y"><LastName>Winn</LastName>
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<Initials>SR</Initials>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
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<MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName>
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<MeshHeading><DescriptorName UI="D017690" MajorTopicYN="Y">Cell Transplantation</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D007260" MajorTopicYN="N">Infusion Pumps</DescriptorName>
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<MeshHeading><DescriptorName UI="D008845" MajorTopicYN="N">Microinjections</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009997" MajorTopicYN="N">Osmotic Pressure</DescriptorName>
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<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
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</MeshHeadingList>
<NumberOfReferences>148</NumberOfReferences>
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