Voxel-based imaging of translocator protein 18kDa (TSPO) in high-resolution PET
Identifieur interne : 000001 ( Pmc/Corpus ); précédent : 000000; suivant : 000002Voxel-based imaging of translocator protein 18kDa (TSPO) in high-resolution PET
Auteurs : Ji Hyun Ko ; Yuko Koshimori ; Romina Mizrahi ; Pablo Rusjan ; Alan A. Wilson ; Anthony E. Lang ; Sylvain Houle ; Antonio P. StrafellaSource :
- Journal of Cerebral Blood Flow & Metabolism [ 0271-678X ] ; 2013.
Abstract
Url:
DOI: 10.1038/jcbfm.2012.203
PubMed: 23281426
PubMed Central: 3587822
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PMC:3587822Le document en format XML
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<author><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Voxel-based imaging of translocator protein 18kDa (TSPO) in high-resolution PET</title>
<author><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name>
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<author><name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name>
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</nlm:aff>
</affiliation>
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<author><name sortKey="Mizrahi, Romina" sort="Mizrahi, Romina" uniqKey="Mizrahi R" first="Romina" last="Mizrahi">Romina Mizrahi</name>
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, Toronto, ON,<country>Canada</country>
</nlm:aff>
</affiliation>
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<author><name sortKey="Rusjan, Pablo" sort="Rusjan, Pablo" uniqKey="Rusjan P" first="Pablo" last="Rusjan">Pablo Rusjan</name>
<affiliation><nlm:aff id="aff1"><institution>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</institution>
, Toronto, ON,<country>Canada</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A" last="Wilson">Alan A. Wilson</name>
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, Toronto, ON,<country>Canada</country>
</nlm:aff>
</affiliation>
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<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name>
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, Toronto, ON,<country>Canada</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"><institution>Movement Disorder Unit, E. J. Safra Program in Parkinson Disease, Toronto Western Hospital, UHN, University of Toronto</institution>
, Toronto, ON,<country>Canada</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name>
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<author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name>
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, Toronto, ON,<country>Canada</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"><institution>Movement Disorder Unit, E. J. Safra Program in Parkinson Disease, Toronto Western Hospital, UHN, University of Toronto</institution>
, Toronto, ON,<country>Canada</country>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Cerebral Blood Flow & Metabolism</title>
<idno type="ISSN">0271-678X</idno>
<idno type="eISSN">1559-7016</idno>
<imprint><date when="2013">2013</date>
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<front><div type="abstract" xml:lang="en"><p><italic>In vivo</italic>
imaging of translocator protein 18 kDa (TSPO) has received significant attention as potential biomarker of microglia activation. Several radioligands have been designed with improved properties. Our group recently developed an <sup>18</sup>
F-labeled TSPO ligand, [<sup>18</sup>
F]-FEPPA, and confirmed its reliability with a 2-tissue compartment model. Here, we extended, in a group of healthy subjects, its suitability for use in voxel-based analysis with the newly proposed graphical analysis approach, Relative-Equilibrium-Gjedde-Patlak (REGP) plot. The REGP plot successfully replicated the total distribution volumes estimated by the 2-tissue compartment model. We also showed its proof-of-concept in a patient with possible meningioma showing increased [<sup>18</sup>
F]-FEPPA total distribution volume.</p>
</div>
</front>
</TEI>
<pmc article-type="letter"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Cereb Blood Flow Metab</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Cereb. Blood Flow Metab</journal-id>
<journal-title-group><journal-title>Journal of Cerebral Blood Flow & Metabolism</journal-title>
</journal-title-group>
<issn pub-type="ppub">0271-678X</issn>
<issn pub-type="epub">1559-7016</issn>
<publisher><publisher-name>Nature Publishing Group</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23281426</article-id>
<article-id pub-id-type="pmc">3587822</article-id>
<article-id pub-id-type="pii">jcbfm2012203</article-id>
<article-id pub-id-type="doi">10.1038/jcbfm.2012.203</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Brief Communication</subject>
</subj-group>
</article-categories>
<title-group><article-title>Voxel-based imaging of translocator protein 18kDa (TSPO) in high-resolution PET</article-title>
<alt-title alt-title-type="running">Voxel-based FEPPA PET imaging meningioma</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Ko</surname>
<given-names>Ji Hyun</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koshimori</surname>
<given-names>Yuko</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mizrahi</surname>
<given-names>Romina</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rusjan</surname>
<given-names>Pablo</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wilson</surname>
<given-names>Alan A</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lang</surname>
<given-names>Anthony E</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Houle</surname>
<given-names>Sylvain</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Strafella</surname>
<given-names>Antonio P</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
<xref ref-type="corresp" rid="caf1">*</xref>
</contrib>
<aff id="aff1"><label>1</label>
<institution>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</institution>
, Toronto, ON,<country>Canada</country>
</aff>
<aff id="aff2"><label>2</label>
<institution>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto</institution>
, Toronto, ON,<country>Canada</country>
</aff>
<aff id="aff3"><label>3</label>
<institution>Movement Disorder Unit, E. J. Safra Program in Parkinson Disease, Toronto Western Hospital, UHN, University of Toronto</institution>
, Toronto, ON,<country>Canada</country>
</aff>
</contrib-group>
<author-notes><corresp id="caf1"><label>*</label>
<institution>CAMH-Research Imaging Centre, Toronto Western Hospital and Institute, University of Toronto</institution>
, 399 Bathurst Street, Toronto, ON, <country>Canada</country>
M5T 2S8. E-mail: <email>antonio.strafella@uhnres.utoronto.ca</email>
or <email>antonio.strafella@camhpet.ca</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>03</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>02</day>
<month>01</month>
<year>2013</year>
</pub-date>
<volume>33</volume>
<issue>3</issue>
<fpage>348</fpage>
<lpage>350</lpage>
<history><date date-type="received"><day>04</day>
<month>09</month>
<year>2012</year>
</date>
<date date-type="rev-recd"><day>16</day>
<month>11</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>12</day>
<month>12</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2013 International Society for Cerebral Blood Flow & Metabolism, Inc.</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder>International Society for Cerebral Blood Flow & Metabolism, Inc.</copyright-holder>
</permissions>
<abstract><p><italic>In vivo</italic>
imaging of translocator protein 18 kDa (TSPO) has received significant attention as potential biomarker of microglia activation. Several radioligands have been designed with improved properties. Our group recently developed an <sup>18</sup>
F-labeled TSPO ligand, [<sup>18</sup>
F]-FEPPA, and confirmed its reliability with a 2-tissue compartment model. Here, we extended, in a group of healthy subjects, its suitability for use in voxel-based analysis with the newly proposed graphical analysis approach, Relative-Equilibrium-Gjedde-Patlak (REGP) plot. The REGP plot successfully replicated the total distribution volumes estimated by the 2-tissue compartment model. We also showed its proof-of-concept in a patient with possible meningioma showing increased [<sup>18</sup>
F]-FEPPA total distribution volume.</p>
</abstract>
<kwd-group><kwd>inflammation</kwd>
<kwd>kinetic modeling</kwd>
<kwd>microglia</kwd>
<kwd>neurooncology</kwd>
<kwd>positron emission tomography</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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