Uncovering the role of the insula in non-motor symptoms of Parkinson’s disease
Identifieur interne : 000028 ( Pmc/Corpus ); précédent : 000027; suivant : 000029Uncovering the role of the insula in non-motor symptoms of Parkinson’s disease
Auteurs : Leigh Christopher ; Yuko Koshimori ; Anthony E. Lang ; Marion Criaud ; Antonio P. StrafellaSource :
- Brain [ 0006-8950 ] ; 2014.
Abstract
The role of the insula in integrating cognitive, affective, autonomic and somatosensory information to guide behaviour is increasingly well recognized. However, the involvement of the insula in Parkinson's disease is often overlooked. Christopher
Url:
DOI: 10.1093/brain/awu084
PubMed: 24736308
PubMed Central: 4107733
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PMC:4107733Le document en format XML
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Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF2">2 Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF3">3 Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name><affiliation><nlm:aff id="awu084-AFF1">1 Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF2">2 Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF3">3 Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation><nlm:aff id="awu084-AFF1">1 Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Criaud, Marion" sort="Criaud, Marion" uniqKey="Criaud M" first="Marion" last="Criaud">Marion Criaud</name><affiliation><nlm:aff id="awu084-AFF2">2 Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF3">3 Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><affiliation><nlm:aff id="awu084-AFF1">1 Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF2">2 Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF3">3 Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24736308</idno><idno type="pmc">4107733</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107733</idno><idno type="RBID">PMC:4107733</idno><idno type="doi">10.1093/brain/awu084</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000028</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000028</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Uncovering the role of the insula in non-motor symptoms of Parkinson’s disease</title><author><name sortKey="Christopher, Leigh" sort="Christopher, Leigh" uniqKey="Christopher L" first="Leigh" last="Christopher">Leigh Christopher</name><affiliation><nlm:aff id="awu084-AFF1">1 Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF2">2 Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF3">3 Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name><affiliation><nlm:aff id="awu084-AFF1">1 Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF2">2 Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF3">3 Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation><nlm:aff id="awu084-AFF1">1 Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Criaud, Marion" sort="Criaud, Marion" uniqKey="Criaud M" first="Marion" last="Criaud">Marion Criaud</name><affiliation><nlm:aff id="awu084-AFF2">2 Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF3">3 Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><affiliation><nlm:aff id="awu084-AFF1">1 Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF2">2 Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="awu084-AFF3">3 Research Institute, UHN, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author></analytic><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The role of the insula in integrating cognitive, affective, autonomic and somatosensory information to guide behaviour is increasingly well recognized. However, the involvement of the insula in Parkinson's disease is often overlooked. Christopher <italic>et al.</italic> review studies linking the insula to non-motor symptoms, including cognitive decline, affective and somatosensory disturbances.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Brain</journal-id><journal-id journal-id-type="iso-abbrev">Brain</journal-id><journal-id journal-id-type="publisher-id">brainj</journal-id><journal-id journal-id-type="hwp">brain</journal-id><journal-title-group><journal-title>Brain</journal-title></journal-title-group><issn pub-type="ppub">0006-8950</issn><issn pub-type="epub">1460-2156</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24736308</article-id><article-id pub-id-type="pmc">4107733</article-id><article-id pub-id-type="doi">10.1093/brain/awu084</article-id><article-id pub-id-type="publisher-id">awu084</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Articles</subject></subj-group><series-title>Editor's Choice</series-title></article-categories><title-group><article-title>Uncovering the role of the insula in non-motor symptoms of Parkinson’s disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Christopher</surname><given-names>Leigh</given-names></name><xref ref-type="aff" rid="awu084-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awu084-AFF2"><sup>2</sup></xref><xref ref-type="aff" rid="awu084-AFF3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Koshimori</surname><given-names>Yuko</given-names></name><xref ref-type="aff" rid="awu084-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awu084-AFF2"><sup>2</sup></xref><xref ref-type="aff" rid="awu084-AFF3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lang</surname><given-names>Anthony E.</given-names></name><xref ref-type="aff" rid="awu084-AFF1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Criaud</surname><given-names>Marion</given-names></name><xref ref-type="aff" rid="awu084-AFF2"><sup>2</sup></xref><xref ref-type="aff" rid="awu084-AFF3"><sup>3</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Strafella</surname><given-names>Antonio P.</given-names></name><xref ref-type="aff" rid="awu084-AFF1"><sup>1</sup></xref><xref ref-type="aff" rid="awu084-AFF2"><sup>2</sup></xref><xref ref-type="aff" rid="awu084-AFF3"><sup>3</sup></xref></contrib><aff id="awu084-AFF1">1 Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada</aff><aff id="awu084-AFF2">2 Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</aff><aff id="awu084-AFF3">3 Research Institute, UHN, University of Toronto, Ontario, Canada</aff></contrib-group><author-notes><corresp>Correspondence to: Antonio P. Strafella, M.D. PhD FRCPC, Toronto Western Hospital and Institute, CAMH-Research Imaging Centre, University of Toronto, Toronto, ON, Canada, M5T 1R8 E-mail: <email>antonio.strafella@uhnres.utoronto.ca</email> or <email>antonio.strafella@camhpet.ca</email></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>8</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>137</volume><issue>8</issue><fpage>2143</fpage><lpage>2154</lpage><history><date date-type="received"><day>16</day><month>1</month><year>2014</year></date><date date-type="rev-recd"><day>6</day><month>2</month><year>2014</year></date><date date-type="accepted"><day>20</day><month>2</month><year>2014</year></date></history><permissions><copyright-statement>© The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract abstract-type="precis"><p>The role of the insula in integrating cognitive, affective, autonomic and somatosensory information to guide behaviour is increasingly well recognized. However, the involvement of the insula in Parkinson's disease is often overlooked. Christopher <italic>et al.</italic> review studies linking the insula to non-motor symptoms, including cognitive decline, affective and somatosensory disturbances.</p></abstract><abstract><p>Patients with Parkinson’s disease experience a range of non-motor symptoms, including cognitive impairment, behavioural changes, somatosensory and autonomic disturbances. The insula, which was once thought to be primarily a limbic cortical structure, is now known to be highly involved in integrating somatosensory, autonomic and cognitive-affective information to guide behaviour. Thus, it acts as a central hub for processing relevant information related to the state of the body as well as cognitive and mood states. Despite these crucial functions, the insula has been largely overlooked as a potential key region in contributing to non-motor symptoms of Parkinson’s disease. The insula is affected in Parkinson’s disease by alpha-synuclein deposition, disruptions in normal neurotransmitter function, alterations in connectivity as well as metabolic and structural changes. Although research focusing on the role of the insula in Parkinson’s disease is scarce, there is evidence from neuroimaging studies linking the insula to cognitive decline, behavioural abnormalities and somatosensory disturbances. Here, we review imaging studies that provide insight into the potential role of the insula in Parkinson’s disease non-motor symptoms.</p></abstract><kwd-group kwd-group-type="keywords"><kwd>Parkinson’s disease</kwd><kwd>neuroimaging</kwd><kwd>insula</kwd><kwd>cognition</kwd><kwd>behaviour</kwd></kwd-group><counts><page-count count="12"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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