Uncovering the role of the insula in non-motor symptoms of Parkinson's disease
Identifieur interne : 000B81 ( Main/Curation ); précédent : 000B80; suivant : 000B82Uncovering the role of the insula in non-motor symptoms of Parkinson's disease
Auteurs : Leigh Christopher [Canada] ; Yuko Koshimori [Canada] ; Anthony E. Lang [Canada] ; Marion Criaud [Canada] ; Antonio P. Strafella [Canada]Source :
- Brain [ 0006-8950 ] ; 2014.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- metabolism : Cerebral Cortex.
- physiopathology : Cerebral Cortex, Parkinson Disease.
- Humans.
Abstract
Patients with Parkinson's disease experience a range of non-motor symptoms, including cognitive impairment, behavioural changes, somatosensory and autonomic disturbances. The insula, which was once thought to be primarily a limbic cortical structure, is now known to be highly involved in integrating somatosensory, autonomic and cognitive-affective information to guide behaviour. Thus, it acts as a central hub for processing relevant information related to the state of the body as well as cognitive and mood states. Despite these crucial functions, the insula has been largely overlooked as a potential key region in contributing to non-motor symptoms of Parkinson's disease. The insula is affected in Parkinson's disease by alpha-synuclein deposition, disruptions in normal neurotransmitter function, alterations in connectivity as well as metabolic and structural changes. Although research focusing on the role of the insula in Parkinson's disease is scarce, there is evidence from neuroimaging studies linking the insula to cognitive decline, behavioural abnormalities and somatosensory disturbances. Here, we review imaging studies that provide insight into the potential role of the insula in Parkinson's disease non-motor symptoms.
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Pascal:14-0194913Le document en format XML
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<front><div type="abstract" xml:lang="en">Patients with Parkinson's disease experience a range of non-motor symptoms, including cognitive impairment, behavioural changes, somatosensory and autonomic disturbances. The insula, which was once thought to be primarily a limbic cortical structure, is now known to be highly involved in integrating somatosensory, autonomic and cognitive-affective information to guide behaviour. Thus, it acts as a central hub for processing relevant information related to the state of the body as well as cognitive and mood states. Despite these crucial functions, the insula has been largely overlooked as a potential key region in contributing to non-motor symptoms of Parkinson's disease. The insula is affected in Parkinson's disease by alpha-synuclein deposition, disruptions in normal neurotransmitter function, alterations in connectivity as well as metabolic and structural changes. Although research focusing on the role of the insula in Parkinson's disease is scarce, there is evidence from neuroimaging studies linking the insula to cognitive decline, behavioural abnormalities and somatosensory disturbances. Here, we review imaging studies that provide insight into the potential role of the insula in Parkinson's disease non-motor symptoms.</div>
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<double idat="0006-8950:2014:Christopher L:uncovering:the:role"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Uncovering the role of the insula in non-motor symptoms of Parkinson's disease</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Uncovering the role of the insula in non-motor symptoms of Parkinson's disease</title>
<author><name sortKey="Christopher, Leigh" sort="Christopher, Leigh" uniqKey="Christopher L" first="Leigh" last="Christopher">Leigh Christopher</name>
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<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
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<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Criaud, Marion" sort="Criaud, Marion" uniqKey="Criaud M" first="Marion" last="Criaud">Marion Criaud</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
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<author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name>
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<s2>Toronto, Ontario</s2>
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</analytic>
<series><title level="j" type="main">Brain</title>
<title level="j" type="abbreviated">Brain</title>
<idno type="ISSN">0006-8950</idno>
<imprint><date when="2014">2014</date>
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<seriesStmt><title level="j" type="main">Brain</title>
<title level="j" type="abbreviated">Brain</title>
<idno type="ISSN">0006-8950</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognition</term>
<term>Motor system disorder</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Trouble moteur</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>Cognition</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Patients with Parkinson's disease experience a range of non-motor symptoms, including cognitive impairment, behavioural changes, somatosensory and autonomic disturbances. The insula, which was once thought to be primarily a limbic cortical structure, is now known to be highly involved in integrating somatosensory, autonomic and cognitive-affective information to guide behaviour. Thus, it acts as a central hub for processing relevant information related to the state of the body as well as cognitive and mood states. Despite these crucial functions, the insula has been largely overlooked as a potential key region in contributing to non-motor symptoms of Parkinson's disease. The insula is affected in Parkinson's disease by alpha-synuclein deposition, disruptions in normal neurotransmitter function, alterations in connectivity as well as metabolic and structural changes. Although research focusing on the role of the insula in Parkinson's disease is scarce, there is evidence from neuroimaging studies linking the insula to cognitive decline, behavioural abnormalities and somatosensory disturbances. Here, we review imaging studies that provide insight into the potential role of the insula in Parkinson's disease non-motor symptoms.</div>
</front>
</TEI>
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<PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Uncovering the role of the insula in non-motor symptoms of Parkinson’s disease</title>
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<orgName type="university">Université de Toronto</orgName>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Uncovering the role of the insula in non-motor symptoms of Parkinson’s disease</title>
<author><name sortKey="Christopher, Leigh" sort="Christopher, Leigh" uniqKey="Christopher L" first="Leigh" last="Christopher">Leigh Christopher</name>
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<author><name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name>
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<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
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<author><name sortKey="Criaud, Marion" sort="Criaud, Marion" uniqKey="Criaud M" first="Marion" last="Criaud">Marion Criaud</name>
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<idno type="ISSN">0006-8950</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebral Cortex (metabolism)</term>
<term>Cerebral Cortex (physiopathology)</term>
<term>Humans</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (physiopathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebral Cortex</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
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<front><div type="abstract" xml:lang="en"><p>The role of the insula in integrating cognitive, affective, autonomic and somatosensory information to guide behaviour is increasingly well recognized. However, the involvement of the insula in Parkinson's disease is often overlooked. Christopher <italic>et al.</italic>
review studies linking the insula to non-motor symptoms, including cognitive decline, affective and somatosensory disturbances.</p>
</div>
</front>
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