Voxel-based imaging of translocator protein 18kDa (TSPO) in high-resolution PET
Identifieur interne : 001345 ( Ncbi/Checkpoint ); précédent : 001344; suivant : 001346Voxel-based imaging of translocator protein 18kDa (TSPO) in high-resolution PET
Auteurs : Ji Hyun Ko [Canada] ; Yuko Koshimori [Canada] ; Romina Mizrahi [Canada] ; Pablo Rusjan [Canada] ; Alan A. Wilson [Canada] ; Anthony E. Lang [Canada] ; Sylvain Houle [Canada] ; Antonio P. Strafella [Canada]Source :
- Journal of Cerebral Blood Flow & Metabolism [ 0271-678X ] ; 2013.
Abstract
Url:
DOI: 10.1038/jcbfm.2012.203
PubMed: 23281426
PubMed Central: 3587822
Affiliations:
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Wilson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Movement Disorder Unit, E. J. Safra Program in Parkinson Disease, Toronto Western Hospital, UHN, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Movement Disorder Unit, E. J. Safra Program in Parkinson Disease, Toronto Western Hospital, UHN, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23281426</idno><idno type="pmc">3587822</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587822</idno><idno type="RBID">PMC:3587822</idno><idno type="doi">10.1038/jcbfm.2012.203</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000001</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000001</idno><idno type="wicri:Area/Pmc/Curation">000001</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000001</idno><idno type="wicri:Area/Pmc/Checkpoint">000554</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000554</idno><idno type="wicri:Area/Ncbi/Merge">001345</idno><idno type="wicri:Area/Ncbi/Curation">001345</idno><idno type="wicri:Area/Ncbi/Checkpoint">001345</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Voxel-based imaging of translocator protein 18kDa (TSPO) in high-resolution PET</title><author><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mizrahi, Romina" sort="Mizrahi, Romina" uniqKey="Mizrahi R" first="Romina" last="Mizrahi">Romina Mizrahi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rusjan, Pablo" sort="Rusjan, Pablo" uniqKey="Rusjan P" first="Pablo" last="Rusjan">Pablo Rusjan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A" last="Wilson">Alan A. Wilson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Movement Disorder Unit, E. J. Safra Program in Parkinson Disease, Toronto Western Hospital, UHN, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Division of Brain, Imaging and Behaviour – Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Movement Disorder Unit, E. J. Safra Program in Parkinson Disease, Toronto Western Hospital, UHN, University of Toronto</institution>, Toronto, ON,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Cerebral Blood Flow & Metabolism</title><idno type="ISSN">0271-678X</idno><idno type="eISSN">1559-7016</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>In vivo</italic> imaging of translocator protein 18 kDa (TSPO) has received significant attention as potential biomarker of microglia activation. Several radioligands have been designed with improved properties. Our group recently developed an <sup>18</sup>F-labeled TSPO ligand, [<sup>18</sup>F]-FEPPA, and confirmed its reliability with a 2-tissue compartment model. Here, we extended, in a group of healthy subjects, its suitability for use in voxel-based analysis with the newly proposed graphical analysis approach, Relative-Equilibrium-Gjedde-Patlak (REGP) plot. The REGP plot successfully replicated the total distribution volumes estimated by the 2-tissue compartment model. We also showed its proof-of-concept in a patient with possible meningioma showing increased [<sup>18</sup>F]-FEPPA total distribution volume.</p></div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name></noRegion><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name><name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name><name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><name sortKey="Mizrahi, Romina" sort="Mizrahi, Romina" uniqKey="Mizrahi R" first="Romina" last="Mizrahi">Romina Mizrahi</name><name sortKey="Rusjan, Pablo" sort="Rusjan, Pablo" uniqKey="Rusjan P" first="Pablo" last="Rusjan">Pablo Rusjan</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P" last="Strafella">Antonio P. Strafella</name><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A" last="Wilson">Alan A. Wilson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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