Intact encoding, impaired consolidation in procedural learning in Parkinson's disease
Identifieur interne : 002675 ( Main/Curation ); précédent : 002674; suivant : 002676Intact encoding, impaired consolidation in procedural learning in Parkinson's disease
Auteurs : Henri Cohen [Canada] ; Emmanuelle Pourcher [Canada]Source :
- Experimental brain research [ 0014-4819 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Brain (metabolism), Brain (physiopathology), Dopamine (deficiency), Female, Human, Humans, Idiopathic, Language Tests, Learning, Learning Disorders (etiology), Learning Disorders (physiopathology), Learning Disorders (psychology), Male, Memory Disorders (etiology), Memory Disorders (physiopathology), Memory Disorders (psychology), Middle Aged, Neural Pathways (metabolism), Neural Pathways (physiopathology), Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson disease, Strategy.
- MESH :
- chemical , deficiency : Dopamine.
- complications : Parkinson Disease.
- etiology : Learning Disorders, Memory Disorders.
- metabolism : Brain, Neural Pathways.
- physiopathology : Brain, Learning Disorders, Memory Disorders, Neural Pathways, Parkinson Disease.
- psychology : Learning Disorders, Memory Disorders, Parkinson Disease.
- Female, Humans, Language Tests, Learning, Male, Middle Aged, Neuropsychological Tests.
Abstract
Idiopathic Parkinson's disease (IPD) patients and matched healthy participants were compared on a non-motor procedural task involving semantically related inverted word pairs, and 3 months later to determine the extent of skill consolidation. IPD patients were found to acquire new procedural skills necessary to read these inverted words, thus indicating that they are not impaired in all types of procedural learning. However, results on post-tests 3 months later, revealed significant group differences with IPD subjects showing little off-line learning relative to the controls. This suggests that a dopamine (DA)-deafferented neural system is not consolidated in the same way that a normally DA-innervated system is, and that impaired maintenance of procedures and routines may place IPD patients in a situation of constant relearning of embedded strategies in motor and non-motor domains.
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Pascal:07-0276680Le document en format XML
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<front><div type="abstract" xml:lang="en">Idiopathic Parkinson's disease (IPD) patients and matched healthy participants were compared on a non-motor procedural task involving semantically related inverted word pairs, and 3 months later to determine the extent of skill consolidation. IPD patients were found to acquire new procedural skills necessary to read these inverted words, thus indicating that they are not impaired in all types of procedural learning. However, results on post-tests 3 months later, revealed significant group differences with IPD subjects showing little off-line learning relative to the controls. This suggests that a dopamine (DA)-deafferented neural system is not consolidated in the same way that a normally DA-innervated system is, and that impaired maintenance of procedures and routines may place IPD patients in a situation of constant relearning of embedded strategies in motor and non-motor domains.</div>
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