Voxel-based imaging of translocator protein 18kDa (TSPO) in high-resolution PET
Identifieur interne : 000C22 ( Main/Exploration ); précédent : 000C21; suivant : 000C23Voxel-based imaging of translocator protein 18kDa (TSPO) in high-resolution PET
Auteurs : Ji Hyun Ko [Canada] ; Yuko Koshimori [Canada] ; Romina Mizrahi [Canada] ; Pablo Rusjan [Canada] ; Alan A. Wilson [Canada] ; Anthony E. Lang [Canada] ; Sylvain Houle [Canada] ; Antonio P. Strafella [Canada]Source :
- Journal of Cerebral Blood Flow & Metabolism [ 0271-678X ] ; 2013.
Abstract
Url:
DOI: 10.1038/jcbfm.2012.203
PubMed: 23281426
PubMed Central: 3587822
Affiliations:
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Le document en format XML
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, Toronto, ON,<country>Canada</country>
</nlm:aff>
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, Toronto, ON,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Movement Disorder Unit, E. J. Safra Program in Parkinson Disease, Toronto Western Hospital, UHN, University of Toronto</institution>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name>
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, Toronto, ON,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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, Toronto, ON,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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, Toronto, ON,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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, Toronto, ON,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<series><title level="j">Journal of Cerebral Blood Flow & Metabolism</title>
<idno type="ISSN">0271-678X</idno>
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<imprint><date when="2013">2013</date>
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<front><div type="abstract" xml:lang="en"><p><italic>In vivo</italic>
imaging of translocator protein 18 kDa (TSPO) has received significant attention as potential biomarker of microglia activation. Several radioligands have been designed with improved properties. Our group recently developed an <sup>18</sup>
F-labeled TSPO ligand, [<sup>18</sup>
F]-FEPPA, and confirmed its reliability with a 2-tissue compartment model. Here, we extended, in a group of healthy subjects, its suitability for use in voxel-based analysis with the newly proposed graphical analysis approach, Relative-Equilibrium-Gjedde-Patlak (REGP) plot. The REGP plot successfully replicated the total distribution volumes estimated by the 2-tissue compartment model. We also showed its proof-of-concept in a patient with possible meningioma showing increased [<sup>18</sup>
F]-FEPPA total distribution volume.</p>
</div>
</front>
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<tree><country name="Canada"><noRegion><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name>
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<name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name>
<name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name>
<name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name>
<name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name>
<name sortKey="Mizrahi, Romina" sort="Mizrahi, Romina" uniqKey="Mizrahi R" first="Romina" last="Mizrahi">Romina Mizrahi</name>
<name sortKey="Rusjan, Pablo" sort="Rusjan, Pablo" uniqKey="Rusjan P" first="Pablo" last="Rusjan">Pablo Rusjan</name>
<name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name>
<name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name>
<name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name>
<name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A" last="Wilson">Alan A. Wilson</name>
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