Stimulation of the subthalamic nucleus and impulsivity: Release your horses
Identifieur interne : 001F52 ( Main/Curation ); précédent : 001F51; suivant : 001F53Stimulation of the subthalamic nucleus and impulsivity: Release your horses
Auteurs : Benedicte Ballanger [Canada] ; Thilo Van Eimeren [Canada] ; Elena Moro [Canada] ; Andres M. Lozano [Canada] ; Clement Hamani [Canada] ; Philippe Boulinguez [France] ; Giovanna Pellecchia [Canada] ; Sylvain Houle [Canada] ; Yu Yan Poon [Canada] ; Anthony E. Lang [Canada] ; Antonio P. Strafella [Canada]Source :
- Annals of Neurology [ 0364-5134 ] ; 2009-12.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Brain Mapping, Cerebrovascular Circulation (physiology), Choice Behavior (physiology), Deep Brain Stimulation (methods), Female, Humans, Impulsive Behavior (diagnostic imaging), Impulsive Behavior (etiology), Impulsive Behavior (therapy), Inhibition (Psychology), Male, Middle Aged, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (diagnostic imaging), Parkinson Disease (therapy), Positron-Emission Tomography (methods), Reaction Time (physiology), Release, Severity of Illness Index, Statistics as Topic, Subthalamic Nucleus (physiology), Subthalamic nucleus.
- MESH :
- complications : Parkinson Disease.
- diagnostic imaging : Impulsive Behavior, Parkinson Disease.
- etiology : Impulsive Behavior.
- methods : Deep Brain Stimulation, Positron-Emission Tomography.
- physiology : Cerebrovascular Circulation, Choice Behavior, Reaction Time, Subthalamic Nucleus.
- therapy : Impulsive Behavior, Parkinson Disease.
- Aged, Brain Mapping, Female, Humans, Inhibition (Psychology), Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Statistics as Topic.
Abstract
In Parkinson disease (PD) patients, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may contribute to certain impulsive behavior during high‐conflict decisions. A neurocomputational model of the basal ganglia has recently been proposed that suggests this behavioral aspect may be related to the role played by the STN in relaying a “hold your horses” signal intended to allow more time to settle on the best option. The aim of the present study was 2‐fold: 1) to extend these observations by providing evidence that the STN may influence and prevent the execution of any response even during low‐conflict decisions; and 2) to identify the neural correlates of this effect.
Url:
- https://api-v5.istex.fr/document/AB7C332B7502633DABAFE6533BC4527DC0142038/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972250
DOI: 10.1002/ana.21795
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<front><div type="abstract">In Parkinson disease (PD) patients, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may contribute to certain impulsive behavior during high‐conflict decisions. A neurocomputational model of the basal ganglia has recently been proposed that suggests this behavioral aspect may be related to the role played by the STN in relaying a “hold your horses” signal intended to allow more time to settle on the best option. The aim of the present study was 2‐fold: 1) to extend these observations by providing evidence that the STN may influence and prevent the execution of any response even during low‐conflict decisions; and 2) to identify the neural correlates of this effect.</div>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Stimulation of the Subthalamic Nucleus and Impulsivity: Release Your Horses</title>
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<series><title level="j" type="main">Annals of neurology</title>
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<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term>
<term>Release</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term>
<term>Noyau sousthalamique</term>
<term>Libération</term>
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<front><div type="abstract" xml:lang="en">Objective: In Parkinson disease (PD) patients, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may contribute to certain impulsive behavior during high-conflict decisions. A neurocomputational model of the basal ganglia has recently been proposed that suggests this behavioral aspect may be related to the role played by the STN in relaying a "hold your horses" signal intended to allow more time to settle on the best option. The aim of the present study was 2-fold: 1) to extend these observations by providing evidence that the STN may influence and prevent the execution of any response even during low-conflict decisions; and 2) to identify the neural correlates of this effect. Methods: We measured regional cerebral blood flow during a Go/NoGo and a control (Go) task to study the motor improvement and response inhibition deficits associated with STN-DBS in patients with PD. Results: Although it improved Unified Parkinson Disease Rating Scale motor ratings and induced a global decrease in reaction time during task performance, STN-DBS impaired response inhibition, as revealed by an increase in commission errors in NoGo trials. These behavioral effects were accompanied by changes in synaptic activity consisting of a reduced activation in the cortical networks responsible for reactive and proactive response inhibition. Interpretation: The present results suggest that although it improves motor functions in PD patients, modulation of STN hyperactivity with DBS may tend at the same time to favor the appearance of impulsive behavior by acting on the gating mechanism involved in response initiation.</div>
</front>
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<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Stimulation of the subthalamic nucleus and impulsivity: Release your horses</title>
<author><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Benedicte" last="Ballanger">Benedicte Ballanger</name>
</author>
<author><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name>
</author>
<author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name>
</author>
<author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
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<author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name>
</author>
<author><name sortKey="Boulinguez, Philippe" sort="Boulinguez, Philippe" uniqKey="Boulinguez P" first="Philippe" last="Boulinguez">Philippe Boulinguez</name>
</author>
<author><name sortKey="Pellecchia, Giovanna" sort="Pellecchia, Giovanna" uniqKey="Pellecchia G" first="Giovanna" last="Pellecchia">Giovanna Pellecchia</name>
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<author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name>
</author>
<author><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu Yan" last="Poon">Yu Yan Poon</name>
</author>
<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
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<author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name>
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<author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name>
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<series><title level="j">Annals of Neurology</title>
<title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title>
<title level="j" type="abbrev">Ann Neurol.</title>
<idno type="ISSN">0364-5134</idno>
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<date type="published" when="2009-12">2009-12</date>
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<term>Brain Mapping</term>
<term>Cerebrovascular Circulation (physiology)</term>
<term>Choice Behavior (physiology)</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Female</term>
<term>Humans</term>
<term>Impulsive Behavior (diagnostic imaging)</term>
<term>Impulsive Behavior (etiology)</term>
<term>Impulsive Behavior (therapy)</term>
<term>Inhibition (Psychology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (therapy)</term>
<term>Positron-Emission Tomography (methods)</term>
<term>Reaction Time (physiology)</term>
<term>Severity of Illness Index</term>
<term>Statistics as Topic</term>
<term>Subthalamic Nucleus (physiology)</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
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<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Impulsive Behavior</term>
</keywords>
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<term>Brain Mapping</term>
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<term>Inhibition (Psychology)</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract">In Parkinson disease (PD) patients, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may contribute to certain impulsive behavior during high‐conflict decisions. A neurocomputational model of the basal ganglia has recently been proposed that suggests this behavioral aspect may be related to the role played by the STN in relaying a “hold your horses” signal intended to allow more time to settle on the best option. The aim of the present study was 2‐fold: 1) to extend these observations by providing evidence that the STN may influence and prevent the execution of any response even during low‐conflict decisions; and 2) to identify the neural correlates of this effect.</div>
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